ATP6AP2 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP6AP2
Entrez Gene ID	41104
Full Name	Vacuolar H[+] ATPase M8.9 accessory subunit
Synonyms	ATP6AP2,CG8444,Dmel\CG8444,VhaM8-9,VhaPRR,dPRR,vhaM8.9
General protein information	Preferred Names Vacuolar H[+] ATPase M8.9 accessory subunit Names CG8444 gene product from transcript CG8444-RA CG8444-PA VhaM8.9-PA vacuolar H[+] ATPase M8.9 accessory subunit
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 85D6-85D7

mRNA and Protein(s)

mRNA	Protein	Name
NM_141619.3	NP_649876.1	ATPase H+ transporting accessory protein 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ATP6AP2	XP_003435545.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003430	XP_311717.4
Drosophila melanogaster (fruit fly)	VhaM8.9	NP_649876.1
	ATP6AP2	XP_001093417.2
Mus musculus (house mouse)	Atp6ap2	NP_081715.1
Rattus norvegicus (Norway rat)	Atp6ap2	NP_001007092.1
Homo sapiens (human)	ATP6AP2	NP_005756.2
Gallus gallus (chicken)	ATP6AP2	NP_001025972.1
Xenopus tropicalis (tropical clawed frog)	atp6ap2	NP_001011319.1
Pan troglodytes (chimpanzee)	ATP6AP2	XP_521010.3
Bos taurus (cattle)	ATP6AP2	NP_001091491.1
Danio rerio (zebrafish)	atp6ap2	NP_998188.2

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the missense mutations in ATP6AP2 lead to impaired V-ATPase assembly and subsequent defects in glycosylation and autophagy.
Title: Mutations in the X-linked

ATP6AP2 disruption leads to cognitive impairment and neurodegeneration, mimicking aspects of the neuropathology associated with ATP6AP2 mutations in humans.
Title: Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.

Two roles for VhaPRR, one for planar cell polarity and another in endosomal trafficking. This dual function establishes VhaPRR as a key factor in epithelial morphogenesis.
Title: Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking.

The Drosophila protein CG8444 is a prorenin receptor (named herein dPRR), and has an evolutionarily conserved role at the receptor level for activation of canonical and noncanonical Wnt/Fz signaling pathways.
Title: Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor.

The transmembrane protein CG8444 (here termed VhaPRR) is needed for planar cell polarity signaling in Drosophila.
Title: Regulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunit.

The following ATP6AP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP6AP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa08182	NM_141619.3 Latest version!	Drosophila melanogaster ATPase H+ transporting accessory protein 2 (ATP6AP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP6AP2 ( NM_141619.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_649876.1 Drosophila melanogaster ATPase H+ transporting accessory protein 2 (ATP6AP2), mRNA.

