CSK cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	CSK
Entrez Gene ID	396396
Full Name	c-src tyrosine kinase
General protein information	Preferred Names c-src tyrosine kinase Names tyrosine-protein kinase CSK C-Src kinase protein kinase src kinase
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
XM_015278794.1	XP_015134280.1	tyrosine-protein kinase CSK isoform X1
NM_205425.1	NP_990756.1	tyrosine-protein kinase CSK
XM_015278794.2	XP_015134280.1	tyrosine-protein kinase CSK isoform X1
XM_025153807.1	XP_025009575.1	tyrosine-protein kinase CSK isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Csk	NP_001025210.1
Drosophila melanogaster (fruit fly)	Csk	NP_788638.1
Homo sapiens (human)	CSK	NP_004374.1
Bos taurus (cattle)	CSK	NP_001068865.1
Danio rerio (zebrafish)	csk	NP_001071067.1
Xenopus tropicalis (tropical clawed frog)	csk	NP_001135615.1
Mus musculus (house mouse)	Csk	NP_031809.2
Gallus gallus (chicken)	CSK	NP_990756.1
Caenorhabditis elegans (roundworm)	csk-1	NP_001021778.1
Pan troglodytes (chimpanzee)	CSK	XP_001138334.3
	CSK	XP_001101521.1
Canis lupus familiaris (dog)	CSK	XP_005638681.1

Gene Ontology
Bibliography

Related articles in PubMed

Electrostatic effects in the folding of the SH3 domain of the c-Src tyrosine kinase: pH-dependence in 3D-domain swapping and amyloid formation.
Bacarizo J, Martinez-Rodriguez S, Martin-Garcia JM, Andujar-Sanchez M, Ortiz-Salmeron E, Neira JL, Camara-Artigas A
PloS one9(12)e113224(2014)

Atomic resolution structures of the c-Src SH3 domain in complex with two high-affinity peptides from classes I and II.
Bacarizo J, Camara-Artigas A
Acta crystallographica. Section D, Biological crystallography69(Pt 5)756-66(2013 May)

Myristoylation and membrane binding regulate c-Src stability and kinase activity.
Patwardhan P, Resh MD
Molecular and cellular biology30(17)4094-107(2010 Sep)

c-Src trafficking and co-localization with the EGF receptor promotes EGF ligand-independent EGF receptor activation and signaling.
Donepudi M, Resh MD
Cellular signalling20(7)1359-67(2008 Jul)

c-Src control of chloride channel support for osteoclast HCl transport and bone resorption.
Edwards JC, Cohen C, Xu W, Schlesinger PH
The Journal of biological chemistry281(38)28011-22(2006 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

electrostatic interactions and solvation of residues close to the folding nucleation site of the c-Src-SH3 domain might play an important role during the folding reaction and the amyloid fibril formation
Title: Electrostatic effects in the folding of the SH3 domain of the c-Src tyrosine kinase: pH-dependence in 3D-domain swapping and amyloid formation.

crystal structures of the c-Src SH3 domain in complex with two high-affinity peptides
Title: Atomic resolution structures of the c-Src SH3 domain in complex with two high-affinity peptides from classes I and II.

Myristoylation exerts a positive effect on c-Src kinase activity.
Title: Myristoylation and membrane binding regulate c-Src stability and kinase activity.

These data suggest that the synergy between c-Src and EGFR also occurs as these two kinases traffic together, and that their co-localization promotes EGFR-mediated signaling.
Title: c-Src trafficking and co-localization with the EGF receptor promotes EGF ligand-independent EGF receptor activation and signaling.

suppression of c-Src interferes with osteoclast bone resorption by disrupting functional co-localization of proton pump and CLIC-5b.
Title: c-Src control of chloride channel support for osteoclast HCl transport and bone resorption.

The following CSK gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CSK cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OGa28136	NM_205425.1 Latest version!	Gallus gallus C-terminal Src kinase (CSK), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OGa40234	XM_025153807.1 Latest version!	Gallus gallus c-src tyrosine kinase (CSK), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$258.30 $369.00
OGa40234	XM_015278794.2 Latest version!	Gallus gallus c-src tyrosine kinase (CSK), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$258.30 $369.00
View Old Accession Versions >>
OGa40234	XM_015278794.1	Gallus gallus c-src tyrosine kinase (CSK), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$258.30 $369.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CSK ( NM_205425.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_990756.1 Gallus gallus C-terminal Src kinase (CSK), mRNA.

