Art1 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Art1
Entrez Gene ID	41295
Full Name	Arginine methyltransferase 1
Synonyms	CG6554,DART1,Dart,Dart1,Dmel\CG6554,dart1
General protein information	Preferred Names Arginine methyltransferase 1 Names CG6554 gene product from transcript CG6554-RA Arg methyltransferase 1 Art1-PA CG6554-PA arginine methyltransferase 1
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 86C6-86C6

mRNA and Protein(s)

mRNA	Protein	Name
NM_141760.4	NP_650017.1	arginine methyltransferase 1

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Art1	NP_650017.1
Neurospora crassa	NCU07459	XP_963910.1
Arabidopsis thaliana (thale cress)	PRMT1A	NP_179557.1
Homo sapiens (human)	PRMT1	NP_001527.3
	LOC719419	XP_001113609.2
Magnaporthe oryzae (rice blast fungus)	MGG_04584	XP_003713607.1
Oryza sativa (rice)	Os09g0359800	NP_001062975.1
Canis lupus familiaris (dog)	PRMT1	XP_851543.1
Mus musculus (house mouse)	Prmt1	NP_062804.1
Eremothecium gossypii	AGOS_AAR190W	NP_982733.1
Danio rerio (zebrafish)	prmt1	NP_956944.2
Caenorhabditis elegans (roundworm)	prmt-1	NP_507909.1
Saccharomyces cerevisiae (baker's yeast)	HMT1	NP_009590.1
Kluyveromyces lactis	KLLA0B07117g	XP_451847.1
Bos taurus (cattle)	PRMT1	NP_001015624.1
Rattus norvegicus (Norway rat)	Prmt1	NP_077339.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003462	XP_311750.4
Schizosaccharomyces pombe (fission yeast)	rmt1	NP_594825.2
Arabidopsis thaliana (thale cress)	PRMT11	NP_194680.1
Xenopus tropicalis (tropical clawed frog)	prmt1	NP_001005629.2

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that knockdown of Dart1 leds to a reduction in methylation of hFUS P525L and aggravated the neurodegenerative phenotype in transgenic flies
Title: Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila.

wild type FUS (FUS-WT) specifically interacts with protein arginine methyltransferases 1 and 8 (PRMT1 and PRMT8) and undergoes asymmetric dimethylation.
Title: Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.

These findings suggest that DART1, a histone arginine methyltransferase, is a co-repressor of EcR that is indispensable for normal pupal development in the intact fly.
Title: Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor.

Identification of DART1 and DART4, protein arginine methyltransferases, that are expressed in various Drosophila developmental stages
Title: Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4.

The following Art1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Art1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa08296	NM_141760.4 Latest version!	Drosophila melanogaster arginine methyltransferase 1 (Art1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Art1 ( NM_141760.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_650017.1 Drosophila melanogaster arginine methyltransferase 1 (Art1), mRNA.

