TXNRD2 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	TXNRD2
Entrez Gene ID	416782
Full Name	thioredoxin reductase 2
General protein information	Preferred Names thioredoxin reductase 2 Names thioredoxin reductase 2, mitochondrial
Gene Type	protein-coding
Organism	Gallus gallus(chicken)
Summary	The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. Studies in chicken suggest that this TrxR is essential for cell viability, playing a crucial role in regulating mitochondria-dependent apoptosis. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001122691.1	NP_001116163.1	thioredoxin reductase 2, mitochondrial
NM_001122691.2	NP_001116163.2	thioredoxin reductase 2, mitochondrial precursor

Pathways from BioSystems

Homologies

	TXNRD2	NP_001152971.1
Drosophila melanogaster (fruit fly)	Trxr-2	NP_524216.1
Drosophila melanogaster (fruit fly)	Trxr-1	NP_727252.1
Anopheles gambiae (African malaria mosquito)	TRXR	XP_003437030.1
Caenorhabditis elegans (roundworm)	trxr-2	NP_498971.1
Homo sapiens (human)	TXNRD2	NP_006431.2
Mus musculus (house mouse)	Txnrd2	NP_038739.2
Rattus norvegicus (Norway rat)	Txnrd2	NP_072106.1
Pan troglodytes (chimpanzee)	TXNRD2	XP_001166615.2
Xenopus tropicalis (tropical clawed frog)	txnrd2	NP_001120487.1
Canis lupus familiaris (dog)	TXNRD2	XP_005636641.1
Bos taurus (cattle)	TXNRD2	NP_777051.1
Gallus gallus (chicken)	TXNRD2	NP_001116163.1

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

Acetyl-L-carnitine suppresses apoptosis of thioredoxin 2-deficient DT40 cells.
Zhu X, Sato EF, Wang Y, Nakamura H, Yodoi J, Inoue M
Archives of biochemistry and biophysics478(2)154-60(2008 Oct)

Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index.
Carre W, Wang X, Porter TE, Nys Y, Tang J, Bernberg E, Morgan R, Burnside J, Aggrey SE, Simon J, Cogburn LA
Physiological genomics25(3)514-24(2006 May)

ESTs from brain and testis of White Leghorn and red junglefowl: annotation, bioinformatic classification of unknown transcripts and analysis of expression levels.
Savolainen P, Fitzsimmons C, Arvestad L, Andersson L, Lundeberg J
Cytogenetic and genome research111(1)79-87(2005)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Thioredoxin-2 (TRX-2) signals caspase-3 and 9, but not caspase-8
Title: Acetyl-L-carnitine suppresses apoptosis of thioredoxin 2-deficient DT40 cells.

Trx-2-deficient DT40 cells undergo mitochondrial apoptosis
Title: Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis.

The following TXNRD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TXNRD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa00907	NM_001122691.1 Latest version!	Gallus gallus thioredoxin reductase 2 (TXNRD2), nuclear gene encoding mitochondrial protein, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00
OGa141660	NM_001122691.2 Latest version!	Gallus gallus thioredoxin reductase 2 (TXNRD2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$342.30 $489.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TXNRD2 ( NM_001122691.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001116163.1 Gallus gallus thioredoxin reductase 2 (TXNRD2), nuclear gene encoding mitochondrial protein, mRNA.

Price & Availability↑

CloneID	OGa00907
Clone ID Related Accession (Same CDS sequence)	NM_001122691.1
Accession Version	NM_001122691.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1557bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2012-05-04
Organism	Gallus gallus(Chicken)
Product	thioredoxin reductase 2, mitochondrial
Comment	VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM439932.1, BU279804.1, CN230808.1, AADN02034786.1, BU143260.1, CR390511.1, DN850367.1, BU466246.1 and BU421959.1. On Mar 19, 2008 this sequence version replaced XM_415076.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. COMPLETENESS: complete on the 3' end.