Price & Availability↑

CloneID	OGa28136
Clone ID Related Accession (Same CDS sequence)	NM_205425.1
Accession Version	NM_205425.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Gallus gallus(chicken)
Product	tyrosine-protein kinase CSK
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M85039.1. ##Evidence-Data-START## Transcript exon combination :: M85039.1 [ECO:0000332] ##Evidence-Data-END##

ATGTCAGGGA TGCAGGCCGT TTGGCCATCC GGTACAGAAT GTATCGCCAA GTACAACTTC 
CACGGTACGG CCGAGCAGGA CCTGCCGTTC AGCAAGGGAG ACGTCCTCAC CATCGTCGCC 
GTCACCAAGG ACCCCAACTG GTACAAGGCG AAGAACAAGG TGGGCCGGGA GGGCATCATC 
CCCGCTAACT ACGTGCAGAA GAGGGAAGGA GTGAAGGCTG GCATCAAGCT CAGCCTCATG 
CCGTGGTTCC ATGGGAAGAT CACACGGGAG CAGGCAGAGA GGCTGCTGTA CCCACCCGAG 
ACGGGGCTGT TCCTGGTGCG GGAGAGCACC AACTACCCCG GGGACTACAC CCTGTGTGTG 
AGCTGTGAGG GCAAGGTGGA GCACTACCGC ATCATTTACT CCTCCAGCAA GCTGAGCATC 
GACGAGGAGG TCTACTTCGA GAACCTGATG CAGCTTGTGG AGCATTACAC CACGGACGCC 
GACGGCCTCT GCTCGCGCCT CATCAAACCG AAGGTGATGG AGGGGACGGT GGCAGCTCAG 
GATGAGTTCT CCCGCAGTGG CTGGGCCCTC AACATGAAGG ACCTCAAGCT GCTGCAAATC 
ATTGGCAAAG GGGAATTTGG AGATGTGATG CTGGGTGATT ACCGGGGGAA CAAAGTCGCC 
GTCAAGTGCA TTAAAAATGA CGCCACAGCG CAGGCTTTCC TGGCAGAAGC GTCCGTGATG 
ACGCAGCTCC GACACAGCAA CCTGGTGCAG CTGCTGGGGG TGATCGTGGA GGAGAAGAGC 
GGCCTCTATA TTGTCACTGA GTATATGGCC AAGGGCAGCC TAGTAGATTA CCTGCGGTCG 
CGTGGGAGGT CGGTCCTAGG CGGAGACTGC CTGCTCAAGT TTTCCTTAGA TGTCTGTGAA 
GCCATGGAGT ACCTGGAAGC CAACAACTTC GTCCACCGGG ACCTGGCGGC GAGGAATGTG 
TTGGTCTCAG AGGACAACAT TGCCAAGGTC AGCGATTTCG GGCTGACAAA GGAAGCGTCG 
TCCACTCAGG ACACGGGGAA GCTGCCTGTG AAGTGGACGG CACCCGAAGC ACTTAGAGAA 
AAGAAATTCT CCACCAAATC GGACGTGTGG AGCTTCGGGA TCCTCCTCTG GGAAATCTAC 
TCCTTCGGGC GAGTGCCTTA TCCGAGAATC CCCCTGAAGG ACGTGGTGCC CCGGGTGGAG 
AAGGGCTATA AGATGGACCC TCCAGACGGC TGCCCGGCCA TCGTCTACGA GGTGATGAAG 
AAGTGCTGGA CGCTGGACCC AGGGCACCGG CCGTCCTTCC ACCAGCTCCG TGAACAGCTA 
GTGCATATCA AAGAGAAGGA GCTCTACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_990756.1
CDS	1..1353
Translation	MSGMQAVWPSGTECIAKYNFHGTAEQDLPFSKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGIKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIIYSSSKLSIDEEVYFENLMQLVEHYTTDADGLCSRLIKPKVMEGTVAAQDEFSRSGWALNMKDLKLLQIIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEANNFVHRDLAARNVLVSEDNIAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDPPDGCPAIVYEVMKKCWTLDPGHRPSFHQLREQLVHIKEKELYL

Target ORF information:

RefSeq Version	NM_205425.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus C-terminal Src kinase (CSK), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_205425.1

ORF Insert Sequence:

