Crz cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Crz
Entrez Gene ID	41742
Full Name	Corazonin
Synonyms	CG3302,COR,CORZ,CRZ,Cora,Dm-Crz,Dmel\CG3302,Drm-COR,cor,crz
General protein information	Preferred Names Corazonin Names CG3302 gene product from transcript CG3302-RA CG3302-PA Crz-PA corazonin preprocorazonin
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 88B3-88B3

mRNA and Protein(s)

mRNA	Protein	Name
NM_079626.3	NP_524350.1	corazonin

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that the Crz action triggers transcriptional changes in the adipocytes that include stress genes and one gene involved in metabolism.
Title: Systemic corazonin signalling modulates stress responses and metabolism in Drosophila.

CrzR-associated signaling pathway is critical for ethanol detoxification via Crz-dependent regulation of ALDH activity and Crz-independent transcriptional regulation of ADH.
Title: Regulation of ethanol-related behavior and ethanol metabolism by the Corazonin neurons and Corazonin receptor in Drosophila melanogaster.

The work presented here identifies two genes, apt and crz, which mediate the fly's sensitivity to ethanol-induced sedation.
Title: A small group of neurosecretory cells expressing the transcriptional regulator apontic and the neuropeptide corazonin mediate ethanol sedation in Drosophila.

Findings indicate that short neuropeptide F (sNPF) and corazonin (CRZ) co-released from a small set of neurons regulate insulin-producing cells (IPCs) stress resistance and metabolism.
Title: Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and corazonin.

Data show that altered corazonin neuron physiology leads to fundamental differences in locomotor activity, and these effects were also sex-dependent.
Title: Corazonin neurons function in sexually dimorphic circuitry that shape behavioral responses to stress in Drosophila.

The following Crz gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Crz cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa04859	NM_079626.3 Latest version!	Drosophila melanogaster corazonin (Crz), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Crz ( NM_079626.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_524350.1 Drosophila melanogaster corazonin (Crz), mRNA.

Price & Availability↑

CloneID	OFa04859
Clone ID Related Accession (Same CDS sequence)	NM_079626.3
Accession Version	NM_079626.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	corazonin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On May 8, 2012 this sequence version replaced NM_079626.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTTGCGCC TCCTGCTGCT GCCCCTCTTC CTCTTCACGC TCTCCATGTG CATGGGCCAG 
ACCTTCCAGT ACTCCCGCGG ATGGACCAAC GGCAAGAGGT CCTTTAACGC CGCATCTCCC 
CTCCTGGCCA ACGGCCATCT CCATCGGGCC AGCGAGCTGG GACTCACGGA TCTCTACGAT 
TTGCAGGATT GGAGCAGCGA TCGTAGGCTC GAGCGCTGTC TATCGCAGCT CCAACGTTCA 
CTGATTGCCA GAAACTGTGT CCCCGGTTCG GACTTCAATG CCAACCGAGT AGATCCGGAT 
CCCGAAAACA GCGCCCATCC CAGACTGAGC AACTCTAATG GCGAGAATGT TTTGTACTCA 
AGTGCCAATA TCCCCAACAG ACATCGCCAG TCCAACGAAC TCCTAGAAGA GCTGAGTGCC 
GCTGGAGGAG CATCCGCCGA ACCCAATGTG TTTGGAAAAC ATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524350.1
CDS	83..547
Translation	MLRLLLLPLFLFTLSMCMGQTFQYSRGWTNGKRSFNAASPLLANGHLHRASELGLTDLYDLQDWSSDRRLERCLSQLQRSLIARNCVPGSDFNANRVDPDPENSAHPRLSNSNGENVLYSSANIPNRHRQSNELLEELSAAGGASAEPNVFGKH

Target ORF information:

RefSeq Version	NM_079626.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster corazonin (Crz), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079626.3

ORF Insert Sequence:

ATGTTGCGCC TCCTGCTGCT GCCCCTCTTC CTCTTCACGC TCTCCATGTG CATGGGCCAG 
ACCTTCCAGT ACTCCCGCGG ATGGACCAAC GGCAAGAGGT CCTTTAACGC CGCATCTCCC 
CTCCTGGCCA ACGGCCATCT CCATCGGGCC AGCGAGCTGG GACTCACGGA TCTCTACGAT 
TTGCAGGATT GGAGCAGCGA TCGTAGGCTC GAGCGCTGTC TATCGCAGCT CCAACGTTCA 
CTGATTGCCA GAAACTGTGT CCCCGGTTCG GACTTCAATG CCAACCGAGT AGATCCGGAT 
CCCGAAAACA GCGCCCATCC CAGACTGAGC AACTCTAATG GCGAGAATGT TTTGTACTCA 
AGTGCCAATA TCCCCAACAG ACATCGCCAG TCCAACGAAC TCCTAGAAGA GCTGAGTGCC 
GCTGGAGGAG CATCCGCCGA ACCCAATGTG TTTGGAAAAC ATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Crz cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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