ATGGCGGCGC TGTGGCGGCG GGGGGAGCGC TTCCTGGGGG TGCCGGGGCT GTGCCGTACG 
GCGCGAGCTC TCTCAGGAAA GAAGGAGTAT GACCTGCTGG TCATTGGTGG TGGATCTGGA 
GGCCTTGCTT GTGCAAAAGA AGCTGCTCAG TTTGGGAAGA ATGTGGCTGT TTTGGATTAC 
GTTGAACCTT CTCCACGAGG AACCAAGTGG GGACTTGGTG GAACTTGTGT AAACGTTGGC 
TGCATTCCTA AAAAGCTTAT GCATCAGGCA GCCCTTTTAG GGGGAGCTCT TAAAGATGCC 
CAGCACTACG GCTGGAGTGT AGCCCACCCA GTTCATCACA ACTGGTCTGT GATGGCTCAA 
GCTGTTCAGA ATTATGTGAA ATCCCTGAAC TGGGGACACA GAGTGCAGCT ACAAGACAAG 
AAGGTGAAAT ATTTCAACAT GAAAGGAAGT TTTTCAGATT CCCATACAGT CTGTGGTATA 
GCAAAAGGAG GTAAAGAGAC TACTCTTACT GCTGAAAAAA TTGTCATTGC TACTGGAGGA 
AGACCAAAAT ATCCTACACA TATTACGGGC GCACTGGAGT ATGGAATCAC AAGTGATGAT 
CTATTCTGGT TAAAAGACTC TCCTGGAAAA ACGTTGGTTG TTGGAGCCAG CTATGTTTCA 
CTTGAATGTG CTGGTTTTCT AACTGGTATT GGATTGGACA CTACAGTCAT AATGAGAATC 
ATAATGAGAA GTATCCCACT TCGTGGATTT GATCAGCAAA TGGCGTCTTT AGTAACTGAG 
CACATGGAAT CTTATGGCAC AAAATTTTTA AAGAAATGTG TCCCAGCGAA AGTTGAAAAA 
TTGGAAAGCA GCAGGTTACA AGTCACCTGG AAAAATACTG AGTTGGGCAC AGAAGAAACG 
GATTCCTTTG ACACAGTGAT GTGGGCAGTA GGCCGGGTCC CTGACATCAA AACTCTCAAT 
TTGGACTCTG TTGGAGTGAA AACTAATTCT GAAACTGGAA AGATCATTGT TGATGCCAGC 
GAAGCTACTT CTGTTCCTCA CATTTATGCA ATTGGAGACA TAACAGAGGG CCGTCCTGAA 
CTGACACCCA CAGCAATAGC TGCAGGGAAA CTGCTGGCTC GGCGTCTTTT TGGCCACTCT 
TCAGAACTGA TGGACTATGA CAATGTACCT ACTACAGTTT TCACTCCCTT GGAATATGGT 
TGTGTTGGAC TGTCAGAAGA AAAGGCTGTG CAGTGTTATG GATCAGATAA TGTTGAGGTA 
TTTCATGCTT ATTATAAACC TCTAGAGTTC ACAGTGGCTG AAAGAGATGC TGCTCAGTGT 
TATATAAAAA TGGTGTGCTT ACGAGAGAGA GAGCAACGAA TCCTTGGCCT TCATTTCATT 
GGACCAAATG CTGGGGAAGT TATTCAAGGA TTTGCTCTTG GAATCAAATG TGGTGCTACA 
TATCCTCAGC TAATGAAGAC AATTGGCATT CACCCTACCT GTGCTGAGGA AATTACCAAG 
TTGCATATTA CAAAACGTTC CGGCCTGGAT GCAACAGTAA CAGGTTGCTG AGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116163.1
CDS	86..1642
Translation	MAALWRRGERFLGVPGLCRTARALSGKKEYDLLVIGGGSGGLACAKEAAQFGKNVAVLDYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQAALLGGALKDAQHYGWSVAHPVHHNWSVMAQAVQNYVKSLNWGHRVQLQDKKVKYFNMKGSFSDSHTVCGIAKGGKETTLTAEKIVIATGGRPKYPTHITGALEYGITSDDLFWLKDSPGKTLVVGASYVSLECAGFLTGIGLDTTVIMRIIMRSIPLRGFDQQMASLVTEHMESYGTKFLKKCVPAKVEKLESSRLQVTWKNTELGTEETDSFDTVMWAVGRVPDIKTLNLDSVGVKTNSETGKIIVDASEATSVPHIYAIGDITEGRPELTPTAIAAGKLLARRLFGHSSELMDYDNVPTTVFTPLEYGCVGLSEEKAVQCYGSDNVEVFHAYYKPLEFTVAERDAAQCYIKMVCLREREQRILGLHFIGPNAGEVIQGFALGIKCGATYPQLMKTIGIHPTCAEEITKLHITKRSGLDATVTGC*G

Target ORF information:

RefSeq Version	NM_001122691.1
Organism	Gallus gallus(Chicken)
Definition	Gallus gallus thioredoxin reductase 2 (TXNRD2), nuclear gene encoding mitochondrial protein, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001122691.1

ORF Insert Sequence:

ATGGCGGCGC TGTGGCGGCG GGGGGAGCGC TTCCTGGGGG TGCCGGGGCT GTGCCGTACG 
GCGCGAGCTC TCTCAGGAAA GAAGGAGTAT GACCTGCTGG TCATTGGTGG TGGATCTGGA 
GGCCTTGCTT GTGCAAAAGA AGCTGCTCAG TTTGGGAAGA ATGTGGCTGT TTTGGATTAC 
GTTGAACCTT CTCCACGAGG AACCAAGTGG GGACTTGGTG GAACTTGTGT AAACGTTGGC 
TGCATTCCTA AAAAGCTTAT GCATCAGGCA GCCCTTTTAG GGGGAGCTCT TAAAGATGCC 
CAGCACTACG GCTGGAGTGT AGCCCACCCA GTTCATCACA ACTGGTCTGT GATGGCTCAA 
GCTGTTCAGA ATTATGTGAA ATCCCTGAAC TGGGGACACA GAGTGCAGCT ACAAGACAAG 
AAGGTGAAAT ATTTCAACAT GAAAGGAAGT TTTTCAGATT CCCATACAGT CTGTGGTATA 
GCAAAAGGAG GTAAAGAGAC TACTCTTACT GCTGAAAAAA TTGTCATTGC TACTGGAGGA 
AGACCAAAAT ATCCTACACA TATTACGGGC GCACTGGAGT ATGGAATCAC AAGTGATGAT 
CTATTCTGGT TAAAAGACTC TCCTGGAAAA ACGTTGGTTG TTGGAGCCAG CTATGTTTCA 
CTTGAATGTG CTGGTTTTCT AACTGGTATT GGATTGGACA CTACAGTCAT AATGAGAATC 
ATAATGAGAA GTATCCCACT TCGTGGATTT GATCAGCAAA TGGCGTCTTT AGTAACTGAG 
CACATGGAAT CTTATGGCAC AAAATTTTTA AAGAAATGTG TCCCAGCGAA AGTTGAAAAA 
TTGGAAAGCA GCAGGTTACA AGTCACCTGG AAAAATACTG AGTTGGGCAC AGAAGAAACG 
GATTCCTTTG ACACAGTGAT GTGGGCAGTA GGCCGGGTCC CTGACATCAA AACTCTCAAT 
TTGGACTCTG TTGGAGTGAA AACTAATTCT GAAACTGGAA AGATCATTGT TGATGCCAGC 
GAAGCTACTT CTGTTCCTCA CATTTATGCA ATTGGAGACA TAACAGAGGG CCGTCCTGAA 
CTGACACCCA CAGCAATAGC TGCAGGGAAA CTGCTGGCTC GGCGTCTTTT TGGCCACTCT 
TCAGAACTGA TGGACTATGA CAATGTACCT ACTACAGTTT TCACTCCCTT GGAATATGGT 
TGTGTTGGAC TGTCAGAAGA AAAGGCTGTG CAGTGTTATG GATCAGATAA TGTTGAGGTA 
TTTCATGCTT ATTATAAACC TCTAGAGTTC ACAGTGGCTG AAAGAGATGC TGCTCAGTGT 
TATATAAAAA TGGTGTGCTT ACGAGAGAGA GAGCAACGAA TCCTTGGCCT TCATTTCATT 
GGACCAAATG CTGGGGAAGT TATTCAAGGA TTTGCTCTTG GAATCAAATG TGGTGCTACA 
TATCCTCAGC TAATGAAGAC AATTGGCATT CACCCTACCT GTGCTGAGGA AATTACCAAG 
TTGCATATTA CAAAACGTTC CGGCCTGGAT GCAACAGTAA CAGGTTGCTG AGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TXNRD2 ( NM_001122691.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001116163.2 Gallus gallus thioredoxin reductase 2 (TXNRD2), mRNA.

Price & Availability↑

CloneID	OGa141660
Clone ID Related Accession (Same CDS sequence)	NM_001122691.2
Accession Version	NM_001122691.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1545bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-16
Organism	Gallus gallus(chicken)
Product	thioredoxin reductase 2, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AADN05000505.1. On Jun 29, 2017 this sequence version replaced NM_001122691.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2201357, SAMEA2201358 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 11927553 protein contains selenocysteine :: PMID: 11927553 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGC TGTGGCGGCG GGGGGAGCGC TTCCTGGGGG TGCCGGGGCT GTGCCGTACG 
GCGCGAGCTC TCTCAGGAAA GAAGGAGTAT GACCTGCTGG TCATTGGTGG TGGATCTGGA 
GGCCTTGCTT GTGCAAAAGA AGCTGCTCAG TTTGGGAAGA ATGTGGCTGT TTTGGATTAC 
GTTGAACCTT CTCCACGAGG AACCAAGTGG GGACTTGGTG GAACTTGTGT AAACGTTGGC 
TGCATTCCTA AAAAGCTTAT GCATCAGGCA GCCCTTTTAG GGGGAGCTCT TAAAGATGCC 
CAGCACTACG GCTGGAGTGT AGCCCACCCA GTTCATCACA ACTGGTCTGT GATGGCTCAA 
GCTGTTCAGA ATTATGTGAA ATCCCTGAAC TGGGGACACA GAGTGCAGCT ACAAGACAAG 
AAGGTGAAAT ATTTCAACAT GAAAGGAAGT TTTTCAGATT CCCATACAGT CTGTGGTATA 
GCAAAAGGAG GTAAAGAGAC TACTCTTACT GCTGAAAAAA TTGTCATTGC TACTGGAGGA 
AGACCAAAAT ATCCTACACA TATTACGGGC GCACTGGAGT ATGGAATCAC AAGTGATGAT 
CTATTCTGGT TAAAAGACTC TCCTGGAAAA ACGTTGGTTG TTGGAGCCAG CTATGTTTCA 
CTTGAATGTG CTGGTTTTCT AACTGGTATT GGATTGGACA CTACAGTCAT AATGAGAAGT 
ATCCCACTTC GTGGATTTGA TCAGCAAATG GCGTCTTTAG TAACTGAGCA CATGGAATCT 
TATGGCACAA AATTTTTAAA GAAATGTGTC CCAGCGAAAG TTGAAAAATT GGAAAGCAGC 
AGGTTACAAG TCACCTGGAA AAATACTGAG TTGGGCACAG AAGAAACGGA TTCCTTTGAC 
ACAGTGATGT GGGCAGTAGG CCGGGTCCCT GACATCAAAA CTCTCAATTT GGACTCTGTT 
GGAGTGAAAA CTAATTCTGA AACTGGAAAG ATCATTGTTG ATGCCAGCGA AGCTACTTCT 
GTTCCTCACA TTTATGCAAT TGGAGACATA ACAGAGGGCC GTCCTGAACT GACACCCACA 
GCAATAGCTG CAGGGAAACT GCTGGCTCGG CGTCTTTTTG GCCACTCTTC AGAACTGATG 
GACTATGACA ATGTACCTAC TACAGTTTTC ACTCCCTTGG AATATGGTTG TGTTGGACTG 
TCAGAAGAAA AGGCTGTGCA GTGTTATGGA TCAGATAATG TTGAGGTATT TCATGCTTAT 
TATAAACCTC TAGAGTTCAC AGTGGCTGAA AGAGATGCTG CTCAGTGTTA TATAAAAATG 
GTGTGCTTAC GAGAGAGAGA GCAACGAATC CTTGGCCTTC ATTTCATTGG ACCAAATGCT 
GGGGAAGTTA TTCAAGGATT TGCTCTTGGA ATCAAATGTG GTGCTACATA TCCTCAGCTA 
ATGAAGACAA TTGGCATTCA CCCTACCTGT GCTGAGGAAA TTACCAAGTT GCATATTACA 
AAACGTTCCG GCCTGGATGC AACAGTAACA GGTTGCTGAG GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116163.2
CDS	86..1630
Translation	MAALWRRGERFLGVPGLCRTARALSGKKEYDLLVIGGGSGGLACAKEAAQFGKNVAVLDYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQAALLGGALKDAQHYGWSVAHPVHHNWSVMAQAVQNYVKSLNWGHRVQLQDKKVKYFNMKGSFSDSHTVCGIAKGGKETTLTAEKIVIATGGRPKYPTHITGALEYGITSDDLFWLKDSPGKTLVVGASYVSLECAGFLTGIGLDTTVIMRSIPLRGFDQQMASLVTEHMESYGTKFLKKCVPAKVEKLESSRLQVTWKNTELGTEETDSFDTVMWAVGRVPDIKTLNLDSVGVKTNSETGKIIVDASEATSVPHIYAIGDITEGRPELTPTAIAAGKLLARRLFGHSSELMDYDNVPTTVFTPLEYGCVGLSEEKAVQCYGSDNVEVFHAYYKPLEFTVAERDAAQCYIKMVCLREREQRILGLHFIGPNAGEVIQGFALGIKCGATYPQLMKTIGIHPTCAEEITKLHITKRSGLDATVTGC*G

Target ORF information:

RefSeq Version	NM_001122691.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus thioredoxin reductase 2 (TXNRD2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001122691.2

ORF Insert Sequence:

ATGGCGGCGC TGTGGCGGCG GGGGGAGCGC TTCCTGGGGG TGCCGGGGCT GTGCCGTACG 
GCGCGAGCTC TCTCAGGAAA GAAGGAGTAT GACCTGCTGG TCATTGGTGG TGGATCTGGA 
GGCCTTGCTT GTGCAAAAGA AGCTGCTCAG TTTGGGAAGA ATGTGGCTGT TTTGGATTAC 
GTTGAACCTT CTCCACGAGG AACCAAGTGG GGACTTGGTG GAACTTGTGT AAACGTTGGC 
TGCATTCCTA AAAAGCTTAT GCATCAGGCA GCCCTTTTAG GGGGAGCTCT TAAAGATGCC 
CAGCACTACG GCTGGAGTGT AGCCCACCCA GTTCATCACA ACTGGTCTGT GATGGCTCAA 
GCTGTTCAGA ATTATGTGAA ATCCCTGAAC TGGGGACACA GAGTGCAGCT ACAAGACAAG 
AAGGTGAAAT ATTTCAACAT GAAAGGAAGT TTTTCAGATT CCCATACAGT CTGTGGTATA 
GCAAAAGGAG GTAAAGAGAC TACTCTTACT GCTGAAAAAA TTGTCATTGC TACTGGAGGA 
AGACCAAAAT ATCCTACACA TATTACGGGC GCACTGGAGT ATGGAATCAC AAGTGATGAT 
CTATTCTGGT TAAAAGACTC TCCTGGAAAA ACGTTGGTTG TTGGAGCCAG CTATGTTTCA 
CTTGAATGTG CTGGTTTTCT AACTGGTATT GGATTGGACA CTACAGTCAT AATGAGAAGT 
ATCCCACTTC GTGGATTTGA TCAGCAAATG GCGTCTTTAG TAACTGAGCA CATGGAATCT 
TATGGCACAA AATTTTTAAA GAAATGTGTC CCAGCGAAAG TTGAAAAATT GGAAAGCAGC 
AGGTTACAAG TCACCTGGAA AAATACTGAG TTGGGCACAG AAGAAACGGA TTCCTTTGAC 
ACAGTGATGT GGGCAGTAGG CCGGGTCCCT GACATCAAAA CTCTCAATTT GGACTCTGTT 
GGAGTGAAAA CTAATTCTGA AACTGGAAAG ATCATTGTTG ATGCCAGCGA AGCTACTTCT 
GTTCCTCACA TTTATGCAAT TGGAGACATA ACAGAGGGCC GTCCTGAACT GACACCCACA 
GCAATAGCTG CAGGGAAACT GCTGGCTCGG CGTCTTTTTG GCCACTCTTC AGAACTGATG 
GACTATGACA ATGTACCTAC TACAGTTTTC ACTCCCTTGG AATATGGTTG TGTTGGACTG 
TCAGAAGAAA AGGCTGTGCA GTGTTATGGA TCAGATAATG TTGAGGTATT TCATGCTTAT 
TATAAACCTC TAGAGTTCAC AGTGGCTGAA AGAGATGCTG CTCAGTGTTA TATAAAAATG 
GTGTGCTTAC GAGAGAGAGA GCAACGAATC CTTGGCCTTC ATTTCATTGG ACCAAATGCT 
GGGGAAGTTA TTCAAGGATT TGCTCTTGGA ATCAAATGTG GTGCTACATA TCCTCAGCTA 
ATGAAGACAA TTGGCATTCA CCCTACCTGT GCTGAGGAAA TTACCAAGTT GCATATTACA 
AAACGTTCCG GCCTGGATGC AACAGTAACA GGTTGCTGAG GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

Acetyl-L-carnitine suppresses apoptosis of thioredoxin 2-deficient DT40 cells.
Archives of biochemistry and biophysics478(2)154-60(2008 Oct)
Zhu X,Sato EF,Wang Y,Nakamura H,Yodoi J,Inoue M

Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index.
Physiological genomics25(3)514-24(2006 May)
Carre W,Wang X,Porter TE,Nys Y,Tang J,Bernberg E,Morgan R,Burnside J,Aggrey SE,Simon J,Cogburn LA

ESTs from brain and testis of White Leghorn and red junglefowl: annotation, bioinformatic classification of unknown transcripts and analysis of expression levels.
Cytogenetic and genome research111(1)79-87(2005)
Savolainen P,Fitzsimmons C,Arvestad L,Andersson L,Lundeberg J

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TXNRD2 cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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