ATGTCAGGGA TGCAGGCCGT TTGGCCATCC GGTACAGAAT GTATCGCCAA GTACAACTTC 
CACGGTACGG CCGAGCAGGA CCTGCCGTTC AGCAAGGGAG ACGTCCTCAC CATCGTCGCC 
GTCACCAAGG ACCCCAACTG GTACAAGGCG AAGAACAAGG TGGGCCGGGA GGGCATCATC 
CCCGCTAACT ACGTGCAGAA GAGGGAAGGA GTGAAGGCTG GCATCAAGCT CAGCCTCATG 
CCGTGGTTCC ATGGGAAGAT CACACGGGAG CAGGCAGAGA GGCTGCTGTA CCCACCCGAG 
ACGGGGCTGT TCCTGGTGCG GGAGAGCACC AACTACCCCG GGGACTACAC CCTGTGTGTG 
AGCTGTGAGG GCAAGGTGGA GCACTACCGC ATCATTTACT CCTCCAGCAA GCTGAGCATC 
GACGAGGAGG TCTACTTCGA GAACCTGATG CAGCTTGTGG AGCATTACAC CACGGACGCC 
GACGGCCTCT GCTCGCGCCT CATCAAACCG AAGGTGATGG AGGGGACGGT GGCAGCTCAG 
GATGAGTTCT CCCGCAGTGG CTGGGCCCTC AACATGAAGG ACCTCAAGCT GCTGCAAATC 
ATTGGCAAAG GGGAATTTGG AGATGTGATG CTGGGTGATT ACCGGGGGAA CAAAGTCGCC 
GTCAAGTGCA TTAAAAATGA CGCCACAGCG CAGGCTTTCC TGGCAGAAGC GTCCGTGATG 
ACGCAGCTCC GACACAGCAA CCTGGTGCAG CTGCTGGGGG TGATCGTGGA GGAGAAGAGC 
GGCCTCTATA TTGTCACTGA GTATATGGCC AAGGGCAGCC TAGTAGATTA CCTGCGGTCG 
CGTGGGAGGT CGGTCCTAGG CGGAGACTGC CTGCTCAAGT TTTCCTTAGA TGTCTGTGAA 
GCCATGGAGT ACCTGGAAGC CAACAACTTC GTCCACCGGG ACCTGGCGGC GAGGAATGTG 
TTGGTCTCAG AGGACAACAT TGCCAAGGTC AGCGATTTCG GGCTGACAAA GGAAGCGTCG 
TCCACTCAGG ACACGGGGAA GCTGCCTGTG AAGTGGACGG CACCCGAAGC ACTTAGAGAA 
AAGAAATTCT CCACCAAATC GGACGTGTGG AGCTTCGGGA TCCTCCTCTG GGAAATCTAC 
TCCTTCGGGC GAGTGCCTTA TCCGAGAATC CCCCTGAAGG ACGTGGTGCC CCGGGTGGAG 
AAGGGCTATA AGATGGACCC TCCAGACGGC TGCCCGGCCA TCGTCTACGA GGTGATGAAG 
AAGTGCTGGA CGCTGGACCC AGGGCACCGG CCGTCCTTCC ACCAGCTCCG TGAACAGCTA 
GTGCATATCA AAGAGAAGGA GCTCTACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSK ( XM_015278794.1 ) cDNA ORF clone, Gallus gallus(chicken) -> XP_015134280.1 Gallus gallus c-src tyrosine kinase (CSK), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OGa40234
Clone ID Related Accession (Same CDS sequence)	XM_015278794.1 , XM_015278794.2 , XM_025153807.1
Accession Version	XM_015278794.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-01-03
Organism	Gallus gallus(chicken)
Product	tyrosine-protein kinase CSK isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003763853.2) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Gallus gallus Annotation Release 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCAGGGA TGCAGGCCGT TTGGCCATCC GGTACAGAAT GTATCGCCAA GTACAACTTC 
CACGGTACGG CCGAGCAGGA CCTGCCGTTC AGCAAGGGAG ACGTCCTCAC CATCGTCGCC 
GTCACCAAGG ACCCCAACTG GTACAAGGCG AAGAACAAGG TGGGCCGGGA GGGCATCATC 
CCCGCTAACT ACGTGCAGAA GAGGGAAGGA GTGAAGGCTG GCATCAAGCT CAGCCTCATG 
CCGTGGTTCC ATGGGAAGAT CACACGGGAG CAGGCAGAGA GGCTGCTGTA CCCACCCGAG 
ACGGGGCTGT TCCTGGTGCG GGAGAGCACC AACTACCCTG GGGACTACAC CCTGTGTGTG 
AGCTGTGAGG GCAAGGTGGA GCACTACCGC ATCATTTACT CCTCCAGCAA GCTGAGCATC 
GATGAGGAGG TCTACTTCGA GAACCTGATG CAGCTTGTGG AGCATTACAC CACGGACGCC 
GACGGGCTCT GCACGCGCCT CATCAAACCG AAGGTGATGG AGGGGACGGT GGCAGCTCAG 
GACGAGTTCT CCCGCAGTGG CTGGGCCCTC AACATGAAGG ACCTCAAGCT GCTGCAAATC 
ATTGGCAAAG GGGAATTTGG AGATGTGATG CTGGGTGATT ACCGGGGGAA CAAAGTCGCC 
GTCAAGTGCA TTAAAAATGA CGCCACAGCG CAGGCTTTCC TGGCAGAAGC ATCCGTGATG 
ACGCAGCTCC GACACAGCAA CCTGGTGCAG CTGCTGGGGG TGATCGTGGA GGAGAAGAGC 
GGCCTCTACA TTGTCACTGA GTATATGGCC AAGGGCAGCC TAGTAGATTA CCTGCGGTCG 
CGTGGGAGGT CGGTCCTAGG CGCAGACTGC CTGCTCAAGT TTTCCTTAGA TGTCTGTGAA 
GCCATGGAGT ACCTGGAAGC CAACAACTTC GTCCACCGGG ACCTGGCGGC GAGGAATGTG 
TTGGTCTCAG AGGACAACAT TGCCAAGGTC AGCGATTTCG GGCTGACAAA GGAAGCGTCG 
TCCACTCAGG ACACGGGGAA GCTGCCTGTG AAGTGGACGG CACCCGAAGC ACTTAGAGAA 
AAGAAATTCT CCACCAAATC GGACGTGTGG AGCTTCGGGA TCCTCCTCTG GGAAATCTAC 
TCCTTCGGGC GAGTGCCTTA TCCGAGAATC CCCCTGAAGG ACGTGGTGCC CCGGGTGGAG 
AAGGGCTATA AGATGGACCC TCCAGACGGC TGCCCGGCCA TCGTCTACGA GGTGATGAAG 
AAGTGCTGGA CGCTGGACCC AGGGCACCGG CCGTCCTTCC ACCAGCTCCG TGAACAGCTA 
GTGCATATCA AAGAGAAGGA GCTCTACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015134280.1
CDS	236..1588
Translation	MSGMQAVWPSGTECIAKYNFHGTAEQDLPFSKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGIKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIIYSSSKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFSRSGWALNMKDLKLLQIIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGADCLLKFSLDVCEAMEYLEANNFVHRDLAARNVLVSEDNIAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDPPDGCPAIVYEVMKKCWTLDPGHRPSFHQLREQLVHIKEKELYL

