prnpa cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	prnpa
Entrez Gene ID	494129
Full Name	prion protein a
Synonyms	PrP rel-2,PrP-2,PrP-like,PrP3,PrPL-P1-like,prnp
General protein information	Preferred Names prion protein a Names prion protein a PrP-rel-2
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_205586.1	NP_991149.1	prion protein a precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior.
Ben-Moshe Livne Z, Alon S, Vallone D, Bayleyen Y, Tovin A, Shainer I, Nisembaum LG, Aviram I, Smadja-Storz S, Fuentes M, Falc?n J, Eisenberg E, Klein DC, Burgess HA, Foulkes NS, Gothilf Y
PLoS genetics12(11)e1006445(2016 Nov)

Zebrafish prion protein PrP2 controls collective migration process during lateral line sensory system development.
Huc-Brandt S, Hieu N, Imberdis T, Cubedo N, Silhol M, Leighton PL, Domaschke T, Allison WT, Perrier V, Rossel M
PloS one9(12)e113331(2014)

Targeted mutation of the gene encoding prion protein in zebrafish reveals a conserved role in neuron excitability.
Fleisch VC, Leighton PL, Wang H, Pillay LM, Ritzel RG, Bhinder G, Roy B, Tierney KB, Ali DW, Waskiewicz AJ, Allison WT
Neurobiology of disease5511-25(2013 Jul)

Conserved roles of the prion protein domains on subcellular localization and cell-cell adhesion.
Solis GP, Radon Y, Sempou E, Jechow K, Stuermer CA, M?laga-Trillo E
PloS one8(7)e70327(2013)

Competition between histamine-like and poly-imidazole coordination sites for Cu(2+) and Zn(2+) ions in zebra-fish peptide of prion-like protein.
Migliorini C, Witkowska D, Valensin D, Kamysz W, Kozlowski H
Dalton transactions (Cambridge, England : 2003)39(37)8663-70(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

an essential role of PrP2 in collective migration process of the primordium and in neuromast formation
Title: Zebrafish prion protein PrP2 controls collective migration process during lateral line sensory system development.

The knockout of Prp2 function in zebrafish independently confirmed hypothesized roles for PrP, identifying deeply conserved functions in post-developmental regulation of neuron excitability.
Title: Targeted mutation of the gene encoding prion protein in zebrafish reveals a conserved role in neuron excitability.

Results show that mutations in mouse and zebrafish prion protein (PrP) similarly affect their subcellular localization patterns.
Title: Conserved roles of the prion protein domains on subcellular localization and cell-cell adhesion.

PrP can modulate E-cadherin-based cell-cell adhesion in zebrafish [review]
Title: PrPs: Proteins with a purpose: Lessons from the zebrafish.

The structure of the single repeat of PrP-rel-2 of zebrafish complexed with Zn(2+) was investigated by NMR spectroscopy at physiological pH .
Title: Structural features of the Zn(2+) complex with the single repeat region of "prion related protein" (PrP-rel-2) of zebrafish zPrP63-70 fragment.

The following prnpa gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the prnpa cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa01366	NM_205586.1 Latest version!	Danio rerio prion protein a (prnpa), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

prnpa ( NM_205586.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_991149.1 Danio rerio prion protein a (prnpa), mRNA.

Price & Availability↑

CloneID	ODa01366
Clone ID Related Accession (Same CDS sequence)	NM_205586.1
Accession Version	NM_205586.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-02-28
Organism	Danio rerio(zebrafish)
Product	prion protein a precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ490524.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ490524.1, EH439634.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505373 [ECO:0000348] ##Evidence-Data-END##

ATGCATTCCA AATTTAAGCT CTTCTCCTTC CTAAACTGCC TGTTGCTGCT GGCTGTGCTG 
CTACCGGTAG CGCAGTCTCG CCGGGGCGGG GGCTTCGGAC GTGGCGGCGG GAGAGGTGGA 
GGCTGGGGAG GCAGCAGCTC GGGTCGCGCG GGCTGGGGTG CAGCTGGAGG GCATCACCGA 
GCTCCACCCG TACACACGGG ACACATGGGG CACATAGGAC ACACAGGACA CACAGGACAC 
ACGGGCTCCT CGGGACACGG AGTCGGCAAG GTGGCTGGTG CGGCGGCGGC AGGAGCTCTT 
GGAGGAATGT TGGTCGGTCA CGGTTTGAGC TCCATGGGGC GACCAGGATA CGGGTATGGG 
TATGGTGGAT ACGGAGGACA CGGCTACGGG TATGGGCATG GATACGGGCA TGGTCATGGA 
CATGGAGGAC ATGGAGGGCA TTCGGGAGAT CATAATGAGA CTGATGCGGA TTATTACTTG 
GATGGTGCTG CAAGTGGACA TGCCTATAGC TGCGTGACAG TGTTTGGACT CATGATGTCT 
TTCTTGATTG GCCACTTCCT GTCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_991149.1
CDS	80..646
Translation	MHSKFKLFSFLNCLLLLAVLLPVAQSRRGGGFGRGGGRGGGWGGSSSGRAGWGAAGGHHRAPPVHTGHMGHIGHTGHTGHTGSSGHGVGKVAGAAAAGALGGMLVGHGLSSMGRPGYGYGYGGYGGHGYGYGHGYGHGHGHGGHGGHSGDHNETDADYYLDGAASGHAYSCVTVFGLMMSFLIGHFLS

Target ORF information:

RefSeq Version	NM_205586.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio prion protein a (prnpa), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_205586.1

ORF Insert Sequence:

ATGCATTCCA AATTTAAGCT CTTCTCCTTC CTAAACTGCC TGTTGCTGCT GGCTGTGCTG 
CTACCGGTAG CGCAGTCTCG CCGGGGCGGG GGCTTCGGAC GTGGCGGCGG GAGAGGTGGA 
GGCTGGGGAG GCAGCAGCTC GGGTCGCGCG GGCTGGGGTG CAGCTGGAGG GCATCACCGA 
GCTCCACCCG TACACACGGG ACACATGGGG CACATAGGAC ACACAGGACA CACAGGACAC 
ACGGGCTCCT CGGGACACGG AGTCGGCAAG GTGGCTGGTG CGGCGGCGGC AGGAGCTCTT 
GGAGGAATGT TGGTCGGTCA CGGTTTGAGC TCCATGGGGC GACCAGGATA CGGGTATGGG 
TATGGTGGAT ACGGAGGACA CGGCTACGGG TATGGGCATG GATACGGGCA TGGTCATGGA 
CATGGAGGAC ATGGAGGGCA TTCGGGAGAT CATAATGAGA CTGATGCGGA TTATTACTTG 
GATGGTGCTG CAAGTGGACA TGCCTATAGC TGCGTGACAG TGTTTGGACT CATGATGTCT 
TTCTTGATTG GCCACTTCCT GTCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior.
PLoS genetics12(11)e1006445(2016 Nov)
Ben-Moshe Livne Z,Alon S,Vallone D,Bayleyen Y,Tovin A,Shainer I,Nisembaum LG,Aviram I,Smadja-Storz S,Fuentes M,Falc?n J,Eisenberg E,Klein DC,Burgess HA,Foulkes NS,Gothilf Y

Zebrafish prion protein PrP2 controls collective migration process during lateral line sensory system development.
PloS one9(12)e113331(2014)
Huc-Brandt S,Hieu N,Imberdis T,Cubedo N,Silhol M,Leighton PL,Domaschke T,Allison WT,Perrier V,Rossel M

Targeted mutation of the gene encoding prion protein in zebrafish reveals a conserved role in neuron excitability.
Neurobiology of disease5511-25(2013 Jul)
Fleisch VC,Leighton PL,Wang H,Pillay LM,Ritzel RG,Bhinder G,Roy B,Tierney KB,Ali DW,Waskiewicz AJ,Allison WT

Conserved roles of the prion protein domains on subcellular localization and cell-cell adhesion.
PloS one8(7)e70327(2013)
Solis GP,Radon Y,Sempou E,Jechow K,Stuermer CA,M?laga-Trillo E

Competition between histamine-like and poly-imidazole coordination sites for Cu(2+) and Zn(2+) ions in zebra-fish peptide of prion-like protein.
Dalton transactions (Cambridge, England : 2003)39(37)8663-70(2010 Oct)
Migliorini C,Witkowska D,Valensin D,Kamysz W,Kozlowski H

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prnpa cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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