rho-7 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	rho-7
Entrez Gene ID	36281
Full Name	rhomboid-7
Synonyms	CG8972,Dmel\CG8972,PARL,R7,Rho-7,Rhomboid-7,anon-WO0138581.3
General protein information	Preferred Names rhomboid-7 Names CG8972 gene product from transcript CG8972-RB CG8972-PA CG8972-PB Rhomboid-7 rho-7-PA rho-7-PB
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 48D5-48D5

mRNA and Protein(s)

mRNA	Protein	Name
NM_078980.4	NP_523704.1	rhomboid-7, isoform A
NM_001299395.1	NP_001286324.1	rhomboid-7, isoform B

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Parl	NP_001030326.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002626	XP_312303.4
Schizosaccharomyces pombe (fission yeast)	SPBC13E7.11	NP_596266.2
Homo sapiens (human)	PARL	NP_061092.3
Danio rerio (zebrafish)	LOC792889	XP_001331983.4
Xenopus tropicalis (tropical clawed frog)	parl	NP_001165755.1
Mus musculus (house mouse)	Parl	NP_001005767.1
Drosophila melanogaster (fruit fly)	rho-7	NP_523704.1
Pan troglodytes (chimpanzee)	PARL	XP_001135897.1
Canis lupus familiaris (dog)	PARL	XP_545224.2
	PARL	XP_001105563.1
Bos taurus (cattle)	PARL	NP_001015596.1
Gallus gallus (chicken)	PARL	XP_422588.4

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results suggest that rho-7 and Opa1-like function in a common molecular pathway affecting mitochondrial function and apoptosis in Drosophila melanogaster.
Title: Rhomboid-7 over-expression results in Opa1-like processing and malfunctioning mitochondria.

found that Rhomboid-7, a mitochondrial protease not previously implicated in PD, acts as an upstream component of this pathway, and showed that it is required to cleave the precursor forms of both Pink1 and Omi
Title: Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin.

The following rho-7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the rho-7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa09666	NM_001299395.1 Latest version!	Drosophila melanogaster rhomboid-7 (rho-7), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OFa09666	NM_078980.4 Latest version!	Drosophila melanogaster rhomboid-7 (rho-7), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

rho-7 ( NM_078980.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_523704.1 Drosophila melanogaster rhomboid-7 (rho-7), transcript variant A, mRNA.

Price & Availability↑

CloneID	OFa09666
Clone ID Related Accession (Same CDS sequence)	NM_078980.4 , NM_001299395.1
Accession Version	NM_078980.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	rhomboid-7, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_078980.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGCTCATGA GTCGAGCGCT TTGCCGGAGC TGGCTACCCC AGGTGGCCCG CAGATGTCAT 
GCTAATGTGA ATGTGCCAAT CCTGCGGATA AACTCTGGTC ATCCGGCGGC GAGGTCATGT 
CGGCAGATTC ACAGCAACCG AAAACAGAGC AGCAACCTGA AGCCGACGAC TGGGGAGCCT 
GCGGCAGCGG AGCAGAACAC CCCGGTGCCG GTGAACAATG TGATCAAGGC GGTGGCCTTC 
ACGGGAGCAT TTACGGTCGG CTGCTTTGCG GGTGCCACCA TCCTGGAGTA CGAGAACACA 
CGTAGCCTAA TCCTAGAAAA GGCTCGCCAG GCGAGATTCG GTTGGTGGCA GAGTCGTTCG 
CTGGCGGACA GGGATTACTG GACACAGATC AAACAAGACA TCCGGCGGCA CTGGGACTCA 
CTGACACCCG GCGACAAGAT GTTTGCTCCT ATCTTACTCT GCAATTTGGT GGCCTTCGCC 
ATGTGGCGGG TGCCCGCTCT GAAATCCACA ATGATTACCT ACTTCACATC CAATCCAGCG 
GCGAAAGTCG TCTGCTGGCC CATGTTCCTG TCCACATTCA GCCATTACTC GGCTATGCAC 
CTTTTCGCCA ATATGTACGT GATGCACAGC TTTGCCAACG CTGCGGCTGT ATCGTTGGGT 
AAAGAGCAAT TCTTAGCGGT CTACCTCAGC GCCGGCGTCT TCTCCAGTCT GATGAGCGTG 
CTCTACAAGG CGGCCACGAG TCAGGCGGGG ATGTCCCTGG GTGCGTCTGG AGCTATAATG 
ACACTGCTGG CCTATGTATG CACCCAGTAT CCGGACACAC AACTTAGCAT TCTCTTTCTA 
CCCGCGTTGA CATTCTCCGC TGGAGCTGGT ATTAAAGTGC TAATGGGCAT CGACTTTGCT 
GGCGTCGTGA TGGGCTGGAA GTTCTTCGAT CACGCAGCGC ATTTGGGCGG CGCCATGTTT 
GGCATCTTTT GGGCCACGTA TGGGGCACAG ATATGGGCAA AGCGCATTGG TCTACTGAAT 
TACTACCATG ACCTGCGCCG GACGAAGCAG AAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_523704.1
CDS	119..1174
Translation	MLMSRALCRSWLPQVARRCHANVNVPILRINSGHPAARSCRQIHSNRKQSSNLKPTTGEPAAAEQNTPVPVNNVIKAVAFTGAFTVGCFAGATILEYENTRSLILEKARQARFGWWQSRSLADRDYWTQIKQDIRRHWDSLTPGDKMFAPILLCNLVAFAMWRVPALKSTMITYFTSNPAAKVVCWPMFLSTFSHYSAMHLFANMYVMHSFANAAAVSLGKEQFLAVYLSAGVFSSLMSVLYKAATSQAGMSLGASGAIMTLLAYVCTQYPDTQLSILFLPALTFSAGAGIKVLMGIDFAGVVMGWKFFDHAAHLGGAMFGIFWATYGAQIWAKRIGLLNYYHDLRRTKQK