Target ORF information:

RefSeq Version	XM_015278794.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus c-src tyrosine kinase (CSK), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015278794.1

ORF Insert Sequence:

ATGTCAGGGA TGCAGGCCGT TTGGCCATCC GGTACAGAAT GTATCGCCAA GTACAACTTC 
CACGGTACGG CCGAGCAGGA CCTGCCGTTC AGCAAGGGAG ACGTCCTCAC CATCGTCGCC 
GTCACCAAGG ACCCCAACTG GTACAAGGCG AAGAACAAGG TGGGCCGGGA GGGCATCATC 
CCCGCTAACT ACGTGCAGAA GAGGGAAGGA GTGAAGGCTG GCATCAAGCT CAGCCTCATG 
CCGTGGTTCC ATGGGAAGAT CACACGGGAG CAGGCAGAGA GGCTGCTGTA CCCACCCGAG 
ACGGGGCTGT TCCTGGTGCG GGAGAGCACC AACTACCCTG GGGACTACAC CCTGTGTGTG 
AGCTGTGAGG GCAAGGTGGA GCACTACCGC ATCATTTACT CCTCCAGCAA GCTGAGCATC 
GATGAGGAGG TCTACTTCGA GAACCTGATG CAGCTTGTGG AGCATTACAC CACGGACGCC 
GACGGGCTCT GCACGCGCCT CATCAAACCG AAGGTGATGG AGGGGACGGT GGCAGCTCAG 
GACGAGTTCT CCCGCAGTGG CTGGGCCCTC AACATGAAGG ACCTCAAGCT GCTGCAAATC 
ATTGGCAAAG GGGAATTTGG AGATGTGATG CTGGGTGATT ACCGGGGGAA CAAAGTCGCC 
GTCAAGTGCA TTAAAAATGA CGCCACAGCG CAGGCTTTCC TGGCAGAAGC ATCCGTGATG 
ACGCAGCTCC GACACAGCAA CCTGGTGCAG CTGCTGGGGG TGATCGTGGA GGAGAAGAGC 
GGCCTCTACA TTGTCACTGA GTATATGGCC AAGGGCAGCC TAGTAGATTA CCTGCGGTCG 
CGTGGGAGGT CGGTCCTAGG CGCAGACTGC CTGCTCAAGT TTTCCTTAGA TGTCTGTGAA 
GCCATGGAGT ACCTGGAAGC CAACAACTTC GTCCACCGGG ACCTGGCGGC GAGGAATGTG 
TTGGTCTCAG AGGACAACAT TGCCAAGGTC AGCGATTTCG GGCTGACAAA GGAAGCGTCG 
TCCACTCAGG ACACGGGGAA GCTGCCTGTG AAGTGGACGG CACCCGAAGC ACTTAGAGAA 
AAGAAATTCT CCACCAAATC GGACGTGTGG AGCTTCGGGA TCCTCCTCTG GGAAATCTAC 
TCCTTCGGGC GAGTGCCTTA TCCGAGAATC CCCCTGAAGG ACGTGGTGCC CCGGGTGGAG 
AAGGGCTATA AGATGGACCC TCCAGACGGC TGCCCGGCCA TCGTCTACGA GGTGATGAAG 
AAGTGCTGGA CGCTGGACCC AGGGCACCGG CCGTCCTTCC ACCAGCTCCG TGAACAGCTA 
GTGCATATCA AAGAGAAGGA GCTCTACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSK ( XM_015278794.2 ) cDNA ORF clone, Gallus gallus(chicken) -> XP_015134280.1 Gallus gallus c-src tyrosine kinase (CSK), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OGa40234
Clone ID Related Accession (Same CDS sequence)	XM_015278794.1 , XM_015278794.2 , XM_025153807.1
Accession Version	XM_015278794.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-16
Organism	Gallus gallus(chicken)
