fzy cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	fzy
Entrez Gene ID	34968
Full Name	fizzy
Synonyms	BG:DS02740.14,CDC20,CG4274,Cdc20,Cdc20/Fizzy,Cdc20/Fzy,Cdc20[Fzy],Cdc20[fizzy],Dmel\CG4274,FZY,Fizzy,Fzy,Fzy/Cdc20,cdc20,cdc20/fizzy,dCDC20,dFZY
General protein information	Preferred Names fizzy Names CG4274 gene product from transcript CG4274-RA CG4274-PA Cdc20 fzy-PA
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2L Map Location: 35F1-35F1\|2-51 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_058153.4	NP_477501.1	fizzy

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	fzy	NP_477501.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009338	XP_310009.4
Oryza sativa (rice)	Os04g0599800	NP_001053754.1
Xenopus tropicalis (tropical clawed frog)	cdc20	NP_988945.1
Homo sapiens (human)	CDC20	NP_001246.2
	CDC20	XP_001090604.2
Danio rerio (zebrafish)	cdc20	NP_998245.1
Eremothecium gossypii	AGOS_AFL014C	NP_985534.1
Schizosaccharomyces pombe (fission yeast)	slp1	NP_593161.1
Magnaporthe oryzae (rice blast fungus)	MGG_01236	XP_003714140.1
Oryza sativa (rice)	Os09g0242300	NP_001062648.2
Pan troglodytes (chimpanzee)	CDC20	NP_001230901.1
Canis lupus familiaris (dog)	CDC20	XP_003639578.1
Bos taurus (cattle)	CDC20	NP_001075905.1
Mus musculus (house mouse)	Cdc20	NP_075712.2
Rattus norvegicus (Norway rat)	Cdc20	NP_741990.1
Kluyveromyces lactis	KLLA0F10791g	XP_455571.1
Neurospora crassa	NCU02616	XP_965019.1
Oryza sativa (rice)	Os02g0700100	NP_001047837.1
Gallus gallus (chicken)	CDC20	NP_001006536.1
Saccharomyces cerevisiae (baker's yeast)	CDC20	NP_011399.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The Bub3-BubR1 complex on broken DNA inhibits the APC/C locally via the sequestration of Cdc20.
Title: Bub3-BubR1-dependent sequestration of Cdc20Fizzy at DNA breaks facilitates the correct segregation of broken chromosomes.

Neuroblasts experiencing catastrophic cellular stress, or overexpressing p53, lose Fzy expression and undergo necrosis. Co-expression of fzy suppresses the death of these neuroblasts.
Title: A novel fizzy/Cdc20-dependent mechanism suppresses necrosis in neural stem cells.

Kinetochore localized Mad2 and Cdc20 is itself insufficient for triggering the mitotic checkpoint when Mps1 is low in Drosophila melanogaster neuroblasts.
Title: Kinetochore localized Mad2 and Cdc20 is itself insufficient for triggering the mitotic checkpoint when Mps1 is low in Drosophila melanogaster neuroblasts.

Data show that the Mad2 kinetochore dimerization recruitment mechanism is conserved and that the recruitment of Cdc20 to kinetochores in Drosophila requires BubR1 but not Mad2.
Title: Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster.

Cyclin B associates with spindle microtubules throughout meiosis I and meiosis II, and dissociates from the meiotic spindle in anaphase II. Fzy and Cort are required for this loss of cyclin B from the meiotic spindle.
Title: The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila.

The following fzy gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the fzy cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa16830	NM_058153.4 Latest version!	Drosophila melanogaster fizzy (fzy), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

fzy ( NM_058153.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_477501.1 Drosophila melanogaster fizzy (fzy), mRNA.

