His2Av cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	His2Av
Entrez Gene ID	43229
Full Name	Histone H2A variant
Synonyms	5499,CG5499,Dmel\CG5499,H2A,H2A.F/Z,H2A.V,H2A.X,H2A.Z,H2AV,H2AV_DROM,H2AX,H2AZ,H2Av,H2AvD,H2a.V,H2av,H2avD,HIS,HIS2AV,HIS2AVD,His,His2,His2A,His2AV,His2AvD,HisH2Av,Hist,Hist2av,gamma-H2AV,gamma-H2Av,gamma-HIS2AV,gamma-His2Av,gammaH2AV,gammaH2Av,h2AvD,his,his2Av,l(3)05146,l(3)810,l(3)97Dd,l(3)L1602
General protein information	Preferred Names Histone H2A variant Names CG5499 gene product from transcript CG5499-RB CG5499-PA CG5499-PB H2A variant His2Av-PA His2Av-PB Histone-2A Histone-2av histone histone 2A variant histone H2A variant histone H2Av histone variant H2Av histone2A histone2Av histone2AvD
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 97D3-97D3

mRNA and Protein(s)

mRNA	Protein	Name
NM_079795.3	NP_524519.1	histone H2A variant, isoform A
NM_001276068.1	NP_001262997.1	histone H2A variant, isoform B

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	H2AFV	XP_510606.3
Kluyveromyces lactis	KLLA0C05918g	XP_452461.1
Arabidopsis thaliana (thale cress)	HTA8	NP_850299.1
Oryza sativa (rice)	Os03g0162200	NP_001049049.1
Bos taurus (cattle)	H2AFV	NP_001033286.1
Drosophila melanogaster (fruit fly)	His2Av	NP_524519.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000306	XP_310818.3
Arabidopsis thaliana (thale cress)	HTA11	NP_191019.1
Oryza sativa (rice)	Os03g0743400	NP_001051232.1
	LOC701962	XP_001097247.1
Rattus norvegicus (Norway rat)	LOC685909	NP_001099489.1
Danio rerio (zebrafish)	h2afva	NP_705930.1
Mus musculus (house mouse)	H2afv	NP_084214.1
Caenorhabditis elegans (roundworm)	htz-1	NP_500569.1
Eremothecium gossypii	AGOS_ACL017C	NP_983387.1
Homo sapiens (human)	H2AFV	NP_036544.1
Saccharomyces cerevisiae (baker's yeast)	HTZ1	NP_014631.1
Schizosaccharomyces pombe (fission yeast)	pht1	NP_595630.3
Neurospora crassa	NCU05347	XP_963338.1
Oryza sativa (rice)	Os10g0418000	NP_001064611.1
Xenopus tropicalis (tropical clawed frog)	h2afv	NP_001016178.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

H2Av or H3S10 phosphorylation by JIL-1 is not required for chromatin decondensation or transcriptional elongation in Drosophila.
Title: H2Av facilitates H3S10 phosphorylation but is not required for heat shock-induced chromatin decondensation or transcriptional elongation.

the H2AZ-like rather than the H2AX-like function of H2AV is primarily required for normal hematopoiesis.
Title: The role of variant histone H2AV in

The nucleosome positioning sequence (NPS) patterns from H2A.Z nucleosomes differ from the NPS patterns from H2A nucleosomes. The purine-purine/pyrimidine-pyrimidine pattern of H2A.Z nucleosomes has major peaks shifted by 10 bp deviated from the H2A nucleosome pattern. The H2A and H2A.Z nucleosomes have different sequence preferences.
Title: Drosophila H2A and H2A.Z Nucleosome Sequences Reveal Different Nucleosome Positioning Sequence Patterns.

The study reports the crystal structure of the H2A.Z-binding domain of Drosophila melanogaster YL1 (dYL1-Z) in complex with an H2A.Z-H2B dimer at 1.9-A resolution.
Title: Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1.

The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation.
Title: The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation.

The following His2Av gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the His2Av cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa06243	NM_001276068.1 Latest version!	Drosophila melanogaster histone H2A variant, transcript variant B (His2Av), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OFa06243	NM_079795.3 Latest version!	Drosophila melanogaster histone H2A variant, transcript variant A (His2Av), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

His2Av ( NM_079795.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_524519.1 Drosophila melanogaster histone H2A variant, transcript variant A (His2Av), mRNA.

