upd2 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	upd2
Entrez Gene ID	32805
Full Name	unpaired 2
Synonyms	CG5988,Dmel\CG5988,UPD2,Upd-like,Upd2,Upd2/Leptin,cg5988,upd
General protein information	Preferred Names unpaired 2 Names CG5988 gene product from transcript CG5988-RB CG5988-PB Unpaired2 upd homolog upd2-PB
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: X Map Location: 17A3-17A3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001370039.1	NP_001356882.1	unpaired 2
NM_133049.4	NP_573277.2	unpaired 2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study identified Unpaired 2 (Upd2), a protein with similarities to type I cytokines, as a secreted factor produced by the fat body in the fed state. When upd2 function is perturbed specifically in the FB, it results in a systemic reduction in growth and alters energy metabolism.
Title: Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion.

upd2 is expressed in a pattern essentially identical to that of upd and demonstrate that the proteins encoded by this region activate JAK/STAT pathway signalling
Title: Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand.

effect of a predicted gene related to unpaired, designated unpaired2, whose expression initiates during germ band extension.
Title: A novel functional activator of the Drosophila JAK/STAT pathway, unpaired2, is revealed by an in vivo reporter of pathway activation.

The following upd2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the upd2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa01992	NM_133049.4 Latest version!	Drosophila melanogaster unpaired 2 (upd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OFa87680	NM_001370039.1 Latest version!	Drosophila melanogaster unpaired 2 (upd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

upd2 ( NM_133049.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_573277.2 Drosophila melanogaster unpaired 2 (upd2), mRNA.

Price & Availability↑

CloneID	OFa01992
Clone ID Related Accession (Same CDS sequence)	NM_133049.4
Accession Version	NM_133049.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-08-15
Organism	Drosophila melanogaster(fruit fly)
Product	unpaired 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_133049.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.18 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGATCCTGA GCGTCGTGAT GCCATTCACC AAGGCGCGAC ACTTGCGCGA CCAGGTGGCA 
CTGGACTACG CCTACGACGA GGACAACTCC GGCCGATCTT CCTCGTCGTC ATCGTCATCC 
TCATCATCGG GTGGCGACAT CCTGCCCGCC TTCGATGTCA ATCCGTATCG CGGTCTGGCC 
GATAGCTTCG GCGAGGGCAG CTACGACAGT GATATGAGTC TCAGCGAGAG TAGCTACGAG 
GAGATCGCCC AGGCGGCCAT CCGGGCTGCC AGGCGGGAGA TGCGCCGTCA GAGGACGCGA 
CACGCGCGCA GCCACAACCT GCGACTCTTC TCCGGCAAAT CAGAGATCCC GGAGTGGGAG 
AACCCGTGCG GAGGCACCTA CACGCCCGAC GAGAGCCTCA GCGATAGCAG CGCCAGCCAA 
GGACGAGTTA TCAAGCGCAA GCACCTCGAA AACTTGCGGA ACATCACGAT GAGCGAATAC 
CAAGATATAA CCCACCGCGC CACCCTGGAG TACGGCAATC TGCAGCACTG GCAGCGCGAG 
TACAAGTTCC TGCCGAACAT GACGAGGCCC ACAAGTGCGG TGAAGCTAAA GACTTGGTAC 
CGCCACATGC AGACCTTCGT GGGCAGCTTC TCATATCTGG GACGGGCGCA GTACAAGTTC 
CGCAAGGATC AGCAGAAGAG CCTCAACGAG GCGGTCACCA AGGAGCTGCA CGACCTGCTG 
GTCAGCGCGC GCTATATGCT CTGCGAGATC GAGTTGACCA TAAACGCCTC CTATCCGAAC 
AGCAATGGTG CGAAGCTGAG CCGCGTTAGC CGGCAGGCGA TGGAGGAGCG TCTCAACTTT 
CACACGCCAG CCAACGGATC CATGGAGGCG GACCAGCGCG ACCTGAAGGT CAGCAAGGAG 
CTGTACTTCC AGTATCTGAA CAACGTGTGG AAGACCCTGC ACCGTGTCCT GCGGCGACCG 
CGACGCAATA GTGCCGAGCG GCGACACCTG GCGGCGATTC ACGGAACTGG TGCGAGCGGG 
CTGCGGGCGG GCAGCTCGGA AATGCTCGAC GTGGGCTCCT CGAACGGATC CGGTGGCAGT 
TCCGGCTCCG ATGGCGGATC CAATGAGTCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573277.2
CDS	174..1286
Translation	MILSVVMPFTKARHLRDQVALDYAYDEDNSGRSSSSSSSSSSSGGDILPAFDVNPYRGLADSFGEGSYDSDMSLSESSYEEIAQAAIRAARREMRRQRTRHARSHNLRLFSGKSEIPEWENPCGGTYTPDESLSDSSASQGRVIKRKHLENLRNITMSEYQDITHRATLEYGNLQHWQREYKFLPNMTRPTSAVKLKTWYRHMQTFVGSFSYLGRAQYKFRKDQQKSLNEAVTKELHDLLVSARYMLCEIELTINASYPNSNGAKLSRVSRQAMEERLNFHTPANGSMEADQRDLKVSKELYFQYLNNVWKTLHRVLRRPRRNSAERRHLAAIHGTGASGLRAGSSEMLDVGSSNGSGGSSGSDGGSNES