Price & Availability↑

CloneID	OFa08296
Clone ID Related Accession (Same CDS sequence)	NM_141760.4
Accession Version	NM_141760.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1131bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	arginine methyltransferase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jul 15, 2014 this sequence version replaced NM_141760.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGCCAGCA CAGACATTCC CATGGAGGCA GCTGTGGAAT CGGCGACCGG CATCACGCCC 
AATTCAAATG CGAACTCAAA CAATGTGGCG AAGAAGCTGC CCGCGGAGGG CTCCACCGGT 
GATAATCCCA ATGCCAACGC CGACGAGATG ACGTCCCGCG ACTATTACTT TGACTCCTAT 
GCCCATTTCG GGATCCACGA GGAGATGCTC AAGGACGAAG TGCGCACCGT CACATACCGC 
AACGCCATGT ACCACAACAA GCATCTGTTT CAGGGCAAGA CCGTACTGGA CGTGGGTTGC 
GGTACCGGCA TTCTCTCCAT GTTCGCTGCC AAAGCCGGTG CTGCTCAGGT GATTGCCGTC 
GACTGCTCCA ACATCATTGA GTTTGCCCGC CAAGTGGTCA TTGACAACAA TCTGCAGGAT 
GTAATCACGG TTGTCAAGGG CAAGATTGAG GAGATTGAGC TTCCAAATGG TATTGAGGGA 
GTGGACATTA TTATTTCCGA GTGGATGGGT TACTGCCTGT TCTACGAATC CATGCTGGAT 
ACAGTGTTGT ACGCTCGGGA CAAGTGGCTG AAGAAGGACG GCATGATGTT CCCAGATAGG 
GGCACGCTGT ATATCACGGC CATCGAGGAC AGACAGTACA AGGACGAGAA GATCAACTGG 
TGGGACGATG TCTACGGCTT CGACATGAGC TGCATTCGTA AGGTGGCCGT GACCGAGCCA 
CTGGTCGACG TGGTCGATCC CAAGCAAGTG GTATCCACAT CTTGCATGGT CAAGGAGGTG 
GATCTGTATA CCGTGCAAAA GGCCGATCTT AACTTCTCGT CCAAGTTCAG CCTATGCATC 
AAGCGCAACG ACTTCGTGCA GGCATTAGTC ACCTACTTTA ATATAGAGTT CACCAAGTGC 
CACAAGCGTC TTGGGTTCAG TACGTCACCA GACTCCACAT ACACGCATTG GAAGCAAACC 
GTGTTCTACC TCGATGACCA CATGACGGCA AAGAAGAACG AGGAGATCAC TGGCACGTTC 
CAGATGAAGC CCAACGAGCG GAACAACCGT GACCTGGACT TCGTCATCGA CATTAATTTC 
AAGGGCGAAT TGTCTCAAAT TCAGGAGTCG AACACATACC GCATGCGCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_650017.1
CDS	113..1243
Translation	MASTDIPMEAAVESATGITPNSNANSNNVAKKLPAEGSTGDNPNANADEMTSRDYYFDSYAHFGIHEEMLKDEVRTVTYRNAMYHNKHLFQGKTVLDVGCGTGILSMFAAKAGAAQVIAVDCSNIIEFARQVVIDNNLQDVITVVKGKIEEIELPNGIEGVDIIISEWMGYCLFYESMLDTVLYARDKWLKKDGMMFPDRGTLYITAIEDRQYKDEKINWWDDVYGFDMSCIRKVAVTEPLVDVVDPKQVVSTSCMVKEVDLYTVQKADLNFSSKFSLCIKRNDFVQALVTYFNIEFTKCHKRLGFSTSPDSTYTHWKQTVFYLDDHMTAKKNEEITGTFQMKPNERNNRDLDFVIDINFKGELSQIQESNTYRMR

Target ORF information:

RefSeq Version	NM_141760.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster arginine methyltransferase 1 (Art1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_141760.4

ORF Insert Sequence:

ATGGCCAGCA CAGACATTCC CATGGAGGCA GCTGTGGAAT CGGCGACCGG CATCACGCCC 
AATTCAAATG CGAACTCAAA CAATGTGGCG AAGAAGCTGC CCGCGGAGGG CTCCACCGGT 
GATAATCCCA ATGCCAACGC CGACGAGATG ACGTCCCGCG ACTATTACTT TGACTCCTAT 
GCCCATTTCG GGATCCACGA GGAGATGCTC AAGGACGAAG TGCGCACCGT CACATACCGC 
AACGCCATGT ACCACAACAA GCATCTGTTT CAGGGCAAGA CCGTACTGGA CGTGGGTTGC 
GGTACCGGCA TTCTCTCCAT GTTCGCTGCC AAAGCCGGTG CTGCTCAGGT GATTGCCGTC 
GACTGCTCCA ACATCATTGA GTTTGCCCGC CAAGTGGTCA TTGACAACAA TCTGCAGGAT 
GTAATCACGG TTGTCAAGGG CAAGATTGAG GAGATTGAGC TTCCAAATGG TATTGAGGGA 
GTGGACATTA TTATTTCCGA GTGGATGGGT TACTGCCTGT TCTACGAATC CATGCTGGAT 
ACAGTGTTGT ACGCTCGGGA CAAGTGGCTG AAGAAGGACG GCATGATGTT CCCAGATAGG 
GGCACGCTGT ATATCACGGC CATCGAGGAC AGACAGTACA AGGACGAGAA GATCAACTGG 
TGGGACGATG TCTACGGCTT CGACATGAGC TGCATTCGTA AGGTGGCCGT GACCGAGCCA 
CTGGTCGACG TGGTCGATCC CAAGCAAGTG GTATCCACAT CTTGCATGGT CAAGGAGGTG 
GATCTGTATA CCGTGCAAAA GGCCGATCTT AACTTCTCGT CCAAGTTCAG CCTATGCATC 
AAGCGCAACG ACTTCGTGCA GGCATTAGTC ACCTACTTTA ATATAGAGTT CACCAAGTGC 
CACAAGCGTC TTGGGTTCAG TACGTCACCA GACTCCACAT ACACGCATTG GAAGCAAACC 
GTGTTCTACC TCGATGACCA CATGACGGCA AAGAAGAACG AGGAGATCAC TGGCACGTTC 
CAGATGAAGC CCAACGAGCG GAACAACCGT GACCTGGACT TCGTCATCGA CATTAATTTC 
AAGGGCGAAT TGTCTCAAAT TCAGGAGTCG AACACATACC GCATGCGCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Art1 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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