Dcp-1 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dcp-1
Entrez Gene ID	37729
Full Name	Death caspase-1
Synonyms	CG5370,DCP-1,DCP1,Dcp1,Dmel\CG5370,ccp1,dcp-1,dcp1,l(2)01862,l(2)02132
General protein information	Preferred Names Death caspase-1 Names CG5370 gene product from transcript CG5370-RA CG5370-PA Dcp-1-PA caspase caspase 1 caspase-1 death caspase-1
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 59E3-59E3

mRNA and Protein(s)

mRNA	Protein	Name
NM_057626.4	NP_476974.1	death caspase-1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CASP7	NP_203124.1
Rattus norvegicus (Norway rat)	Casp7	NP_071596.1
Canis lupus familiaris (dog)	CASP7	XP_005637795.1
Bos taurus (cattle)	CASP7	XP_002698555.1
Gallus gallus (chicken)	CASP7	XP_421764.3
Drosophila melanogaster (fruit fly)	Ice	NP_524551.2
Drosophila melanogaster (fruit fly)	Dcp-1	NP_476974.1
Pan troglodytes (chimpanzee)	CASP7	XP_508043.2
	CASP7	XP_001090833.1
Danio rerio (zebrafish)	casp7	NP_001018443.1
Mus musculus (house mouse)	Casp7	NP_031637.1
Anopheles gambiae (African malaria mosquito)	CASPS7	XP_316795.2
Xenopus tropicalis (tropical clawed frog)	casp7	NP_001016299.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

drICE and dcp-1 function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE but not dcp-1, but required drICE and dcp-1 when drICE activity was reduced via hypomorphic mutation.
Title: The role of the effector caspases drICE and dcp-1 for cell death and corpse clearance in the developing optic lobe in Drosophila.

Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1, and ice
Title: Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis.

Autophagy suppresses Dcp-1-mediated apoptotic cell death, whereas Dcp-1 positively regulates autophagy, possibly through feedback regulation.
Title: A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes.

HeT-A mRNA is derepressed in mRNA degradation mutants dcp1, indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.
Title: piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline.

Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein Bruce function to regulate both autophagy and starvation-induced cell death in Drosophila.
Title: Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis.

The following Dcp-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dcp-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa11052	NM_057626.4 Latest version!	Drosophila melanogaster death caspase-1 (Dcp-1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dcp-1 ( NM_057626.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_476974.1 Drosophila melanogaster death caspase-1 (Dcp-1), mRNA.

