mbpb cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	mbpb
Entrez Gene ID	368319
Full Name	myelin basic protein b
Synonyms	sb:cb183,si:dkey-241k19.2,wu:fb71b08
General protein information	Preferred Names myelin basic protein b Names myelin basic protein Golli
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)
Summary	This gene encodes the classic myelin basic protein, a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. In humans (see PubMed ID 7504278), related transcripts found in bone marrow and the immune system arise from a longer form of the gene (referred to as Golli-MBP), which includes additional exons upstream of the exons of classic myelin basic protein. Similar to human, the zebrafish gene is characterized by alternate transcription start sites and splicing, although the full-length nature of all has yet to be determined. [provided by RefSeq, Sep 2012].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001271460.1	NP_001258389.1	myelin basic protein isoform 1
NM_001271459.1	NP_001258388.1	myelin basic protein isoform 2
XM_005157835.2	XP_005157892.1	myelin basic protein isoform X1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	mbpb	NP_001258388.1
Xenopus tropicalis (tropical clawed frog)	mbp	NP_001016592.1
Mus musculus (house mouse)	Mbp	NP_034907.1
Gallus gallus (chicken)	MBP	NP_990611.1
Pan troglodytes (chimpanzee)	MBP	NP_001229999.1
	LOC720908	XP_001116855.1
Bos taurus (cattle)	MBP	NP_001193603.1
Homo sapiens (human)	MBP	NP_001020272.1
Canis lupus familiaris (dog)	MBP	XP_005615353.1

Gene Ontology
Bibliography

Related articles in PubMed

Evolution of complexity in the zebrafish synapse proteome.
Bay?s ?, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD, Grant SG
Nature communications814613(2017 Mar)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.
Boczonadi V, M?ller JS, Pyle A, Munkley J, Dor T, Quartararo J, Ferrero I, Karcagi V, Giunta M, Polvikoski T, Birchall D, Princzinger A, Cinnamon Y, L?tzkendorf S, Piko H, Reza M, Florez L, Santibanez-Koref M, Griffin H, Schuelke M, Elpeleg O, Kalaydjieva L, Lochm?ller H, Elliott DJ, Chinnery PF, Edvardson S, Horvath R
Nature communications54287(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following mbpb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the mbpb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ODa21062	NM_001271460.1 Latest version!	Danio rerio myelin basic protein b (mbpb), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
ODa35777	NM_001271459.1 Latest version!	Danio rerio myelin basic protein b (mbpb), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
ODa21061	XM_005157835.2 Latest version!	Danio rerio myelin basic protein b (mbpb), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

mbpb ( NM_001271460.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001258389.1 Danio rerio myelin basic protein b (mbpb), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ODa21062
Clone ID Related Accession (Same CDS sequence)	NM_001271460.1
Accession Version	NM_001271460.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 366bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Danio rerio(zebrafish)
Product	myelin basic protein isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CU459091.8 and EH585066.1. Transcript Variant: This variant (1) encodes a classic myelin basic protein isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: EH582017.1, EH585066.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505372, SAMEA3505375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCATCTG CAAGCTCTTC GCAGTCAACA TTCAGGCTGG GCCGTACTAA GAAGAACCCT 
ACCGTTATGG ATCAGATCGG AAAGTTCTTT GGAGGGGAGA AGAAGAAGAA GGGGAAGGGG 
TCTTTTCGTG GTGGTTTATC CTCGTCGCCC CAGAGATCGA GCGCATCTCC TCGTCGCCGC 
CCAGATGAGA ACGCGGTCAT GCACTTTCTC AGAACCATTG TTTCTCCCTC TACCCCCAAA 
TCTAGGAGAG AGCAGAAATC ACAGAGCTCC ACTAAAGGAC AAAAGGGACG TGGAGAGAGT 
CAAGGCACCC TAACTCGGAT CTTCAAAATG GGAGGAAGCC AGTCTGCTTC ATCTTCCAAG 
CGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258389.1
CDS	172..537
Translation	MASASSSQSTFRLGRTKKNPTVMDQIGKFFGGEKKKKGKGSFRGGLSSSPQRSSASPRRRPDENAVMHFLRTIVSPSTPKSRREQKSQSSTKGQKGRGESQGTLTRIFKMGGSQSASSSKR

