drk cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	drk
Entrez Gene ID	36497
Full Name	downstream of receptor kinase
Synonyms	24/1,CG6033,DRK,Dmel\CG6033,Drk,Drk/Grb2,E(sev)2B,GRB2,Grb-2,Grb/drk,Grb2,Grb2/drk,P1112,Su(sev)R1,crkl,l(2)10626,l(2)k13809
General protein information	Preferred Names downstream of receptor kinase Names CG6033 gene product from transcript CG6033-RF CG6033-PA CG6033-PB CG6033-PC CG6033-PD CG6033-PF downstream of receptor kinases downstream receptor kinase drk-PA drk-PB drk-PC drk-PD drk-PF enhancer of sevenless-2B
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 50A13-50A13\|2-70 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_165995.2	NP_725303.1	downstream of receptor kinase, isoform C
NM_165994.2	NP_725302.1	downstream of receptor kinase, isoform B
NM_057510.4	NP_476858.1	downstream of receptor kinase, isoform A
NM_165998.2	NP_725306.1	downstream of receptor kinase, isoform F
NM_165996.2	NP_725304.1	downstream of receptor kinase, isoform D

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GRB2	NP_001233546.1
Canis lupus familiaris (dog)	GRB2	XP_540431.2
Rattus norvegicus (Norway rat)	Grb2	NP_110473.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011768	XP_320742.3
Caenorhabditis elegans (roundworm)	sem-5	NP_509342.1
Drosophila melanogaster (fruit fly)	drk	NP_725306.1
Danio rerio (zebrafish)	grb2b	NP_998200.1
Mus musculus (house mouse)	Grb2	NP_032189.1
Gallus gallus (chicken)	GRB2	NP_989742.1
Xenopus tropicalis (tropical clawed frog)	grb2	NP_001008130.1
Homo sapiens (human)	GRB2	NP_002077.1
Bos taurus (cattle)	GRB2	NP_001029802.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identifies DRK/DOS/SOS as the upstream Rac GEF complex required for glial responses to axonal injury, and demonstrates a critical requirement for multiple GEFs in efficient glial activation after injury and internalization/degradation of axonal debris
Title: DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris.

Drk plays a negative role in EGFR signaling by enhancing receptor endocytosis through cooperating with the RING domain of D-Cbl.
Title: D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis.

Structural characterizations of the drkN SH3 domain unfolded state.
Title: Improved structural characterizations of the drkN SH3 domain unfolded state suggest a compact ensemble with native-like and non-native structure.

Signalling from the pTyr (YB) Neu (ErbB-2) autophosphorylation site was affected by a haplosufficiency in drk (Grb-2), and in genes thought to function downstream of Grb-2: dab, sos, csw (Shp-2), and dos (Gab-1).
Title: Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model.

residue-specific pK(a) values for a thermodynamically unstable Src homology 3 domain, enabling the calculation of the pH dependence of stability based on simple analytical expressions
Title: Site-specific contributions to the pH dependence of protein stability.

The following drk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the drk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OFa09877	NM_057510.4 Latest version!	Drosophila melanogaster downstream of receptor kinase (drk), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OFa09877	NM_165994.2 Latest version!	Drosophila melanogaster downstream of receptor kinase (drk), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OFa09877	NM_165995.2 Latest version!	Drosophila melanogaster downstream of receptor kinase (drk), transcript variant C, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OFa09877	NM_165996.2 Latest version!	Drosophila melanogaster downstream of receptor kinase (drk), transcript variant D, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OFa09877	NM_165998.2 Latest version!	Drosophila melanogaster downstream of receptor kinase (drk), transcript variant F, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

drk ( NM_165995.2 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_725303.1 Drosophila melanogaster downstream of receptor kinase (drk), transcript variant C, mRNA.

