Gcn5 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gcn5
Entrez Gene ID	39431
Full Name	Gcn5 acetyltransferase
Synonyms	Ada4,CG4107,Dmel\CG4107,GCN5,Gcn5/PCAF,Gcn5/Pcaf,KAT,KAT2,P/CAF,PCAF,Pcaf,anon-WO0172774.89,dGCN5,dGCN5 HAT,dGcn5,dGcn5i,dKAT2,dPCAF,dmGCN5,dmHAG401,gcn5,p/CAF,pCAF
General protein information	Preferred Names Gcn5 acetyltransferase Names CG4107 gene product from transcript CG4107-RA CG4107-PA Gcn5 ortholog Gcn5-PA pcaf
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3L Map Location: 69C4-69C4

mRNA and Protein(s)

mRNA	Protein	Name
NM_140329.3	NP_648586.2	Gcn5 acetyltransferase

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	KAT2A	XP_548094.3
Rattus norvegicus (Norway rat)	Kat2a	NP_001100520.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004434	XP_313721.3
Gallus gallus (chicken)	KAT2A	XP_004948702.1
Bos taurus (cattle)	KAT2A	XP_003587495.2
Pan troglodytes (chimpanzee)	KAT2A	XP_511500.2
Danio rerio (zebrafish)	kat2a	XP_001922732.1
Drosophila melanogaster (fruit fly)	Pcaf	NP_648586.2
Magnaporthe oryzae (rice blast fungus)	MGG_11716	XP_003710047.1
Homo sapiens (human)	KAT2A	NP_066564.2
Mus musculus (house mouse)	Kat2a	NP_001033099.1
Xenopus tropicalis (tropical clawed frog)	kat2a	XP_002939088.2

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

that Gcn5 is dispensable for the transcriptional silencing of bam, but interacts with Cyclin A to facilitate proper turnover in germline stem cells
Title: Gcn5 determines the fate of

Results support the model that CP190 recruits Gcn5 and thereby activates chromatin.
Title: Chromatin binding of Gcn5 in Drosophila is largely mediated by CP190.

The C-terminal domains of ADA2 proteins determine selective incorporation into GCN5-containing complexes that target histone H3 or H4 for acetylation.
Title: The C-terminal domains of ADA2 proteins determine selective incorporation into GCN5-containing complexes that target histone H3 or H4 for acetylation.

partial loss of Pcaf significantly enhanced polyglutamine pathologyin a Drosophila model of Huntington's disease
Title: Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease.

Site-specific acetylation of Iswi by Gcn5.
Title: Site-specific acetylation of ISWI by GCN5.

The following Gcn5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gcn5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa20861	NM_140329.3 Latest version!	Drosophila melanogaster Gcn5 acetyltransferase (Gcn5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gcn5 ( NM_140329.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_648586.2 Drosophila melanogaster Gcn5 acetyltransferase (Gcn5), mRNA.

