esg cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	esg
Entrez Gene ID	34903
Full Name	escargot
Synonyms	4B7,BG:DS07851.7,CG3758,Dmel\CG3758,Esg,br43,dgl,flg,l(2)07082,l(2)35Ce,l(2)4B7,l(2)br43,l(2)esg,l35Ce,shof,wiz
General protein information	Preferred Names escargot Names CG3758 gene product from transcript CG3758-RA CG3758-PA D.m.Escargot Fusion-1 double glazed esg-PA esgargot fleabag shut off wizard
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2L Map Location: 35D2-35D2

mRNA and Protein(s)

mRNA	Protein	Name
NM_057252.4	NP_476600.1	escargot

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	esg	NP_476600.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008274	XP_317196.4

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Esg controls specification of cell types in trachea and suppresses ERK signaling in fusion cells to control cells' differential migratory behavior.
Title: Escargot controls the sequential specification of two tracheal tip cell types by suppressing FGF signaling in Drosophila.

Escargot and Scratch regulate neural commitment by antagonizing Notch activity in Drosophila sensory organs
Title: Escargot and Scratch regulate neural commitment by antagonizing Notch activity in Drosophila sensory organs.

CySCs mutant for esg are not maintained as stem cells, but remain capable of differentiating normally along the cyst cell lineage. In contrast, esg mutant CySCs that give rise to a closely related lineage, the apical hub cells, cannot maintain hub cell identity. this dual regulatory role is due to simultaneous control by Esg of overlapping genetic programs. Similar results were obtained with intestinal stem cells.
Title: Simultaneous control of stemness and differentiation by the transcription factor Escargot in adult stem cells: How can we tease them apart?

Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8-Escargot switch.
Title: Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8-Escargot switch.

Authors demonstrate that Esg plays a pivotal role in intestinal homeostasis, maintaining the stem cell pool while influencing fate decisions through modulation of Notch activity.
Title: Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot.

The following esg gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the esg cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa15916	NM_057252.4 Latest version!	Drosophila melanogaster escargot (esg), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

esg ( NM_057252.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_476600.1 Drosophila melanogaster escargot (esg), mRNA.

Price & Availability↑

CloneID	OFa15916
Clone ID Related Accession (Same CDS sequence)	NM_057252.4
Accession Version	NM_057252.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1413bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	escargot
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033779). On Jul 15, 2014 this sequence version replaced NM_057252.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGCATACCG TGGAAGACAT GTTGGTGGAG AAAAACTACA GCAAGTGCCC GCTAAAAAAG 
CGCCCAGTTA ATTACCAGTT CGAGGCGCCT CAAAATCACA GTAACACCCC AAATGAGCCG 
CAGGATTTGT GCGTAAAGAA AATGGAAATT CTGGAGGAAA ATCCCTCCGA GGAACTGATC 
AACGTCAGCG ATTGTTGCGA GGACGAGGGT GTGGATGTAG ATCATACAGA TGATGAACAC 
ATCGAGGAGG AGGACGAGGA CGTCGATGTG GATGTGGACT CGGACCCAAA TCAGACCCAG 
GCTGCGGCTT TAGCTGCTGC CGCAGCTGTG GCCGCCGCTG CAGCCGCCTC CGTGGTTGTG 
CCCACGCCCA CATACCCGAA ATATCCCTGG AACAACTTCC ACATGTCGCC CTACACCGCC 
GAGTTCTACA GGACCATCAA TCAGCAGGGT CATCAGATTT TGCCGCTGCG TGGCGATCTC 
ATTGCGCCCA GTTCGCCGAG TGACTCGCTG GGCTCCCTGT CGCCGCCACC ACATCATTAC 
CTTCATGGTC GCGCAAGCTC CGTTTCCCCG CCCATGAGAT CTGAAATCAT CCATAGACCA 
ATCGGCGTGC GGCAGCACCG TTTCCTGCCC TATCCACAGA TGCCCGGTTA TCCGAGCTTG 
GGCGGCTATA CCCATACCCA TCATCACCAT GCGCCTATCT CGCCGGCTTA TTCCGAGAAT 
TCCTACTACT CCATGCGATC GATGACGCCT GAATCCAGCT GCAGCTCCTC GCTGCCCGAG 
GATCTATCCC TGAAACACAA GAACCTGAAC TTGAATCTAA ACACTAGCCA GCCGGGAGAG 
CAAGCAGCAG CCAAAACCGG GGATATGTCG CCCGAAACTA TGCCGAATGC CTCCGCCAAG 
AAGGACAAGA ACCAGCCGCC GCGTTACCAG TGCCCGGATT GCCAGAAATC TTACTCCACC 
TTCTCCGGGC TGACCAAACA TCAGCAGTTC CATTGCCCGG CCGCCGAGGG TAATCAGGTG 
AAGAAGTCCT TCAGCTGCAA GGATTGTGAC AAGACCTATG TTTCGTTGGG TGCCCTCAAG 
ATGCACATTC GCACCCACAC GTTGCCCTGC AAGTGCAATC TGTGCGGCAA GGCCTTCTCG 
CGACCATGGC TGCTGCAAGG ACACATTCGC ACTCATACGG GAGAGAAGCC CTTCAGTTGC 
CAGCATTGCC ACCGGGCCTT TGCAGATCGC TCGAATCTGC GAGCACATCT GCAGACCCAC 
TCGGACATCA AGAAGTACTC CTGCACCAGT TGCTCGAAGA CCTTCTCGCG GATGTCCCTC 
CTAACCAAGC ATTCAGAGGG CGGATGTCCT GGCGGCAGTG CAGGATCCTC CAGCAGCAGC 
GAACTCAACT ACGCCGGCTA TGCCGAGCCG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476600.1
CDS	229..1641
Translation	MHTVEDMLVEKNYSKCPLKKRPVNYQFEAPQNHSNTPNEPQDLCVKKMEILEENPSEELINVSDCCEDEGVDVDHTDDEHIEEEDEDVDVDVDSDPNQTQAAALAAAAAVAAAAAASVVVPTPTYPKYPWNNFHMSPYTAEFYRTINQQGHQILPLRGDLIAPSSPSDSLGSLSPPPHHYLHGRASSVSPPMRSEIIHRPIGVRQHRFLPYPQMPGYPSLGGYTHTHHHHAPISPAYSENSYYSMRSMTPESSCSSSLPEDLSLKHKNLNLNLNTSQPGEQAAAKTGDMSPETMPNASAKKDKNQPPRYQCPDCQKSYSTFSGLTKHQQFHCPAAEGNQVKKSFSCKDCDKTYVSLGALKMHIRTHTLPCKCNLCGKAFSRPWLLQGHIRTHTGEKPFSCQHCHRAFADRSNLRAHLQTHSDIKKYSCTSCSKTFSRMSLLTKHSEGGCPGGSAGSSSSSELNYAGYAEP