Product	tyrosine-protein kinase CSK isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006097.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XM_015278794.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCAGGGA TGCAGGCCGT TTGGCCATCC GGTACAGAAT GTATCGCCAA GTACAACTTC 
CACGGTACGG CCGAGCAGGA CCTGCCGTTC AGCAAGGGAG ACGTCCTCAC CATCGTCGCC 
GTCACCAAGG ACCCCAACTG GTACAAGGCG AAGAACAAGG TGGGCCGGGA GGGCATCATC 
CCCGCTAACT ACGTGCAGAA GAGGGAAGGA GTGAAGGCTG GCATCAAGCT CAGCCTCATG 
CCGTGGTTCC ATGGGAAGAT CACACGGGAG CAGGCAGAGA GGCTGCTGTA CCCACCCGAG 
ACGGGGCTGT TCCTGGTGCG GGAGAGCACC AACTACCCTG GGGACTACAC CCTGTGTGTG 
AGCTGTGAGG GCAAGGTGGA GCACTACCGC ATCATTTACT CCTCCAGCAA GCTGAGCATC 
GATGAGGAGG TCTACTTCGA GAACCTGATG CAGCTTGTGG AGCATTACAC CACGGACGCC 
GACGGGCTCT GCACGCGCCT CATCAAACCG AAGGTGATGG AGGGGACGGT GGCAGCTCAG 
GACGAGTTCT CCCGCAGTGG CTGGGCCCTC AACATGAAGG ACCTCAAGCT GCTGCAAATC 
ATTGGCAAAG GGGAATTTGG AGATGTGATG CTGGGTGATT ACCGGGGGAA CAAAGTCGCC 
GTCAAGTGCA TTAAAAATGA CGCCACAGCG CAGGCTTTCC TGGCAGAAGC ATCCGTGATG 
ACGCAGCTCC GACACAGCAA CCTGGTGCAG CTGCTGGGGG TGATCGTGGA GGAGAAGAGC 
GGCCTCTACA TTGTCACTGA GTATATGGCC AAGGGCAGCC TAGTAGATTA CCTGCGGTCG 
CGTGGGAGGT CGGTCCTAGG CGCAGACTGC CTGCTCAAGT TTTCCTTAGA TGTCTGTGAA 
GCCATGGAGT ACCTGGAAGC CAACAACTTC GTCCACCGGG ACCTGGCGGC GAGGAATGTG 
TTGGTCTCAG AGGACAACAT TGCCAAGGTC AGCGATTTCG GGCTGACAAA GGAAGCGTCG 
TCCACTCAGG ACACGGGGAA GCTGCCTGTG AAGTGGACGG CACCCGAAGC ACTTAGAGAA 
AAGAAATTCT CCACCAAATC GGACGTGTGG AGCTTCGGGA TCCTCCTCTG GGAAATCTAC 
TCCTTCGGGC GAGTGCCTTA TCCGAGAATC CCCCTGAAGG ACGTGGTGCC CCGGGTGGAG 
AAGGGCTATA AGATGGACCC TCCAGACGGC TGCCCGGCCA TCGTCTACGA GGTGATGAAG 
AAGTGCTGGA CGCTGGACCC AGGGCACCGG CCGTCCTTCC ACCAGCTCCG TGAACAGCTA 
GTGCATATCA AAGAGAAGGA GCTCTACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015134280.1
CDS	243..1595
Translation	MSGMQAVWPSGTECIAKYNFHGTAEQDLPFSKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGIKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIIYSSSKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFSRSGWALNMKDLKLLQIIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGADCLLKFSLDVCEAMEYLEANNFVHRDLAARNVLVSEDNIAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDPPDGCPAIVYEVMKKCWTLDPGHRPSFHQLREQLVHIKEKELYL

