Cdlc2 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdlc2
Entrez Gene ID	33319
Full Name	Cytoplasmic dynein light chain 2
Synonyms	CG5450,Cdcl2,Dmel\CG5450,anon-WO0140519.117,dlc
General protein information	Preferred Names Cytoplasmic dynein light chain 2 Names CG5450 gene product from transcript CG5450-RC 8kd dynein light chain CG5450-PA CG5450-PB CG5450-PC Cdlc2-PA Cdlc2-PB Cdlc2-PC cyto dynein light chain 2 cytoplasmic dynein cytoplasmic dynein light chain 2 dynein
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2L Map Location: 22A1-22A1

mRNA and Protein(s)

mRNA	Protein	Name
NM_058060.4	NP_477408.1	cytoplasmic dynein light chain 2, isoform A
NM_164412.2	NP_722698.1	cytoplasmic dynein light chain 2, isoform B
NM_001258907.2	NP_001245836.1	cytoplasmic dynein light chain 2, isoform C

Pathways from BioSystems

Homologies

Homo sapiens (human)	DYNLL2	NP_542408.1
Mus musculus (house mouse)	Dynll2	NP_080832.1
Rattus norvegicus (Norway rat)	Dynll2	NP_542428.1
Drosophila melanogaster (fruit fly)	ctp	NP_001245530.1
Drosophila melanogaster (fruit fly)	Cdlc2	NP_001245836.1
Magnaporthe oryzae (rice blast fungus)	MGG_15645	XP_003714113.1
Danio rerio (zebrafish)	dynll2a	NP_956393.1
Xenopus tropicalis (tropical clawed frog)	dynll2	NP_001165079.1
Pan troglodytes (chimpanzee)	DYNLL2	NP_001229550.1
Canis lupus familiaris (dog)	DYNLL2	XP_005624774.1
Bos taurus (cattle)	DYNLL2	NP_001106774.1
Gallus gallus (chicken)	DYNLL2	XP_004946822.1
Danio rerio (zebrafish)	dynll2b	NP_001025171.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001335	XP_321810.4
Caenorhabditis elegans (roundworm)	dlc-1	NP_498422.1
Schizosaccharomyces pombe (fission yeast)	dlc2	NP_594368.1
Oryza sativa (rice)	Os01g0256400	NP_001042625.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show assembled dynein IC as an elongated, flexible polybivalent duplex, and suggest that polybivalency is an important general mechanism for constructing stable yet reversible and functionally versatile complexes.
Title: Multivalency in the assembly of intrinsically disordered Dynein intermediate chain.

Dynein-mediated transport of specific RNAs along specialized networks of microtubules increases the efficiency of their delivery, over the flow of general cytoplasmic components, into the oocyte
Title: A Dynein-dependent shortcut rapidly delivers axis determination transcripts into the Drosophila oocyte.

Dynein light chain 1 regulates dynamin-mediated F-actin assembly during sperm individualization in Drosophila
Title: Dynein light chain 1 regulates dynamin-mediated F-actin assembly during sperm individualization in Drosophila.

dynein-dynactin, abnormal spindle protein (Asp), and KLP10A have roles in Drosophila spindle pole organization
Title: Spindle pole organization in Drosophila S2 cells by dynein, abnormal spindle protein (Asp), and KLP10A.

We propose that Msn functions together with Bic-D to regulate the apical localization of dynein in generating directed nuclear migration within differentiating R-cell precursor cells.
Title: The Ste20-like kinase misshapen functions together with Bicaudal-D and dynein in driving nuclear migration in the developing drosophila eye.

The following Cdlc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdlc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OFa13449	NM_058060.4 Latest version!	Drosophila melanogaster cytoplasmic dynein light chain 2, transcript variant A (Cdlc2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OFa13449	NM_001258907.2 Latest version!	Drosophila melanogaster cytoplasmic dynein light chain 2, transcript variant C (Cdlc2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OFa13449	NM_164412.2 Latest version!	Drosophila melanogaster cytoplasmic dynein light chain 2, transcript variant B (Cdlc2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdlc2 ( NM_058060.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_477408.1 Drosophila melanogaster cytoplasmic dynein light chain 2, transcript variant A (Cdlc2), mRNA.

Price & Availability↑

CloneID	OFa13449
Clone ID Related Accession (Same CDS sequence)	NM_058060.4 , NM_164412.2 , NM_001258907.2
Accession Version	NM_058060.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	cytoplasmic dynein light chain 2, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033779). On Jul 15, 2014 this sequence version replaced NM_058060.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCGGATC GCAAGGCGGT GATCAAGAAC GCTGACATGA GCGAGGAGAT GCAGCAGGAC 
GCTGTTGACT GCGCCACCCA GGCCCTGGAG AAGTACAACA TCGAGAAGGA CATCGCCGCC 
TTCATCAAGA AGGAGTTCGA CAAGAAGTAC AACCCCACCT GGCACTGCAT CGTGGGCCGC 
AACTTCGGAT CCTATGTGAC CCACGAGACG CGCCACTTCA TCTATTTCTA CCTGGGCCAG 
GTGGCCATTC TGCTCTTCAA GAGCGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_477408.1
CDS	156..425
Translation	MSDRKAVIKNADMSEEMQQDAVDCATQALEKYNIEKDIAAFIKKEFDKKYNPTWHCIVGRNFGSYVTHETRHFIYFYLGQVAILLFKSG

