IL1B cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL1B
Entrez Gene ID	395196
Full Name	interleukin 1, beta
Synonyms	IL-1BETA,IL1beta
General protein information	Preferred Names interleukin 1, beta Names interleukin-1 beta IL-1 beta
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204524.1	NP_989855.1	interleukin-1 beta
XM_015297469.1	XP_015152955.1	interleukin-1 beta isoform X1

Pathways from BioSystems

Homologies

	IL1RN	XP_001091833.1
Canis lupus familiaris (dog)	IL1RN	NP_001003096.1
Mus musculus (house mouse)	Il1rn	NP_001034790.1
Homo sapiens (human)	IL1RN	NP_776214.1
Pan troglodytes (chimpanzee)	IL1RN	XP_003949932.1
Bos taurus (cattle)	IL1RN	NP_776782.1
Rattus norvegicus (Norway rat)	Il1rn	NP_071530.1
Gallus gallus (chicken)	IL1B	NP_989855.1

Gene Ontology
Bibliography

Related articles in PubMed

Structure and function of chicken interleukin-1 beta mutants: uncoupling of receptor binding and in vivo biological activity.
Chen WT, Huang WY, Chen T, Salawu EO, Wang D, Lee YZ, Chang YY, Yang LW, Sue SC, Wang X, Yin HS
Scientific reports627729(2016 Jun)

Arsenic Trioxide Attenuates NF-?B and Cytokine mRNA Levels in the Livers of Cocks.
Zhang K, Zhao P, Guo G, Guo Y, Tian L, Sun X, Li S, He Y, Sun Y, Chai H, Zhang W, Xing M
Biological trace element research170(2)432-7(2016 Apr)

Ammonia concentration and relative humidity in poultry houses affect the immune response of broilers.
Wei FX, Hu XF, Xu B, Zhang MH, Li SY, Sun QY, Lin P
Genetics and molecular research : GMR14(2)3160-9(2015 Apr)

The effects of subcutaneous and intraocular administration of class B ODN CpG in chicken on the expression of TLR21, IFN-? and IL-1?.
Chrz?stek K, Wieliczko A
Polish journal of veterinary sciences17(4)593-9(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results showed that the expression levels of IL-6, IL-8, TNF-alpha, and NF-kappaB which seemed to be a critical mediator in the inflammatory response tended to increase in the birds chronically treated with As2O3. However, the mRNA expression levels of IL-4, IL-12beta, and IL-1beta were decreased in the experiment.
Title: Arsenic Trioxide Attenuates NF-?B and Cytokine mRNA Levels in the Livers of Cocks.

Data indicate that high levels of ammonia (NH3) caused increase in interleukin 1 beta (IL-1beta) gene expression in the experimental period and interleukin 4 (IL-4) gene expression in the first week.
Title: Ammonia concentration and relative humidity in poultry houses affect the immune response of broilers.

Effect of hydrogen bonding on the stability and foldimng of il-1 beta protein
Title: Case study of hydrogen bonding in a hydrophobic cavity.

The effect of class B CpG ODN administered by subcutaneous or intraocular injection on cytokine expression in chickens is reported.
Title: The effects of subcutaneous and intraocular administration of class B ODN CpG in chicken on the expression of TLR21, IFN-? and IL-1?.

This study provides the first in vivo evidence of the actions of ceramide and IL-1beta in mediating overfeeding-induced follicle atresia and progression of ovarian involution in broiler hens.
Title: Ceramide accumulation and up-regulation of proinflammatory interleukin-1? exemplify lipotoxicity to mediate declines of reproductive efficacy of broiler hens.

The following IL1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa25653	NM_204524.1 Latest version!	Gallus gallus interleukin 1, beta (IL1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OGa45451	XM_015297469.1 Latest version!	Gallus gallus interleukin 1, beta (IL1B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL1B ( NM_204524.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_989855.1 Gallus gallus interleukin 1, beta (IL1B), mRNA.

