FMRFa cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	FMRFa
Entrez Gene ID	36030
Full Name	FMRFamide
Synonyms	CG2346,DPKQDFMRF-amide,DPKQDFMRFamide,Dmel\CG2346,Drm-FMRF-1,Drm-FMRF-2,Drm-FMRF-3,Drm-FMRF-4,Drm-FMRF-5,Drm-FMRFa1,Drm-FMRFa2,Drm-FMRFa3,Drm-FMRFa4,FMRF,FMRFa-1,FMRFa-2,FMRFa-3,FMRFa-4,FMRFa-5,FMRFa-6,FMRFa-7,FMRFa-8,FMRFa-like,Fmrf,dFMRF,dFMRFa,dFMRFa-1,dFMRFa-2,dFMRFa-3,dFMRFa-4,dFMRFa-5,dFMRFa-6,dFMRFa-7,dFMRFa-8,dFmrf,dFmrfa,fmrf
General protein information	Preferred Names FMRFamide Names CG2346 gene product from transcript CG2346-RA CG2346-PA DPKQDFMRFamide Drm-FMRFamide-1 Drm-FMRFamide-2 Drm-FMRFamide-3 Drm-FMRFamide-4 Drm-FMRFamide-5 FMRF amide homologue precursor FMRF-amide FMRFa-PA FMRFamide prohormone FMRFamide-related FRMFamide SDNFMRFamide TPAEDFMRFamide amino acid amidated neuropeptide dFMRFamide
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 46C4-46C4

mRNA and Protein(s)

mRNA	Protein	Name
NM_078945.4	NP_523669.2	FMRFamide

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Animals mutant for either FMRFamide or for the FMRFamide receptor (FR) have a reduced recovery sleep in response to heat stress.
Title: FMRFamide signaling promotes stress-induced sleep in Drosophila.

DPKQDFMRFamide induces contractions via a G-protein coupled FMRFamide receptor in muscle cells but does not appear to act via cAMP, cGMP, CaMKII or arachidonic acid.
Title: Mode of action of a Drosophila FMRFamide in inducing muscle contraction.

Klu is expressed specifically in the postmitotic Ap4/FMRFa neuron, promoting its differentiation through the initiation of BMP signaling
Title: Klumpfuss controls FMRFamide expression by enabling BMP signaling within the NB5-6 lineage.

DPKQDFMRFamide modulates both synaptic function and behavior through coincident detection mediated by FMRF receptor and dromyosuppressin receptor-2.
Title: Peptide-induced modulation of synaptic transmission and escape response in Drosophila requires two G-protein-coupled receptors.

hybridization in situ shows a lack of co-localization of mRNAs for the circadian neuropeptide PDF and FMRFamide in brains of the flies Musca domestica and Drosophila melanogaster
Title: Double-labelled in situ hybridization reveals the lack of co-localization of mRNAs for the circadian neuropeptide PDF and FMRFamide in brains of the flies Musca domestica and Drosophila melanogaster.

The following FMRFa gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FMRFa cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa09418	NM_078945.4 Latest version!	Drosophila melanogaster FMRFamide (FMRFa), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FMRFa ( NM_078945.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_523669.2 Drosophila melanogaster FMRFamide (FMRFa), mRNA.