Price & Availability↑

CloneID	OFa20861
Clone ID Related Accession (Same CDS sequence)	NM_140329.3
Accession Version	NM_140329.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2442bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Gcn5 acetyltransferase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jan 31, 2011 this sequence version replaced NM_140329.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCTGGTG GTCCATCCAT AACGATAAAA AGCCAACCAA TCGATGGTAA CAACACGGGC 
AACGCTGCGG CGCAACAGCA GCAGCAGGCA GCGAATGGCG CAGCAACCGC TGGTGCATCT 
GGAGCCGCTG GCAGCGCCCA GAATCCAGGA CACGGAGGAG CTGCGTCCGG CGCTGGCAGT 
GTGCCGGCAG AGGGAACGCG CCAGAACAGC CTACAGCGCA TTCAGCAGCG AAAGCAAAAG 
GTCTTCAATC TGCCCGTGCC ACAGAAACTG GCCAAATTGT CGATGTATTC CGCCTGCCAG 
TCTGAGGGAT GCCGTTGCAC CGGCTGGAAG ACACCGCAGG AAAATCGCCA CCGTGACGTC 
GAGTCCTCCT ACTGTCCGGA GTTCAACGAG GAGTGCCGCA ACACCAGCTG TCGCCATTCG 
CTGAGATCGC ACATAGCCCA TCTGGACAAT ATATCCAGTT CCAGCATGAA CGAGCTACTG 
GGCGCCATTA TAGACATGGA GAACCTATTC ATGTCCATGC AGCGCGTCGA GGACGAGGAC 
ACCAAGAAGG TGTACCAGTA CCTCTTCCGT TTGCTGCGCC AGTGCGTCCT CACGCGCCAG 
CAGGCGGTCA TCCGGGGTCC TCTCGGCGAT CCACCATTCG AGACGCCGTG CATCACCAAG 
GCTGTGCTCT CGTTGGTCTT CTACAAGTAC AATCACCTGA GCACGCCTGA ACTCCAAACC 
ATGACCGAGG TGGCCAAGAC GTTCTTGAAC TTTCTGAACC ACTACAACTT TGAATCGCCG 
TCGACCAGGA GAGGAGATCT CACCCACGAG GATGCCTCTA ACTACAAAAT CAACTACACC 
AGGTGGTTGG TGTTCTGCCA CGTGCCCGCC TTCTGTAACT CCCTGCGCCA ATGTGAAACG 
TCCCTAGTGT TTGGACGAAC GCTCCTGCGC ACCGTTTTCC AGTGCATGTC GCAGCAGCTG 
AAAAAGAAGT GCATCTCCGA GCGGGATCGC TTTCCCGAGG ACAAGCGTTC GATCATCACG 
CTGATGCCGA AGTTTTTGGA AACGCTTCGC GCCGAATTGC TCAAGGATGA TTCGCCCATC 
TGGGATACCA GCTACCGCCC GTCAAATTCC TTTGTCATCC AGCAGAGAAA GCGTAACCAG 
GAGGTGGCAA ATGTACCCAT TGGTCCCAGT GCAGCAAGCA TTGGTGGAAA CAAGAGGACC 
AGTGTGGGTG AACCGCTCCA CAAGCGAATC AAAAAGGAGC CCACCGATCG TCCAAGCAGT 
GAGAATTTGG ATGACCTGCC TGCGGATGTA GTAATGCGCG CCATGAAATC GGTGTCCGAG 
TCGAAGACCA CCAACAAAGC GGAAATTCTC TTTCCGGTTA ATGTGTCGCG GGATGAGAAC 
GTCAAGGCGG AGGAGCAGAA GCGAGCCATT GAGTTCCATG TGGTGGGCAA TTCGCTGACC 