Price & Availability↑

CloneID	OFa06243
Clone ID Related Accession (Same CDS sequence)	NM_079795.3 , NM_001276068.1
Accession Version	NM_079795.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	histone H2A variant, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jan 16, 2013 this sequence version replaced NM_079795.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGCTGGCG GTAAAGCAGG CAAGGATTCG GGCAAGGCCA AGGCGAAGGC GGTATCGCGT 
TCCGCGCGCG CGGGTCTTCA GTTCCCCGTG GGTCGCATCC ATCGTCATCT CAAGAGCCGC 
ACTACGTCAC ATGGACGCGT CGGAGCCACT GCAGCCGTGT ACTCCGCTGC CATATTGGAA 
TACCTGACCG CCGAGGTCCT GGAGTTGGCA GGCAACGCAT CGAAGGACTT GAAAGTGAAA 
CGTATCACTC CTCGCCACTT ACAGCTCGCC ATTCGCGGAG ACGAGGAGCT GGACAGCCTG 
ATCAAGGCAA CCATCGCTGG TGGCGGTGTC ATTCCGCACA TACACAAGTC GCTGATCGGC 
AAAAAGGAGG AAACGGTGCA GGATCCGCAG CGGAAGGGCA ACGTCATTCT GTCGCAGGCC 
TACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524519.1
CDS	165..590
Translation	MAGGKAGKDSGKAKAKAVSRSARAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKEETVQDPQRKGNVILSQAY

Target ORF information:

RefSeq Version	NM_079795.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster histone H2A variant, transcript variant A (His2Av), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079795.3

ORF Insert Sequence:

ATGGCTGGCG GTAAAGCAGG CAAGGATTCG GGCAAGGCCA AGGCGAAGGC GGTATCGCGT 
TCCGCGCGCG CGGGTCTTCA GTTCCCCGTG GGTCGCATCC ATCGTCATCT CAAGAGCCGC 
ACTACGTCAC ATGGACGCGT CGGAGCCACT GCAGCCGTGT ACTCCGCTGC CATATTGGAA 
TACCTGACCG CCGAGGTCCT GGAGTTGGCA GGCAACGCAT CGAAGGACTT GAAAGTGAAA 
CGTATCACTC CTCGCCACTT ACAGCTCGCC ATTCGCGGAG ACGAGGAGCT GGACAGCCTG 
ATCAAGGCAA CCATCGCTGG TGGCGGTGTC ATTCCGCACA TACACAAGTC GCTGATCGGC 
AAAAAGGAGG AAACGGTGCA GGATCCGCAG CGGAAGGGCA ACGTCATTCT GTCGCAGGCC 
TACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

His2Av ( NM_001276068.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001262997.1 Drosophila melanogaster histone H2A variant, transcript variant B (His2Av), mRNA.

Price & Availability↑

CloneID	OFa06243
Clone ID Related Accession (Same CDS sequence)	NM_079795.3 , NM_001276068.1
Accession Version	NM_001276068.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	histone H2A variant, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGCTGGCG GTAAAGCAGG CAAGGATTCG GGCAAGGCCA AGGCGAAGGC GGTATCGCGT 
TCCGCGCGCG CGGGTCTTCA GTTCCCCGTG GGTCGCATCC ATCGTCATCT CAAGAGCCGC 
ACTACGTCAC ATGGACGCGT CGGAGCCACT GCAGCCGTGT ACTCCGCTGC CATATTGGAA 
TACCTGACCG CCGAGGTCCT GGAGTTGGCA GGCAACGCAT CGAAGGACTT GAAAGTGAAA 
CGTATCACTC CTCGCCACTT ACAGCTCGCC ATTCGCGGAG ACGAGGAGCT GGACAGCCTG 
ATCAAGGCAA CCATCGCTGG TGGCGGTGTC ATTCCGCACA TACACAAGTC GCTGATCGGC 
AAAAAGGAGG AAACGGTGCA GGATCCGCAG CGGAAGGGCA ACGTCATTCT GTCGCAGGCC 
TACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001262997.1
CDS	165..590
Translation	MAGGKAGKDSGKAKAKAVSRSARAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKEETVQDPQRKGNVILSQAY

Target ORF information:

RefSeq Version	NM_001276068.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster histone H2A variant, transcript variant B (His2Av), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001276068.1

ORF Insert Sequence:

ATGGCTGGCG GTAAAGCAGG CAAGGATTCG GGCAAGGCCA AGGCGAAGGC GGTATCGCGT 
TCCGCGCGCG CGGGTCTTCA GTTCCCCGTG GGTCGCATCC ATCGTCATCT CAAGAGCCGC 
ACTACGTCAC ATGGACGCGT CGGAGCCACT GCAGCCGTGT ACTCCGCTGC CATATTGGAA 
TACCTGACCG CCGAGGTCCT GGAGTTGGCA GGCAACGCAT CGAAGGACTT GAAAGTGAAA 
CGTATCACTC CTCGCCACTT ACAGCTCGCC ATTCGCGGAG ACGAGGAGCT GGACAGCCTG 
ATCAAGGCAA CCATCGCTGG TGGCGGTGTC ATTCCGCACA TACACAAGTC GCTGATCGGC 
AAAAAGGAGG AAACGGTGCA GGATCCGCAG CGGAAGGGCA ACGTCATTCT GTCGCAGGCC 
TACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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His2Av cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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