Target ORF information:

RefSeq Version	XM_015278794.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus c-src tyrosine kinase (CSK), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015278794.2

ORF Insert Sequence:

ATGTCAGGGA TGCAGGCCGT TTGGCCATCC GGTACAGAAT GTATCGCCAA GTACAACTTC 
CACGGTACGG CCGAGCAGGA CCTGCCGTTC AGCAAGGGAG ACGTCCTCAC CATCGTCGCC 
GTCACCAAGG ACCCCAACTG GTACAAGGCG AAGAACAAGG TGGGCCGGGA GGGCATCATC 
CCCGCTAACT ACGTGCAGAA GAGGGAAGGA GTGAAGGCTG GCATCAAGCT CAGCCTCATG 
CCGTGGTTCC ATGGGAAGAT CACACGGGAG CAGGCAGAGA GGCTGCTGTA CCCACCCGAG 
ACGGGGCTGT TCCTGGTGCG GGAGAGCACC AACTACCCTG GGGACTACAC CCTGTGTGTG 
AGCTGTGAGG GCAAGGTGGA GCACTACCGC ATCATTTACT CCTCCAGCAA GCTGAGCATC 
GATGAGGAGG TCTACTTCGA GAACCTGATG CAGCTTGTGG AGCATTACAC CACGGACGCC 
GACGGGCTCT GCACGCGCCT CATCAAACCG AAGGTGATGG AGGGGACGGT GGCAGCTCAG 
GACGAGTTCT CCCGCAGTGG CTGGGCCCTC AACATGAAGG ACCTCAAGCT GCTGCAAATC 
ATTGGCAAAG GGGAATTTGG AGATGTGATG CTGGGTGATT ACCGGGGGAA CAAAGTCGCC 
GTCAAGTGCA TTAAAAATGA CGCCACAGCG CAGGCTTTCC TGGCAGAAGC ATCCGTGATG 
ACGCAGCTCC GACACAGCAA CCTGGTGCAG CTGCTGGGGG TGATCGTGGA GGAGAAGAGC 
GGCCTCTACA TTGTCACTGA GTATATGGCC AAGGGCAGCC TAGTAGATTA CCTGCGGTCG 
CGTGGGAGGT CGGTCCTAGG CGCAGACTGC CTGCTCAAGT TTTCCTTAGA TGTCTGTGAA 
GCCATGGAGT ACCTGGAAGC CAACAACTTC GTCCACCGGG ACCTGGCGGC GAGGAATGTG 
TTGGTCTCAG AGGACAACAT TGCCAAGGTC AGCGATTTCG GGCTGACAAA GGAAGCGTCG 
TCCACTCAGG ACACGGGGAA GCTGCCTGTG AAGTGGACGG CACCCGAAGC ACTTAGAGAA 
AAGAAATTCT CCACCAAATC GGACGTGTGG AGCTTCGGGA TCCTCCTCTG GGAAATCTAC 
TCCTTCGGGC GAGTGCCTTA TCCGAGAATC CCCCTGAAGG ACGTGGTGCC CCGGGTGGAG 
AAGGGCTATA AGATGGACCC TCCAGACGGC TGCCCGGCCA TCGTCTACGA GGTGATGAAG 
AAGTGCTGGA CGCTGGACCC AGGGCACCGG CCGTCCTTCC ACCAGCTCCG TGAACAGCTA 
GTGCATATCA AAGAGAAGGA GCTCTACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSK ( XM_025153807.1 ) cDNA ORF clone, Gallus gallus(chicken) -> XP_025009575.1 Gallus gallus c-src tyrosine kinase (CSK), transcript variant X2, mRNA.

