Cdk7 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdk7
Entrez Gene ID	31441
Full Name	Cyclin-dependent kinase 7
Synonyms	CD 7,CDK7,CG3319,DmCDK7,DmCdk7,DmMO15,DmMo15,Dmcdk7,Dmel\CG3319,Mo15,cdk-7,cdk7,dCdk7,p40[MO15]
General protein information	Preferred Names Cyclin-dependent kinase 7 Names CG3319 gene product from transcript CG3319-RA CG3319-PA Cdk7-PA Mo15
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: X Map Location: 4F4-4F4

mRNA and Protein(s)

mRNA	Protein	Name
NM_078489.3	NP_511044.1	Cyclin-dependent kinase 7

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CDK7	XP_001160482.1
Canis lupus familiaris (dog)	CDK7	XP_850424.1
Bos taurus (cattle)	CDK7	NP_001069183.1
Gallus gallus (chicken)	CDK7	XP_001234587.2
Magnaporthe oryzae (rice blast fungus)	MGG_13401	XP_003711393.1
	CDK7	XP_001092242.1
Danio rerio (zebrafish)	cdk7	NP_998126.2
Drosophila melanogaster (fruit fly)	Cdk7	NP_511044.1
Homo sapiens (human)	CDK7	NP_001790.1
Mus musculus (house mouse)	Cdk7	NP_034004.2
Schizosaccharomyces pombe (fission yeast)	mcs6	NP_596349.1
Neurospora crassa	NCU03659	XP_960739.1
Rattus norvegicus (Norway rat)	Cdk7	XP_006231929.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002646	XP_312281.3
Caenorhabditis elegans (roundworm)	cdk-7	NP_490952.2
Saccharomyces cerevisiae (baker's yeast)	KIN28	NP_010175.1
Kluyveromyces lactis	KLLA0E14785g	XP_454616.1
Eremothecium gossypii	AGOS_ADL283W	NP_983813.1
Arabidopsis thaliana (thale cress)	CAK4	NP_176847.1
Xenopus tropicalis (tropical clawed frog)	cdk7	NP_001017219.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genetic and biochemical analyses reveal a functional interaction of MSL1 with CDK7, a subunit of the Cdk-activating kinase (CAK) complex of the general transcription factor TFIIH. Importantly, MSL1 depletion leads to decreased phosphorylation of Ser5 of RNA polymerase II.
Title: Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation.

CDK7 is required for the mitochondrial localization of Hid and induction of apoptosis.
Title: CDK7 regulates the mitochondrial localization of a tail-anchored proapoptotic protein, Hid.

The multitask protein Xpd also plays an essential role in cell cycle regulation that appears to be independent of transcription or nucleotide excision repair.
Title: Drosophila Xpd regulates Cdk7 localization, mitotic kinase activity, spindle dynamics, and chromosome segregation.

Cdk7 is required for full activation of Drosophila heat-shock genes and RNA polymerase II phosphorylation in vivo.
Title: Cdk7 is required for full activation of Drosophila heat shock genes and RNA polymerase II phosphorylation in vivo.

The following Cdk7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdk7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa00836	NM_078489.3 Latest version!	Drosophila melanogaster Cyclin-dependent kinase 7 (Cdk7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdk7 ( NM_078489.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_511044.1 Drosophila melanogaster Cyclin-dependent kinase 7 (Cdk7), mRNA.

