Rabex-5 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rabex-5
Entrez Gene ID	38144
Full Name	Rabaptin-5-associated exchange factor for Rab5
Synonyms	CG9139,Dmel\CG9139,RabGEF1,Rabex5
General protein information	Preferred Names Rabaptin-5-associated exchange factor for Rab5 Names CG9139 gene product from transcript CG9139-RA CG9139-PA Rabaptin-5-associated exchange factor for Rab5 ortholog Rabex-5-PA
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3L Map Location: 61F5-61F5

mRNA and Protein(s)

mRNA	Protein	Name
NM_138249.3	NP_612093.1	Rabaptin-5-associated exchange factor for Rab5

Pathways from BioSystems

Homologies

	LOC695887	XP_002803299.1
Mus musculus (house mouse)	Rabgef1	NP_001185988.1
Drosophila melanogaster (fruit fly)	Rabex-5	NP_612093.1
Pan troglodytes (chimpanzee)	RABGEF1	XP_003318527.1
Rattus norvegicus (Norway rat)	Rabgef1	NP_001101803.1
Homo sapiens (human)	RABGEF1	NP_001273990.1
Canis lupus familiaris (dog)	RABGEF1	XP_005620983.1
Bos taurus (cattle)	RABGEF1	NP_777016.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005551	XP_315556.4
Caenorhabditis elegans (roundworm)	rabx-5	NP_499337.3
Oryza sativa (rice)	Os03g0842700	NP_001051858.1
Danio rerio (zebrafish)	rabgef1	NP_957137.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rabex-5 plays an important role in Drosophila hematopoiesis and might serve as an axis coordinating Ras and Notch signaling in the lymph gland.
Title: Drosophila Rabex-5 restricts Notch activity in hematopoietic cells and maintains hematopoietic homeostasis.

this study finds that several functions of Rabaptin-5 are conserved in Drosophila, including its GTP-dependent binding of Rab5,itsability to modulate endosomal dynamics and its interaction with Rabex- 5.
Title: Rabaptin-5 and Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster.

Rabex-5(CG9139) restricts Ras signaling to establish organism size, wing vein pattern, and eye versus antennal fate
Title: Rabex-5 ubiquitin ligase activity restricts Ras signaling to establish pathway homeostasis in Drosophila.

The following Rabex-5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rabex-5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa17127	NM_138249.3 Latest version!	Drosophila melanogaster Rabaptin-5-associated exchange factor for Rab5 (Rabex-5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rabex-5 ( NM_138249.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_612093.1 Drosophila melanogaster Rabaptin-5-associated exchange factor for Rab5 (Rabex-5), mRNA.