Price & Availability↑

CloneID	OFa09418
Clone ID Related Accession (Same CDS sequence)	NM_078945.4
Accession Version	NM_078945.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1044bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	FMRFamide
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_078945.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGGCATTG CCTTGATGTT CCTGCTGGCC CTGTACCAGA TGCAGTCGGC CATCCACAGC 
GAGATCATCG ATACGCCCAA CTATGCGGGC AACTCGTTGC AGGACGCTGA CTCCGAGGTG 
AGTCCACCGC AGGACAATGA CCTGGTAGAT GCACTGCTCG GCAACGATCA GACCGAGAGG 
GCGGAGCTGG AGTTCCGGCA CCCCATCTCT GTGATTGGCA TCGACTACTC GAAGAACGCC 
GTGGTGCTGC ACTTCCAGAA ACACGGCCGG AAACCGCGCT ACAAGTACGA TCCCGAGCTG 
GAGGCCAAGC GAAGGTCCGT GCAGGACAAC TTCATGCACT TCGGCAAGAG GCAGGCGGAG 
CAGCTGCCAC CGGAGGGCAG CTATGCTGAA TCCGATGAAC TGGAGGGCAT GGCCAAGCGA 
GCAGCTATGG ATCGGTATGG CAGAGATCCC AAGCAGGACT TCATGCGGTT TGGTCGGGAT 
CCGAAACAGG ACTTCATGAG GTTTGGCAGG GATCCAAAGC AGGACTTCAT GAGATTCGGT 
CGGGATCCCA AGCAGGATTT CATGAGATTC GGTCGAGATC CCAAGCAGGA TTTCATGAGG 
TTTGGACGCA CTCCGGCTGA GGATTTCATG AGGTTCGGAC GCACTCCGGC GGAGGACTTC 
ATGAGGTTCG GACGCTCCGA CAATTTCATG CGCTTCGGAC GCAGTCCCCA CGAGGAGCTT 
CGCAGTCCCA AACAGGATTT CATGCGATTC GGTCGCCCGG ACAACTTCAT GCGCTTCGGG 
CGTTCCGCTC CGCAGGATTT TGTGCGCTCC GGGAAGATGG ACTCAAACTT CATTCGATTC 
GGTAAGAGCT TGAAGCCGGC GGCTCCCGAG TCCAAGCCAG TCAAGTCCAA TCAAGGCAAC 
CCAGGCGAAC GCAGTCCAGT GGACAAGGCC ATGACGGAGC TGTTCAAGAA ACAGGAGCTG 
CAGGATCAGC AGGTGAAGAA CGGCGCACAG GCGACCACCA CGCAGGATGG GAGTGTGGAA 
CAGGACCAGT TCTTCGGCCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_523669.2
CDS	109..1152
Translation	MGIALMFLLALYQMQSAIHSEIIDTPNYAGNSLQDADSEVSPPQDNDLVDALLGNDQTERAELEFRHPISVIGIDYSKNAVVLHFQKHGRKPRYKYDPELEAKRRSVQDNFMHFGKRQAEQLPPEGSYAESDELEGMAKRAAMDRYGRDPKQDFMRFGRDPKQDFMRFGRDPKQDFMRFGRDPKQDFMRFGRDPKQDFMRFGRTPAEDFMRFGRTPAEDFMRFGRSDNFMRFGRSPHEELRSPKQDFMRFGRPDNFMRFGRSAPQDFVRSGKMDSNFIRFGKSLKPAAPESKPVKSNQGNPGERSPVDKAMTELFKKQELQDQQVKNGAQATTTQDGSVEQDQFFGQ

Target ORF information:

RefSeq Version	NM_078945.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster FMRFamide (FMRFa), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_078945.4

ORF Insert Sequence:

ATGGGCATTG CCTTGATGTT CCTGCTGGCC CTGTACCAGA TGCAGTCGGC CATCCACAGC 
GAGATCATCG ATACGCCCAA CTATGCGGGC AACTCGTTGC AGGACGCTGA CTCCGAGGTG 
AGTCCACCGC AGGACAATGA CCTGGTAGAT GCACTGCTCG GCAACGATCA GACCGAGAGG 
GCGGAGCTGG AGTTCCGGCA CCCCATCTCT GTGATTGGCA TCGACTACTC GAAGAACGCC 
GTGGTGCTGC ACTTCCAGAA ACACGGCCGG AAACCGCGCT ACAAGTACGA TCCCGAGCTG 
GAGGCCAAGC GAAGGTCCGT GCAGGACAAC TTCATGCACT TCGGCAAGAG GCAGGCGGAG 
CAGCTGCCAC CGGAGGGCAG CTATGCTGAA TCCGATGAAC TGGAGGGCAT GGCCAAGCGA 
GCAGCTATGG ATCGGTATGG CAGAGATCCC AAGCAGGACT TCATGCGGTT TGGTCGGGAT 
CCGAAACAGG ACTTCATGAG GTTTGGCAGG GATCCAAAGC AGGACTTCAT GAGATTCGGT 
CGGGATCCCA AGCAGGATTT CATGAGATTC GGTCGAGATC CCAAGCAGGA TTTCATGAGG 
TTTGGACGCA CTCCGGCTGA GGATTTCATG AGGTTCGGAC GCACTCCGGC GGAGGACTTC 
ATGAGGTTCG GACGCTCCGA CAATTTCATG CGCTTCGGAC GCAGTCCCCA CGAGGAGCTT 
CGCAGTCCCA AACAGGATTT CATGCGATTC GGTCGCCCGG ACAACTTCAT GCGCTTCGGG 
CGTTCCGCTC CGCAGGATTT TGTGCGCTCC GGGAAGATGG ACTCAAACTT CATTCGATTC 
GGTAAGAGCT TGAAGCCGGC GGCTCCCGAG TCCAAGCCAG TCAAGTCCAA TCAAGGCAAC 
CCAGGCGAAC GCAGTCCAGT GGACAAGGCC ATGACGGAGC TGTTCAAGAA ACAGGAGCTG 
CAGGATCAGC AGGTGAAGAA CGGCGCACAG GCGACCACCA CGCAGGATGG GAGTGTGGAA 
CAGGACCAGT TCTTCGGCCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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FMRFa cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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