mks1 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	mks1
Entrez Gene ID	556706
Full Name	Meckel syndrome, type 1
Synonyms	si:dkey-189h5.2,wu:fc54h05,zgc:153149
General protein information	Preferred Names Meckel syndrome, type 1 Names Meckel syndrome type 1 protein fc54h05
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001077373.2	NP_001070841.2	Meckel syndrome type 1 protein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC101905689	XP_005220007.1
Rattus norvegicus (Norway rat)	Mks1	NP_001030089.2
Pan troglodytes (chimpanzee)	MKS1	XP_001172592.1
Mus musculus (house mouse)	Mks1	NP_001034773.2
Gallus gallus (chicken)	MKS1	XP_415705.3
Danio rerio (zebrafish)	mks1	NP_001070841.2
Xenopus tropicalis (tropical clawed frog)	mks1	NP_001039150.1
Canis lupus familiaris (dog)	MKS1	XP_003639341.1
Homo sapiens (human)	MKS1	NP_060247.2

Gene Ontology
Bibliography

Related articles in PubMed

Cilia-Associated Genes Play Differing Roles in Aminoglycoside-Induced Hair Cell Death in Zebrafish.
Stawicki TM, Hernandez L, Esterberg R, Linbo T, Owens KN, Shah AN, Thapa N, Roberts B, Moens CB, Rubel EW, Raible DW
G3 (Bethesda, Md.)6(7)2225-35(2016 07)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum.
Davis EE, Zhang Q, Liu Q, Diplas BH, Davey LM, Hartley J, Stoetzel C, Szymanska K, Ramaswami G, Logan CV, Muzny DM, Young AC, Wheeler DA, Cruz P, Morgan M, Lewis LR, Cherukuri P, Maskeri B, Hansen NF, Mullikin JC, Blakesley RW, Bouffard GG, , Gyapay G, Rieger S, T?nshoff B, Kern I, Soliman NA, Neuhaus TJ, Swoboda KJ, Kayserili H, Gallagher TE, Lewis RA, Bergmann C, Otto EA, Saunier S, Scambler PJ, Beales PL, Gleeson JG, Maher ER, Atti?-Bitach T, Dollfus H, Johnson CA, Green ED, Gibbs RA, Hildebrandt F, Pierce EA, Katsanis N
Nature genetics43(3)189-96(2011 Mar)

Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome.
Leitch CC, Zaghloul NA, Davis EE, Stoetzel C, Diaz-Font A, Rix S, Alfadhel M, Al-Fadhel M, Lewis RA, Eyaid W, Banin E, Dollfus H, Beales PL, Badano JL, Katsanis N
Nature genetics40(4)443-8(2008 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following mks1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the mks1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa31215	NM_001077373.2 Latest version!	Danio rerio MKS transition zone complex subunit 1 (mks1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

mks1 ( NM_001077373.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001070841.2 Danio rerio MKS transition zone complex subunit 1 (mks1), mRNA.