Price & Availability↑

CloneID	OFa08182
Clone ID Related Accession (Same CDS sequence)	NM_141619.3
Accession Version	NM_141619.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	ATPase H+ transporting accessory protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jul 15, 2014 this sequence version replaced NM_141619.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTTGAGAG TTTTCGTGAT TTTCTCGCTG TTTATAGCGG CCATCAATGC CTCTGGCGAA 
TTCACCGTGC TGAACCGTCC CAAGGCAATC AGTTTCAAGG GCAACGATGC ACTGGAAAGC 
CACTACGTGG GTGATGTACT CTACGCTTCC ATGGGCAACG CCGTCAGCGG CGATACCAAC 
TGGAACGGAC TGACCATCAA CGATCCCTTC AACCTGGCCA AGGGCGTCAT TCTGGTGCAT 
GTCCAGGGCA TTGGTCACGT GACCACCGCC GGCAACGTCA AGACCTACGA GCTGACAGGC 
TCCGGAACGG ACGCCTCTCT GAACGCCCTG GCCGCCGAAC TGGAGGCAGC CAACGAGCCC 
GTCTGCGATA TTAACTTTGA GCAGTTCGAC GATGGCGTTC AAGCCTGGAA GTCCTGCTTT 
GGTGATTTCG AGGCCCCAGC CGCCAAGCCC ACCAAGCACC TGAACCCCTC TCTGCACACC 
GCTGACAAGC AGTTCCTCCA GGAGGTTGGA TTCATCAACA GTGCCGCCGA TCATCTGGCT 
GAGATGGCCA AGCCCTCGAA TGTCCTGATG CTGCGCGTTT CCGTCGATGG AGTGGCCAAG 
GCTCATGGCG AGAAGTCCGT GGCCGTGGAG GAGGCCAACA AATTGCTGTC GGCCGCTATC 
AGCCGCCTGC TTGCTGCCTC CCAGAAGTCC AGCGACTCGG TTCTGTTTGT CCAGACCACG 
GAGAAGGACG TGGCAGCATC GCGTGCCAAG CGTGATACCA TTGCCGCTTC CACCACCAAT 
CCCTACAACC TGGCCGTCTA CTACGGCAGC GACTACCCGG TGATCTTCAA CATCATCCTG 
TGGTTCATGG TCGTCTTCGG ACTGTCTCTG CTGGCTATCT GCTACGCCAT CGCTGCCATG 
GATCCCGGCA GGGACTCCAT CATTTACCGC ATGACCTCTA CCCGCATCAA GAAGGACAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_649876.1
CDS	88..1050
Translation	MLRVFVIFSLFIAAINASGEFTVLNRPKAISFKGNDALESHYVGDVLYASMGNAVSGDTNWNGLTINDPFNLAKGVILVHVQGIGHVTTAGNVKTYELTGSGTDASLNALAAELEAANEPVCDINFEQFDDGVQAWKSCFGDFEAPAAKPTKHLNPSLHTADKQFLQEVGFINSAADHLAEMAKPSNVLMLRVSVDGVAKAHGEKSVAVEEANKLLSAAISRLLAASQKSSDSVLFVQTTEKDVAASRAKRDTIAASTTNPYNLAVYYGSDYPVIFNIILWFMVVFGLSLLAICYAIAAMDPGRDSIIYRMTSTRIKKDN

Target ORF information:

RefSeq Version	NM_141619.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster ATPase H+ transporting accessory protein 2 (ATP6AP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_141619.3

ORF Insert Sequence:

ATGTTGAGAG TTTTCGTGAT TTTCTCGCTG TTTATAGCGG CCATCAATGC CTCTGGCGAA 
TTCACCGTGC TGAACCGTCC CAAGGCAATC AGTTTCAAGG GCAACGATGC ACTGGAAAGC 
CACTACGTGG GTGATGTACT CTACGCTTCC ATGGGCAACG CCGTCAGCGG CGATACCAAC 
TGGAACGGAC TGACCATCAA CGATCCCTTC AACCTGGCCA AGGGCGTCAT TCTGGTGCAT 
GTCCAGGGCA TTGGTCACGT GACCACCGCC GGCAACGTCA AGACCTACGA GCTGACAGGC 
TCCGGAACGG ACGCCTCTCT GAACGCCCTG GCCGCCGAAC TGGAGGCAGC CAACGAGCCC 
GTCTGCGATA TTAACTTTGA GCAGTTCGAC GATGGCGTTC AAGCCTGGAA GTCCTGCTTT 
GGTGATTTCG AGGCCCCAGC CGCCAAGCCC ACCAAGCACC TGAACCCCTC TCTGCACACC 
GCTGACAAGC AGTTCCTCCA GGAGGTTGGA TTCATCAACA GTGCCGCCGA TCATCTGGCT 
GAGATGGCCA AGCCCTCGAA TGTCCTGATG CTGCGCGTTT CCGTCGATGG AGTGGCCAAG 
GCTCATGGCG AGAAGTCCGT GGCCGTGGAG GAGGCCAACA AATTGCTGTC GGCCGCTATC 
AGCCGCCTGC TTGCTGCCTC CCAGAAGTCC AGCGACTCGG TTCTGTTTGT CCAGACCACG 
GAGAAGGACG TGGCAGCATC GCGTGCCAAG CGTGATACCA TTGCCGCTTC CACCACCAAT 
CCCTACAACC TGGCCGTCTA CTACGGCAGC GACTACCCGG TGATCTTCAA CATCATCCTG 
TGGTTCATGG TCGTCTTCGG ACTGTCTCTG CTGGCTATCT GCTACGCCAT CGCTGCCATG 
GATCCCGGCA GGGACTCCAT CATTTACCGC ATGACCTCTA CCCGCATCAA GAAGGACAAC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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ATP6AP2 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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