AAACCGGTGG ACAAGCAGAC TGTTTTGTGG CTACTGGGCC TGCAGCTCGT ATTTGCCTAT 
CAGCTACCCG AGATGCCGCG CGAGTACATC AGCCAGTTGG TTTTCGACAC CAAGCACAAA 
ACACTGGCGC TCATCAAGGA AAACCAACCC ATCGGCGGCA TCTGTTTCCG CCCGTTTCCG 
TCGCAAGGCT TCACCGAGAT CGTTTTCTGC GCGGTCACCA TGTCGGAACA AGTTAAGGGC 
TATGGCACGC ACTTGATGAA CCACTTGAAG GACTACAGCA TACAGAGGGG TATCAAGCAT 
CTGCTCACAT TCGCCGATTG CGATGCCATC GGGTACTTCA AGAAGCAGGG TTTCTCCAAG 
GACATCAAAT TGGCGCGACC AGTTTATGCG GGCTACATCA AGGAGTACGA TAGTGCTACT 
CTCATGCACT GCGAGCTGCA TCCAAGCATT GTGAACACGC AGTTCATAGC TGTAATTCGC 
AGTCAGAGCG AGATTCTGAA GGAGCTGATC GCACAGCGCC ACAACGAGGT GCAGAAAGTA 
AGACCCGGCT TGACTTGCTT CAAGGAGGGC CTGCCCGTGA TTCCCGTGGA ATCGATTCCT 
GGTCTGCGGG AGATCGGTTG GAAGCCGCAA AATCGTCCGG CGCGCTCATC GCGACCCCTC 
GAGGAATCCA CCGATCCGGA GAAGCTGGCC ACGTCCTTTG CATCCGTGCT GCAATCCGTG 
CGCCAGCACA CCACCGCCTG GCCCTTCCTG CGCCCGGTGA CCGCGGCCGA AGTTCCGGAC 
TACTACGATC ACATTAAATA TCCCATGGAC CTGAAGACCA TGGGCGAGCG CCTGAAGAAG 
GGTTACTACC AAACGCGCCG CCTGTTCATG GCGGACATGG CGCGCATTTT CTCCAACTGT 
CGGTTCTACA ATTCGCCCGA CACCGAGTAT TATCGGTGTG CCAACTCCCT GGAGCGCTAC 
TTCCAGACCA AGATGCGCGA GCTGGGGCTG TGGGACAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_648586.2
CDS	112..2553
Translation	MSGGPSITIKSQPIDGNNTGNAAAQQQQQAANGAATAGASGAAGSAQNPGHGGAASGAGSVPAEGTRQNSLQRIQQRKQKVFNLPVPQKLAKLSMYSACQSEGCRCTGWKTPQENRHRDVESSYCPEFNEECRNTSCRHSLRSHIAHLDNISSSSMNELLGAIIDMENLFMSMQRVEDEDTKKVYQYLFRLLRQCVLTRQQAVIRGPLGDPPFETPCITKAVLSLVFYKYNHLSTPELQTMTEVAKTFLNFLNHYNFESPSTRRGDLTHEDASNYKINYTRWLVFCHVPAFCNSLRQCETSLVFGRTLLRTVFQCMSQQLKKKCISERDRFPEDKRSIITLMPKFLETLRAELLKDDSPIWDTSYRPSNSFVIQQRKRNQEVANVPIGPSAASIGGNKRTSVGEPLHKRIKKEPTDRPSSENLDDLPADVVMRAMKSVSESKTTNKAEILFPVNVSRDENVKAEEQKRAIEFHVVGNSLTKPVDKQTVLWLLGLQLVFAYQLPEMPREYISQLVFDTKHKTLALIKENQPIGGICFRPFPSQGFTEIVFCAVTMSEQVKGYGTHLMNHLKDYSIQRGIKHLLTFADCDAIGYFKKQGFSKDIKLARPVYAGYIKEYDSATLMHCELHPSIVNTQFIAVIRSQSEILKELIAQRHNEVQKVRPGLTCFKEGLPVIPVESIPGLREIGWKPQNRPARSSRPLEESTDPEKLATSFASVLQSVRQHTTAWPFLRPVTAAEVPDYYDHIKYPMDLKTMGERLKKGYYQTRRLFMADMARIFSNCRFYNSPDTEYYRCANSLERYFQTKMRELGLWDK

