Ilp6 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ilp6
Entrez Gene ID	31220
Full Name	Insulin-like peptide 6
Synonyms	CG14049,DILP,DILP-6,DILP6,Dilp,Dilp 6,Dilp6,Dmel\CG14049,Ilp,Ilp-6,dILP6,dIlp6,dilp,dilp-6,dilp6,ilp6
General protein information	Preferred Names Insulin-like peptide 6 Names CG14049 gene product from transcript CG14049-RA CG14049-PA CG14049-PB CG14049-PC CG14049-PD Ilp6-PA Ilp6-PB Ilp6-PC Ilp6-PD drosophila insulin-like peptide 6 insulin-like peptide insulin-like peptide 6
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: X Map Location: 3A1-3A1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001201610.2	NP_001188539.1	Insulin-like peptide 6, isoform C
NM_130644.4	NP_570000.1	Insulin-like peptide 6, isoform A
NM_001201609.1	NP_001188538.1	Insulin-like peptide 6, isoform B
NM_001272256.1	NP_001259185.1	Insulin-like peptide 6, isoform D

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

suggest a feedback system in the interaction between juvenile hormone and DILP6 in which DILP6 negatively regulates the JH titre via an increase in the hormone degradation and a decrease in its synthesis
Title: Insulin-like peptide DILP6 regulates juvenile hormone and dopamine metabolism in Drosophila females.

Fat body-derived Drosophila insulin-like peptide 6 induces lipid uptake in oenocytes, promoting lipid turnover during fasting and increasing starvation tolerance.
Title: Control of metabolic adaptation to fasting by dILP6-induced insulin signaling in Drosophila oenocytes.

Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain.
Title: Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain.

Study shows that during metamorphosis, when feeding stops, a specific DILP (Dilp6) is produced by the fat body and relays the growth signal; expression of DILP6 during pupal development is controlled by the steroid hormone ecdysone.
Title: A Drosophila insulin-like peptide promotes growth during nonfeeding states.

Shows that Drosophila insulin-like peptide 6 (DILP6), which is structurally similar to vertebrate insulin-like growth factor (IGF), is predominantly expressed in the fat body, a functional equivalent of the vertebrate liver and adipocytes.
Title: A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila.

The following Ilp6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ilp6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OFa00595	NM_001201610.2 Latest version!	Drosophila melanogaster Insulin-like peptide 6 (Ilp6), transcript variant C, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OFa00595	NM_001272256.1 Latest version!	Drosophila melanogaster Insulin-like peptide 6 (Ilp6), transcript variant D, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OFa00595	NM_130644.4 Latest version!	Drosophila melanogaster Insulin-like peptide 6 (Ilp6), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OFa00595	NM_001201609.1 Latest version!	Drosophila melanogaster Insulin-like peptide 6 (Ilp6), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ilp6 ( NM_001201610.2 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001188539.1 Drosophila melanogaster Insulin-like peptide 6 (Ilp6), transcript variant C, mRNA.

Price & Availability↑

CloneID	OFa00595
Clone ID Related Accession (Same CDS sequence)	NM_001201610.2 , NM_130644.4 , NM_001201609.1 , NM_001272256.1
Accession Version	NM_001201610.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Insulin-like peptide 6, isoform C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On May 8, 2012 this sequence version replaced NM_001201610.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGTTCTCA AAGTGCCGAC GTCCAAAGTC CTGCTAGTCC TGGCCACCTT GTTCGCCGTG 
GCGGCGATGA TCAGCAGCTG GATGCCCCAG GTGGCGGCCA GTCCGCTCGC ACCCACGGAA 
TACGAACAGA GACGCATGAT GTGCTCCACC GGCCTCAGCG ATGTGATACA GAAGATATGC 
GTAAGCGGAA CGGTGGCCCT TGGCGATGTA TTTCCCAACA GTTTCGGGAA GCGCAGGAAG 
CGCGACTTGC AGAACGTAAC CGATTTGTGC TGCAAGTCGG GTGGCTGCAC CTACAGGGAG 
CTCTTGCAGT ACTGCAAAGG ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001188539.1
CDS	373..696
Translation	MVLKVPTSKVLLVLATLFAVAAMISSWMPQVAASPLAPTEYEQRRMMCSTGLSDVIQKICVSGTVALGDVFPNSFGKRRKRDLQNVTDLCCKSGGCTYRELLQYCKG

