SRA1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SRA1
Entrez Gene ID	10011
Full Name	steroid receptor RNA activator 1
Synonyms	SRA,SRAP,STRAA1,pp7684
General protein information	Preferred Names steroid receptor RNA activator 1 Names steroid receptor RNA activator 1 steroid receptor RNA activator 1 (complexes with NCOA1) steroid receptor RNA activator protein steroid receptor coactivator
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.3
Summary	Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012].
Disorder MIM:	603819

mRNA and Protein(s)

mRNA	Protein	Name
NM_001253764.1	NP_001240693.1	steroid receptor RNA activator 1 isoform 2
NM_001035235.3	NP_001030312.2	steroid receptor RNA activator 1 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SRA1	XP_001137717.2
	SRA1	XP_001086694.2
Homo sapiens (human)	SRA1	NP_001030312.2
Danio rerio (zebrafish)	sra1	NP_001002047.1
Mus musculus (house mouse)	Sra1	NP_079567.2
Canis lupus familiaris (dog)	SRA1	XP_005617340.1
Rattus norvegicus (Norway rat)	Sra1	NP_899158.3
Xenopus tropicalis (tropical clawed frog)	sra1	NP_001107371.1
Bos taurus (cattle)	SRA1	NP_001073110.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural architecture of the human long non-coding RNA, steroid receptor RNA activator.
Novikova IV, Hennelly SP, Sanbonmatsu KY
Nucleic acids research40(11)5034-51(2012 Jun)

Steroid Receptor RNA Activator bi-faceted genetic system: Heads or Tails?
Cooper C, Vincett D, Yan Y, Hamedani MK, Myal Y, Leygue E
Biochimie93(11)1973-80(2011 Nov)

Steroid Receptor RNA Activator - A nuclear receptor coregulator with multiple partners: Insights and challenges.
Colley SM, Leedman PJ
Biochimie93(11)1966-72(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SRA1 was down expressed in HCC and its level was associated with tumor size and GLU level in patients with HCC for the first time. SRA1 may be a helpful biomarker to diagnostic HCC.
Title: Decreased expression of LncRNA SRA1 in hepatocellular carcinoma and its clinical significance.

Results identified H15-H18 domains in SRA gene playing a key role in regulating ER-mediated transcription.
Title: Truncated SRA RNA derivatives inhibit estrogen receptor-?-mediated transcription.

REVIEW: Biologic function and role in disease
Title: Steroid receptor RNA activator: Biologic function and role in disease.

By studying a cohort of idiopathic hypogonadotropic hypogonadism, our findings strongly suggest that SRA1 gene function is required for initiation of puberty in humans
Title: Idiopathic Hypogonadotropic Hypogonadism Caused by Inactivating Mutations in SRA1.

These findings suggest that SRA genetic variants may contribute to breast cancer risk
Title: Genetic variants in lncRNA SRA and risk of breast cancer.