Target ORF information:

RefSeq Version	NM_140329.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Gcn5 acetyltransferase (Gcn5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_140329.3

ORF Insert Sequence:

ATGTCTGGTG GTCCATCCAT AACGATAAAA AGCCAACCAA TCGATGGTAA CAACACGGGC 
AACGCTGCGG CGCAACAGCA GCAGCAGGCA GCGAATGGCG CAGCAACCGC TGGTGCATCT 
GGAGCCGCTG GCAGCGCCCA GAATCCAGGA CACGGAGGAG CTGCGTCCGG CGCTGGCAGT 
GTGCCGGCAG AGGGAACGCG CCAGAACAGC CTACAGCGCA TTCAGCAGCG AAAGCAAAAG 
GTCTTCAATC TGCCCGTGCC ACAGAAACTG GCCAAATTGT CGATGTATTC CGCCTGCCAG 
TCTGAGGGAT GCCGTTGCAC CGGCTGGAAG ACACCGCAGG AAAATCGCCA CCGTGACGTC 
GAGTCCTCCT ACTGTCCGGA GTTCAACGAG GAGTGCCGCA ACACCAGCTG TCGCCATTCG 
CTGAGATCGC ACATAGCCCA TCTGGACAAT ATATCCAGTT CCAGCATGAA CGAGCTACTG 
GGCGCCATTA TAGACATGGA GAACCTATTC ATGTCCATGC AGCGCGTCGA GGACGAGGAC 
ACCAAGAAGG TGTACCAGTA CCTCTTCCGT TTGCTGCGCC AGTGCGTCCT CACGCGCCAG 
CAGGCGGTCA TCCGGGGTCC TCTCGGCGAT CCACCATTCG AGACGCCGTG CATCACCAAG 
GCTGTGCTCT CGTTGGTCTT CTACAAGTAC AATCACCTGA GCACGCCTGA ACTCCAAACC 
ATGACCGAGG TGGCCAAGAC GTTCTTGAAC TTTCTGAACC ACTACAACTT TGAATCGCCG 
TCGACCAGGA GAGGAGATCT CACCCACGAG GATGCCTCTA ACTACAAAAT CAACTACACC 
AGGTGGTTGG TGTTCTGCCA CGTGCCCGCC TTCTGTAACT CCCTGCGCCA ATGTGAAACG 
TCCCTAGTGT TTGGACGAAC GCTCCTGCGC ACCGTTTTCC AGTGCATGTC GCAGCAGCTG 
AAAAAGAAGT GCATCTCCGA GCGGGATCGC TTTCCCGAGG ACAAGCGTTC GATCATCACG 
CTGATGCCGA AGTTTTTGGA AACGCTTCGC GCCGAATTGC TCAAGGATGA TTCGCCCATC 
TGGGATACCA GCTACCGCCC GTCAAATTCC TTTGTCATCC AGCAGAGAAA GCGTAACCAG 
GAGGTGGCAA ATGTACCCAT TGGTCCCAGT GCAGCAAGCA TTGGTGGAAA CAAGAGGACC 
AGTGTGGGTG AACCGCTCCA CAAGCGAATC AAAAAGGAGC CCACCGATCG TCCAAGCAGT 
GAGAATTTGG ATGACCTGCC TGCGGATGTA GTAATGCGCG CCATGAAATC GGTGTCCGAG 
TCGAAGACCA CCAACAAAGC GGAAATTCTC TTTCCGGTTA ATGTGTCGCG GGATGAGAAC 
GTCAAGGCGG AGGAGCAGAA GCGAGCCATT GAGTTCCATG TGGTGGGCAA TTCGCTGACC 
AAACCGGTGG ACAAGCAGAC TGTTTTGTGG CTACTGGGCC TGCAGCTCGT ATTTGCCTAT 
CAGCTACCCG AGATGCCGCG CGAGTACATC AGCCAGTTGG TTTTCGACAC CAAGCACAAA 
ACACTGGCGC TCATCAAGGA AAACCAACCC ATCGGCGGCA TCTGTTTCCG CCCGTTTCCG 
TCGCAAGGCT TCACCGAGAT CGTTTTCTGC GCGGTCACCA TGTCGGAACA AGTTAAGGGC 
TATGGCACGC ACTTGATGAA CCACTTGAAG GACTACAGCA TACAGAGGGG TATCAAGCAT 
CTGCTCACAT TCGCCGATTG CGATGCCATC GGGTACTTCA AGAAGCAGGG TTTCTCCAAG 
GACATCAAAT TGGCGCGACC AGTTTATGCG GGCTACATCA AGGAGTACGA TAGTGCTACT 
CTCATGCACT GCGAGCTGCA TCCAAGCATT GTGAACACGC AGTTCATAGC TGTAATTCGC 
AGTCAGAGCG AGATTCTGAA GGAGCTGATC GCACAGCGCC ACAACGAGGT GCAGAAAGTA 
AGACCCGGCT TGACTTGCTT CAAGGAGGGC CTGCCCGTGA TTCCCGTGGA ATCGATTCCT 
GGTCTGCGGG AGATCGGTTG GAAGCCGCAA AATCGTCCGG CGCGCTCATC GCGACCCCTC 
GAGGAATCCA CCGATCCGGA GAAGCTGGCC ACGTCCTTTG CATCCGTGCT GCAATCCGTG 
CGCCAGCACA CCACCGCCTG GCCCTTCCTG CGCCCGGTGA CCGCGGCCGA AGTTCCGGAC 
TACTACGATC ACATTAAATA TCCCATGGAC CTGAAGACCA TGGGCGAGCG CCTGAAGAAG 
GGTTACTACC AAACGCGCCG CCTGTTCATG GCGGACATGG CGCGCATTTT CTCCAACTGT 
CGGTTCTACA ATTCGCCCGA CACCGAGTAT TATCGGTGTG CCAACTCCCT GGAGCGCTAC 
TTCCAGACCA AGATGCGCGA GCTGGGGCTG TGGGACAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Gcn5 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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