FOXL2 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	FOXL2
Entrez Gene ID	503512
Full Name	forkhead box L2
General protein information	Preferred Names forkhead box L2 Names forkhead box protein L2 transcription factor FOXL2
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001012612.1	NP_001012630.1	forkhead box protein L2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	FOXL2	NP_001012630.1
Danio rerio (zebrafish)	foxl2	NP_001038717.1
Xenopus tropicalis (tropical clawed frog)	foxl2	XP_004917868.1

Gene Ontology
Bibliography

Related articles in PubMed

Association of novel polymorphisms of forkhead box L2 and growth differentiation factor-9 genes with egg production traits in local Chinese Dagu hens.
Qin N, Liu Q, Zhang YY, Fan XC, Xu XX, Lv ZC, Wei ML, Jing Y, Mu F, Xu RF
Poultry science94(1)88-95(2015 Jan)

Cooperative Effects of FOXL2 with the Members of TGF-? Superfamily on FSH Receptor mRNA Expression and Granulosa Cell Proliferation from Hen Prehierarchical Follicles.
Qin N, Fan XC, Xu XX, Tyasi TL, Li SJ, Zhang YY, Wei ML, Xu RF
PloS one10(10)e0141062(2015)

Aromatase inhibition reduces expression of FOXL2 in the embryonic chicken ovary.
Hudson QJ, Smith CA, Sinclair AH
Developmental dynamics : an official publication of the American Association of Anatomists233(3)1052-5(2005 Jul)

Isolation of chicken homolog of the FOXL2 gene and comparison of its expression patterns with those of aromatase during ovarian development.
Govoroun MS, Pannetier M, Pailhoux E, Cocquet J, Brillard JP, Couty I, Batellier F, Cotinot C
Developmental dynamics : an official publication of the American Association of Anatomists231(4)859-70(2004 Dec)

Etiology of ovarian failure in blepharophimosis ptosis epicanthus inversus syndrome: FOXL2 is a conserved, early-acting gene in vertebrate ovarian development.
Loffler KA, Zarkower D, Koopman P
Endocrinology144(7)3237-43(2003 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Collectively, the two SNPs identified in this study (A238G for FOXL2 and G1609T for GDF9) might be used as possible genetic molecular markers to aid in the improvement of egg production traits in chicken breeding.
Title: Association of novel polymorphisms of forkhead box L2 and growth differentiation factor-9 genes with egg production traits in local Chinese Dagu hens.

Cooperative effects have been found of FOXL2 with the members of TGF-beta superfamily on FSH receptor mRNA expression and granulosa cell proliferation from hen prehierarchical follicles.
Title: Cooperative Effects of FOXL2 with the Members of TGF-? Superfamily on FSH Receptor mRNA Expression and Granulosa Cell Proliferation from Hen Prehierarchical Follicles.

FOXL2 lies upstream of aromatase in avian sex determination
Title: Aromatase inhibition reduces expression of FOXL2 in the embryonic chicken ovary.

FoxL2 is an early regulator of ovarian development in birds and may be involved in aromatase transcription regulation
Title: Isolation of chicken homolog of the FOXL2 gene and comparison of its expression patterns with those of aromatase during ovarian development.

The following FOXL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa01079	NM_001012612.1 Latest version!	Gallus gallus forkhead box L2 (FOXL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FOXL2 ( NM_001012612.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001012630.1 Gallus gallus forkhead box L2 (FOXL2), mRNA.

Price & Availability↑

CloneID	OGa01079
Clone ID Related Accession (Same CDS sequence)	NM_001012612.1
Accession Version	NM_001012612.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-24
Organism	Gallus gallus(chicken)
Product	forkhead box protein L2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY487165.1. ##Evidence-Data-START## Transcript exon combination :: AY487165.1 [ECO:0000332] ##Evidence-Data-END##

ATGATGAGCG GCTACGCGGA CGGCGAGGAG GACGCGGTGG CGATGCTGGC CCATGACGGC 
GGCGGCAGCA AGGAGCCGGA GCGGGGCAAG GAGGAACTGA GCGCCGAGAA GGGCCCCGAG 
AAGCCGGACC CGTCGCAGAA GCCCCCCTAC TCCTACGTGG CCCTGATCGC CATGGCCATA 
CGGGAGAGCG CCGAGAAGAG GCTCACGCTG TCCGGGATCT ACCAGTACAT CATCAGCAAG 
TTCCCTTTCT ACGAGAAGAA CAAGAAGGGC TGGCAGAACA GCATCCGCCA CAACCTCAGC 
CTCAACGAGT GCTTCATCAA GGTGCCCCGC GAGGGCGGCG GCGAGCGCAA GGGCAACTAC 
TGGACGCTGG ACCCCGCCTG CGAGGACATG TTCGAGAAGG GCAACTACCG CCGGCGGCGG 
AGGATGAAGC GGCCTTTCCG GCCGCCCCCG ACTCACTTCC AGCCCGGCAA GAGCCTCTTC 
GGCCCCGACG GCTACGGCTA CCTCTCCCCG CCCAAGTACC TGCAGTCCAC CTTCATGAAC 
AACTCGTGGC CGCTGCCGCA GCCCCCCGCG CCCGTGCCCT ACGCCTCTTG CCAGATGTCC 
GGCGGCAGCG TCAGCCCCGT CAACGTGAAA GGACTCTCGG GCCCTGCCTC CTACGGCCCC 
TACTCGCGGG TGCAGAGCGT GGCGCTGCCT GGCATGGTGA ACTCCTACAA CGGCGTGGCC 
CACCCGCACC ACCCGCACGC CCACCACCCG CAGCAGCTGG GCCCGGCCAG CCCCGCGCCG 
CCCGCCGCCC CGGCTGCGAA CGGAGCCGGC CTCCAGTTCG CCTGCGCCCG CCAGCCCGCC 
GAGCTGTCCG TCATGCACTG TTCCTACTGG GAGCACGACA GCAAACACGG CGCCCTGCAC 
TCCCGCATTG ACATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012630.1
CDS	7..924
Translation	MMSGYADGEEDAVAMLAHDGGGSKEPERGKEELSAEKGPEKPDPSQKPPYSYVALIAMAIRESAEKRLTLSGIYQYIISKFPFYEKNKKGWQNSIRHNLSLNECFIKVPREGGGERKGNYWTLDPACEDMFEKGNYRRRRRMKRPFRPPPTHFQPGKSLFGPDGYGYLSPPKYLQSTFMNNSWPLPQPPAPVPYASCQMSGGSVSPVNVKGLSGPASYGPYSRVQSVALPGMVNSYNGVAHPHHPHAHHPQQLGPASPAPPAAPAANGAGLQFACARQPAELSVMHCSYWEHDSKHGALHSRIDI