Target ORF information:

RefSeq Version	NM_078980.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster rhomboid-7 (rho-7), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_078980.4

ORF Insert Sequence:

ATGCTCATGA GTCGAGCGCT TTGCCGGAGC TGGCTACCCC AGGTGGCCCG CAGATGTCAT 
GCTAATGTGA ATGTGCCAAT CCTGCGGATA AACTCTGGTC ATCCGGCGGC GAGGTCATGT 
CGGCAGATTC ACAGCAACCG AAAACAGAGC AGCAACCTGA AGCCGACGAC TGGGGAGCCT 
GCGGCAGCGG AGCAGAACAC CCCGGTGCCG GTGAACAATG TGATCAAGGC GGTGGCCTTC 
ACGGGAGCAT TTACGGTCGG CTGCTTTGCG GGTGCCACCA TCCTGGAGTA CGAGAACACA 
CGTAGCCTAA TCCTAGAAAA GGCTCGCCAG GCGAGATTCG GTTGGTGGCA GAGTCGTTCG 
CTGGCGGACA GGGATTACTG GACACAGATC AAACAAGACA TCCGGCGGCA CTGGGACTCA 
CTGACACCCG GCGACAAGAT GTTTGCTCCT ATCTTACTCT GCAATTTGGT GGCCTTCGCC 
ATGTGGCGGG TGCCCGCTCT GAAATCCACA ATGATTACCT ACTTCACATC CAATCCAGCG 
GCGAAAGTCG TCTGCTGGCC CATGTTCCTG TCCACATTCA GCCATTACTC GGCTATGCAC 
CTTTTCGCCA ATATGTACGT GATGCACAGC TTTGCCAACG CTGCGGCTGT ATCGTTGGGT 
AAAGAGCAAT TCTTAGCGGT CTACCTCAGC GCCGGCGTCT TCTCCAGTCT GATGAGCGTG 
CTCTACAAGG CGGCCACGAG TCAGGCGGGG ATGTCCCTGG GTGCGTCTGG AGCTATAATG 
ACACTGCTGG CCTATGTATG CACCCAGTAT CCGGACACAC AACTTAGCAT TCTCTTTCTA 
CCCGCGTTGA CATTCTCCGC TGGAGCTGGT ATTAAAGTGC TAATGGGCAT CGACTTTGCT 
GGCGTCGTGA TGGGCTGGAA GTTCTTCGAT CACGCAGCGC ATTTGGGCGG CGCCATGTTT 
GGCATCTTTT GGGCCACGTA TGGGGCACAG ATATGGGCAA AGCGCATTGG TCTACTGAAT 
TACTACCATG ACCTGCGCCG GACGAAGCAG AAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

rho-7 ( NM_001299395.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001286324.1 Drosophila melanogaster rhomboid-7 (rho-7), transcript variant B, mRNA.

Price & Availability↑

CloneID	OFa09666
Clone ID Related Accession (Same CDS sequence)	NM_078980.4 , NM_001299395.1
Accession Version	NM_001299395.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	rhomboid-7, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGCTCATGA GTCGAGCGCT TTGCCGGAGC TGGCTACCCC AGGTGGCCCG CAGATGTCAT 
GCTAATGTGA ATGTGCCAAT CCTGCGGATA AACTCTGGTC ATCCGGCGGC GAGGTCATGT 
CGGCAGATTC ACAGCAACCG AAAACAGAGC AGCAACCTGA AGCCGACGAC TGGGGAGCCT 
GCGGCAGCGG AGCAGAACAC CCCGGTGCCG GTGAACAATG TGATCAAGGC GGTGGCCTTC 
ACGGGAGCAT TTACGGTCGG CTGCTTTGCG GGTGCCACCA TCCTGGAGTA CGAGAACACA 
CGTAGCCTAA TCCTAGAAAA GGCTCGCCAG GCGAGATTCG GTTGGTGGCA GAGTCGTTCG 
CTGGCGGACA GGGATTACTG GACACAGATC AAACAAGACA TCCGGCGGCA CTGGGACTCA 
CTGACACCCG GCGACAAGAT GTTTGCTCCT ATCTTACTCT GCAATTTGGT GGCCTTCGCC 
ATGTGGCGGG TGCCCGCTCT GAAATCCACA ATGATTACCT ACTTCACATC CAATCCAGCG 
GCGAAAGTCG TCTGCTGGCC CATGTTCCTG TCCACATTCA GCCATTACTC GGCTATGCAC 
CTTTTCGCCA ATATGTACGT GATGCACAGC TTTGCCAACG CTGCGGCTGT ATCGTTGGGT 
AAAGAGCAAT TCTTAGCGGT CTACCTCAGC GCCGGCGTCT TCTCCAGTCT GATGAGCGTG 
CTCTACAAGG CGGCCACGAG TCAGGCGGGG ATGTCCCTGG GTGCGTCTGG AGCTATAATG 
ACACTGCTGG CCTATGTATG CACCCAGTAT CCGGACACAC AACTTAGCAT TCTCTTTCTA 
CCCGCGTTGA CATTCTCCGC TGGAGCTGGT ATTAAAGTGC TAATGGGCAT CGACTTTGCT 
GGCGTCGTGA TGGGCTGGAA GTTCTTCGAT CACGCAGCGC ATTTGGGCGG CGCCATGTTT 
GGCATCTTTT GGGCCACGTA TGGGGCACAG ATATGGGCAA AGCGCATTGG TCTACTGAAT 
TACTACCATG ACCTGCGCCG GACGAAGCAG AAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001286324.1
CDS	119..1174
Translation	MLMSRALCRSWLPQVARRCHANVNVPILRINSGHPAARSCRQIHSNRKQSSNLKPTTGEPAAAEQNTPVPVNNVIKAVAFTGAFTVGCFAGATILEYENTRSLILEKARQARFGWWQSRSLADRDYWTQIKQDIRRHWDSLTPGDKMFAPILLCNLVAFAMWRVPALKSTMITYFTSNPAAKVVCWPMFLSTFSHYSAMHLFANMYVMHSFANAAAVSLGKEQFLAVYLSAGVFSSLMSVLYKAATSQAGMSLGASGAIMTLLAYVCTQYPDTQLSILFLPALTFSAGAGIKVLMGIDFAGVVMGWKFFDHAAHLGGAMFGIFWATYGAQIWAKRIGLLNYYHDLRRTKQK

Target ORF information:

RefSeq Version	NM_001299395.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster rhomboid-7 (rho-7), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001299395.1

ORF Insert Sequence:

ATGCTCATGA GTCGAGCGCT TTGCCGGAGC TGGCTACCCC AGGTGGCCCG CAGATGTCAT 
GCTAATGTGA ATGTGCCAAT CCTGCGGATA AACTCTGGTC ATCCGGCGGC GAGGTCATGT 
CGGCAGATTC ACAGCAACCG AAAACAGAGC AGCAACCTGA AGCCGACGAC TGGGGAGCCT 
GCGGCAGCGG AGCAGAACAC CCCGGTGCCG GTGAACAATG TGATCAAGGC GGTGGCCTTC 
ACGGGAGCAT TTACGGTCGG CTGCTTTGCG GGTGCCACCA TCCTGGAGTA CGAGAACACA 
CGTAGCCTAA TCCTAGAAAA GGCTCGCCAG GCGAGATTCG GTTGGTGGCA GAGTCGTTCG 
CTGGCGGACA GGGATTACTG GACACAGATC AAACAAGACA TCCGGCGGCA CTGGGACTCA 
CTGACACCCG GCGACAAGAT GTTTGCTCCT ATCTTACTCT GCAATTTGGT GGCCTTCGCC 
ATGTGGCGGG TGCCCGCTCT GAAATCCACA ATGATTACCT ACTTCACATC CAATCCAGCG 
GCGAAAGTCG TCTGCTGGCC CATGTTCCTG TCCACATTCA GCCATTACTC GGCTATGCAC 
CTTTTCGCCA ATATGTACGT GATGCACAGC TTTGCCAACG CTGCGGCTGT ATCGTTGGGT 
AAAGAGCAAT TCTTAGCGGT CTACCTCAGC GCCGGCGTCT TCTCCAGTCT GATGAGCGTG 
CTCTACAAGG CGGCCACGAG TCAGGCGGGG ATGTCCCTGG GTGCGTCTGG AGCTATAATG 
ACACTGCTGG CCTATGTATG CACCCAGTAT CCGGACACAC AACTTAGCAT TCTCTTTCTA 
CCCGCGTTGA CATTCTCCGC TGGAGCTGGT ATTAAAGTGC TAATGGGCAT CGACTTTGCT 
GGCGTCGTGA TGGGCTGGAA GTTCTTCGAT CACGCAGCGC ATTTGGGCGG CGCCATGTTT 
GGCATCTTTT GGGCCACGTA TGGGGCACAG ATATGGGCAA AGCGCATTGG TCTACTGAAT 
TACTACCATG ACCTGCGCCG GACGAAGCAG AAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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rho-7 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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