Price & Availability↑

CloneID	OFa17127
Clone ID Related Accession (Same CDS sequence)	NM_138249.3
Accession Version	NM_138249.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2091bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Rabaptin-5-associated exchange factor for Rab5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jan 16, 2013 this sequence version replaced NM_138249.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCAACGG CGGCGCGACC TCCGTCTTTG CGGCTGGGCC AGCAGGACCT CAAGTGCCGT 
TCAGGATGCG GGTTTTACGG AACCCCCCAA AACGAAGGAT TGTGCTCGAT GTGCTTCCGA 
GAAAAGTTTA ATGATAAGCA GCGGAAGTTG AAGCAGACGG GTGGCGAGAC GGGTCCTGGA 
TCCTCTTCCT CGGTCGCCAC CTTGGATCGC CGATCGCCAC AGCATGCGCA CCTCCAGGGA 
AAAGTGGAGC AGCAGGTCAG GAAGCCGTCG GACAAGGAGC AGGACAACTT GGGAACCCTG 
CAAAAGAAAA AGTTTACCGC TGTGCTGCAA AAAACTCTGC AGGCGGGAGC CCAAAAAATT 
ACCCAACAGC GTGGTCATGT GCCGGATCCC ACGGAGGGCC AGTTCCTACT GCAATTGCGG 
CAACTTCGCA TTCCCGACGA TGGCAAGCGG AAACTCAAGC TTGAAATCCA GCGTTTGGAC 
AGCGACATCC GCAAGTATAT GAACGGAAAT GGCGGCAAAA ACATCAACGA ACTATCAGAT 
TTGGTTCAAA ACGCCTACAC CAAAGTCTCA GACATTGTGC ACAACGATCC CAGCTTCGAG 
ATAGCCACCA ACGAGGATCG CGATAGTGCC ATTGACTTCT TTGAGAAAGT GGTGATGACG 
CAGAACCACA AATTTCTCTT CAGTCCCTAT TTCACTACCG ATGAGGACAG TGACGTGAAG 
GTGCAGAAGC GGATACGCCA GCTGAGCTGG ATTACGGCCA AGCATCTGGA CTGCAGCATC 
GACGAGGTCA ACTCGGAGGC CAGGGATCTG GTTTACAATG CTATATCCGA GCTGGTGGGC 
ATAGATTCGT ACTATTCGCC GCAGGAGAAG CTGCAGTGCA CTTGGCGCTG CTGTAGGCAC 
ATCTTTGAGC TTCTGAAGCG GGCAACTGGA GGACCCGCCA GTGCGGATGA CTTCCTACCC 
GCCCTAATAT TCGTCGTGCT TAAGGCAAAT CCAGTGCGAC TGCACAGCAA CATCAACTTC 
GTTACGCGCT TCACAAACGC TTCGCGGCTG ATGAGCGGCG AGAGTGGCTA CTACTTTACC 
AATCTGTGCT CCGCCATCGC CTTCATAGAG AATCTGAATG GCGAGAGTCT GGGCGTCAGC 
AGCGAGGAGT TCGAGGCTCT GATGTCCGGA CAGCAGCCCT ACAGCACGCC CTGGGAAAGT 
GCCCTGTTGG CCTGCGAGAG CCTTCACCTG ATATCCGAGA ACATGAAGCG AATGGAGATG 
CTGCAGAAAA GGAACGCCCT GATAAGCTCT GGAATAACTT CATTTGAAAA AGAGCTTATC 
GATTTCCAAA GAGAGGTGAC GGAACGAGTA GACACCGTGA TTGCCAAGGC CCCACTCAAC 
CTGCTGCCCA TCAAAACACC CGCTTTTCTG ATTGGTCAAG CCAGGGCGCA CCTTCTCAAC 
GAAAGCGAGG CTGGTCATTA TCAAGCGAAT ATGCTGCACG GCGGCTCATT GACCTCCCAG 
TCGCTGACAG CAGCCGGTGG GTTGGTAAAG CCCGCAGCGG CGTCTAAAGA ATCTGGATTG 
TCCCTTAAGG ATACCAGCAT GAGTTCGATG GGCCGTCTGT CGCCACTTCA GCAGAACGTT 
CAGCCAGCCG ATCACCTCTT CGCCTCTCCA ATCTTTAACT ACACCGCGTT TGATGCCGTC 
TCGCTCTTGG AGGAGCCTGT GCCCGATGCG AACACAGACG TACTCATGCT GGGCTCCGAG 
TTTCAAGGAG GCCTGACCAA TATCAACTAC GACTTCGACT TGTCGGATCA AAGTGGGGAA 
AACAGCACTG CGGACGAGTC AAAGCTGAAT CTCGACGAAT TCGACCCCTT GGCGCAGAAG 
GGCCTAGTTG CCAAGCCACC GCCGCCTCTG CCGGAGACCA GTCTGCTGGA TAGCACAACG 
GATAGCCTTA TAGATAGCGA AGTGCCCGGC ACAGCTGTCC TGCTTCCATC CCCTCTGAAG 
CCCGAGGTGT CCAACTACCG GGGCTTCTCA AACTTCGATA TTCCCAGCAT CTCGTGCAAC 
ACGGGAGACT TTAGTTCTCT GGGACAGGAC GGCGCGGATG CTCCCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612093.1
CDS	114..2204
Translation	MSTAARPPSLRLGQQDLKCRSGCGFYGTPQNEGLCSMCFREKFNDKQRKLKQTGGETGPGSSSSVATLDRRSPQHAHLQGKVEQQVRKPSDKEQDNLGTLQKKKFTAVLQKTLQAGAQKITQQRGHVPDPTEGQFLLQLRQLRIPDDGKRKLKLEIQRLDSDIRKYMNGNGGKNINELSDLVQNAYTKVSDIVHNDPSFEIATNEDRDSAIDFFEKVVMTQNHKFLFSPYFTTDEDSDVKVQKRIRQLSWITAKHLDCSIDEVNSEARDLVYNAISELVGIDSYYSPQEKLQCTWRCCRHIFELLKRATGGPASADDFLPALIFVVLKANPVRLHSNINFVTRFTNASRLMSGESGYYFTNLCSAIAFIENLNGESLGVSSEEFEALMSGQQPYSTPWESALLACESLHLISENMKRMEMLQKRNALISSGITSFEKELIDFQREVTERVDTVIAKAPLNLLPIKTPAFLIGQARAHLLNESEAGHYQANMLHGGSLTSQSLTAAGGLVKPAAASKESGLSLKDTSMSSMGRLSPLQQNVQPADHLFASPIFNYTAFDAVSLLEEPVPDANTDVLMLGSEFQGGLTNINYDFDLSDQSGENSTADESKLNLDEFDPLAQKGLVAKPPPPLPETSLLDSTTDSLIDSEVPGTAVLLPSPLKPEVSNYRGFSNFDIPSISCNTGDFSSLGQDGADAPK

Target ORF information:

RefSeq Version	NM_138249.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Rabaptin-5-associated exchange factor for Rab5 (Rabex-5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138249.3

ORF Insert Sequence:

ATGTCAACGG CGGCGCGACC TCCGTCTTTG CGGCTGGGCC AGCAGGACCT CAAGTGCCGT 
TCAGGATGCG GGTTTTACGG AACCCCCCAA AACGAAGGAT TGTGCTCGAT GTGCTTCCGA 
GAAAAGTTTA ATGATAAGCA GCGGAAGTTG AAGCAGACGG GTGGCGAGAC GGGTCCTGGA 
TCCTCTTCCT CGGTCGCCAC CTTGGATCGC CGATCGCCAC AGCATGCGCA CCTCCAGGGA 
AAAGTGGAGC AGCAGGTCAG GAAGCCGTCG GACAAGGAGC AGGACAACTT GGGAACCCTG 
CAAAAGAAAA AGTTTACCGC TGTGCTGCAA AAAACTCTGC AGGCGGGAGC CCAAAAAATT 
ACCCAACAGC GTGGTCATGT GCCGGATCCC ACGGAGGGCC AGTTCCTACT GCAATTGCGG 
CAACTTCGCA TTCCCGACGA TGGCAAGCGG AAACTCAAGC TTGAAATCCA GCGTTTGGAC 
AGCGACATCC GCAAGTATAT GAACGGAAAT GGCGGCAAAA ACATCAACGA ACTATCAGAT 
TTGGTTCAAA ACGCCTACAC CAAAGTCTCA GACATTGTGC ACAACGATCC CAGCTTCGAG 
ATAGCCACCA ACGAGGATCG CGATAGTGCC ATTGACTTCT TTGAGAAAGT GGTGATGACG 
CAGAACCACA AATTTCTCTT CAGTCCCTAT TTCACTACCG ATGAGGACAG TGACGTGAAG 
GTGCAGAAGC GGATACGCCA GCTGAGCTGG ATTACGGCCA AGCATCTGGA CTGCAGCATC 
GACGAGGTCA ACTCGGAGGC CAGGGATCTG GTTTACAATG CTATATCCGA GCTGGTGGGC 
ATAGATTCGT ACTATTCGCC GCAGGAGAAG CTGCAGTGCA CTTGGCGCTG CTGTAGGCAC 
ATCTTTGAGC TTCTGAAGCG GGCAACTGGA GGACCCGCCA GTGCGGATGA CTTCCTACCC 
GCCCTAATAT TCGTCGTGCT TAAGGCAAAT CCAGTGCGAC TGCACAGCAA CATCAACTTC 
GTTACGCGCT TCACAAACGC TTCGCGGCTG ATGAGCGGCG AGAGTGGCTA CTACTTTACC 
AATCTGTGCT CCGCCATCGC CTTCATAGAG AATCTGAATG GCGAGAGTCT GGGCGTCAGC 
AGCGAGGAGT TCGAGGCTCT GATGTCCGGA CAGCAGCCCT ACAGCACGCC CTGGGAAAGT 
GCCCTGTTGG CCTGCGAGAG CCTTCACCTG ATATCCGAGA ACATGAAGCG AATGGAGATG 
CTGCAGAAAA GGAACGCCCT GATAAGCTCT GGAATAACTT CATTTGAAAA AGAGCTTATC 
GATTTCCAAA GAGAGGTGAC GGAACGAGTA GACACCGTGA TTGCCAAGGC CCCACTCAAC 
CTGCTGCCCA TCAAAACACC CGCTTTTCTG ATTGGTCAAG CCAGGGCGCA CCTTCTCAAC 
GAAAGCGAGG CTGGTCATTA TCAAGCGAAT ATGCTGCACG GCGGCTCATT GACCTCCCAG 
TCGCTGACAG CAGCCGGTGG GTTGGTAAAG CCCGCAGCGG CGTCTAAAGA ATCTGGATTG 
TCCCTTAAGG ATACCAGCAT GAGTTCGATG GGCCGTCTGT CGCCACTTCA GCAGAACGTT 
CAGCCAGCCG ATCACCTCTT CGCCTCTCCA ATCTTTAACT ACACCGCGTT TGATGCCGTC 
TCGCTCTTGG AGGAGCCTGT GCCCGATGCG AACACAGACG TACTCATGCT GGGCTCCGAG 
TTTCAAGGAG GCCTGACCAA TATCAACTAC GACTTCGACT TGTCGGATCA AAGTGGGGAA 
AACAGCACTG CGGACGAGTC AAAGCTGAAT CTCGACGAAT TCGACCCCTT GGCGCAGAAG 
GGCCTAGTTG CCAAGCCACC GCCGCCTCTG CCGGAGACCA GTCTGCTGGA TAGCACAACG 
GATAGCCTTA TAGATAGCGA AGTGCCCGGC ACAGCTGTCC TGCTTCCATC CCCTCTGAAG 
CCCGAGGTGT CCAACTACCG GGGCTTCTCA AACTTCGATA TTCCCAGCAT CTCGTGCAAC 
ACGGGAGACT TTAGTTCTCT GGGACAGGAC GGCGCGGATG CTCCCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Rabex-5 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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