Price & Availability↑

CloneID	ODa31215
Clone ID Related Accession (Same CDS sequence)	NM_001077373.2
Accession Version	NM_001077373.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1680bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-07
Organism	Danio rerio(zebrafish)
Product	Meckel syndrome type 1 protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR753838.10. On Jan 22, 2009 this sequence version replaced NM_001077373.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: GFIL01026542.1, GDQH01026443.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGGCTGACG GCTGGTGCTC TGACAACGGA GAATCGGTTT ACCGTTCCAG GGATGCAGTT 
AAAAACTTCC GAATACGAGT GCGCATTCAG CGTGTGACCT CCACAGCAGC CCTGTCTGAA 
CACCTCCATC AGCAAGTGCT TTCTCAGCAG GAGAGAGGAG TTATAGAGTT GGAAACCTTC 
AGCACTCAGA CGGCCTCCTC GACTGATGAG GAGGAGCTTG TGGTTGCTTG GCAAGAGAAG 
TTCTTTAGTC AGTATGAAGT GGACCTTTAC CAGACAGAGT CAAACTGCCA GACACCACTG 
GAGCGTCAGT ATCACACGGA TATAATGGCA ATGGAAAGAT CCAAAAGAAG GCAAAACCAG 
CGCATTTTCA CCTACACAGA TTTTGATCGC TTTTCCAAGT GGGAAGAGCA AGCTCAGAGT 
CTGGTGATTC CAGCTCAGCC TACACCTACT TTCCTAGCAG AACGCATGGC CAATGTAAGA 
CACAGGAGAC AAGAGAGGCG TCCCGCAGAG TCGAATGTTC CCAAGTCCCG TTTAATCACA 
TGGGAACCTT CAGAGGAGTT TGTGAAGAAC AGTCACATCA TCAACACGCC AGTGCAGACC 
ATGTACATCA TGGCTGATCT TGGACCTACA GGAAAGTTGG GCCTGAAAGA GAATGAATAT 
GTTTTATGCA CAATAAAAGC GGACGGCAAT GGAGTAATCT CAATAAAACC AGACTTTAAC 
AACAACAGAG GAGCCTACAG GCTGGAAACA GAGGGGGAGA AGAGGGAAGT GTGGAGGTTG 
TATCTGGAGA ACGCCTCATC AGACATTCAA GCAGAGGAGA AAGACAGAGA GCAGCGCATG 
TACCGAGATC TGTACACACG TCACAAAGAT TACCTCAACA GCCTGGTTGG CCAAGACTTT 
GAAATGCCAC CTCCAGGGAT ACTCCGTCTG ATTGTAAATG GAGAGATTGT TTCAGCTCAG 
GGTTATGAGT ATGACAATCT GTATGTCCAC TTCTTCGTGG ATTTACCAAA CAATTGGTCC 
AGTGTTTCCT CTCATTGTCT GTCTGGTGTG ACTCAGACAT GTCGCACACG CAGTATAGAA 
AAGGAAGATG TCGCTTTCTT CTCCTATCCA TTCAGCTTTG AGACCTTCTT CCATAAAGAG 
GATGAGTCTG ATGGGTCATT ACCACAGTGG CCAGTGCTGT ATTTTAAAGT TCTCTCACTG 
GATTTCTGGC AGCGCTTTAG AACTGAGGGC TATGGCTATT TGGTCATCCC TTCAACATCA 
GGGCGTCATA GAATGACCTG CCGCACATGG AGAGCAGTCC AGCGTGGCAC AGTGGCAGAA 
CTGAGACGCT TCTTCATTGG TGGAGCTCCT GAACTCGAGG ACATCAGTTA CGTCAGAATA 
CCTGGCACTT TTAAGGGAGA GAGATTGAGT CGCTTTGGCT TTCGCACTCA GACCACTGGA 
AGTGTGACCT TTACTCTTAA TTGTATCCAG CATGCCAGGG CTTTTATTGA TGCCAGCACA 
CTGAAGAAGA GAAGACAGAC TGTTCTGGAT CAGTTGGGGG GCCACAGTCA GCAAGGCTCT 
GTCTATAATG TTTTGGAAGC GTTTCAGAGG GCCCATAAGC GCATGCAGGA GGCCAGAGAG 
ACTTTACCCA GAGACCTCAT CAACACGTCT GCACTATTAA ACTCAGAGTC TTCTGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001070841.2
CDS	216..1895
Translation	MADGWCSDNGESVYRSRDAVKNFRIRVRIQRVTSTAALSEHLHQQVLSQQERGVIELETFSTQTASSTDEEELVVAWQEKFFSQYEVDLYQTESNCQTPLERQYHTDIMAMERSKRRQNQRIFTYTDFDRFSKWEEQAQSLVIPAQPTPTFLAERMANVRHRRQERRPAESNVPKSRLITWEPSEEFVKNSHIINTPVQTMYIMADLGPTGKLGLKENEYVLCTIKADGNGVISIKPDFNNNRGAYRLETEGEKREVWRLYLENASSDIQAEEKDREQRMYRDLYTRHKDYLNSLVGQDFEMPPPGILRLIVNGEIVSAQGYEYDNLYVHFFVDLPNNWSSVSSHCLSGVTQTCRTRSIEKEDVAFFSYPFSFETFFHKEDESDGSLPQWPVLYFKVLSLDFWQRFRTEGYGYLVIPSTSGRHRMTCRTWRAVQRGTVAELRRFFIGGAPELEDISYVRIPGTFKGERLSRFGFRTQTTGSVTFTLNCIQHARAFIDASTLKKRRQTVLDQLGGHSQQGSVYNVLEAFQRAHKRMQEARETLPRDLINTSALLNSESSA

Target ORF information:

RefSeq Version	NM_001077373.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio MKS transition zone complex subunit 1 (mks1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001077373.2

ORF Insert Sequence:

ATGGCTGACG GCTGGTGCTC TGACAACGGA GAATCGGTTT ACCGTTCCAG GGATGCAGTT 
AAAAACTTCC GAATACGAGT GCGCATTCAG CGTGTGACCT CCACAGCAGC CCTGTCTGAA 
CACCTCCATC AGCAAGTGCT TTCTCAGCAG GAGAGAGGAG TTATAGAGTT GGAAACCTTC 
AGCACTCAGA CGGCCTCCTC GACTGATGAG GAGGAGCTTG TGGTTGCTTG GCAAGAGAAG 
TTCTTTAGTC AGTATGAAGT GGACCTTTAC CAGACAGAGT CAAACTGCCA GACACCACTG 
GAGCGTCAGT ATCACACGGA TATAATGGCA ATGGAAAGAT CCAAAAGAAG GCAAAACCAG 
CGCATTTTCA CCTACACAGA TTTTGATCGC TTTTCCAAGT GGGAAGAGCA AGCTCAGAGT 
CTGGTGATTC CAGCTCAGCC TACACCTACT TTCCTAGCAG AACGCATGGC CAATGTAAGA 
CACAGGAGAC AAGAGAGGCG TCCCGCAGAG TCGAATGTTC CCAAGTCCCG TTTAATCACA 
TGGGAACCTT CAGAGGAGTT TGTGAAGAAC AGTCACATCA TCAACACGCC AGTGCAGACC 
ATGTACATCA TGGCTGATCT TGGACCTACA GGAAAGTTGG GCCTGAAAGA GAATGAATAT 
GTTTTATGCA CAATAAAAGC GGACGGCAAT GGAGTAATCT CAATAAAACC AGACTTTAAC 
AACAACAGAG GAGCCTACAG GCTGGAAACA GAGGGGGAGA AGAGGGAAGT GTGGAGGTTG 
TATCTGGAGA ACGCCTCATC AGACATTCAA GCAGAGGAGA AAGACAGAGA GCAGCGCATG 
TACCGAGATC TGTACACACG TCACAAAGAT TACCTCAACA GCCTGGTTGG CCAAGACTTT 
GAAATGCCAC CTCCAGGGAT ACTCCGTCTG ATTGTAAATG GAGAGATTGT TTCAGCTCAG 
GGTTATGAGT ATGACAATCT GTATGTCCAC TTCTTCGTGG ATTTACCAAA CAATTGGTCC 
AGTGTTTCCT CTCATTGTCT GTCTGGTGTG ACTCAGACAT GTCGCACACG CAGTATAGAA 
AAGGAAGATG TCGCTTTCTT CTCCTATCCA TTCAGCTTTG AGACCTTCTT CCATAAAGAG 
GATGAGTCTG ATGGGTCATT ACCACAGTGG CCAGTGCTGT ATTTTAAAGT TCTCTCACTG 
GATTTCTGGC AGCGCTTTAG AACTGAGGGC TATGGCTATT TGGTCATCCC TTCAACATCA 
GGGCGTCATA GAATGACCTG CCGCACATGG AGAGCAGTCC AGCGTGGCAC AGTGGCAGAA 
CTGAGACGCT TCTTCATTGG TGGAGCTCCT GAACTCGAGG ACATCAGTTA CGTCAGAATA 
CCTGGCACTT TTAAGGGAGA GAGATTGAGT CGCTTTGGCT TTCGCACTCA GACCACTGGA 
AGTGTGACCT TTACTCTTAA TTGTATCCAG CATGCCAGGG CTTTTATTGA TGCCAGCACA 
CTGAAGAAGA GAAGACAGAC TGTTCTGGAT CAGTTGGGGG GCCACAGTCA GCAAGGCTCT 
GTCTATAATG TTTTGGAAGC GTTTCAGAGG GCCCATAAGC GCATGCAGGA GGCCAGAGAG 
ACTTTACCCA GAGACCTCAT CAACACGTCT GCACTATTAA ACTCAGAGTC TTCTGCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cilia-Associated Genes Play Differing Roles in Aminoglycoside-Induced Hair Cell Death in Zebrafish.
G3 (Bethesda, Md.)6(7)2225-35(2016 07)
Stawicki TM,Hernandez L,Esterberg R,Linbo T,Owens KN,Shah AN,Thapa N,Roberts B,Moens CB,Rubel EW,Raible DW

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum.
Nature genetics43(3)189-96(2011 Mar)
Davis EE,Zhang Q,Liu Q,Diplas BH,Davey LM,Hartley J,Stoetzel C,Szymanska K,Ramaswami G,Logan CV,Muzny DM,Young AC,Wheeler DA,Cruz P,Morgan M,Lewis LR,Cherukuri P,Maskeri B,Hansen NF,Mullikin JC,Blakesley RW,Bouffard GG,,Gyapay G,Rieger S,T?nshoff B,Kern I,Soliman NA,Neuhaus TJ,Swoboda KJ,Kayserili H,Gallagher TE,Lewis RA,Bergmann C,Otto EA,Saunier S,Scambler PJ,Beales PL,Gleeson JG,Maher ER,Atti?-Bitach T,Dollfus H,Johnson CA,Green ED,Gibbs RA,Hildebrandt F,Pierce EA,Katsanis N

Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome.
Nature genetics40(4)443-8(2008 Apr)
Leitch CC,Zaghloul NA,Davis EE,Stoetzel C,Diaz-Font A,Rix S,Alfadhel M,Al-Fadhel M,Lewis RA,Eyaid W,Banin E,Dollfus H,Beales PL,Badano JL,Katsanis N

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mks1 cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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