Target ORF information:

RefSeq Version	NM_001201610.2
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Insulin-like peptide 6 (Ilp6), transcript variant C, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001201610.2

ORF Insert Sequence:

ATGGTTCTCA AAGTGCCGAC GTCCAAAGTC CTGCTAGTCC TGGCCACCTT GTTCGCCGTG 
GCGGCGATGA TCAGCAGCTG GATGCCCCAG GTGGCGGCCA GTCCGCTCGC ACCCACGGAA 
TACGAACAGA GACGCATGAT GTGCTCCACC GGCCTCAGCG ATGTGATACA GAAGATATGC 
GTAAGCGGAA CGGTGGCCCT TGGCGATGTA TTTCCCAACA GTTTCGGGAA GCGCAGGAAG 
CGCGACTTGC AGAACGTAAC CGATTTGTGC TGCAAGTCGG GTGGCTGCAC CTACAGGGAG 
CTCTTGCAGT ACTGCAAAGG ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ilp6 ( NM_130644.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_570000.1 Drosophila melanogaster Insulin-like peptide 6 (Ilp6), transcript variant A, mRNA.

Price & Availability↑

CloneID	OFa00595
Clone ID Related Accession (Same CDS sequence)	NM_001201610.2 , NM_130644.4 , NM_001201609.1 , NM_001272256.1
Accession Version	NM_130644.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Insulin-like peptide 6, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On May 8, 2012 this sequence version replaced NM_130644.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGTTCTCA AAGTGCCGAC GTCCAAAGTC CTGCTAGTCC TGGCCACCTT GTTCGCCGTG 
GCGGCGATGA TCAGCAGCTG GATGCCCCAG GTGGCGGCCA GTCCGCTCGC ACCCACGGAA 
TACGAACAGA GACGCATGAT GTGCTCCACC GGCCTCAGCG ATGTGATACA GAAGATATGC 
GTAAGCGGAA CGGTGGCCCT TGGCGATGTA TTTCCCAACA GTTTCGGGAA GCGCAGGAAG 
CGCGACTTGC AGAACGTAAC CGATTTGTGC TGCAAGTCGG GTGGCTGCAC CTACAGGGAG 
CTCTTGCAGT ACTGCAAAGG ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570000.1
CDS	1340..1663
Translation	MVLKVPTSKVLLVLATLFAVAAMISSWMPQVAASPLAPTEYEQRRMMCSTGLSDVIQKICVSGTVALGDVFPNSFGKRRKRDLQNVTDLCCKSGGCTYRELLQYCKG

Target ORF information:

RefSeq Version	NM_130644.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Insulin-like peptide 6 (Ilp6), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130644.4

ORF Insert Sequence:

ATGGTTCTCA AAGTGCCGAC GTCCAAAGTC CTGCTAGTCC TGGCCACCTT GTTCGCCGTG 
GCGGCGATGA TCAGCAGCTG GATGCCCCAG GTGGCGGCCA GTCCGCTCGC ACCCACGGAA 
TACGAACAGA GACGCATGAT GTGCTCCACC GGCCTCAGCG ATGTGATACA GAAGATATGC 
GTAAGCGGAA CGGTGGCCCT TGGCGATGTA TTTCCCAACA GTTTCGGGAA GCGCAGGAAG 
CGCGACTTGC AGAACGTAAC CGATTTGTGC TGCAAGTCGG GTGGCTGCAC CTACAGGGAG 
CTCTTGCAGT ACTGCAAAGG ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ilp6 ( NM_001201609.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001188538.1 Drosophila melanogaster Insulin-like peptide 6 (Ilp6), transcript variant B, mRNA.