Price & Availability↑

CloneID	OFa00836
Clone ID Related Accession (Same CDS sequence)	NM_078489.3
Accession Version	NM_078489.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Cyclin-dependent kinase 7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_078489.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGCTGCCCA ATGCGAATGA CAAAACGGAA CGCTATGCCA AGCTATCCTT CCTCGGCGAG 
GGTCAGTTTG CCACAGTTTA CAAGGCGCGC GACACGGTGA CCAACCAAAT TGTGGCCGTA 
AAGAAGATCA AGAAGGGATC GCGCGAGGAT GCACGCGACG GTATCAACAG GACAGCGCTG 
CGTGAGATCA AGATATTGCA GGAGCTGCAG CACGAGAATA TCATTGGCTT GGTGGACGTT 
TTCGGTCAAC TTTCGAATGT CTCGCTGGTT TTCGACTTCA TGGACACGGA TCTGGAGGTG 
ATCATCAAGG ATAACAAGAT TATATTAACG CAGGCGAACA TCAAGGCCTA TGCCATCATG 
ACGCTAAAGG GTCTGGAGTA TTTGCATCTC AATTGGATAC TGCACCGCGA TTTGAAGCCC 
AACAATTTGC TGGTCAACAG CGATGGCATC CTAAAGATTG GCGATTTCGG TTTGGCCAAG 
TCCTTCGGTT CGCCCAATCG CATTTACACG CACCACGTGG TCACACGCTG GTATCGTTCG 
CCCGAATTGC TCTTTGGCGC CCGACAATAT GGCACCGGTG TGGATATGTG GGCAGTTGGC 
TGCATTTTGG CTGAACTTAT GCTGCGAGTG CCGTTCATGC CGGGCGATTC GGATCTGGAT 
CAGCTGACAC GGATCTTTTC CACACTGGGA ACACCCACGG AAGCTGAATG GCCGCATTTG 
AGCAAACTGC ACGACTATCT GCAGTTTCGC AACTTTCCGG GCACACCATT GGACAATATA 
TTCACCGCCG CGGGCAATGA CTTGATCCAT CTGATGCAAC GCCTGTTTGC CATGAATCCG 
CTGCGGCGTG TGTCCTGCCG CGAGGCACTG AGCATGCCGT ATTTCGCTAA CAAACCGGCG 
CCCACAGTGG GTCCCAAGTT GCCAATGCCG TCGGCCATTC TGGCCGCCAA GGAGGGCGCC 
AATCCGCAGA CCGGCGACAC GAAGCCTGCG CTCAAGCGCA AGCTGGTCGA GACTACGGTG 
AGGGGCAATG GATTGGCCCA GAAGAAGCGG CTGCAGTTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_511044.1
CDS	90..1151
Translation	MLPNANDKTERYAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENIIGLVDVFGQLSNVSLVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNFPGTPLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYFANKPAPTVGPKLPMPSAILAAKEGANPQTGDTKPALKRKLVETTVRGNGLAQKKRLQF

Target ORF information:

RefSeq Version	NM_078489.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Cyclin-dependent kinase 7 (Cdk7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_078489.3

ORF Insert Sequence:

ATGCTGCCCA ATGCGAATGA CAAAACGGAA CGCTATGCCA AGCTATCCTT CCTCGGCGAG 
GGTCAGTTTG CCACAGTTTA CAAGGCGCGC GACACGGTGA CCAACCAAAT TGTGGCCGTA 
AAGAAGATCA AGAAGGGATC GCGCGAGGAT GCACGCGACG GTATCAACAG GACAGCGCTG 
CGTGAGATCA AGATATTGCA GGAGCTGCAG CACGAGAATA TCATTGGCTT GGTGGACGTT 
TTCGGTCAAC TTTCGAATGT CTCGCTGGTT TTCGACTTCA TGGACACGGA TCTGGAGGTG 
ATCATCAAGG ATAACAAGAT TATATTAACG CAGGCGAACA TCAAGGCCTA TGCCATCATG 
ACGCTAAAGG GTCTGGAGTA TTTGCATCTC AATTGGATAC TGCACCGCGA TTTGAAGCCC 
AACAATTTGC TGGTCAACAG CGATGGCATC CTAAAGATTG GCGATTTCGG TTTGGCCAAG 
TCCTTCGGTT CGCCCAATCG CATTTACACG CACCACGTGG TCACACGCTG GTATCGTTCG 
CCCGAATTGC TCTTTGGCGC CCGACAATAT GGCACCGGTG TGGATATGTG GGCAGTTGGC 
TGCATTTTGG CTGAACTTAT GCTGCGAGTG CCGTTCATGC CGGGCGATTC GGATCTGGAT 
CAGCTGACAC GGATCTTTTC CACACTGGGA ACACCCACGG AAGCTGAATG GCCGCATTTG 
AGCAAACTGC ACGACTATCT GCAGTTTCGC AACTTTCCGG GCACACCATT GGACAATATA 
TTCACCGCCG CGGGCAATGA CTTGATCCAT CTGATGCAAC GCCTGTTTGC CATGAATCCG 
CTGCGGCGTG TGTCCTGCCG CGAGGCACTG AGCATGCCGT ATTTCGCTAA CAAACCGGCG 
CCCACAGTGG GTCCCAAGTT GCCAATGCCG TCGGCCATTC TGGCCGCCAA GGAGGGCGCC 
AATCCGCAGA CCGGCGACAC GAAGCCTGCG CTCAAGCGCA AGCTGGTCGA GACTACGGTG 
AGGGGCAATG GATTGGCCCA GAAGAAGCGG CTGCAGTTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Cdk7 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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