Target ORF information:

RefSeq Version	NM_133049.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster unpaired 2 (upd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133049.4

ORF Insert Sequence:

ATGATCCTGA GCGTCGTGAT GCCATTCACC AAGGCGCGAC ACTTGCGCGA CCAGGTGGCA 
CTGGACTACG CCTACGACGA GGACAACTCC GGCCGATCTT CCTCGTCGTC ATCGTCATCC 
TCATCATCGG GTGGCGACAT CCTGCCCGCC TTCGATGTCA ATCCGTATCG CGGTCTGGCC 
GATAGCTTCG GCGAGGGCAG CTACGACAGT GATATGAGTC TCAGCGAGAG TAGCTACGAG 
GAGATCGCCC AGGCGGCCAT CCGGGCTGCC AGGCGGGAGA TGCGCCGTCA GAGGACGCGA 
CACGCGCGCA GCCACAACCT GCGACTCTTC TCCGGCAAAT CAGAGATCCC GGAGTGGGAG 
AACCCGTGCG GAGGCACCTA CACGCCCGAC GAGAGCCTCA GCGATAGCAG CGCCAGCCAA 
GGACGAGTTA TCAAGCGCAA GCACCTCGAA AACTTGCGGA ACATCACGAT GAGCGAATAC 
CAAGATATAA CCCACCGCGC CACCCTGGAG TACGGCAATC TGCAGCACTG GCAGCGCGAG 
TACAAGTTCC TGCCGAACAT GACGAGGCCC ACAAGTGCGG TGAAGCTAAA GACTTGGTAC 
CGCCACATGC AGACCTTCGT GGGCAGCTTC TCATATCTGG GACGGGCGCA GTACAAGTTC 
CGCAAGGATC AGCAGAAGAG CCTCAACGAG GCGGTCACCA AGGAGCTGCA CGACCTGCTG 
GTCAGCGCGC GCTATATGCT CTGCGAGATC GAGTTGACCA TAAACGCCTC CTATCCGAAC 
AGCAATGGTG CGAAGCTGAG CCGCGTTAGC CGGCAGGCGA TGGAGGAGCG TCTCAACTTT 
CACACGCCAG CCAACGGATC CATGGAGGCG GACCAGCGCG ACCTGAAGGT CAGCAAGGAG 
CTGTACTTCC AGTATCTGAA CAACGTGTGG AAGACCCTGC ACCGTGTCCT GCGGCGACCG 
CGACGCAATA GTGCCGAGCG GCGACACCTG GCGGCGATTC ACGGAACTGG TGCGAGCGGG 
CTGCGGGCGG GCAGCTCGGA AATGCTCGAC GTGGGCTCCT CGAACGGATC CGGTGGCAGT 
TCCGGCTCCG ATGGCGGATC CAATGAGTCT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

upd2 ( NM_001370039.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001356882.1 Drosophila melanogaster unpaired 2 (upd2), mRNA.

Price & Availability↑

CloneID	OFa87680
Clone ID Related Accession (Same CDS sequence)	NM_001370039.1
Accession Version	NM_001370039.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1221bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	unpaired 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGCCAGCCT TTACCTTAAA CGCCAGCCAA CAGAGCCAAA GCAGCCGCAG CAGCAGGAGT 
GCACACAGCA GCTGGAGCTG CCACAGCCGG CAGGTGCTGC TAGTGATCAT GATCCTGAGC 
GTCGTGATGC CATTCACCAA GGCGCGACAC TTGCGCGACC AGGTGGCACT GGACTACGCC 
TACGACGAGG ACAACTCCGG CCGATCTTCC TCGTCGTCAT CGTCATCCTC ATCATCGGGT 
GGCGACATCC TGCCCGCCTT CGATGTCAAT CCGTATCGCG GTCTGGCCGA TAGCTTCGGC 
GAGGGCAGCT ACGACAGTGA TATGAGTCTC AGCGAGAGTA GCTACGAGGA GATCGCCCAG 
GCGGCCATCC GGGCTGCCAG GCGGGAGATG CGCCGTCAGA GGACGCGACA CGCGCGCAGC 
CACAACCTGC GACTCTTCTC CGGCAAATCA GAGATCCCGG AGTGGGAGAA CCCGTGCGGA 
GGCACCTACA CGCCCGACGA GAGCCTCAGC GATAGCAGCG CCAGCCAAGG ACGAGTTATC 
AAGCGCAAGC ACCTCGAAAA CTTGCGGAAC ATCACGATGA GCGAATACCA AGATATAACC 
CACCGCGCCA CCCTGGAGTA CGGCAATCTG CAGCACTGGC AGCGCGAGTA CAAGTTCCTG 
CCGAACATGA CGAGGCCCAC AAGTGCGGTG AAGCTAAAGA CTTGGTACCG CCACATGCAG 
ACCTTCGTGG GCAGCTTCTC ATATCTGGGA CGGGCGCAGT ACAAGTTCCG CAAGGATCAG 
CAGAAGAGCC TCAACGAGGC GGTCACCAAG GAGCTGCACG ACCTGCTGGT CAGCGCGCGC 
TATATGCTCT GCGAGATCGA GTTGACCATA AACGCCTCCT ATCCGAACAG CAATGGTGCG 
AAGCTGAGCC GCGTTAGCCG GCAGGCGATG GAGGAGCGTC TCAACTTTCA CACGCCAGCC 
AACGGATCCA TGGAGGCGGA CCAGCGCGAC CTGAAGGTCA GCAAGGAGCT GTACTTCCAG 
TATCTGAACA ACGTGTGGAA GACCCTGCAC CGTGTCCTGC GGCGACCGCG ACGCAATAGT 
GCCGAGCGGC GACACCTGGC GGCGATTCAC GGAACTGGTG CGAGCGGGCT GCGGGCGGGC 
AGCTCGGAAA TGCTCGACGT GGGCTCCTCG AACGGATCCG GTGGCAGTTC CGGCTCCGAT 
GGCGGATCCA ATGAGTCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001356882.1
CDS	66..1286
Translation	MPAFTLNASQQSQSSRSSRSAHSSWSCHSRQVLLVIMILSVVMPFTKARHLRDQVALDYAYDEDNSGRSSSSSSSSSSSGGDILPAFDVNPYRGLADSFGEGSYDSDMSLSESSYEEIAQAAIRAARREMRRQRTRHARSHNLRLFSGKSEIPEWENPCGGTYTPDESLSDSSASQGRVIKRKHLENLRNITMSEYQDITHRATLEYGNLQHWQREYKFLPNMTRPTSAVKLKTWYRHMQTFVGSFSYLGRAQYKFRKDQQKSLNEAVTKELHDLLVSARYMLCEIELTINASYPNSNGAKLSRVSRQAMEERLNFHTPANGSMEADQRDLKVSKELYFQYLNNVWKTLHRVLRRPRRNSAERRHLAAIHGTGASGLRAGSSEMLDVGSSNGSGGSSGSDGGSNES