Price & Availability↑

CloneID	OGa25653
Clone ID Related Accession (Same CDS sequence)	NM_204524.1
Accession Version	NM_204524.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-24
Organism	Gallus gallus(chicken)
Product	interleukin-1 beta
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y15006.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y15006.1, HM179638.1 [ECO:0000332] ##Evidence-Data-END##

ATGGCGTTCG TTCCCGACCT GGACGTGCTG GAGAGCAGCA GCCTCAGCGA AGAGACCTTC 
TACGGCCCCT CCTGCCTCTG CCTGCAGAAG AAGCCTCGCC TGGATTCTGA GCACACCACA 
GTGGACGTGC AGGTGACGGT GCGGAAGGGA CGTGGTGCCC GGAGCTTTCG GCGGGCCGCC 
GTGCTGGTGG TGGCCATGAC CAAACTGCTG CGGAGGCCGA GGAGCAGGGA CTTTGCTGAC 
AGCGACCTGA GCGCGCTCCT GGAGGAGGTT TTTGAGCCCG TCACCTTCCA GCGGCTGGAG 
AGCAGCTACG CCGGGGCGCC CGCCTTCCGC TACACCCGCT CACAGTCCTT CGACATCTTC 
GACATCAACC AGAAGTGCTT CGTGCTGGAG TCACCCACCC AGCTGGTGGC CCTGCACCTC 
CAGGGGCCCT CCTCCAGCCA GAAAGTGAGG CTCAACATTG CGCTGTACCG GCCCCGAGGC 
CCACGGGGCA GCGCTGGAAC TGGGCAGATG CCAGTGGCAC TGGGCATCAA GGGCTACAAG 
CTCTACATGT CGTGTGTGAT GAGCGGCACC GAGCCCACAC TGCAGCTGGA GGAAGCCGAC 
GTCATGCGGG ACATCGACAG CGTCGAGCTG ACCCGCTTCA TCTTCTACCG CCTGGACAGC 
CCGACTGAGG GCACCACGCG CTTCGAGTCG GCCGCCTTCC CCGGGTGGTT CATCTGCACC 
TCCCTGCAGC CCCGGCAGCC CGTGGGCATC ACCAACCAAC CCGACCAGGT CAACATCGCC 
ACCTACAAGC TAAGTGGGCG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_989855.1
CDS	33..836
Translation	MAFVPDLDVLESSSLSEETFYGPSCLCLQKKPRLDSEHTTVDVQVTVRKGRGARSFRRAAVLVVAMTKLLRRPRSRDFADSDLSALLEEVFEPVTFQRLESSYAGAPAFRYTRSQSFDIFDINQKCFVLESPTQLVALHLQGPSSSQKVRLNIALYRPRGPRGSAGTGQMPVALGIKGYKLYMSCVMSGTEPTLQLEEADVMRDIDSVELTRFIFYRLDSPTEGTTRFESAAFPGWFICTSLQPRQPVGITNQPDQVNIATYKLSGR

Target ORF information:

RefSeq Version	NM_204524.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus interleukin 1, beta (IL1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204524.1

ORF Insert Sequence:

ATGGCGTTCG TTCCCGACCT GGACGTGCTG GAGAGCAGCA GCCTCAGCGA AGAGACCTTC 
TACGGCCCCT CCTGCCTCTG CCTGCAGAAG AAGCCTCGCC TGGATTCTGA GCACACCACA 
GTGGACGTGC AGGTGACGGT GCGGAAGGGA CGTGGTGCCC GGAGCTTTCG GCGGGCCGCC 
GTGCTGGTGG TGGCCATGAC CAAACTGCTG CGGAGGCCGA GGAGCAGGGA CTTTGCTGAC 
AGCGACCTGA GCGCGCTCCT GGAGGAGGTT TTTGAGCCCG TCACCTTCCA GCGGCTGGAG 
AGCAGCTACG CCGGGGCGCC CGCCTTCCGC TACACCCGCT CACAGTCCTT CGACATCTTC 
GACATCAACC AGAAGTGCTT CGTGCTGGAG TCACCCACCC AGCTGGTGGC CCTGCACCTC 
CAGGGGCCCT CCTCCAGCCA GAAAGTGAGG CTCAACATTG CGCTGTACCG GCCCCGAGGC 
CCACGGGGCA GCGCTGGAAC TGGGCAGATG CCAGTGGCAC TGGGCATCAA GGGCTACAAG 
CTCTACATGT CGTGTGTGAT GAGCGGCACC GAGCCCACAC TGCAGCTGGA GGAAGCCGAC 
GTCATGCGGG ACATCGACAG CGTCGAGCTG ACCCGCTTCA TCTTCTACCG CCTGGACAGC 
CCGACTGAGG GCACCACGCG CTTCGAGTCG GCCGCCTTCC CCGGGTGGTT CATCTGCACC 
TCCCTGCAGC CCCGGCAGCC CGTGGGCATC ACCAACCAAC CCGACCAGGT CAACATCGCC 
ACCTACAAGC TAAGTGGGCG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL1B ( XM_015297469.1 ) cDNA ORF clone, Gallus gallus(chicken) -> XP_015152955.1 Gallus gallus interleukin 1, beta (IL1B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OGa45451
Clone ID Related Accession (Same CDS sequence)	XM_015297469.1
Accession Version	XM_015297469.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-16
Organism	Gallus gallus(chicken)
Product	interleukin-1 beta isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006109.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAATCC CGCACGGCAG CCGCTTCCTT CCAGCGCTCC TTGAAAACGC GTCGCTCAGC 
AGCGGGGCTC AGAGCGCACC GAAGGCAGCG GGAGGAGCAC AGCACCGCGG GCTGCCTTCA 
CCCTCAGCTT TCACGCTGGG CACAGAGATG GCGTTCGTTC CCGACCTGGA CGTGCTGGAG 
AGCAGCAGCC TCAGCGAAGA GACCTTCTAC GGCCCCTCCT GCCTCTGCCT GCAGAAGGTA 
AGGATGGGAG GGCTGGGCGG CACGGTGGCG CGGTGCCGTG GCAGCGTGGG GCACTCAGCC 
GCAGCCTTCT CCCCGCAGAA GCCTCGCCTG GATTCTGAGC ACACCACAGT GGACGTGCAG 
GTGACGGTGC GGAAGGGACG TGGTGCCCGG AGCTTTCGGC GGGCCGCCGT GCTGGTGGTG 
GCCATGACCA AACTGCTGCG GAGGCCGAGG AGCAGGGACT TTGCTGACAG CGACCTGAGC 
GCGCTCCTGG AGGAGGTTTT TGAGCCCGTC ACCTTCCAGC GGCTGGAGAG CAGCTACGCC 
GGGGCGCCCG CCTTCCGCTA CACCCGCTCA CAGTCCTTCG ACATCTTCGA CATCAACCAG 
AAGTGCTTCG TGCTGGAGTC ACCCACCCAG CTGGTGGCCC TGCACCTCCA GGGGCCCTCA 
TCCAGCCAGA AAGTGAGGCT CAACATTGCG CTGTACCGGC CCCGAGGCCC ACGGGGCAGC 
GCTGGAACTG GGCAGATGCC AGTGGCACTG GGCATCAAGG GCTACAAGCT CTACATGTCG 
TGTGTGATGA GCGGCACCGA GCCCACACTG CAGCTGGAGG AAGCCGACGT CATGCGGGAC 
ATCGACAGCG TCGAGCTGAC CCGCTTCATC TTCTACCGCC TGGACAGCCC GACTGAGGGC 
ACCACGCGCT TCGAGTCGGC CGCCTTCCCC GGGTGGTTCA TCTGCACCTC CCTGCAGCCC 
CGGCAGCCCG TGGGCATCAC CAACCAACCC GACCAGGTCA ACATCGCCAC CTACAAGCTA 
AGTGGGCGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015152955.1
CDS	16..1047
Translation	MEIPHGSRFLPALLENASLSSGAQSAPKAAGGAQHRGLPSPSAFTLGTEMAFVPDLDVLESSSLSEETFYGPSCLCLQKVRMGGLGGTVARCRGSVGHSAAAFSPQKPRLDSEHTTVDVQVTVRKGRGARSFRRAAVLVVAMTKLLRRPRSRDFADSDLSALLEEVFEPVTFQRLESSYAGAPAFRYTRSQSFDIFDINQKCFVLESPTQLVALHLQGPSSSQKVRLNIALYRPRGPRGSAGTGQMPVALGIKGYKLYMSCVMSGTEPTLQLEEADVMRDIDSVELTRFIFYRLDSPTEGTTRFESAAFPGWFICTSLQPRQPVGITNQPDQVNIATYKLSGR

