Drs cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Drs
Entrez Gene ID	38419
Full Name	Drosomycin
Synonyms	BcDNA:LP03851,CG10810,Crp,DIM 19,DIM 21,DRO,DROM,DROS,DRS,Dmel\CG10810,Drm,Drom,Dros,Droso,IM21,dmy1,drm,drom,dros,drs,drsm
General protein information	Preferred Names Drosomycin Names CG10810 gene product from transcript CG10810-RA CG10810-PA Cysteine-rich-protein Drosomycin-B Drs-PA cysteine-rich peptide drosomcycin drosomyci drosomycin drosomycin precursor drosomycine drosomyocin drosomysin drosophila immune induced molecule 19 immune induced molecule 21
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3L Map Location: 63D2-63D2

mRNA and Protein(s)

mRNA	Protein	Name
NM_079177.4	NP_523901.1	drosomycin

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results, not only revealed a novel function and modulation pattern of miR-958, but also provided a new insight into the underlying molecular mechanisms of Toll signaling in regulation of innate immunity.
Title: miR-958 inhibits Toll signaling and Drosomycin expression via direct targeting of Toll and Dif in Drosophila melanogaster.

In 14-3-3epsilon mutants, there was a reduced release of the anti-microbial peptide Drosomycin into the haemolymph
Title: Drosophila 14-3-3? has a crucial role in anti-microbial peptide secretion and innate immunity.

identified five cationic residues (R6, K8, R20, R21 and K38) whose alterations significantly affected the antifungal activity
Title: Functional role of charged residues in drosomycin, a Drosophila antifungal peptide.

Expression of the AMP gene drosomycin (a Toll target) was blocked when expression of the Toll ligand Spatzle was knocked down in haemocytes.
Title: Toll-dependent antimicrobial responses in Drosophila larval fat body require Sp?tzle secreted by haemocytes.

Similarity in sequence, structure and biological activity suggests that drosomycin and some defensin molecules from plants and fungi could originate from a common ancestor.
Title: Drosomycin, an essential component of antifungal defence in Drosophila.

The following Drs gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Drs cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa17385	NM_079177.4 Latest version!	Drosophila melanogaster drosomycin (Drs), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Drs ( NM_079177.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_523901.1 Drosophila melanogaster drosomycin (Drs), mRNA.

Price & Availability↑

CloneID	OFa17385
Clone ID Related Accession (Same CDS sequence)	NM_079177.4
Accession Version	NM_079177.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 213bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	drosomycin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jan 16, 2013 this sequence version replaced NM_079177.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGATGCAGA TCAAGTACTT GTTCGCCCTC TTCGCTGTCC TGATGCTGGT GGTCCTGGGA 
GCCAACGAGG CCGATGCCGA CTGCCTGTCC GGAAGATACA AGGGTCCCTG TGCCGTCTGG 
GACAACGAGA CCTGTCGTCG TGTGTGCAAG GAGGAGGGAC GCTCCAGTGG CCACTGCAGC 
CCCAGTCTGA AGTGCTGGTG CGAAGGATGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_523901.1
CDS	64..276
Translation	MMQIKYLFALFAVLMLVVLGANEADADCLSGRYKGPCAVWDNETCRRVCKEEGRSSGHCSPSLKCWCEGC

Target ORF information:

RefSeq Version	NM_079177.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster drosomycin (Drs), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079177.4

ORF Insert Sequence:

ATGATGCAGA TCAAGTACTT GTTCGCCCTC TTCGCTGTCC TGATGCTGGT GGTCCTGGGA 
GCCAACGAGG CCGATGCCGA CTGCCTGTCC GGAAGATACA AGGGTCCCTG TGCCGTCTGG 
GACAACGAGA CCTGTCGTCG TGTGTGCAAG GAGGAGGGAC GCTCCAGTGG CCACTGCAGC 
CCCAGTCTGA AGTGCTGGTG CGAAGGATGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Drs cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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