Ctr1B cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ctr1B
Entrez Gene ID	40989
Full Name	Copper transporter 1B
Synonyms	CG7459,Dmel\CG7459,ctr1B
General protein information	Preferred Names Copper transporter 1B Names CG7459 gene product from transcript CG7459-RA CG7459-PA Ctr1B-PA copper transporter 1B
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 84F11-84F11

mRNA and Protein(s)

mRNA	Protein	Name
NM_141533.4	NP_649790.1	copper transporter 1B

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Using a model of HD, we found that altered expression of Ctr1B or ATP7 in the brain, or modulation of dietary copper availability, significantly modified the phenotypes caused by human Htt exon1-polyQ expression.
Title: Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding.

Data indicate that MTF-1 is capable of binding to different regions of MtnA and Ctr1b genes depending on different metal stimulation.
Title: Single nucleotide in the MTF-1 binding site can determine metal-specific transcription activation.

Here, it is reported that mutant flies lacking Ctr1B are extremely sensitive to cadmium and mercury treatment, but can be rescued by excess copper in the food.
Title: Mercury and cadmium trigger expression of the copper importer Ctr1B, which enables Drosophila to thrive on heavy metal-loaded food.

copper acquisition through the Drosophila Ctr1B transporter is crucial for normal growth and in early and specific stages of metazoan development
Title: A copper-regulated transporter required for copper acquisition, pigmentation, and specific stages of development in Drosophila melanogaster.

The following Ctr1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ctr1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa08130	NM_141533.4 Latest version!	Drosophila melanogaster copper transporter 1B (Ctr1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ctr1B ( NM_141533.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_649790.1 Drosophila melanogaster copper transporter 1B (Ctr1B), mRNA.

Price & Availability↑

CloneID	OFa08130
Clone ID Related Accession (Same CDS sequence)	NM_141533.4
Accession Version	NM_141533.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 525bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	copper transporter 1B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jul 15, 2014 this sequence version replaced NM_141533.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGATCACG GCTCGGATGA CAGCACCAGC ACGGCCAAGT CCTGCCCTAT GATCATGGTG 
TTCCACGCTG GACACTGCGA GCGAATTTTG TGGCGCGGAT GGGTGGCGTC CACTGTGACG 
GAGTTCGTGC TCTCCGCCCT GGCCATCTTC CTGGTGTCCT TCCTGTATGA GGCGCTCAAG 
TTCCTGCGAC AGCAACTGGC GCGCAGGGAA GCCCGTCGAG CAAGCGAGCA GCTGGCGGCG 
GAGCAGCGTA GGAAGAACGA GGCTCCGGCA GCCGGAGGAT GCTGCTCGGA AGCTCCCCTG 
GCGGAGCCGA GGGAGCAGAC CTACTGGCAG CGCTTGTTCG CCTCGTCGCA CATCGTCCAG 
TCCCTGCTGA ACCTGCTGCA GATCGTCATC TCGTACCTGC TGATGCTGAT CTTCATGACC 
TTCAACTACT GGCTGTGCCT GGCAGTGATC CTGGGACTGG GTCTGGGCTA CTTCTTCTTC 
GGCTGGAACA AGAAGAATCC CGACGAGAGC GAGTGCTGTC CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_649790.1
CDS	126..650
Translation	MDHGSDDSTSTAKSCPMIMVFHAGHCERILWRGWVASTVTEFVLSALAIFLVSFLYEALKFLRQQLARREARRASEQLAAEQRRKNEAPAAGGCCSEAPLAEPREQTYWQRLFASSHIVQSLLNLLQIVISYLLMLIFMTFNYWLCLAVILGLGLGYFFFGWNKKNPDESECCP

Target ORF information:

RefSeq Version	NM_141533.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster copper transporter 1B (Ctr1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_141533.4

ORF Insert Sequence:

ATGGATCACG GCTCGGATGA CAGCACCAGC ACGGCCAAGT CCTGCCCTAT GATCATGGTG 
TTCCACGCTG GACACTGCGA GCGAATTTTG TGGCGCGGAT GGGTGGCGTC CACTGTGACG 
GAGTTCGTGC TCTCCGCCCT GGCCATCTTC CTGGTGTCCT TCCTGTATGA GGCGCTCAAG 
TTCCTGCGAC AGCAACTGGC GCGCAGGGAA GCCCGTCGAG CAAGCGAGCA GCTGGCGGCG 
GAGCAGCGTA GGAAGAACGA GGCTCCGGCA GCCGGAGGAT GCTGCTCGGA AGCTCCCCTG 
GCGGAGCCGA GGGAGCAGAC CTACTGGCAG CGCTTGTTCG CCTCGTCGCA CATCGTCCAG 
TCCCTGCTGA ACCTGCTGCA GATCGTCATC TCGTACCTGC TGATGCTGAT CTTCATGACC 
TTCAACTACT GGCTGTGCCT GGCAGTGATC CTGGGACTGG GTCTGGGCTA CTTCTTCTTC 
GGCTGGAACA AGAAGAATCC CGACGAGAGC GAGTGCTGTC CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Ctr1B cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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