Target ORF information:

RefSeq Version	XM_015297469.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus interleukin 1, beta (IL1B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015297469.1

ORF Insert Sequence:

ATGGAAATCC CGCACGGCAG CCGCTTCCTT CCAGCGCTCC TTGAAAACGC GTCGCTCAGC 
AGCGGGGCTC AGAGCGCACC GAAGGCAGCG GGAGGAGCAC AGCACCGCGG GCTGCCTTCA 
CCCTCAGCTT TCACGCTGGG CACAGAGATG GCGTTCGTTC CCGACCTGGA CGTGCTGGAG 
AGCAGCAGCC TCAGCGAAGA GACCTTCTAC GGCCCCTCCT GCCTCTGCCT GCAGAAGGTA 
AGGATGGGAG GGCTGGGCGG CACGGTGGCG CGGTGCCGTG GCAGCGTGGG GCACTCAGCC 
GCAGCCTTCT CCCCGCAGAA GCCTCGCCTG GATTCTGAGC ACACCACAGT GGACGTGCAG 
GTGACGGTGC GGAAGGGACG TGGTGCCCGG AGCTTTCGGC GGGCCGCCGT GCTGGTGGTG 
GCCATGACCA AACTGCTGCG GAGGCCGAGG AGCAGGGACT TTGCTGACAG CGACCTGAGC 
GCGCTCCTGG AGGAGGTTTT TGAGCCCGTC ACCTTCCAGC GGCTGGAGAG CAGCTACGCC 
GGGGCGCCCG CCTTCCGCTA CACCCGCTCA CAGTCCTTCG ACATCTTCGA CATCAACCAG 
AAGTGCTTCG TGCTGGAGTC ACCCACCCAG CTGGTGGCCC TGCACCTCCA GGGGCCCTCA 
TCCAGCCAGA AAGTGAGGCT CAACATTGCG CTGTACCGGC CCCGAGGCCC ACGGGGCAGC 
GCTGGAACTG GGCAGATGCC AGTGGCACTG GGCATCAAGG GCTACAAGCT CTACATGTCG 
TGTGTGATGA GCGGCACCGA GCCCACACTG CAGCTGGAGG AAGCCGACGT CATGCGGGAC 
ATCGACAGCG TCGAGCTGAC CCGCTTCATC TTCTACCGCC TGGACAGCCC GACTGAGGGC 
ACCACGCGCT TCGAGTCGGC CGCCTTCCCC GGGTGGTTCA TCTGCACCTC CCTGCAGCCC 
CGGCAGCCCG TGGGCATCAC CAACCAACCC GACCAGGTCA ACATCGCCAC CTACAAGCTA 
AGTGGGCGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure and function of chicken interleukin-1 beta mutants: uncoupling of receptor binding and in vivo biological activity.
Scientific reports627729(2016 Jun)
Chen WT,Huang WY,Chen T,Salawu EO,Wang D,Lee YZ,Chang YY,Yang LW,Sue SC,Wang X,Yin HS

Arsenic Trioxide Attenuates NF-?B and Cytokine mRNA Levels in the Livers of Cocks.
Biological trace element research170(2)432-7(2016 Apr)
Zhang K,Zhao P,Guo G,Guo Y,Tian L,Sun X,Li S,He Y,Sun Y,Chai H,Zhang W,Xing M

Ammonia concentration and relative humidity in poultry houses affect the immune response of broilers.
Genetics and molecular research : GMR14(2)3160-9(2015 Apr)
Wei FX,Hu XF,Xu B,Zhang MH,Li SY,Sun QY,Lin P

The effects of subcutaneous and intraocular administration of class B ODN CpG in chicken on the expression of TLR21, IFN-? and IL-1?.
Polish journal of veterinary sciences17(4)593-9(2014)
Chrz?stek K,Wieliczko A

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IL1B cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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