Price & Availability↑

CloneID	OFa00595
Clone ID Related Accession (Same CDS sequence)	NM_001201610.2 , NM_130644.4 , NM_001201609.1 , NM_001272256.1
Accession Version	NM_001201609.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Insulin-like peptide 6, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGTTCTCA AAGTGCCGAC GTCCAAAGTC CTGCTAGTCC TGGCCACCTT GTTCGCCGTG 
GCGGCGATGA TCAGCAGCTG GATGCCCCAG GTGGCGGCCA GTCCGCTCGC ACCCACGGAA 
TACGAACAGA GACGCATGAT GTGCTCCACC GGCCTCAGCG ATGTGATACA GAAGATATGC 
GTAAGCGGAA CGGTGGCCCT TGGCGATGTA TTTCCCAACA GTTTCGGGAA GCGCAGGAAG 
CGCGACTTGC AGAACGTAAC CGATTTGTGC TGCAAGTCGG GTGGCTGCAC CTACAGGGAG 
CTCTTGCAGT ACTGCAAAGG ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001188538.1
CDS	66..389
Translation	MVLKVPTSKVLLVLATLFAVAAMISSWMPQVAASPLAPTEYEQRRMMCSTGLSDVIQKICVSGTVALGDVFPNSFGKRRKRDLQNVTDLCCKSGGCTYRELLQYCKG

Target ORF information:

RefSeq Version	NM_001201609.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Insulin-like peptide 6 (Ilp6), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001201609.1

ORF Insert Sequence:

ATGGTTCTCA AAGTGCCGAC GTCCAAAGTC CTGCTAGTCC TGGCCACCTT GTTCGCCGTG 
GCGGCGATGA TCAGCAGCTG GATGCCCCAG GTGGCGGCCA GTCCGCTCGC ACCCACGGAA 
TACGAACAGA GACGCATGAT GTGCTCCACC GGCCTCAGCG ATGTGATACA GAAGATATGC 
GTAAGCGGAA CGGTGGCCCT TGGCGATGTA TTTCCCAACA GTTTCGGGAA GCGCAGGAAG 
CGCGACTTGC AGAACGTAAC CGATTTGTGC TGCAAGTCGG GTGGCTGCAC CTACAGGGAG 
CTCTTGCAGT ACTGCAAAGG ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ilp6 ( NM_001272256.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001259185.1 Drosophila melanogaster Insulin-like peptide 6 (Ilp6), transcript variant D, mRNA.

Price & Availability↑

CloneID	OFa00595
Clone ID Related Accession (Same CDS sequence)	NM_001201610.2 , NM_130644.4 , NM_001201609.1 , NM_001272256.1
Accession Version	NM_001272256.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Insulin-like peptide 6, isoform D
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGTTCTCA AAGTGCCGAC GTCCAAAGTC CTGCTAGTCC TGGCCACCTT GTTCGCCGTG 
GCGGCGATGA TCAGCAGCTG GATGCCCCAG GTGGCGGCCA GTCCGCTCGC ACCCACGGAA 
TACGAACAGA GACGCATGAT GTGCTCCACC GGCCTCAGCG ATGTGATACA GAAGATATGC 
GTAAGCGGAA CGGTGGCCCT TGGCGATGTA TTTCCCAACA GTTTCGGGAA GCGCAGGAAG 
CGCGACTTGC AGAACGTAAC CGATTTGTGC TGCAAGTCGG GTGGCTGCAC CTACAGGGAG 
CTCTTGCAGT ACTGCAAAGG ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001259185.1
CDS	134..457
Translation	MVLKVPTSKVLLVLATLFAVAAMISSWMPQVAASPLAPTEYEQRRMMCSTGLSDVIQKICVSGTVALGDVFPNSFGKRRKRDLQNVTDLCCKSGGCTYRELLQYCKG

Target ORF information:

RefSeq Version	NM_001272256.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Insulin-like peptide 6 (Ilp6), transcript variant D, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001272256.1

ORF Insert Sequence:

ATGGTTCTCA AAGTGCCGAC GTCCAAAGTC CTGCTAGTCC TGGCCACCTT GTTCGCCGTG 
GCGGCGATGA TCAGCAGCTG GATGCCCCAG GTGGCGGCCA GTCCGCTCGC ACCCACGGAA 
TACGAACAGA GACGCATGAT GTGCTCCACC GGCCTCAGCG ATGTGATACA GAAGATATGC 
GTAAGCGGAA CGGTGGCCCT TGGCGATGTA TTTCCCAACA GTTTCGGGAA GCGCAGGAAG 
CGCGACTTGC AGAACGTAAC CGATTTGTGC TGCAAGTCGG GTGGCTGCAC CTACAGGGAG 
CTCTTGCAGT ACTGCAAAGG ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Ilp6 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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