Target ORF information:

RefSeq Version	NM_057252.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster escargot (esg), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057252.4

ORF Insert Sequence:

ATGCATACCG TGGAAGACAT GTTGGTGGAG AAAAACTACA GCAAGTGCCC GCTAAAAAAG 
CGCCCAGTTA ATTACCAGTT CGAGGCGCCT CAAAATCACA GTAACACCCC AAATGAGCCG 
CAGGATTTGT GCGTAAAGAA AATGGAAATT CTGGAGGAAA ATCCCTCCGA GGAACTGATC 
AACGTCAGCG ATTGTTGCGA GGACGAGGGT GTGGATGTAG ATCATACAGA TGATGAACAC 
ATCGAGGAGG AGGACGAGGA CGTCGATGTG GATGTGGACT CGGACCCAAA TCAGACCCAG 
GCTGCGGCTT TAGCTGCTGC CGCAGCTGTG GCCGCCGCTG CAGCCGCCTC CGTGGTTGTG 
CCCACGCCCA CATACCCGAA ATATCCCTGG AACAACTTCC ACATGTCGCC CTACACCGCC 
GAGTTCTACA GGACCATCAA TCAGCAGGGT CATCAGATTT TGCCGCTGCG TGGCGATCTC 
ATTGCGCCCA GTTCGCCGAG TGACTCGCTG GGCTCCCTGT CGCCGCCACC ACATCATTAC 
CTTCATGGTC GCGCAAGCTC CGTTTCCCCG CCCATGAGAT CTGAAATCAT CCATAGACCA 
ATCGGCGTGC GGCAGCACCG TTTCCTGCCC TATCCACAGA TGCCCGGTTA TCCGAGCTTG 
GGCGGCTATA CCCATACCCA TCATCACCAT GCGCCTATCT CGCCGGCTTA TTCCGAGAAT 
TCCTACTACT CCATGCGATC GATGACGCCT GAATCCAGCT GCAGCTCCTC GCTGCCCGAG 
GATCTATCCC TGAAACACAA GAACCTGAAC TTGAATCTAA ACACTAGCCA GCCGGGAGAG 
CAAGCAGCAG CCAAAACCGG GGATATGTCG CCCGAAACTA TGCCGAATGC CTCCGCCAAG 
AAGGACAAGA ACCAGCCGCC GCGTTACCAG TGCCCGGATT GCCAGAAATC TTACTCCACC 
TTCTCCGGGC TGACCAAACA TCAGCAGTTC CATTGCCCGG CCGCCGAGGG TAATCAGGTG 
AAGAAGTCCT TCAGCTGCAA GGATTGTGAC AAGACCTATG TTTCGTTGGG TGCCCTCAAG 
ATGCACATTC GCACCCACAC GTTGCCCTGC AAGTGCAATC TGTGCGGCAA GGCCTTCTCG 
CGACCATGGC TGCTGCAAGG ACACATTCGC ACTCATACGG GAGAGAAGCC CTTCAGTTGC 
CAGCATTGCC ACCGGGCCTT TGCAGATCGC TCGAATCTGC GAGCACATCT GCAGACCCAC 
TCGGACATCA AGAAGTACTC CTGCACCAGT TGCTCGAAGA CCTTCTCGCG GATGTCCCTC 
CTAACCAAGC ATTCAGAGGG CGGATGTCCT GGCGGCAGTG CAGGATCCTC CAGCAGCAGC 
GAACTCAACT ACGCCGGCTA TGCCGAGCCG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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esg cDNA ORF clone, Drosophila melanogaster(fruit fly)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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