Price & Availability↑

CloneID	OFa09877
Clone ID Related Accession (Same CDS sequence)	NM_165995.2 , NM_165994.2 , NM_057510.4 , NM_165998.2 , NM_165996.2
Accession Version	NM_165995.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	downstream of receptor kinase, isoform C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_165995.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGAAGCGA TTGCCAAACA CGATTTCTCT GCGACGGCTG ACGACGAGCT GAGTTTTCGC 
AAAACTCAGA TTCTAAAGAT ATTAAATATG GAAGACGATT CAAATTGGTA TCGCGCGGAG 
CTGGATGGAA AGGAAGGCCT CATACCTAGT AATTACATAG AAATGAAGAA TCACGACTGG 
TATTACGGAC GCATCACACG CGCCGATGCT GAGAAGCTGC TGTCAAATAA GCACGAAGGC 
GCCTTCTTGA TACGCATCAG CGAATCCAGT CCCGGCGATT TCTCCTTATC AGTCAAATGC 
CCCGATGGCG TTCAGCATTT CAAGGTTCTG CGCGATGCCC AAAGCAAATT CTTCCTCTGG 
GTGGTCAAGT TCAACTCCCT CAACGAACTG GTCGAATATC ATCGGACGGC GAGCGTGTCC 
CGGTCGCAGG ATGTCAAATT GCGTGATATG ATACCTGAAG AGATGCTCGT GCAGGCGCTG 
TACGATTTTG TGCCACAGGA ATCCGGGGAA TTGGACTTCA GACGCGGCGA TGTCATCACC 
GTCACAGATC GCTCCGATGA GAACTGGTGG AACGGCGAGA TCGGCAATAG GAAAGGCATC 
TTCCCAGCAA CTTATGTGAC GCCATATCAT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_725303.1
CDS	255..890
Translation	MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDWYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWVVKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYDFVPQESGELDFRRGDVITVTDRSDENWWNGEIGNRKGIFPATYVTPYHS

Target ORF information:

RefSeq Version	NM_165995.2
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster downstream of receptor kinase (drk), transcript variant C, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_165995.2

ORF Insert Sequence:

ATGGAAGCGA TTGCCAAACA CGATTTCTCT GCGACGGCTG ACGACGAGCT GAGTTTTCGC 
AAAACTCAGA TTCTAAAGAT ATTAAATATG GAAGACGATT CAAATTGGTA TCGCGCGGAG 
CTGGATGGAA AGGAAGGCCT CATACCTAGT AATTACATAG AAATGAAGAA TCACGACTGG 
TATTACGGAC GCATCACACG CGCCGATGCT GAGAAGCTGC TGTCAAATAA GCACGAAGGC 
GCCTTCTTGA TACGCATCAG CGAATCCAGT CCCGGCGATT TCTCCTTATC AGTCAAATGC 
CCCGATGGCG TTCAGCATTT CAAGGTTCTG CGCGATGCCC AAAGCAAATT CTTCCTCTGG 
GTGGTCAAGT TCAACTCCCT CAACGAACTG GTCGAATATC ATCGGACGGC GAGCGTGTCC 
CGGTCGCAGG ATGTCAAATT GCGTGATATG ATACCTGAAG AGATGCTCGT GCAGGCGCTG 
TACGATTTTG TGCCACAGGA ATCCGGGGAA TTGGACTTCA GACGCGGCGA TGTCATCACC 
GTCACAGATC GCTCCGATGA GAACTGGTGG AACGGCGAGA TCGGCAATAG GAAAGGCATC 
TTCCCAGCAA CTTATGTGAC GCCATATCAT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

drk ( NM_165994.2 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_725302.1 Drosophila melanogaster downstream of receptor kinase (drk), transcript variant B, mRNA.

Price & Availability↑

CloneID	OFa09877
Clone ID Related Accession (Same CDS sequence)	NM_165995.2 , NM_165994.2 , NM_057510.4 , NM_165998.2 , NM_165996.2
Accession Version	NM_165994.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	downstream of receptor kinase, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_165994.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGAAGCGA TTGCCAAACA CGATTTCTCT GCGACGGCTG ACGACGAGCT GAGTTTTCGC 
AAAACTCAGA TTCTAAAGAT ATTAAATATG GAAGACGATT CAAATTGGTA TCGCGCGGAG 
CTGGATGGAA AGGAAGGCCT CATACCTAGT AATTACATAG AAATGAAGAA TCACGACTGG 
TATTACGGAC GCATCACACG CGCCGATGCT GAGAAGCTGC TGTCAAATAA GCACGAAGGC 
GCCTTCTTGA TACGCATCAG CGAATCCAGT CCCGGCGATT TCTCCTTATC AGTCAAATGC 
CCCGATGGCG TTCAGCATTT CAAGGTTCTG CGCGATGCCC AAAGCAAATT CTTCCTCTGG 
GTGGTCAAGT TCAACTCCCT CAACGAACTG GTCGAATATC ATCGGACGGC GAGCGTGTCC 
CGGTCGCAGG ATGTCAAATT GCGTGATATG ATACCTGAAG AGATGCTCGT GCAGGCGCTG 
TACGATTTTG TGCCACAGGA ATCCGGGGAA TTGGACTTCA GACGCGGCGA TGTCATCACC 
GTCACAGATC GCTCCGATGA GAACTGGTGG AACGGCGAGA TCGGCAATAG GAAAGGCATC 
TTCCCAGCAA CTTATGTGAC GCCATATCAT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_725302.1
CDS	284..919
Translation	MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDWYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWVVKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYDFVPQESGELDFRRGDVITVTDRSDENWWNGEIGNRKGIFPATYVTPYHS

Target ORF information:

RefSeq Version	NM_165994.2
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster downstream of receptor kinase (drk), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_165994.2

ORF Insert Sequence:

ATGGAAGCGA TTGCCAAACA CGATTTCTCT GCGACGGCTG ACGACGAGCT GAGTTTTCGC 
AAAACTCAGA TTCTAAAGAT ATTAAATATG GAAGACGATT CAAATTGGTA TCGCGCGGAG 
CTGGATGGAA AGGAAGGCCT CATACCTAGT AATTACATAG AAATGAAGAA TCACGACTGG 
TATTACGGAC GCATCACACG CGCCGATGCT GAGAAGCTGC TGTCAAATAA GCACGAAGGC 
GCCTTCTTGA TACGCATCAG CGAATCCAGT CCCGGCGATT TCTCCTTATC AGTCAAATGC 
CCCGATGGCG TTCAGCATTT CAAGGTTCTG CGCGATGCCC AAAGCAAATT CTTCCTCTGG 
GTGGTCAAGT TCAACTCCCT CAACGAACTG GTCGAATATC ATCGGACGGC GAGCGTGTCC 
CGGTCGCAGG ATGTCAAATT GCGTGATATG ATACCTGAAG AGATGCTCGT GCAGGCGCTG 
TACGATTTTG TGCCACAGGA ATCCGGGGAA TTGGACTTCA GACGCGGCGA TGTCATCACC 
GTCACAGATC GCTCCGATGA GAACTGGTGG AACGGCGAGA TCGGCAATAG GAAAGGCATC 
TTCCCAGCAA CTTATGTGAC GCCATATCAT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

drk ( NM_057510.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_476858.1 Drosophila melanogaster downstream of receptor kinase (drk), transcript variant A, mRNA.

Price & Availability↑

CloneID	OFa09877
Clone ID Related Accession (Same CDS sequence)	NM_165995.2 , NM_165994.2 , NM_057510.4 , NM_165998.2 , NM_165996.2
Accession Version	NM_057510.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	downstream of receptor kinase, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_057510.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGAAGCGA TTGCCAAACA CGATTTCTCT GCGACGGCTG ACGACGAGCT GAGTTTTCGC 
AAAACTCAGA TTCTAAAGAT ATTAAATATG GAAGACGATT CAAATTGGTA TCGCGCGGAG 
CTGGATGGAA AGGAAGGCCT CATACCTAGT AATTACATAG AAATGAAGAA TCACGACTGG 
TATTACGGAC GCATCACACG CGCCGATGCT GAGAAGCTGC TGTCAAATAA GCACGAAGGC 
GCCTTCTTGA TACGCATCAG CGAATCCAGT CCCGGCGATT TCTCCTTATC AGTCAAATGC 
CCCGATGGCG TTCAGCATTT CAAGGTTCTG CGCGATGCCC AAAGCAAATT CTTCCTCTGG 
GTGGTCAAGT TCAACTCCCT CAACGAACTG GTCGAATATC ATCGGACGGC GAGCGTGTCC 
CGGTCGCAGG ATGTCAAATT GCGTGATATG ATACCTGAAG AGATGCTCGT GCAGGCGCTG 
TACGATTTTG TGCCACAGGA ATCCGGGGAA TTGGACTTCA GACGCGGCGA TGTCATCACC 
GTCACAGATC GCTCCGATGA GAACTGGTGG AACGGCGAGA TCGGCAATAG GAAAGGCATC 
TTCCCAGCAA CTTATGTGAC GCCATATCAT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476858.1
CDS	353..988
Translation	MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDWYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWVVKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYDFVPQESGELDFRRGDVITVTDRSDENWWNGEIGNRKGIFPATYVTPYHS

Target ORF information:

RefSeq Version	NM_057510.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster downstream of receptor kinase (drk), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057510.4

ORF Insert Sequence:

ATGGAAGCGA TTGCCAAACA CGATTTCTCT GCGACGGCTG ACGACGAGCT GAGTTTTCGC 
AAAACTCAGA TTCTAAAGAT ATTAAATATG GAAGACGATT CAAATTGGTA TCGCGCGGAG 
CTGGATGGAA AGGAAGGCCT CATACCTAGT AATTACATAG AAATGAAGAA TCACGACTGG 
TATTACGGAC GCATCACACG CGCCGATGCT GAGAAGCTGC TGTCAAATAA GCACGAAGGC 
GCCTTCTTGA TACGCATCAG CGAATCCAGT CCCGGCGATT TCTCCTTATC AGTCAAATGC 
CCCGATGGCG TTCAGCATTT CAAGGTTCTG CGCGATGCCC AAAGCAAATT CTTCCTCTGG 
GTGGTCAAGT TCAACTCCCT CAACGAACTG GTCGAATATC ATCGGACGGC GAGCGTGTCC 
CGGTCGCAGG ATGTCAAATT GCGTGATATG ATACCTGAAG AGATGCTCGT GCAGGCGCTG 
TACGATTTTG TGCCACAGGA ATCCGGGGAA TTGGACTTCA GACGCGGCGA TGTCATCACC 
GTCACAGATC GCTCCGATGA GAACTGGTGG AACGGCGAGA TCGGCAATAG GAAAGGCATC 
TTCCCAGCAA CTTATGTGAC GCCATATCAT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

drk ( NM_165998.2 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_725306.1 Drosophila melanogaster downstream of receptor kinase (drk), transcript variant F, mRNA.

Price & Availability↑

CloneID	OFa09877
Clone ID Related Accession (Same CDS sequence)	NM_165995.2 , NM_165994.2 , NM_057510.4 , NM_165998.2 , NM_165996.2
Accession Version	NM_165998.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	downstream of receptor kinase, isoform F
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_165998.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGAAGCGA TTGCCAAACA CGATTTCTCT GCGACGGCTG ACGACGAGCT GAGTTTTCGC 
AAAACTCAGA TTCTAAAGAT ATTAAATATG GAAGACGATT CAAATTGGTA TCGCGCGGAG 
CTGGATGGAA AGGAAGGCCT CATACCTAGT AATTACATAG AAATGAAGAA TCACGACTGG 
TATTACGGAC GCATCACACG CGCCGATGCT GAGAAGCTGC TGTCAAATAA GCACGAAGGC 
GCCTTCTTGA TACGCATCAG CGAATCCAGT CCCGGCGATT TCTCCTTATC AGTCAAATGC 
CCCGATGGCG TTCAGCATTT CAAGGTTCTG CGCGATGCCC AAAGCAAATT CTTCCTCTGG 
GTGGTCAAGT TCAACTCCCT CAACGAACTG GTCGAATATC ATCGGACGGC GAGCGTGTCC 
CGGTCGCAGG ATGTCAAATT GCGTGATATG ATACCTGAAG AGATGCTCGT GCAGGCGCTG 
TACGATTTTG TGCCACAGGA ATCCGGGGAA TTGGACTTCA GACGCGGCGA TGTCATCACC 
GTCACAGATC GCTCCGATGA GAACTGGTGG AACGGCGAGA TCGGCAATAG GAAAGGCATC 
TTCCCAGCAA CTTATGTGAC GCCATATCAT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_725306.1
CDS	186..821
Translation	MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDWYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWVVKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYDFVPQESGELDFRRGDVITVTDRSDENWWNGEIGNRKGIFPATYVTPYHS

Target ORF information:

RefSeq Version	NM_165998.2
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster downstream of receptor kinase (drk), transcript variant F, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_165998.2

ORF Insert Sequence:

ATGGAAGCGA TTGCCAAACA CGATTTCTCT GCGACGGCTG ACGACGAGCT GAGTTTTCGC 
AAAACTCAGA TTCTAAAGAT ATTAAATATG GAAGACGATT CAAATTGGTA TCGCGCGGAG 
CTGGATGGAA AGGAAGGCCT CATACCTAGT AATTACATAG AAATGAAGAA TCACGACTGG 
TATTACGGAC GCATCACACG CGCCGATGCT GAGAAGCTGC TGTCAAATAA GCACGAAGGC 
GCCTTCTTGA TACGCATCAG CGAATCCAGT CCCGGCGATT TCTCCTTATC AGTCAAATGC 
CCCGATGGCG TTCAGCATTT CAAGGTTCTG CGCGATGCCC AAAGCAAATT CTTCCTCTGG 
GTGGTCAAGT TCAACTCCCT CAACGAACTG GTCGAATATC ATCGGACGGC GAGCGTGTCC 
CGGTCGCAGG ATGTCAAATT GCGTGATATG ATACCTGAAG AGATGCTCGT GCAGGCGCTG 
TACGATTTTG TGCCACAGGA ATCCGGGGAA TTGGACTTCA GACGCGGCGA TGTCATCACC 
GTCACAGATC GCTCCGATGA GAACTGGTGG AACGGCGAGA TCGGCAATAG GAAAGGCATC 
TTCCCAGCAA CTTATGTGAC GCCATATCAT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

