AvBD13 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	AvBD13
Entrez Gene ID	414877
Full Name	avian beta-defensin 13
Synonyms	GAL13,Gal-11,Gal11,gal-13
General protein information	Preferred Names avian beta-defensin 13 Names gallinacin-13 beta-defensin 13 gallinacin-11
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001001780.1	NP_001001780.1	gallinacin-13 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Avian host defense peptides.
Cuperus T, Coorens M, van Dijk A, Haagsman HP
Developmental and comparative immunology41(3)352-69(2013 Nov)

Chicken intestine defensins activated murine peripheral blood mononuclear cells through the TLR4-NF-kappaB pathway.
Yang Y, Jiang Y, Yin Q, Liang H, She R
Veterinary immunology and immunopathology133(1)59-65(2010 Jan)

Primary structure and antibacterial activity of chicken bone marrow-derived beta-defensins.
Derache C, Labas V, Aucagne V, Meudal H, Landon C, Delmas AF, Magallon T, Lalmanach AC
Antimicrobial agents and chemotherapy53(11)4647-55(2009 Nov)

Avian beta-defensin nomenclature: a community proposed update.
Lynn DJ, Higgs R, Lloyd AT, O'Farrelly C, Herv?-Gr?pinet V, Nys Y, Brinkman FS, Yu PL, Soulier A, Kaiser P, Zhang G, Lehrer RI
Immunology letters110(1)86-9(2007 May)

The synthetic form of a novel chicken beta-defensin identified in silico is predominantly active against intestinal pathogens.
Higgs R, Lynn DJ, Gaines S, McMahon J, Tierney J, James T, Lloyd AT, Mulcahy G, O'Farrelly C
Immunogenetics57(1-2)90-8(2005 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

beta-defensin 13 can activate NH-kappaB, induce the inflammatory cytokines IL-12 and IFN-alpha, and up-regulate CD80 and monocyte proliferation.
Title: Chicken intestine defensins activated murine peripheral blood mononuclear cells through the TLR4-NF-kappaB pathway.

The chicken genome encodes only beta-defensins. The 13 chicken beta-defensin genes are clustered densely within a 86-Kb distance on the chromosome 3q3.5-q3.7. The deduced peptides share the characteristic defensin motif.
Title: A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins.

The following AvBD13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AvBD13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa27625	NM_001001780.1 Latest version!	Gallus gallus avian beta-defensin 13 (AvBD13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AvBD13 ( NM_001001780.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001001780.1 Gallus gallus avian beta-defensin 13 (AvBD13), mRNA.

Price & Availability↑

CloneID	OGa27625
Clone ID Related Accession (Same CDS sequence)	NM_001001780.1
Accession Version	NM_001001780.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Gallus gallus(chicken)
Product	gallinacin-13 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY621315.1. ##Evidence-Data-START## Transcript exon combination :: AY621315.1 [ECO:0000332] ##Evidence-Data-END##

ATGAGGATCC TCCAGCTGCT CTTTGCCATC GTTGTCATTC TCCTCCTCCA GGATGCGCCT 
GCAAGAGGTT TTTCAGACAG CCAGCTGTGC AGGAACAACC ATGGCCACTG CCGGAGGCTC 
TGCTTCCACA TGGAGAGCTG GGCTGGGAGC TGCATGAACG GCCGCCTGCG CTGCTGCAGG 
TTCTCCACCA AGCAGCCCTT TTCCAACCCT AAACATTCAG TGCTGCACAC AGCAGAGCAG 
GACCCTTCCC CAAGCCTTGG AGGGACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001780.1
CDS	1..270
Translation	MRILQLLFAIVVILLLQDAPARGFSDSQLCRNNHGHCRRLCFHMESWAGSCMNGRLRCCRFSTKQPFSNPKHSVLHTAEQDPSPSLGGT

Target ORF information:

RefSeq Version	NM_001001780.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus avian beta-defensin 13 (AvBD13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001780.1

ORF Insert Sequence:

ATGAGGATCC TCCAGCTGCT CTTTGCCATC GTTGTCATTC TCCTCCTCCA GGATGCGCCT 
GCAAGAGGTT TTTCAGACAG CCAGCTGTGC AGGAACAACC ATGGCCACTG CCGGAGGCTC 
TGCTTCCACA TGGAGAGCTG GGCTGGGAGC TGCATGAACG GCCGCCTGCG CTGCTGCAGG 
TTCTCCACCA AGCAGCCCTT TTCCAACCCT AAACATTCAG TGCTGCACAC AGCAGAGCAG 
GACCCTTCCC CAAGCCTTGG AGGGACGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Avian host defense peptides.
Developmental and comparative immunology41(3)352-69(2013 Nov)
Cuperus T,Coorens M,van Dijk A,Haagsman HP

Chicken intestine defensins activated murine peripheral blood mononuclear cells through the TLR4-NF-kappaB pathway.
Veterinary immunology and immunopathology133(1)59-65(2010 Jan)
Yang Y,Jiang Y,Yin Q,Liang H,She R

Primary structure and antibacterial activity of chicken bone marrow-derived beta-defensins.
Antimicrobial agents and chemotherapy53(11)4647-55(2009 Nov)
Derache C,Labas V,Aucagne V,Meudal H,Landon C,Delmas AF,Magallon T,Lalmanach AC

Avian beta-defensin nomenclature: a community proposed update.
Immunology letters110(1)86-9(2007 May)
Lynn DJ,Higgs R,Lloyd AT,O'Farrelly C,Herv?-Gr?pinet V,Nys Y,Brinkman FS,Yu PL,Soulier A,Kaiser P,Zhang G,Lehrer RI

The synthetic form of a novel chicken beta-defensin identified in silico is predominantly active against intestinal pathogens.
Immunogenetics57(1-2)90-8(2005 Apr)
Higgs R,Lynn DJ,Gaines S,McMahon J,Tierney J,James T,Lloyd AT,Mulcahy G,O'Farrelly C