Target ORF information:

RefSeq Version	NM_001370039.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster unpaired 2 (upd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001370039.1

ORF Insert Sequence:

ATGCCAGCCT TTACCTTAAA CGCCAGCCAA CAGAGCCAAA GCAGCCGCAG CAGCAGGAGT 
GCACACAGCA GCTGGAGCTG CCACAGCCGG CAGGTGCTGC TAGTGATCAT GATCCTGAGC 
GTCGTGATGC CATTCACCAA GGCGCGACAC TTGCGCGACC AGGTGGCACT GGACTACGCC 
TACGACGAGG ACAACTCCGG CCGATCTTCC TCGTCGTCAT CGTCATCCTC ATCATCGGGT 
GGCGACATCC TGCCCGCCTT CGATGTCAAT CCGTATCGCG GTCTGGCCGA TAGCTTCGGC 
GAGGGCAGCT ACGACAGTGA TATGAGTCTC AGCGAGAGTA GCTACGAGGA GATCGCCCAG 
GCGGCCATCC GGGCTGCCAG GCGGGAGATG CGCCGTCAGA GGACGCGACA CGCGCGCAGC 
CACAACCTGC GACTCTTCTC CGGCAAATCA GAGATCCCGG AGTGGGAGAA CCCGTGCGGA 
GGCACCTACA CGCCCGACGA GAGCCTCAGC GATAGCAGCG CCAGCCAAGG ACGAGTTATC 
AAGCGCAAGC ACCTCGAAAA CTTGCGGAAC ATCACGATGA GCGAATACCA AGATATAACC 
CACCGCGCCA CCCTGGAGTA CGGCAATCTG CAGCACTGGC AGCGCGAGTA CAAGTTCCTG 
CCGAACATGA CGAGGCCCAC AAGTGCGGTG AAGCTAAAGA CTTGGTACCG CCACATGCAG 
ACCTTCGTGG GCAGCTTCTC ATATCTGGGA CGGGCGCAGT ACAAGTTCCG CAAGGATCAG 
CAGAAGAGCC TCAACGAGGC GGTCACCAAG GAGCTGCACG ACCTGCTGGT CAGCGCGCGC 
TATATGCTCT GCGAGATCGA GTTGACCATA AACGCCTCCT ATCCGAACAG CAATGGTGCG 
AAGCTGAGCC GCGTTAGCCG GCAGGCGATG GAGGAGCGTC TCAACTTTCA CACGCCAGCC 
AACGGATCCA TGGAGGCGGA CCAGCGCGAC CTGAAGGTCA GCAAGGAGCT GTACTTCCAG 
TATCTGAACA ACGTGTGGAA GACCCTGCAC CGTGTCCTGC GGCGACCGCG ACGCAATAGT 
GCCGAGCGGC GACACCTGGC GGCGATTCAC GGAACTGGTG CGAGCGGGCT GCGGGCGGGC 
AGCTCGGAAA TGCTCGACGT GGGCTCCTCG AACGGATCCG GTGGCAGTTC CGGCTCCGAT 
GGCGGATCCA ATGAGTCTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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upd2 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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