drk ( NM_165996.2 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_725304.1 Drosophila melanogaster downstream of receptor kinase (drk), transcript variant D, mRNA.

Price & Availability↑

CloneID	OFa09877
Clone ID Related Accession (Same CDS sequence)	NM_165995.2 , NM_165994.2 , NM_057510.4 , NM_165998.2 , NM_165996.2
Accession Version	NM_165996.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	downstream of receptor kinase, isoform D
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_165996.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGAAGCGA TTGCCAAACA CGATTTCTCT GCGACGGCTG ACGACGAGCT GAGTTTTCGC 
AAAACTCAGA TTCTAAAGAT ATTAAATATG GAAGACGATT CAAATTGGTA TCGCGCGGAG 
CTGGATGGAA AGGAAGGCCT CATACCTAGT AATTACATAG AAATGAAGAA TCACGACTGG 
TATTACGGAC GCATCACACG CGCCGATGCT GAGAAGCTGC TGTCAAATAA GCACGAAGGC 
GCCTTCTTGA TACGCATCAG CGAATCCAGT CCCGGCGATT TCTCCTTATC AGTCAAATGC 
CCCGATGGCG TTCAGCATTT CAAGGTTCTG CGCGATGCCC AAAGCAAATT CTTCCTCTGG 
GTGGTCAAGT TCAACTCCCT CAACGAACTG GTCGAATATC ATCGGACGGC GAGCGTGTCC 
CGGTCGCAGG ATGTCAAATT GCGTGATATG ATACCTGAAG AGATGCTCGT GCAGGCGCTG 
TACGATTTTG TGCCACAGGA ATCCGGGGAA TTGGACTTCA GACGCGGCGA TGTCATCACC 
GTCACAGATC GCTCCGATGA GAACTGGTGG AACGGCGAGA TCGGCAATAG GAAAGGCATC 
TTCCCAGCAA CTTATGTGAC GCCATATCAT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_725304.1
CDS	404..1039
Translation	MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDWYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWVVKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYDFVPQESGELDFRRGDVITVTDRSDENWWNGEIGNRKGIFPATYVTPYHS

Target ORF information:

RefSeq Version	NM_165996.2
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster downstream of receptor kinase (drk), transcript variant D, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_165996.2

ORF Insert Sequence:

ATGGAAGCGA TTGCCAAACA CGATTTCTCT GCGACGGCTG ACGACGAGCT GAGTTTTCGC 
AAAACTCAGA TTCTAAAGAT ATTAAATATG GAAGACGATT CAAATTGGTA TCGCGCGGAG 
CTGGATGGAA AGGAAGGCCT CATACCTAGT AATTACATAG AAATGAAGAA TCACGACTGG 
TATTACGGAC GCATCACACG CGCCGATGCT GAGAAGCTGC TGTCAAATAA GCACGAAGGC 
GCCTTCTTGA TACGCATCAG CGAATCCAGT CCCGGCGATT TCTCCTTATC AGTCAAATGC 
CCCGATGGCG TTCAGCATTT CAAGGTTCTG CGCGATGCCC AAAGCAAATT CTTCCTCTGG 
GTGGTCAAGT TCAACTCCCT CAACGAACTG GTCGAATATC ATCGGACGGC GAGCGTGTCC 
CGGTCGCAGG ATGTCAAATT GCGTGATATG ATACCTGAAG AGATGCTCGT GCAGGCGCTG 
TACGATTTTG TGCCACAGGA ATCCGGGGAA TTGGACTTCA GACGCGGCGA TGTCATCACC 
GTCACAGATC GCTCCGATGA GAACTGGTGG AACGGCGAGA TCGGCAATAG GAAAGGCATC 
TTCCCAGCAA CTTATGTGAC GCCATATCAT TCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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drk cDNA ORF clone, Drosophila melanogaster(fruit fly)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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