Target ORF information:

RefSeq Version	NM_001271460.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio myelin basic protein b (mbpb), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271460.1

ORF Insert Sequence:

ATGGCATCTG CAAGCTCTTC GCAGTCAACA TTCAGGCTGG GCCGTACTAA GAAGAACCCT 
ACCGTTATGG ATCAGATCGG AAAGTTCTTT GGAGGGGAGA AGAAGAAGAA GGGGAAGGGG 
TCTTTTCGTG GTGGTTTATC CTCGTCGCCC CAGAGATCGA GCGCATCTCC TCGTCGCCGC 
CCAGATGAGA ACGCGGTCAT GCACTTTCTC AGAACCATTG TTTCTCCCTC TACCCCCAAA 
TCTAGGAGAG AGCAGAAATC ACAGAGCTCC ACTAAAGGAC AAAAGGGACG TGGAGAGAGT 
CAAGGCACCC TAACTCGGAT CTTCAAAATG GGAGGAAGCC AGTCTGCTTC ATCTTCCAAG 
CGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

mbpb ( NM_001271459.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001258388.1 Danio rerio myelin basic protein b (mbpb), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ODa35777
Clone ID Related Accession (Same CDS sequence)	NM_001271459.1
Accession Version	NM_001271459.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Danio rerio(zebrafish)
Product	myelin basic protein isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL845419.18, CB354061.1 and CU459091.8. On or before Sep 28, 2012 this sequence version replaced XM_001923576.2, XM_001335515.3, XM_003200130.1. Transcript Variant: This variant (2) contains three exons unique to Golli-MBP and exon 1 of the classic myelin basic protein. It encodes a Golli-MBP isoform (2). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: GDQH01009138.1, GFIL01006361.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCAGC ATCTTGGAAA ACGTGAGCCA CTTTCTGTTT CCAAGGGATC CTCAACAGTA 
TCTGAACACA TCAATTCAAC AGACACGCCG GCGGAGTCAC AAGATGAGGT ATTTGGACTG 
GGGGAGGCAG ACCTCAACCA GAACAATGGC TGCTCCAGCA AGAGTCCAGT GGTGACTGAC 
TCCATGAATG CTGAAGTACA TCACAGCAGC TGGAACCAGC CGAACACAGT CGACCCTAAT 
GCCTCAGGGC CACGCCCACA TTTGGTCCGC CTCTTTTCGC GAGATGCCCC AGGTCGCGAG 
GACAACACCT TCAAAGACCG TCCCTCGGAG TCTGACGAGC TGCAGACTAT CCACGAGCAC 
GGCGGAGCTG GATCAGAGTG CGAGTCCGAG GGCACCGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258388.1
CDS	210..611
Translation	MGQHLGKREPLSVSKGSSTVSEHINSTDTPAESQDEVFGLGEADLNQNNGCSSKSPVVTDSMNAEVHHSSWNQPNTVDPNASGPRPHLVRLFSRDAPGREDNTFKDRPSESDELQTIHEHGGAGSECESEGTE

Target ORF information:

RefSeq Version	NM_001271459.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio myelin basic protein b (mbpb), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271459.1

ORF Insert Sequence:

ATGGGGCAGC ATCTTGGAAA ACGTGAGCCA CTTTCTGTTT CCAAGGGATC CTCAACAGTA 
TCTGAACACA TCAATTCAAC AGACACGCCG GCGGAGTCAC AAGATGAGGT ATTTGGACTG 
GGGGAGGCAG ACCTCAACCA GAACAATGGC TGCTCCAGCA AGAGTCCAGT GGTGACTGAC 
TCCATGAATG CTGAAGTACA TCACAGCAGC TGGAACCAGC CGAACACAGT CGACCCTAAT 
GCCTCAGGGC CACGCCCACA TTTGGTCCGC CTCTTTTCGC GAGATGCCCC AGGTCGCGAG 
GACAACACCT TCAAAGACCG TCCCTCGGAG TCTGACGAGC TGCAGACTAT CCACGAGCAC 
GGCGGAGCTG GATCAGAGTG CGAGTCCGAG GGCACCGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

mbpb ( XM_005157835.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> XP_005157892.1 Danio rerio myelin basic protein b (mbpb), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ODa21061
Clone ID Related Accession (Same CDS sequence)	XM_005157835.2
Accession Version	XM_005157835.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 408bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-14
Organism	Danio rerio(zebrafish)
Product	myelin basic protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007127.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 24, 2014 this sequence version replaced XM_005157835.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCATGG GGCAGCATCT TGGAAAACGT GAGCCACTTT CTGTTTCCAA GGGATCCTCA 
ACAGTATCTG AACACATCAA TTCAACAGAC ACGCCGGCGG AGTCACAAGA TGAGGTATTT 
GGACTGGGGG AGGCAGACCT CAACCAGAAC AATGGCTGCT CCAGCAAGAG TCCAGTGGTG 
ACTGACTCCA TGAATGCTGA AGTACATCAC AGCAGCTGGA ACCAGCCGAA CACAGTCGAC 
CCTAATGCCT CAGGGCCACG CCCACATTTG GTCCGCCTCT TTTCGCGAGA TGCCCCAGGT 
CGCGAGGACA ACACCTTCAA AGACCGTCCC TCGGAGTCTG ACGAGCTGCA GACTATCCAC 
GAGCACGGCG GAGCTGGATC AGAGTGCGAG TCCGAGGGCA CCGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005157892.1
CDS	162..569
Translation	MSMGQHLGKREPLSVSKGSSTVSEHINSTDTPAESQDEVFGLGEADLNQNNGCSSKSPVVTDSMNAEVHHSSWNQPNTVDPNASGPRPHLVRLFSRDAPGREDNTFKDRPSESDELQTIHEHGGAGSECESEGTE

Target ORF information:

RefSeq Version	XM_005157835.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio myelin basic protein b (mbpb), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005157835.2

ORF Insert Sequence:

ATGAGCATGG GGCAGCATCT TGGAAAACGT GAGCCACTTT CTGTTTCCAA GGGATCCTCA 
ACAGTATCTG AACACATCAA TTCAACAGAC ACGCCGGCGG AGTCACAAGA TGAGGTATTT 
GGACTGGGGG AGGCAGACCT CAACCAGAAC AATGGCTGCT CCAGCAAGAG TCCAGTGGTG 
ACTGACTCCA TGAATGCTGA AGTACATCAC AGCAGCTGGA ACCAGCCGAA CACAGTCGAC 
CCTAATGCCT CAGGGCCACG CCCACATTTG GTCCGCCTCT TTTCGCGAGA TGCCCCAGGT 
CGCGAGGACA ACACCTTCAA AGACCGTCCC TCGGAGTCTG ACGAGCTGCA GACTATCCAC 
GAGCACGGCG GAGCTGGATC AGAGTGCGAG TCCGAGGGCA CCGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evolution of complexity in the zebrafish synapse proteome.
Nature communications814613(2017 Mar)
Bay?s ?,Collins MO,Reig-Viader R,Gou G,Goulding D,Izquierdo A,Choudhary JS,Emes RD,Grant SG

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.
Nature communications54287(2014 Jul)
Boczonadi V,M?ller JS,Pyle A,Munkley J,Dor T,Quartararo J,Ferrero I,Karcagi V,Giunta M,Polvikoski T,Birchall D,Princzinger A,Cinnamon Y,L?tzkendorf S,Piko H,Reza M,Florez L,Santibanez-Koref M,Griffin H,Schuelke M,Elpeleg O,Kalaydjieva L,Lochm?ller H,Elliott DJ,Chinnery PF,Edvardson S,Horvath R

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mbpb cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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