Price & Availability↑

CloneID	OFa16830
Clone ID Related Accession (Same CDS sequence)	NM_058153.4
Accession Version	NM_058153.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1581bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	fizzy
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033779). On Jan 16, 2013 this sequence version replaced NM_058153.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCGCAGT TCAATTTTGT GAGCGATTTG CAGAATGCTC TCATCATGGA CGGCGAGACG 
CGCGGACCTG CGCCCAGGTG GAAGAAGAAG CTGGAGGCGT CTCTAAATGG AAGTGTGAAT 
ACCACTCGGT CGGTGCTATC CGTCTCGTAC AACACCAGTT TCTCGGGTGT CCAGGCGCCC 
ACGAAAACTC CGGGCAAGAG CAGCGAGGGC AAGACCAAGA AGTCCAACAC CACGCCCTCT 
AAGACGCCAG GAGGCGGAGA TCGCTTTATT CCGAATCGGG CGGCTACCAA CTTTGAGTTA 
GCACACTTTC TGGTGAACAA AGACTCCGGC GATAAGTCCG ATGAGGAGAA CGACAAGGCC 
ACCTCGAGCA ACAGCAACGA GAGCAATGTC CAGGCTTCGG CTCACAAGGG CGACCGGCAG 
AAACTCATCT CTGAAGTGGC CCAGGTCGGT GACTCCAAGG GCGGGCGCAT TTTGTGCTAC 
CAAAACAAGG CTCCCGCTGC TCCAGAAACA CACAACAATC CCCTGAAGGT CGTGTACTCC 
ATTAAGACAC CCATATCCAC AAAGAGTGGC TCACGCTATA TACCCACCAC ATCCGAGAGG 
ATTCTGGATG CACCTGATTT TATTAACGAT TACTATTTAA ATCTTATGGA TTGGAGTGCC 
GACAATATAG TGGCTGTGGC CTTGGGCAGT TGCGTCTATT TGTGGAACGC ACAGACCGGA 
AATATCGAGC AGCTTACGGA GTTTGAGGAG GGCGACTACG CAGGCTCGCT ATCGTGGATC 
CAGGAGGGGC AGATACTTGC CATCGGCAAC AGCACCGGTG CCGTGGAGCT GTGGGACTGC 
TCCAAAGTGA AGCGTCTGCG AGTGATGGAT GGACACAGTG CCCGAGTGGG ATCCTTGGCC 
TGGAACTCAT TCCTGGTTTC CTCTGGCAGC CGGGATGGCA CCATTGTCCA CCACGATGTG 
CGTGCACGTG AGCACAAGCT TTCCACATTG TCCGGACACA CGCAGGAGGT TTGCGGCCTA 
AAGTGGTCCA CGGATTTCAA GTATTTGGCT AGCGGAGGCA ACGACAATCT GGTGAATGTT 
TGGTCGGCGG CCAGCGGTGG CGTGGGAACT GCCACCGATC CCTTGCACAA ATTCAACGAC 
CATCAAGCTG CAGTGCGTGC CTTGGCCTGG TGTCCCTGGC AACCAAGTAC TCTAGCCTCT 
GGAGGCGGCA CCGCCGATCG CTGCATCAAG TTCTGGAATG TGAACAATGG CACTTTAATG 
AAATCCGTGG ACTCCAAGTC GCAGGTCTGT TCTCTGCTCT TTTCTCGCCA CTACAAGGAG 
CTGATCTCTG CGCATGGTTT TGCTAACAAC CAACTGACCA TTTGGAAATA CCCAACAATG 
GTGAAGCAAG CCGATTTGAC TGGACACACG TCACGAGTTC TCCAGATGGC CATGTCTCCG 
GACGGCAGCA CAGTGATCAG CGCCGGAGCT GATGAAACCC TGCGTCTTTG GAACTGCTTC 
GCTCCCGATC CGTTGGCGTC CAAGAAGGCA GTTTCGACCA GCAAGGGCAA ACAGAGCGTG 
TTCCGACAGA GCATCCGTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_477501.1
CDS	146..1726
Translation	MSQFNFVSDLQNALIMDGETRGPAPRWKKKLEASLNGSVNTTRSVLSVSYNTSFSGVQAPTKTPGKSSEGKTKKSNTTPSKTPGGGDRFIPNRAATNFELAHFLVNKDSGDKSDEENDKATSSNSNESNVQASAHKGDRQKLISEVAQVGDSKGGRILCYQNKAPAAPETHNNPLKVVYSIKTPISTKSGSRYIPTTSERILDAPDFINDYYLNLMDWSADNIVAVALGSCVYLWNAQTGNIEQLTEFEEGDYAGSLSWIQEGQILAIGNSTGAVELWDCSKVKRLRVMDGHSARVGSLAWNSFLVSSGSRDGTIVHHDVRAREHKLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWSAASGGVGTATDPLHKFNDHQAAVRALAWCPWQPSTLASGGGTADRCIKFWNVNNGTLMKSVDSKSQVCSLLFSRHYKELISAHGFANNQLTIWKYPTMVKQADLTGHTSRVLQMAMSPDGSTVISAGADETLRLWNCFAPDPLASKKAVSTSKGKQSVFRQSIR

Target ORF information:

RefSeq Version	NM_058153.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster fizzy (fzy), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_058153.4

ORF Insert Sequence:

ATGTCGCAGT TCAATTTTGT GAGCGATTTG CAGAATGCTC TCATCATGGA CGGCGAGACG 
CGCGGACCTG CGCCCAGGTG GAAGAAGAAG CTGGAGGCGT CTCTAAATGG AAGTGTGAAT 
ACCACTCGGT CGGTGCTATC CGTCTCGTAC AACACCAGTT TCTCGGGTGT CCAGGCGCCC 
ACGAAAACTC CGGGCAAGAG CAGCGAGGGC AAGACCAAGA AGTCCAACAC CACGCCCTCT 
AAGACGCCAG GAGGCGGAGA TCGCTTTATT CCGAATCGGG CGGCTACCAA CTTTGAGTTA 
GCACACTTTC TGGTGAACAA AGACTCCGGC GATAAGTCCG ATGAGGAGAA CGACAAGGCC 
ACCTCGAGCA ACAGCAACGA GAGCAATGTC CAGGCTTCGG CTCACAAGGG CGACCGGCAG 
AAACTCATCT CTGAAGTGGC CCAGGTCGGT GACTCCAAGG GCGGGCGCAT TTTGTGCTAC 
CAAAACAAGG CTCCCGCTGC TCCAGAAACA CACAACAATC CCCTGAAGGT CGTGTACTCC 
ATTAAGACAC CCATATCCAC AAAGAGTGGC TCACGCTATA TACCCACCAC ATCCGAGAGG 
ATTCTGGATG CACCTGATTT TATTAACGAT TACTATTTAA ATCTTATGGA TTGGAGTGCC 
GACAATATAG TGGCTGTGGC CTTGGGCAGT TGCGTCTATT TGTGGAACGC ACAGACCGGA 
AATATCGAGC AGCTTACGGA GTTTGAGGAG GGCGACTACG CAGGCTCGCT ATCGTGGATC 
CAGGAGGGGC AGATACTTGC CATCGGCAAC AGCACCGGTG CCGTGGAGCT GTGGGACTGC 
TCCAAAGTGA AGCGTCTGCG AGTGATGGAT GGACACAGTG CCCGAGTGGG ATCCTTGGCC 
TGGAACTCAT TCCTGGTTTC CTCTGGCAGC CGGGATGGCA CCATTGTCCA CCACGATGTG 
CGTGCACGTG AGCACAAGCT TTCCACATTG TCCGGACACA CGCAGGAGGT TTGCGGCCTA 
AAGTGGTCCA CGGATTTCAA GTATTTGGCT AGCGGAGGCA ACGACAATCT GGTGAATGTT 
TGGTCGGCGG CCAGCGGTGG CGTGGGAACT GCCACCGATC CCTTGCACAA ATTCAACGAC 
CATCAAGCTG CAGTGCGTGC CTTGGCCTGG TGTCCCTGGC AACCAAGTAC TCTAGCCTCT 
GGAGGCGGCA CCGCCGATCG CTGCATCAAG TTCTGGAATG TGAACAATGG CACTTTAATG 
AAATCCGTGG ACTCCAAGTC GCAGGTCTGT TCTCTGCTCT TTTCTCGCCA CTACAAGGAG 
CTGATCTCTG CGCATGGTTT TGCTAACAAC CAACTGACCA TTTGGAAATA CCCAACAATG 
GTGAAGCAAG CCGATTTGAC TGGACACACG TCACGAGTTC TCCAGATGGC CATGTCTCCG 
GACGGCAGCA CAGTGATCAG CGCCGGAGCT GATGAAACCC TGCGTCTTTG GAACTGCTTC 
GCTCCCGATC CGTTGGCGTC CAAGAAGGCA GTTTCGACCA GCAAGGGCAA ACAGAGCGTG 
TTCCGACAGA GCATCCGTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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fzy cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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