edn1 cDNA ORF clone, Danio rerio(zebrafish)

Essential Role of Nr2f Nuclear Receptors in Patterning the Vertebrate Upper Jaw.
Barske L, Rataud P, Behizad K, Del Rio L, Cox SG, Crump JG
Developmental cell(2018 Jan)

Nkx2.5 regulates endothelin converting enzyme-1 during pharyngeal arch patterning.
Ikl? JM, Tavares AL, King M, Ding H, Colombo S, Firulli BA, Firulli AB, Targoff KL, Yelon D, Clouthier DE
Genesis (New York, N.Y. : 2000)55(3)(2017 Mar)

Phylogenetic analysis of conserved grhl-binding sites in gene regulatory regions identified endothelin-1 (edn1) as a putative direct grhl3 target gene, and this was confirmed by chromatin precipitation assays in embryos.
Title: Grainyhead-like 3 regulation of endothelin-1 in the pharyngeal endoderm is critical for growth and development of the craniofacial skeleton.

Data suggest that edn1/ednraa (endothelin-1/endothelin-1 receptor type A) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase in zebrafish embryonic skin.
Title: Endothelin-1 regulates H?-ATPase-dependent transepithelial H? secretion in zebrafish.

EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.
Title: Overexpression of endothelin 1 triggers hepatocarcinogenesis in zebrafish and promotes cell proliferation and migration through the AKT pathway.

These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.
Title: edn1 and hand2 Interact in early regulation of pharyngeal arch outgrowth during zebrafish development.

Endothelin 1 combines with Bone Morphogenetic Proteins to pattern the dorsal-ventral axis of the craniofacial skeleton.
Title: Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton.