FTO cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	FTO
Entrez Gene ID	415718
Full Name	FTO, alpha-ketoglutarate dependent dioxygenase
General protein information	Preferred Names FTO, alpha-ketoglutarate dependent dioxygenase Names alpha-ketoglutarate-dependent dioxygenase FTO alpha-ketoglutarate dependent dioxygenase FTO fat mass and obesity associated protein fto
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001185147.1	NP_001172076.1	alpha-ketoglutarate-dependent dioxygenase FTO

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	fto	NP_001017273.1
Homo sapiens (human)	FTO	NP_001073901.1
Pan troglodytes (chimpanzee)	FTO	XP_510968.2
Gallus gallus (chicken)	FTO	NP_001172076.1
Bos taurus (cattle)	FTO	NP_001091611.1
Rattus norvegicus (Norway rat)	Fto	NP_001034802.1
	FTO	XP_001092038.1
Danio rerio (zebrafish)	fto	XP_001345910.4
Canis lupus familiaris (dog)	FTO	XP_535301.4
Mus musculus (house mouse)	Fto	NP_036066.2

Gene Ontology
Bibliography

Related articles in PubMed

Tissue- and breed-specific expression of the chicken fat mass- and obesity-associated gene (FTO).
Song C, Song WT, Shu JT, Tao ZY, Zhu WQ, Di C, Li HF
Genetics and molecular research : GMR14(3)10500-6(2015 Sep)

Fatmass and obesity associated (FTO) gene regulates gluconeogenesis in chicken embryo fibroblast cells.
Guo F, Zhang Y, Zhang C, Wang S, Ni Y, Zhao R
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology179149-56(2015 Jan)

Expression of miR-33 from an SREBF2 intron targets the FTO gene in the chicken.
Shao F, Wang X, Yu J, Jiang H, Zhu B, Gu Z
PloS one9(3)e91236(2014)

Chicken FTO gene: tissue-specific expression, brain distribution, breed difference and effect of fasting.
Wang Y, Rao K, Yuan L, Everaert N, Buyse J, Grossmann R, Zhao R
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology163(3-4)246-52(2012 Nov)

Variation in sequence and expression of the avian FTO, and association with glucose metabolism, body weight, fatness and body composition in chickens.
Jia X, Nie Q, Lamont SJ, Zhang X
International journal of obesity (2005)36(8)1054-61(2012 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FTO expression displays tissue- and breed-specific expression patterns.
Title: Tissue- and breed-specific expression of the chicken fat mass- and obesity-associated gene (FTO).

chicken FTO regulates gluconeogenesis in DF-1 cells through enhanced transcriptional regulation of G6PC gene by C/EBP-beta and phospho-CREB1.
Title: Fatmass and obesity associated (FTO) gene regulates gluconeogenesis in chicken embryo fibroblast cells.

miR-33 from an SREBF2 intron might play an important role in lipid metabolism in the chicken liver by negatively regulating the expression of the FTO gene
Title: Expression of miR-33 from an SREBF2 intron targets the FTO gene in the chicken.

Adult layers expressed higher FTO mRNA in liver and visceral fat, while adult broilers showed higher expression in hypothalamus and cerebellum.
Title: Chicken FTO gene: tissue-specific expression, brain distribution, breed difference and effect of fasting.

These data collectively indicate that FTO is related to glucose metabolism, body weight, fatness and body composition in birds, thus expanding knowledge of FTO function to non-mammalian species.
Title: Variation in sequence and expression of the avian FTO, and association with glucose metabolism, body weight, fatness and body composition in chickens.

The following FTO gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FTO cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa25736	NM_001185147.1 Latest version!	Gallus gallus FTO, alpha-ketoglutarate dependent dioxygenase (FTO), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FTO ( NM_001185147.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001172076.1 Gallus gallus FTO, alpha-ketoglutarate dependent dioxygenase (FTO), mRNA.

Price & Availability↑

CloneID	OGa25736
Clone ID Related Accession (Same CDS sequence)	NM_001185147.1
Accession Version	NM_001185147.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1524bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-15
Organism	Gallus gallus(chicken)
Product	alpha-ketoglutarate-dependent dioxygenase FTO
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from HM050377.1. On Jun 8, 2010 this sequence version replaced XM_414084.1. ##Evidence-Data-START## Transcript exon combination :: HM050377.1 [ECO:0000332] ##Evidence-Data-END##

ATGAAGAGGA GAGCAGGGGA GCGGGAGAAG GAACTGAAGA AAAAAAAGCT TCTTGAAGAG 
CTTGGAGAGG GCAAACTTCC ATACCTGACA CCAGCTGATG CTGATTTTCA TCATTTGCAG 
AAGACCAGAT ATTCCAAGCT AATTTTCAGA AAGTCGGATA CAGTACCTGA AGAGCTCCAT 
CAGATGGTAC AAGATGGCTT TTTGACCTTG AGGAAACATG GTTGTTTTTT TCAAGATCTT 
GTAAGGATCA AAGGAAAAGA TTTTTTTACC CCAGTGTCTC GTATATTAAT TGGAAAGCCA 
GGATGCACTT ACAAGTACTT GAACACAAGA TTATTTACAG TTCCTTGGCC TACTGAGGGT 
TGTGAAATAA AATATTGCAG TCCTCAAATA CATGATGCTT GTAAAGCATT AATCAAACTT 
AATGACTACT TGCATATTGA AGCAGTCAAG GCATTACAAG GACAAAATCT GTTAGACACC 
AAAGATACTA CTGTAATAGA TAGGGAGCAA AATTTTGCTA CTTCGCTTAT AGAGAAAGGG 
TCTTTTTCAA AAGATCAAAG CAGCTGTTAC GTACCAGAGG ATGACTACAC AAGTCTAAAT 
AACAGAACAT CTTATAACTT GACTTTATTA AATTATATGG ATCCACTACA AATGCCATAC 
TTGAAACAAG AGCCTTATTT TGAAATGGGG AACATGGCAG TGAGTTGGCA TCATGATGAG 
AATCTGGTTG AGAGGTCAAC AGTTGCTGTG TACAGCTACA GCTGTGAAGG TTCATCAGCT 
GAAGAAGCTA CTGATTGGAA CCTGAAGGGA AGAGACCCAG CTGTTTGGCA TGTAGGCTTG 
AAGGTAGCGT GGGACATAGA GACACCTGGA TTAGCAATAC CACTTCACCA AGGCGACCTC 
TACTTGATGC TTGATGATCT CAATATGACA CACCAGCACT GTGTTCTGGC TGGCTTTTCA 
CCTCGGTTCA GCTCCACCCA CAGAGTGGCA GATTGTTCAA GAGGAACATT GGAATACATA 
TTTGGGCAAT GTGAACTGGC ACTCCAGAAT TTGCAAACTG ATTCTAATTC AACAGCTTTA 
TCTCTGAAAT CACTGGAAAC TGCAGTTATA AAGCAAATGG AAGAAATACA TAATGAGGTT 
GAATTTGAGT GGCTTAGGCA GTTTTGGTTT CAAGGCGAGC GGTATTTGAA ATGCACTGAC 
TGGTGGCTTA AGCCTATGGC TAAACTGGAA GAATTTTGGA GAAAAATGGA GCTTATGACG 
AGCCTGGTCC TCCAAGAAGT TCGAAAAAAG GAGCAAACTG AAGAACAAAG GAATGAAACC 
ATCAGCTGCT TACTGCTAGT TCTTGCCGAG CGACAAAGGC TGCGTAATGA ATGGGCAGCA 
AGATGCCAGT CAGAAGCAGC GGAGAGCTTG CCAGAAGAGC AGAAGCCAGA ATGCCATCCC 
TTCTGGACAA ATGAAGAAAG TAACATGCCT CTGCCACTTG ATCTTGAAGA AGTAATTGTT 
CATCTACAAA ATCTTGTTCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001172076.1
CDS	81..1604
Translation	MKRRAGEREKELKKKKLLEELGEGKLPYLTPADADFHHLQKTRYSKLIFRKSDTVPEELHQMVQDGFLTLRKHGCFFQDLVRIKGKDFFTPVSRILIGKPGCTYKYLNTRLFTVPWPTEGCEIKYCSPQIHDACKALIKLNDYLHIEAVKALQGQNLLDTKDTTVIDREQNFATSLIEKGSFSKDQSSCYVPEDDYTSLNNRTSYNLTLLNYMDPLQMPYLKQEPYFEMGNMAVSWHHDENLVERSTVAVYSYSCEGSSAEEATDWNLKGRDPAVWHVGLKVAWDIETPGLAIPLHQGDLYLMLDDLNMTHQHCVLAGFSPRFSSTHRVADCSRGTLEYIFGQCELALQNLQTDSNSTALSLKSLETAVIKQMEEIHNEVEFEWLRQFWFQGERYLKCTDWWLKPMAKLEEFWRKMELMTSLVLQEVRKKEQTEEQRNETISCLLLVLAERQRLRNEWAARCQSEAAESLPEEQKPECHPFWTNEESNMPLPLDLEEVIVHLQNLVQ

Target ORF information:

RefSeq Version	NM_001185147.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus FTO, alpha-ketoglutarate dependent dioxygenase (FTO), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001185147.1

ORF Insert Sequence:

ATGAAGAGGA GAGCAGGGGA GCGGGAGAAG GAACTGAAGA AAAAAAAGCT TCTTGAAGAG 
CTTGGAGAGG GCAAACTTCC ATACCTGACA CCAGCTGATG CTGATTTTCA TCATTTGCAG 
AAGACCAGAT ATTCCAAGCT AATTTTCAGA AAGTCGGATA CAGTACCTGA AGAGCTCCAT 
CAGATGGTAC AAGATGGCTT TTTGACCTTG AGGAAACATG GTTGTTTTTT TCAAGATCTT 
GTAAGGATCA AAGGAAAAGA TTTTTTTACC CCAGTGTCTC GTATATTAAT TGGAAAGCCA 
GGATGCACTT ACAAGTACTT GAACACAAGA TTATTTACAG TTCCTTGGCC TACTGAGGGT 
TGTGAAATAA AATATTGCAG TCCTCAAATA CATGATGCTT GTAAAGCATT AATCAAACTT 
AATGACTACT TGCATATTGA AGCAGTCAAG GCATTACAAG GACAAAATCT GTTAGACACC 
AAAGATACTA CTGTAATAGA TAGGGAGCAA AATTTTGCTA CTTCGCTTAT AGAGAAAGGG 
TCTTTTTCAA AAGATCAAAG CAGCTGTTAC GTACCAGAGG ATGACTACAC AAGTCTAAAT 
AACAGAACAT CTTATAACTT GACTTTATTA AATTATATGG ATCCACTACA AATGCCATAC 
TTGAAACAAG AGCCTTATTT TGAAATGGGG AACATGGCAG TGAGTTGGCA TCATGATGAG 
AATCTGGTTG AGAGGTCAAC AGTTGCTGTG TACAGCTACA GCTGTGAAGG TTCATCAGCT 
GAAGAAGCTA CTGATTGGAA CCTGAAGGGA AGAGACCCAG CTGTTTGGCA TGTAGGCTTG 
AAGGTAGCGT GGGACATAGA GACACCTGGA TTAGCAATAC CACTTCACCA AGGCGACCTC 
TACTTGATGC TTGATGATCT CAATATGACA CACCAGCACT GTGTTCTGGC TGGCTTTTCA 
CCTCGGTTCA GCTCCACCCA CAGAGTGGCA GATTGTTCAA GAGGAACATT GGAATACATA 
TTTGGGCAAT GTGAACTGGC ACTCCAGAAT TTGCAAACTG ATTCTAATTC AACAGCTTTA 
TCTCTGAAAT CACTGGAAAC TGCAGTTATA AAGCAAATGG AAGAAATACA TAATGAGGTT 
GAATTTGAGT GGCTTAGGCA GTTTTGGTTT CAAGGCGAGC GGTATTTGAA ATGCACTGAC 
TGGTGGCTTA AGCCTATGGC TAAACTGGAA GAATTTTGGA GAAAAATGGA GCTTATGACG 
AGCCTGGTCC TCCAAGAAGT TCGAAAAAAG GAGCAAACTG AAGAACAAAG GAATGAAACC 
ATCAGCTGCT TACTGCTAGT TCTTGCCGAG CGACAAAGGC TGCGTAATGA ATGGGCAGCA 
AGATGCCAGT CAGAAGCAGC GGAGAGCTTG CCAGAAGAGC AGAAGCCAGA ATGCCATCCC 
TTCTGGACAA ATGAAGAAAG TAACATGCCT CTGCCACTTG ATCTTGAAGA AGTAATTGTT 
CATCTACAAA ATCTTGTTCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tissue- and breed-specific expression of the chicken fat mass- and obesity-associated gene (FTO).
Genetics and molecular research : GMR14(3)10500-6(2015 Sep)
Song C,Song WT,Shu JT,Tao ZY,Zhu WQ,Di C,Li HF

Fatmass and obesity associated (FTO) gene regulates gluconeogenesis in chicken embryo fibroblast cells.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology179149-56(2015 Jan)
Guo F,Zhang Y,Zhang C,Wang S,Ni Y,Zhao R

Expression of miR-33 from an SREBF2 intron targets the FTO gene in the chicken.
PloS one9(3)e91236(2014)
Shao F,Wang X,Yu J,Jiang H,Zhu B,Gu Z

Chicken FTO gene: tissue-specific expression, brain distribution, breed difference and effect of fasting.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology163(3-4)246-52(2012 Nov)
Wang Y,Rao K,Yuan L,Everaert N,Buyse J,Grossmann R,Zhao R

Variation in sequence and expression of the avian FTO, and association with glucose metabolism, body weight, fatness and body composition in chickens.
International journal of obesity (2005)36(8)1054-61(2012 Aug)
Jia X,Nie Q,Lamont SJ,Zhang X

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FTO cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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