Gene Symbol | DJ-1alpha |
Entrez Gene ID | 36543 |
Full Name | CG6646 gene product from transcript CG6646-RA |
Synonyms | CG6646,DJ-1,DJ-1A,DJ-1a,Dmel\CG6646 |
Gene Type | protein-coding |
Organism | Drosophila melanogaster(fruit fly) |
Genome |
ORF » Species Summary » Drosophila melanogaster » DJ-1alpha cDNA ORF clone
Gene Symbol | DJ-1alpha |
Entrez Gene ID | 36543 |
Full Name | CG6646 gene product from transcript CG6646-RA |
Synonyms | CG6646,DJ-1,DJ-1A,DJ-1a,Dmel\CG6646 |
Gene Type | protein-coding |
Organism | Drosophila melanogaster(fruit fly) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_137072.1 | NP_610916.1 | DJ-1alpha |
Homo sapiens (human) | PARK7 | NP_009193.2 |
Canis lupus familiaris (dog) | PARK7 | XP_859031.1 |
Mus musculus (house mouse) | Park7 | NP_065594.2 |
Gallus gallus (chicken) | PARK7 | NP_989916.1 |
Danio rerio (zebrafish) | park7 | NP_001005938.1 |
Caenorhabditis elegans (roundworm) | djr-1.2 | NP_504132.1 |
Oryza sativa (rice) | Os06g0531200 | NP_001057783.2 |
Bos taurus (cattle) | PARK7 | NP_001015572.1 |
Drosophila melanogaster (fruit fly) | DJ-1alpha | NP_610916.1 |
Caenorhabditis elegans (roundworm) | djr-1.1 | NP_493696.1 |
Oryza sativa (rice) | Os01g0217800 | NP_001042407.2 |
Drosophila melanogaster (fruit fly) | dj-1beta | NP_651825.3 |
Arabidopsis thaliana (thale cress) | AT1G53280 | NP_564626.1 |
Rattus norvegicus (Norway rat) | Park7 | NP_001264180.1 |
Schizosaccharomyces pombe (fission yeast) | SPAC22E12.03c | NP_594829.1 |
Arabidopsis thaliana (thale cress) | AT3G14990 | NP_188117.1 |
Xenopus tropicalis (tropical clawed frog) | park7 | NP_001015851.1 |
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
trimethyl isocitrate (TIC), a cell permeable isocitrate, protected mammalian DJ-1 null DA cells from oxidative stress in an IDH-dependent manner. These results suggest that isocitrate and its derivatives are novel treatments for Parkinson's disease associated with DJ-1 dysfunction
Title: Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH).
Flies deleted for DJ-1 manifest similar defects as pink1 and parkin mutants: male sterility, shortened lifespan, and reduced climbing ability.
Title: DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function.
Overexpression of DJ-1alpha in dopaminergic neurons is sufficient to confer protection against paraquat insult.
Title: Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress.
Data show that DJ-1 is a key negative regulator of PTEN that may be a useful prognostic marker for cancer.
Title: DJ-1, a novel regulator of the tumor suppressor PTEN.
The following DJ-1alpha gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DJ-1alpha cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OFa12518 | |
Clone ID Related Accession (Same CDS sequence) | NM_137072.1 | |
Accession Version | NM_137072.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-24 | |
Organism | Drosophila melanogaster(fruit fly) | |
Product | DJ-1alpha | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END## |
1 | ATGCTTTCAG TTTTGAGGAA ATCATTTCCA AATGGGGTCA CCCATGCTCA TCGCGTGATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_610916.1 |
CDS | 25..678 |
Translation |
Target ORF information:
Target ORF information:
|
NM_137072.1 |
1 | ATGCTTTCAG TTTTGAGGAA ATCATTTCCA AATGGGGTCA CCCATGCTCA TCGCGTGATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data. |
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders. |
Sequence finishing and mapping of Drosophila melanogaster heterochromatin. |
The Release 5.1 annotation of Drosophila melanogaster heterochromatin. |
Combined evidence annotation of transposable elements in genome sequences. |