The following SRA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SRA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu20132	NM_001035235.3 Latest version!	Homo sapiens steroid receptor RNA activator 1 (SRA1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu20048	NM_001253764.1 Latest version!	Homo sapiens steroid receptor RNA activator 1 (SRA1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SRA1 ( NM_001035235.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001030312.2 Homo sapiens steroid receptor RNA activator 1 (SRA1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20132
Clone ID Related Accession (Same CDS sequence)	NM_001035235.3
Accession Version	NM_001035235.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	steroid receptor RNA activator 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF318361.1, CX165918.1, AK024640.1 and AI140060.1. This sequence is a reference standard in the RefSeqGene project. On Dec 2, 2011 this sequence version replaced NM_001035235.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.527460.1, SRR1803614.73008.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## multifunctional gene product(s) :: PMID: 21771633 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACGCGCT GCCCCGCTGG CCAAGCGGAA GTGGAGATGG CGGAGCTGTA CGTGAAGCCG 
GGCAACAAGG AACGCGGCTG GAACGACCCG CCGCAGTTCT CATACGGGCT GCAGACCCAG 
GCCGGCGGAC CCAGGCGCTC GCTGCTTACC AAGAGGGTCG CCGCACCCCA GGATGGATCC 
CCCAGAGTCC CCGCATCAGA GACTTCTCCT GGGCCTCCCC CAATGGGGCC TCCACCTCCT 
TCAAGTAAGG CTCCCAGGTC CCCACCTGTG GGGAGTGGTC CTGCCTCTGG CGTGGAGCCC 
ACAAGTTTCC CAGTCGAGTC TGAGGCTGTG ATGGAGGATG TGCTGAGACC TTTGGAACAG 
GCATTGGAAG ACTGCCGTGG CCACACAAGG AAGCAGGTAT GTGATGACAT CAGCCGACGC 
CTGGCACTGC TGCAGGAACA GTGGGCTGGA GGAAAGTTGT CAATACCTGT AAAGAAGAGA 
ATGGCTCTAC TGGTGCAAGA GCTTTCAAGC CACCGGTGGG ACGCAGCAGA TGACATCCAC 
CGCTCCCTCA TGGTTGACCA TGTGACTGAG GTCAGTCAGT GGATGGTAGG AGTTAAAAGA 
TTAATTGCAG AAAAGAGGAG TCTGTTTTCA GAGGAGGCAG CCAATGAAGA GAAATCTGCA 
GCCACAGCTG AGAAGAACCA TACCATACCA GGCTTCCAGC AGGCTTCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001030312.2
CDS	606..1316
Translation	MTRCPAGQAEVEMAELYVKPGNKERGWNDPPQFSYGLQTQAGGPRRSLLTKRVAAPQDGSPRVPASETSPGPPPMGPPPPSSKAPRSPPVGSGPASGVEPTSFPVESEAVMEDVLRPLEQALEDCRGHTRKQVCDDISRRLALLQEQWAGGKLSIPVKKRMALLVQELSSHRWDAADDIHRSLMVDHVTEVSQWMVGVKRLIAEKRSLFSEEAANEEKSAATAEKNHTIPGFQQAS

Target ORF information:

RefSeq Version	NM_001035235.3
Organism	Homo sapiens(human)
Definition	Homo sapiens steroid receptor RNA activator 1 (SRA1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001035235.3

ORF Insert Sequence:

ATGACGCGCT GCCCCGCTGG CCAAGCGGAA GTGGAGATGG CGGAGCTGTA CGTGAAGCCG 
GGCAACAAGG AACGCGGCTG GAACGACCCG CCGCAGTTCT CATACGGGCT GCAGACCCAG 
GCCGGCGGAC CCAGGCGCTC GCTGCTTACC AAGAGGGTCG CCGCACCCCA GGATGGATCC 
CCCAGAGTCC CCGCATCAGA GACTTCTCCT GGGCCTCCCC CAATGGGGCC TCCACCTCCT 
TCAAGTAAGG CTCCCAGGTC CCCACCTGTG GGGAGTGGTC CTGCCTCTGG CGTGGAGCCC 
ACAAGTTTCC CAGTCGAGTC TGAGGCTGTG ATGGAGGATG TGCTGAGACC TTTGGAACAG 
GCATTGGAAG ACTGCCGTGG CCACACAAGG AAGCAGGTAT GTGATGACAT CAGCCGACGC 
CTGGCACTGC TGCAGGAACA GTGGGCTGGA GGAAAGTTGT CAATACCTGT AAAGAAGAGA 
ATGGCTCTAC TGGTGCAAGA GCTTTCAAGC CACCGGTGGG ACGCAGCAGA TGACATCCAC 
CGCTCCCTCA TGGTTGACCA TGTGACTGAG GTCAGTCAGT GGATGGTAGG AGTTAAAAGA 
TTAATTGCAG AAAAGAGGAG TCTGTTTTCA GAGGAGGCAG CCAATGAAGA GAAATCTGCA 
GCCACAGCTG AGAAGAACCA TACCATACCA GGCTTCCAGC AGGCTTCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SRA1 ( NM_001253764.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001240693.1 Homo sapiens steroid receptor RNA activator 1 (SRA1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20048
Clone ID Related Accession (Same CDS sequence)	NM_001253764.1
Accession Version	NM_001253764.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	steroid receptor RNA activator 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC067895.1, BU553214.1, BQ052761.1 and AI140060.1. Transcript Variant: This variant (2) retains a segment in the 5' coding region and lacks a downstream coding exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct segment in the N-terminal region, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.300689.1, BU553214.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## multifunctional gene product(s) :: PMID: 21771633 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGC TGTACGTGAA GCCGGGTGAG CGCAGCCGGC GGGCTAGGGC ACTAGGTTGT 
CGCCCCGGCC TAGGCTGGGG GCGGTTGCGG CGCTTAGTAT GGACCCTCTG TCTCCCCCAG 
CCCCAGTATA AGCTAACAGT GGAGTTCCGG GCTCGCTTCA CACATCCCTC GCCTCCGCAG 
GCAACAAGGA ACGCGGCTGG AACGACCCGC CGCAGTTCTC ATACGGGCTG CAGACCCAGG 
CCGGCGGACC CAGGCGCTCG CTGCTTACCA AGAGGGTCGC CGCACCCCAG GATGGATCCC 
CCAGAGAAGC AGGTATGTGA TGACATCAGC CGACGCCTGG CACTGCTGCA GGAACAGTGG 
GCTGGAGGAA AGTTGTCAAT ACCTGTAAAG AAGAGAATGG CTCTACTGGT GCAAGAGCTT 
TCAAGCCACC GGTGGGACGC AGCAGATGAC ATCCACCGCT CCCTCATGGT TGACCATGTG 
ACTGAGGTCA GTCAGTGGAT GGTAGGAGTT AAAAGATTAA TTGCAGAAAA GAGGAGTCTG 
TTTTCAGAGG AGGCAGCCAA TGAAGAGAAA TCTGCAGCCA CAGCTGAGAA GAACCATACC 
ATACCAGGCT TCCAGCAGGC TTCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001240693.1
CDS	5..631
Translation	MAELYVKPGERSRRARALGCRPGLGWGRLRRLVWTLCLPQPQYKLTVEFRARFTHPSPPQATRNAAGTTRRSSHTGCRPRPADPGARCLPRGSPHPRMDPPEKQVCDDISRRLALLQEQWAGGKLSIPVKKRMALLVQELSSHRWDAADDIHRSLMVDHVTEVSQWMVGVKRLIAEKRSLFSEEAANEEKSAATAEKNHTIPGFQQAS