Price & Availability↑

CloneID	OFa11052
Clone ID Related Accession (Same CDS sequence)	NM_057626.4
Accession Version	NM_057626.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	death caspase-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_057626.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGACCGACG AGTGCGTAAC CAGAAACTAC GGAGTAGGCA TTCGCAGCCC AAATGGATCG 
GAAAATCGGG GCAGCTTTAT AATGGCTGAT AATACCGATG CCAAGGGCTG TACGCCGGAG 
TCTCTTGTTG TTGGTGGTGC AACTGCAGCG AGCCCCTTGC CGGCCAACAA GTTTGTGGCT 
CGAATGCCCG TGGAACGATA TGCAAGCGAA TACAACATGA GTCACAAGCA CCGCGGAGTT 
GCGCTGATCT TCAACCACGA ATTCTTCGAC ATACCCTCGC TGAAGAGCCG CACCGGAACA 
AATGTCGATG CCCAAGAGCT GAAAAAGGCC TTTGAAAACC TGGGATTCGC GGTGTCCGTG 
CACAAGGACT GCAAGTTGAG GGACATCCTG AAGCACGTGG GGAAGGCCGC CGAGTTGGAC 
CACACGGACA ACGACTGCCT TGCGGTGGCC ATACTCTCGC ACGGGGAGCA CGGCTACCTG 
TACGCCAAGG ATACGCAGTA CAAGCTGGAC AACATCTGGC ACTACTTCAC TGCCACCTTC 
TGCCCCTCGC TGGCGGGCAA GCCGAAGCTG TTCTTCATCC AAGCCTGCCA GGGCGATCGC 
TTGGACGGAG GCATCACTCT GGAGAAGGGC GTTACCGAGA CGGACGGGGA GTCCTCGACG 
AGCTACAAGA TACCCATACA CGCCGACTTT CTCTTCTCCT ACTCGACCAT TCCGGGCTAC 
TTCTCCTGGC GCAACATCAA CAATGGCTCC TGGTACATGC AATCGCTGAT CCGCGAGCTG 
AACGCCAATG GCAAAAAGTA CGACCTGCTC ACCCTGCTTA CATTCGTTAA CCAGCGCGTA 
GCCCTAGACT TTGAGTCGAA CGTGCCCGCC ACACCGATGA TGGATCGCCA GAAGCAAATA 
CCGTGCCTCA CCTCCATGCT GACGCGCATA CTGCGCTTCG GCGACAAGCC GAACGGCAAT 
AAGGCTGGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476974.1
CDS	411..1382
Translation	MTDECVTRNYGVGIRSPNGSENRGSFIMADNTDAKGCTPESLVVGGATAASPLPANKFVARMPVERYASEYNMSHKHRGVALIFNHEFFDIPSLKSRTGTNVDAQELKKAFENLGFAVSVHKDCKLRDILKHVGKAAELDHTDNDCLAVAILSHGEHGYLYAKDTQYKLDNIWHYFTATFCPSLAGKPKLFFIQACQGDRLDGGITLEKGVTETDGESSTSYKIPIHADFLFSYSTIPGYFSWRNINNGSWYMQSLIRELNANGKKYDLLTLLTFVNQRVALDFESNVPATPMMDRQKQIPCLTSMLTRILRFGDKPNGNKAG

Target ORF information:

RefSeq Version	NM_057626.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster death caspase-1 (Dcp-1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057626.4

ORF Insert Sequence:

ATGACCGACG AGTGCGTAAC CAGAAACTAC GGAGTAGGCA TTCGCAGCCC AAATGGATCG 
GAAAATCGGG GCAGCTTTAT AATGGCTGAT AATACCGATG CCAAGGGCTG TACGCCGGAG 
TCTCTTGTTG TTGGTGGTGC AACTGCAGCG AGCCCCTTGC CGGCCAACAA GTTTGTGGCT 
CGAATGCCCG TGGAACGATA TGCAAGCGAA TACAACATGA GTCACAAGCA CCGCGGAGTT 
GCGCTGATCT TCAACCACGA ATTCTTCGAC ATACCCTCGC TGAAGAGCCG CACCGGAACA 
AATGTCGATG CCCAAGAGCT GAAAAAGGCC TTTGAAAACC TGGGATTCGC GGTGTCCGTG 
CACAAGGACT GCAAGTTGAG GGACATCCTG AAGCACGTGG GGAAGGCCGC CGAGTTGGAC 
CACACGGACA ACGACTGCCT TGCGGTGGCC ATACTCTCGC ACGGGGAGCA CGGCTACCTG 
TACGCCAAGG ATACGCAGTA CAAGCTGGAC AACATCTGGC ACTACTTCAC TGCCACCTTC 
TGCCCCTCGC TGGCGGGCAA GCCGAAGCTG TTCTTCATCC AAGCCTGCCA GGGCGATCGC 
TTGGACGGAG GCATCACTCT GGAGAAGGGC GTTACCGAGA CGGACGGGGA GTCCTCGACG 
AGCTACAAGA TACCCATACA CGCCGACTTT CTCTTCTCCT ACTCGACCAT TCCGGGCTAC 
TTCTCCTGGC GCAACATCAA CAATGGCTCC TGGTACATGC AATCGCTGAT CCGCGAGCTG 
AACGCCAATG GCAAAAAGTA CGACCTGCTC ACCCTGCTTA CATTCGTTAA CCAGCGCGTA 
GCCCTAGACT TTGAGTCGAA CGTGCCCGCC ACACCGATGA TGGATCGCCA GAAGCAAATA 
CCGTGCCTCA CCTCCATGCT GACGCGCATA CTGCGCTTCG GCGACAAGCC GAACGGCAAT 
AAGGCTGGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Dcp-1 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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