fln cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	fln
Entrez Gene ID	40185
Full Name	flightin
Synonyms	CG7445,Dmel\CG7445,Fln,Ftn,mp27
General protein information	Preferred Names flightin Names CG7445 gene product from transcript CG7445-RA CG7445-PA CG7445-PB fln-PA fln-PB
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3L Map Location: 76D8-76D8

mRNA and Protein(s)

mRNA	Protein	Name
NM_079450.4	NP_524174.1	flightin, isoform A
NM_001275155.1	NP_001262084.1	flightin, isoform B

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	fln	NP_001262084.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007249	XP_308552.4

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

phosphorylation of D. melanogaster flightin is modulated during flight
Title: Intrinsic disorder and multiple phosphorylations constrain the evolution of the flightin N-terminal region.

COOH terminus of flightin is necessary for normal myofilament lattice organization, thereby facilitating the cross-bridge binding required to achieve high power output for flight.
Title: COOH-terminal truncation of flightin decreases myofilament lattice organization, cross-bridge binding, and power output in Drosophila indirect flight muscle.

used atomic force microscopy to study the morphological and mechanical properties of fully hydrated native thick filaments isolated from indirect flight muscle of normal and mutants lacking flightin
Title: Flightin is necessary for length determination, structural integrity, and large bending stiffness of insect flight muscle thick filaments.

Myofilin is probably needed for filament assembly in all muscles, and flightin for stability of flight muscle thick filaments in adult flies
Title: Myofilin, a protein in the thick filaments of insect muscle.

Results illustrate the importance of flightin in flight muscle development and function.
Title: Flight muscle properties and aerodynamic performance of Drosophila expressing a flightin transgene.

The following fln gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the fln cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa19042	NM_079450.4 Latest version!	Drosophila melanogaster flightin (fln), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OFa19042	NM_001275155.1 Latest version!	Drosophila melanogaster flightin (fln), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

fln ( NM_079450.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_524174.1 Drosophila melanogaster flightin (fln), transcript variant A, mRNA.

Price & Availability↑

CloneID	OFa19042
Clone ID Related Accession (Same CDS sequence)	NM_079450.4 , NM_001275155.1
Accession Version	NM_079450.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	flightin, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jul 15, 2014 this sequence version replaced NM_079450.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGCAGACG AAGAAGATCC ATGGGGTTTC GACGACGGCG GCGAGGAGGA GAAGGCGGCA 
TCCACCCAGG CGGGCACTCC GGCCCCACCC TCAAAAGCAC CGAGTGTGGC ATCCGATCAC 
AAGGCTGATA GCGTCGTGGC TGGCACTCCG GCCAACGAGG AGGCTGCTCC GGAAGAGGTA 
GAAGAAATCA AAGCACCGCC GCCTCCGCCA GAAGACGATG GTTACAGGAA ACCGGTGCAG 
CTCTACCGCC ACTGGGTCAG GCCGAAGTTT CTGCAATACA AATACATGTA CAACTACAGA 
ACCAACTATT ACGATGATGT AATTGACTAT ATCGACAAAA AACAAACTGG AGTGGCCCGG 
GAAATACCAA GACCACAGAC GTGGGCGGAA CGTGTCCTGC GCACACGGAA TATCAGTGGC 
AGTGACATTG ATTCGTATGC ACCGGCAAAG AGGGACAAAC AACTAATTCA AACACTGGCG 
GCCTCGATAA GAACTTATAA TTACCACACC AAGGCATATA TCAACCAAAG GTATGCCAGT 
GTCCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524174.1
CDS	77..625
Translation	MADEEDPWGFDDGGEEEKAASTQAGTPAPPSKAPSVASDHKADSVVAGTPANEEAAPEEVEEIKAPPPPPEDDGYRKPVQLYRHWVRPKFLQYKYMYNYRTNYYDDVIDYIDKKQTGVAREIPRPQTWAERVLRTRNISGSDIDSYAPAKRDKQLIQTLAASIRTYNYHTKAYINQRYASVL

Target ORF information:

RefSeq Version	NM_079450.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster flightin (fln), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079450.4

ORF Insert Sequence:

ATGGCAGACG AAGAAGATCC ATGGGGTTTC GACGACGGCG GCGAGGAGGA GAAGGCGGCA 
TCCACCCAGG CGGGCACTCC GGCCCCACCC TCAAAAGCAC CGAGTGTGGC ATCCGATCAC 
AAGGCTGATA GCGTCGTGGC TGGCACTCCG GCCAACGAGG AGGCTGCTCC GGAAGAGGTA 
GAAGAAATCA AAGCACCGCC GCCTCCGCCA GAAGACGATG GTTACAGGAA ACCGGTGCAG 
CTCTACCGCC ACTGGGTCAG GCCGAAGTTT CTGCAATACA AATACATGTA CAACTACAGA 
ACCAACTATT ACGATGATGT AATTGACTAT ATCGACAAAA AACAAACTGG AGTGGCCCGG 
GAAATACCAA GACCACAGAC GTGGGCGGAA CGTGTCCTGC GCACACGGAA TATCAGTGGC 
AGTGACATTG ATTCGTATGC ACCGGCAAAG AGGGACAAAC AACTAATTCA AACACTGGCG 
GCCTCGATAA GAACTTATAA TTACCACACC AAGGCATATA TCAACCAAAG GTATGCCAGT 
GTCCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

fln ( NM_001275155.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001262084.1 Drosophila melanogaster flightin (fln), transcript variant B, mRNA.

Price & Availability↑

CloneID	OFa19042
Clone ID Related Accession (Same CDS sequence)	NM_079450.4 , NM_001275155.1
Accession Version	NM_001275155.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	flightin, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGCAGACG AAGAAGATCC ATGGGGTTTC GACGACGGCG GCGAGGAGGA GAAGGCGGCA 
TCCACCCAGG CGGGCACTCC GGCCCCACCC TCAAAAGCAC CGAGTGTGGC ATCCGATCAC 
AAGGCTGATA GCGTCGTGGC TGGCACTCCG GCCAACGAGG AGGCTGCTCC GGAAGAGGTA 
GAAGAAATCA AAGCACCGCC GCCTCCGCCA GAAGACGATG GTTACAGGAA ACCGGTGCAG 
CTCTACCGCC ACTGGGTCAG GCCGAAGTTT CTGCAATACA AATACATGTA CAACTACAGA 
ACCAACTATT ACGATGATGT AATTGACTAT ATCGACAAAA AACAAACTGG AGTGGCCCGG 
GAAATACCAA GACCACAGAC GTGGGCGGAA CGTGTCCTGC GCACACGGAA TATCAGTGGC 
AGTGACATTG ATTCGTATGC ACCGGCAAAG AGGGACAAAC AACTAATTCA AACACTGGCG 
GCCTCGATAA GAACTTATAA TTACCACACC AAGGCATATA TCAACCAAAG GTATGCCAGT 
GTCCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001262084.1
CDS	277..825
Translation	MADEEDPWGFDDGGEEEKAASTQAGTPAPPSKAPSVASDHKADSVVAGTPANEEAAPEEVEEIKAPPPPPEDDGYRKPVQLYRHWVRPKFLQYKYMYNYRTNYYDDVIDYIDKKQTGVAREIPRPQTWAERVLRTRNISGSDIDSYAPAKRDKQLIQTLAASIRTYNYHTKAYINQRYASVL

Target ORF information:

RefSeq Version	NM_001275155.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster flightin (fln), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001275155.1

ORF Insert Sequence:

ATGGCAGACG AAGAAGATCC ATGGGGTTTC GACGACGGCG GCGAGGAGGA GAAGGCGGCA 
TCCACCCAGG CGGGCACTCC GGCCCCACCC TCAAAAGCAC CGAGTGTGGC ATCCGATCAC 
AAGGCTGATA GCGTCGTGGC TGGCACTCCG GCCAACGAGG AGGCTGCTCC GGAAGAGGTA 
GAAGAAATCA AAGCACCGCC GCCTCCGCCA GAAGACGATG GTTACAGGAA ACCGGTGCAG 
CTCTACCGCC ACTGGGTCAG GCCGAAGTTT CTGCAATACA AATACATGTA CAACTACAGA 
ACCAACTATT ACGATGATGT AATTGACTAT ATCGACAAAA AACAAACTGG AGTGGCCCGG 
GAAATACCAA GACCACAGAC GTGGGCGGAA CGTGTCCTGC GCACACGGAA TATCAGTGGC 
AGTGACATTG ATTCGTATGC ACCGGCAAAG AGGGACAAAC AACTAATTCA AACACTGGCG 
GCCTCGATAA GAACTTATAA TTACCACACC AAGGCATATA TCAACCAAAG GTATGCCAGT 
GTCCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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fln cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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