Target ORF information:

RefSeq Version	NM_001253764.1
Organism	Homo sapiens(human)
Definition	Homo sapiens steroid receptor RNA activator 1 (SRA1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001253764.1

ORF Insert Sequence:

ATGGCGGAGC TGTACGTGAA GCCGGGTGAG CGCAGCCGGC GGGCTAGGGC ACTAGGTTGT 
CGCCCCGGCC TAGGCTGGGG GCGGTTGCGG CGCTTAGTAT GGACCCTCTG TCTCCCCCAG 
CCCCAGTATA AGCTAACAGT GGAGTTCCGG GCTCGCTTCA CACATCCCTC GCCTCCGCAG 
GCAACAAGGA ACGCGGCTGG AACGACCCGC CGCAGTTCTC ATACGGGCTG CAGACCCAGG 
CCGGCGGACC CAGGCGCTCG CTGCTTACCA AGAGGGTCGC CGCACCCCAG GATGGATCCC 
CCAGAGAAGC AGGTATGTGA TGACATCAGC CGACGCCTGG CACTGCTGCA GGAACAGTGG 
GCTGGAGGAA AGTTGTCAAT ACCTGTAAAG AAGAGAATGG CTCTACTGGT GCAAGAGCTT 
TCAAGCCACC GGTGGGACGC AGCAGATGAC ATCCACCGCT CCCTCATGGT TGACCATGTG 
ACTGAGGTCA GTCAGTGGAT GGTAGGAGTT AAAAGATTAA TTGCAGAAAA GAGGAGTCTG 
TTTTCAGAGG AGGCAGCCAA TGAAGAGAAA TCTGCAGCCA CAGCTGAGAA GAACCATACC 
ATACCAGGCT TCCAGCAGGC TTCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural architecture of the human long non-coding RNA, steroid receptor RNA activator.
Nucleic acids research40(11)5034-51(2012 Jun)
Novikova IV,Hennelly SP,Sanbonmatsu KY

Steroid Receptor RNA Activator bi-faceted genetic system: Heads or Tails?
Biochimie93(11)1973-80(2011 Nov)
Cooper C,Vincett D,Yan Y,Hamedani MK,Myal Y,Leygue E

Steroid Receptor RNA Activator - A nuclear receptor coregulator with multiple partners: Insights and challenges.
Biochimie93(11)1966-72(2011 Nov)
Colley SM,Leedman PJ

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SRA1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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