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CloneID	OGa40234
Clone ID Related Accession (Same CDS sequence)	XM_015278794.1 , XM_015278794.2 , XM_025153807.1
Accession Version	XM_025153807.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-16
Organism	Gallus gallus(chicken)
Product	tyrosine-protein kinase CSK isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006097.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCAGGGA TGCAGGCCGT TTGGCCATCC GGTACAGAAT GTATCGCCAA GTACAACTTC 
CACGGTACGG CCGAGCAGGA CCTGCCGTTC AGCAAGGGAG ACGTCCTCAC CATCGTCGCC 
GTCACCAAGG ACCCCAACTG GTACAAGGCG AAGAACAAGG TGGGCCGGGA GGGCATCATC 
CCCGCTAACT ACGTGCAGAA GAGGGAAGGA GTGAAGGCTG GCATCAAGCT CAGCCTCATG 
CCGTGGTTCC ATGGGAAGAT CACACGGGAG CAGGCAGAGA GGCTGCTGTA CCCACCCGAG 
ACGGGGCTGT TCCTGGTGCG GGAGAGCACC AACTACCCTG GGGACTACAC CCTGTGTGTG 
AGCTGTGAGG GCAAGGTGGA GCACTACCGC ATCATTTACT CCTCCAGCAA GCTGAGCATC 
GATGAGGAGG TCTACTTCGA GAACCTGATG CAGCTTGTGG AGCATTACAC CACGGACGCC 
GACGGGCTCT GCACGCGCCT CATCAAACCG AAGGTGATGG AGGGGACGGT GGCAGCTCAG 
GACGAGTTCT CCCGCAGTGG CTGGGCCCTC AACATGAAGG ACCTCAAGCT GCTGCAAATC 
ATTGGCAAAG GGGAATTTGG AGATGTGATG CTGGGTGATT ACCGGGGGAA CAAAGTCGCC 
GTCAAGTGCA TTAAAAATGA CGCCACAGCG CAGGCTTTCC TGGCAGAAGC ATCCGTGATG 
ACGCAGCTCC GACACAGCAA CCTGGTGCAG CTGCTGGGGG TGATCGTGGA GGAGAAGAGC 
GGCCTCTACA TTGTCACTGA GTATATGGCC AAGGGCAGCC TAGTAGATTA CCTGCGGTCG 
CGTGGGAGGT CGGTCCTAGG CGCAGACTGC CTGCTCAAGT TTTCCTTAGA TGTCTGTGAA 
GCCATGGAGT ACCTGGAAGC CAACAACTTC GTCCACCGGG ACCTGGCGGC GAGGAATGTG 
TTGGTCTCAG AGGACAACAT TGCCAAGGTC AGCGATTTCG GGCTGACAAA GGAAGCGTCG 
TCCACTCAGG ACACGGGGAA GCTGCCTGTG AAGTGGACGG CACCCGAAGC ACTTAGAGAA 
AAGAAATTCT CCACCAAATC GGACGTGTGG AGCTTCGGGA TCCTCCTCTG GGAAATCTAC 
TCCTTCGGGC GAGTGCCTTA TCCGAGAATC CCCCTGAAGG ACGTGGTGCC CCGGGTGGAG 
AAGGGCTATA AGATGGACCC TCCAGACGGC TGCCCGGCCA TCGTCTACGA GGTGATGAAG 
AAGTGCTGGA CGCTGGACCC AGGGCACCGG CCGTCCTTCC ACCAGCTCCG TGAACAGCTA 
GTGCATATCA AAGAGAAGGA GCTCTACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_025009575.1
CDS	463..1815
Translation	MSGMQAVWPSGTECIAKYNFHGTAEQDLPFSKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGIKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIIYSSSKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFSRSGWALNMKDLKLLQIIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGADCLLKFSLDVCEAMEYLEANNFVHRDLAARNVLVSEDNIAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDPPDGCPAIVYEVMKKCWTLDPGHRPSFHQLREQLVHIKEKELYL

Target ORF information:

RefSeq Version	XM_025153807.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus c-src tyrosine kinase (CSK), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_025153807.1

ORF Insert Sequence:

ATGTCAGGGA TGCAGGCCGT TTGGCCATCC GGTACAGAAT GTATCGCCAA GTACAACTTC 
CACGGTACGG CCGAGCAGGA CCTGCCGTTC AGCAAGGGAG ACGTCCTCAC CATCGTCGCC 
GTCACCAAGG ACCCCAACTG GTACAAGGCG AAGAACAAGG TGGGCCGGGA GGGCATCATC 
CCCGCTAACT ACGTGCAGAA GAGGGAAGGA GTGAAGGCTG GCATCAAGCT CAGCCTCATG 
CCGTGGTTCC ATGGGAAGAT CACACGGGAG CAGGCAGAGA GGCTGCTGTA CCCACCCGAG 
ACGGGGCTGT TCCTGGTGCG GGAGAGCACC AACTACCCTG GGGACTACAC CCTGTGTGTG 
AGCTGTGAGG GCAAGGTGGA GCACTACCGC ATCATTTACT CCTCCAGCAA GCTGAGCATC 
GATGAGGAGG TCTACTTCGA GAACCTGATG CAGCTTGTGG AGCATTACAC CACGGACGCC 
GACGGGCTCT GCACGCGCCT CATCAAACCG AAGGTGATGG AGGGGACGGT GGCAGCTCAG 
GACGAGTTCT CCCGCAGTGG CTGGGCCCTC AACATGAAGG ACCTCAAGCT GCTGCAAATC 
ATTGGCAAAG GGGAATTTGG AGATGTGATG CTGGGTGATT ACCGGGGGAA CAAAGTCGCC 
GTCAAGTGCA TTAAAAATGA CGCCACAGCG CAGGCTTTCC TGGCAGAAGC ATCCGTGATG 
ACGCAGCTCC GACACAGCAA CCTGGTGCAG CTGCTGGGGG TGATCGTGGA GGAGAAGAGC 
GGCCTCTACA TTGTCACTGA GTATATGGCC AAGGGCAGCC TAGTAGATTA CCTGCGGTCG 
CGTGGGAGGT CGGTCCTAGG CGCAGACTGC CTGCTCAAGT TTTCCTTAGA TGTCTGTGAA 
GCCATGGAGT ACCTGGAAGC CAACAACTTC GTCCACCGGG ACCTGGCGGC GAGGAATGTG 
TTGGTCTCAG AGGACAACAT TGCCAAGGTC AGCGATTTCG GGCTGACAAA GGAAGCGTCG 
TCCACTCAGG ACACGGGGAA GCTGCCTGTG AAGTGGACGG CACCCGAAGC ACTTAGAGAA 
AAGAAATTCT CCACCAAATC GGACGTGTGG AGCTTCGGGA TCCTCCTCTG GGAAATCTAC 
TCCTTCGGGC GAGTGCCTTA TCCGAGAATC CCCCTGAAGG ACGTGGTGCC CCGGGTGGAG 
AAGGGCTATA AGATGGACCC TCCAGACGGC TGCCCGGCCA TCGTCTACGA GGTGATGAAG 
AAGTGCTGGA CGCTGGACCC AGGGCACCGG CCGTCCTTCC ACCAGCTCCG TGAACAGCTA 
GTGCATATCA AAGAGAAGGA GCTCTACCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Electrostatic effects in the folding of the SH3 domain of the c-Src tyrosine kinase: pH-dependence in 3D-domain swapping and amyloid formation.
PloS one9(12)e113224(2014)
Bacarizo J,Martinez-Rodriguez S,Martin-Garcia JM,Andujar-Sanchez M,Ortiz-Salmeron E,Neira JL,Camara-Artigas A

Atomic resolution structures of the c-Src SH3 domain in complex with two high-affinity peptides from classes I and II.
Acta crystallographica. Section D, Biological crystallography69(Pt 5)756-66(2013 May)
Bacarizo J,Camara-Artigas A

Myristoylation and membrane binding regulate c-Src stability and kinase activity.
Molecular and cellular biology30(17)4094-107(2010 Sep)
Patwardhan P,Resh MD

c-Src trafficking and co-localization with the EGF receptor promotes EGF ligand-independent EGF receptor activation and signaling.
Cellular signalling20(7)1359-67(2008 Jul)
Donepudi M,Resh MD

c-Src control of chloride channel support for osteoclast HCl transport and bone resorption.
The Journal of biological chemistry281(38)28011-22(2006 Sep)
Edwards JC,Cohen C,Xu W,Schlesinger PH

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CSK cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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