Target ORF information:

RefSeq Version	NM_001012612.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus forkhead box L2 (FOXL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012612.1

ORF Insert Sequence:

ATGATGAGCG GCTACGCGGA CGGCGAGGAG GACGCGGTGG CGATGCTGGC CCATGACGGC 
GGCGGCAGCA AGGAGCCGGA GCGGGGCAAG GAGGAACTGA GCGCCGAGAA GGGCCCCGAG 
AAGCCGGACC CGTCGCAGAA GCCCCCCTAC TCCTACGTGG CCCTGATCGC CATGGCCATA 
CGGGAGAGCG CCGAGAAGAG GCTCACGCTG TCCGGGATCT ACCAGTACAT CATCAGCAAG 
TTCCCTTTCT ACGAGAAGAA CAAGAAGGGC TGGCAGAACA GCATCCGCCA CAACCTCAGC 
CTCAACGAGT GCTTCATCAA GGTGCCCCGC GAGGGCGGCG GCGAGCGCAA GGGCAACTAC 
TGGACGCTGG ACCCCGCCTG CGAGGACATG TTCGAGAAGG GCAACTACCG CCGGCGGCGG 
AGGATGAAGC GGCCTTTCCG GCCGCCCCCG ACTCACTTCC AGCCCGGCAA GAGCCTCTTC 
GGCCCCGACG GCTACGGCTA CCTCTCCCCG CCCAAGTACC TGCAGTCCAC CTTCATGAAC 
AACTCGTGGC CGCTGCCGCA GCCCCCCGCG CCCGTGCCCT ACGCCTCTTG CCAGATGTCC 
GGCGGCAGCG TCAGCCCCGT CAACGTGAAA GGACTCTCGG GCCCTGCCTC CTACGGCCCC 
TACTCGCGGG TGCAGAGCGT GGCGCTGCCT GGCATGGTGA ACTCCTACAA CGGCGTGGCC 
CACCCGCACC ACCCGCACGC CCACCACCCG CAGCAGCTGG GCCCGGCCAG CCCCGCGCCG 
CCCGCCGCCC CGGCTGCGAA CGGAGCCGGC CTCCAGTTCG CCTGCGCCCG CCAGCCCGCC 
GAGCTGTCCG TCATGCACTG TTCCTACTGG GAGCACGACA GCAAACACGG CGCCCTGCAC 
TCCCGCATTG ACATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association of novel polymorphisms of forkhead box L2 and growth differentiation factor-9 genes with egg production traits in local Chinese Dagu hens.
Poultry science94(1)88-95(2015 Jan)
Qin N,Liu Q,Zhang YY,Fan XC,Xu XX,Lv ZC,Wei ML,Jing Y,Mu F,Xu RF

Cooperative Effects of FOXL2 with the Members of TGF-? Superfamily on FSH Receptor mRNA Expression and Granulosa Cell Proliferation from Hen Prehierarchical Follicles.
PloS one10(10)e0141062(2015)
Qin N,Fan XC,Xu XX,Tyasi TL,Li SJ,Zhang YY,Wei ML,Xu RF

Aromatase inhibition reduces expression of FOXL2 in the embryonic chicken ovary.
Developmental dynamics : an official publication of the American Association of Anatomists233(3)1052-5(2005 Jul)
Hudson QJ,Smith CA,Sinclair AH

Isolation of chicken homolog of the FOXL2 gene and comparison of its expression patterns with those of aromatase during ovarian development.
Developmental dynamics : an official publication of the American Association of Anatomists231(4)859-70(2004 Dec)
Govoroun MS,Pannetier M,Pailhoux E,Cocquet J,Brillard JP,Couty I,Batellier F,Cotinot C

Etiology of ovarian failure in blepharophimosis ptosis epicanthus inversus syndrome: FOXL2 is a conserved, early-acting gene in vertebrate ovarian development.
Endocrinology144(7)3237-43(2003 Jul)
Loffler KA,Zarkower D,Koopman P