Target ORF information:

RefSeq Version	NM_058060.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster cytoplasmic dynein light chain 2, transcript variant A (Cdlc2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_058060.4

ORF Insert Sequence:

ATGTCGGATC GCAAGGCGGT GATCAAGAAC GCTGACATGA GCGAGGAGAT GCAGCAGGAC 
GCTGTTGACT GCGCCACCCA GGCCCTGGAG AAGTACAACA TCGAGAAGGA CATCGCCGCC 
TTCATCAAGA AGGAGTTCGA CAAGAAGTAC AACCCCACCT GGCACTGCAT CGTGGGCCGC 
AACTTCGGAT CCTATGTGAC CCACGAGACG CGCCACTTCA TCTATTTCTA CCTGGGCCAG 
GTGGCCATTC TGCTCTTCAA GAGCGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cdlc2 ( NM_164412.2 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_722698.1 Drosophila melanogaster cytoplasmic dynein light chain 2, transcript variant B (Cdlc2), mRNA.

Price & Availability↑

CloneID	OFa13449
Clone ID Related Accession (Same CDS sequence)	NM_058060.4 , NM_164412.2 , NM_001258907.2
Accession Version	NM_164412.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	cytoplasmic dynein light chain 2, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033779). On Jul 15, 2014 this sequence version replaced NM_164412.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCGGATC GCAAGGCGGT GATCAAGAAC GCTGACATGA GCGAGGAGAT GCAGCAGGAC 
GCTGTTGACT GCGCCACCCA GGCCCTGGAG AAGTACAACA TCGAGAAGGA CATCGCCGCC 
TTCATCAAGA AGGAGTTCGA CAAGAAGTAC AACCCCACCT GGCACTGCAT CGTGGGCCGC 
AACTTCGGAT CCTATGTGAC CCACGAGACG CGCCACTTCA TCTATTTCTA CCTGGGCCAG 
GTGGCCATTC TGCTCTTCAA GAGCGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_722698.1
CDS	102..371
Translation	MSDRKAVIKNADMSEEMQQDAVDCATQALEKYNIEKDIAAFIKKEFDKKYNPTWHCIVGRNFGSYVTHETRHFIYFYLGQVAILLFKSG

Target ORF information:

RefSeq Version	NM_164412.2
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster cytoplasmic dynein light chain 2, transcript variant B (Cdlc2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_164412.2

ORF Insert Sequence:

ATGTCGGATC GCAAGGCGGT GATCAAGAAC GCTGACATGA GCGAGGAGAT GCAGCAGGAC 
GCTGTTGACT GCGCCACCCA GGCCCTGGAG AAGTACAACA TCGAGAAGGA CATCGCCGCC 
TTCATCAAGA AGGAGTTCGA CAAGAAGTAC AACCCCACCT GGCACTGCAT CGTGGGCCGC 
AACTTCGGAT CCTATGTGAC CCACGAGACG CGCCACTTCA TCTATTTCTA CCTGGGCCAG 
GTGGCCATTC TGCTCTTCAA GAGCGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cdlc2 ( NM_001258907.2 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001245836.1 Drosophila melanogaster cytoplasmic dynein light chain 2, transcript variant C (Cdlc2), mRNA.

Price & Availability↑

CloneID	OFa13449
Clone ID Related Accession (Same CDS sequence)	NM_058060.4 , NM_164412.2 , NM_001258907.2
Accession Version	NM_001258907.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	cytoplasmic dynein light chain 2, isoform C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033779). On Jul 15, 2014 this sequence version replaced NM_001258907.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCGGATC GCAAGGCGGT GATCAAGAAC GCTGACATGA GCGAGGAGAT GCAGCAGGAC 
GCTGTTGACT GCGCCACCCA GGCCCTGGAG AAGTACAACA TCGAGAAGGA CATCGCCGCC 
TTCATCAAGA AGGAGTTCGA CAAGAAGTAC AACCCCACCT GGCACTGCAT CGTGGGCCGC 
AACTTCGGAT CCTATGTGAC CCACGAGACG CGCCACTTCA TCTATTTCTA CCTGGGCCAG 
GTGGCCATTC TGCTCTTCAA GAGCGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001245836.1
CDS	152..421
Translation	MSDRKAVIKNADMSEEMQQDAVDCATQALEKYNIEKDIAAFIKKEFDKKYNPTWHCIVGRNFGSYVTHETRHFIYFYLGQVAILLFKSG

Target ORF information:

RefSeq Version	NM_001258907.2
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster cytoplasmic dynein light chain 2, transcript variant C (Cdlc2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001258907.2

ORF Insert Sequence:

ATGTCGGATC GCAAGGCGGT GATCAAGAAC GCTGACATGA GCGAGGAGAT GCAGCAGGAC 
GCTGTTGACT GCGCCACCCA GGCCCTGGAG AAGTACAACA TCGAGAAGGA CATCGCCGCC 
TTCATCAAGA AGGAGTTCGA CAAGAAGTAC AACCCCACCT GGCACTGCAT CGTGGGCCGC 
AACTTCGGAT CCTATGTGAC CCACGAGACG CGCCACTTCA TCTATTTCTA CCTGGGCCAG 
GTGGCCATTC TGCTCTTCAA GAGCGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Cdlc2 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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