FASLG cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	FASLG
Entrez Gene ID	442968
Full Name	Fas ligand
Synonyms	FASL,TNLG1A
General protein information	Preferred Names Fas ligand Names tumor necrosis factor ligand superfamily member 6 tumor necrosis factor ligand 1A
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001287153.1	NP_001274082.1	tumor necrosis factor ligand superfamily member 6

Pathways from BioSystems

Homologies

Homo sapiens (human)	FASLG	NP_000630.1
Bos taurus (cattle)	FASLG	NP_001092329.1
Xenopus tropicalis (tropical clawed frog)	faslg	XP_002934199.2
Canis lupus familiaris (dog)	FASLG	XP_854009.1
Pan troglodytes (chimpanzee)	FASLG	XP_524967.2
	FASLG	NP_001028010.1
Mus musculus (house mouse)	Fasl	NP_034307.1
Danio rerio (zebrafish)	faslg	NP_001036166.1
Rattus norvegicus (Norway rat)	Faslg	NP_037040.1
Gallus gallus (chicken)	FASLG	NP_001026730.1

Gene Ontology
Bibliography

Related articles in PubMed

Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.
Premzl M
Immunogenetics68(2)125-32(2016 Feb)

CD95 (FAS) and CD178 (FASL) induce the apoptosis of CD4+ and CD8+ cells isolated from the peripheral blood and spleen of dogs naturally infected with Leishmania spp.
Silva KL, Melo LM, Perosso J, Oliveira BB, Santos PS, Eug?nio Fde R, Lima VM
Veterinary parasitology197(3-4)470-6(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results enhance the current understanding of the immune response in dogs infected with L. chagasi, facilitating the future development of therapeutic interventions to reduce lymphocyte depletion.
Title: CD95 (FAS) and CD178 (FASL) induce the apoptosis of CD4+ and CD8+ cells isolated from the peripheral blood and spleen of dogs naturally infected with Leishmania spp.

The following FASLG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FASLG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00423	NM_001287153.1 Latest version!	Canis lupus familiaris Fas ligand (FASLG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$174.30 $249.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FASLG ( NM_001287153.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001274082.1 Canis lupus familiaris Fas ligand (FASLG), mRNA.

Price & Availability↑

CloneID	OCe00423
Clone ID Related Accession (Same CDS sequence)	NM_001287153.1
Accession Version	NM_001287153.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-22
Organism	Canis lupus familiaris(dog)
Product	tumor necrosis factor ligand superfamily member 6
Comment	Comment: INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from AAEX03005210.1. On Nov 29, 2013 this sequence version replaced XM_848916.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments and orthologous data. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCATC CCTTGAATTA CCCCTACCCC CAAATCTACT GGGTGGACAG CAGTGCCAAC 
TCTCCTTGGG CCTCTCCAGG GTCAGTCCTC CCGTGTCCAT CCTCTGTGCC AGGGAGGCCC 
GGGCAAAGGA GGCCACCGCC ACCACCGCCG ACACTACCAC CACCACCACC ACCACCACCA 
CCACCACCAC CACCACCACC GCTGCCTCCA CTGCCACTGC CACCTCTGAA GACGAGGAGG 
GACCACAACA CAGGCCTGTG TCTCCTTGTG ATGTTTTTCA TGGTTCTGGT GGCCCTGGTC 
GGATTGGGGC TGGGGATGTT TCAGCTCTTC CATCTACAGA AGGAGCTGGC TGAACTCCGA 
GAGTCTACCA GCGAAAGGCA TGTAGCACCA TCTTTGGAGA AGCAAATAGG TCAACCCAAT 
CCACCTTCTG AAAAAAGGGA GCTGAGGAAA GTGGCCCATT TAACAGGCAA GCCCAACTCA 
AGATCCATCC CTCTGGAATG GGAAGACACA TACGGAATTG CCCTTGTCTC TGGGGTGAAG 
TATAAGAAGG GTGGCCTTGT GATCAATGAT ACTGGGTTGT ACTTTGTGTA TTCCAAAGTG 
TACTTCAGGG GTCAGTCCTG CAACAACAAG CCCCTGAACC ACAAGGTCTA TATGAGGAAC 
TCTAAATATC CCCAGGACCT GATGCTGATG GAGGGGAAGA TCATGAACTA CTGCACTACA 
GGCCAGATGT GGGCTCGTAG CAGCTACTTG GGGGCAGTAT TCAATCTCAC CAGTGCTGAC 
CATTTGTATG TCAATGTATC TGAACTATCT CTGGTCAGTT TTGAAGAATC TAAGACATTT 
TTTGGCTTAT ATAAGCTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001274082.1
CDS	161..1021
Translation	MQHPLNYPYPQIYWVDSSANSPWASPGSVLPCPSSVPGRPGQRRPPPPPPTLPPPPPPPPPPPPPPPLPPLPLPPLKTRRDHNTGLCLLVMFFMVLVALVGLGLGMFQLFHLQKELAELRESTSERHVAPSLEKQIGQPNPPSEKRELRKVAHLTGKPNSRSIPLEWEDTYGIALVSGVKYKKGGLVINDTGLYFVYSKVYFRGQSCNNKPLNHKVYMRNSKYPQDLMLMEGKIMNYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSLVSFEESKTFFGLYKL

Target ORF information:

RefSeq Version	NM_001287153.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris Fas ligand (FASLG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001287153.1

ORF Insert Sequence:

ATGCAGCATC CCTTGAATTA CCCCTACCCC CAAATCTACT GGGTGGACAG CAGTGCCAAC 
TCTCCTTGGG CCTCTCCAGG GTCAGTCCTC CCGTGTCCAT CCTCTGTGCC AGGGAGGCCC 
GGGCAAAGGA GGCCACCGCC ACCACCGCCG ACACTACCAC CACCACCACC ACCACCACCA 
CCACCACCAC CACCACCACC GCTGCCTCCA CTGCCACTGC CACCTCTGAA GACGAGGAGG 
GACCACAACA CAGGCCTGTG TCTCCTTGTG ATGTTTTTCA TGGTTCTGGT GGCCCTGGTC 
GGATTGGGGC TGGGGATGTT TCAGCTCTTC CATCTACAGA AGGAGCTGGC TGAACTCCGA 
GAGTCTACCA GCGAAAGGCA TGTAGCACCA TCTTTGGAGA AGCAAATAGG TCAACCCAAT 
CCACCTTCTG AAAAAAGGGA GCTGAGGAAA GTGGCCCATT TAACAGGCAA GCCCAACTCA 
AGATCCATCC CTCTGGAATG GGAAGACACA TACGGAATTG CCCTTGTCTC TGGGGTGAAG 
TATAAGAAGG GTGGCCTTGT GATCAATGAT ACTGGGTTGT ACTTTGTGTA TTCCAAAGTG 
TACTTCAGGG GTCAGTCCTG CAACAACAAG CCCCTGAACC ACAAGGTCTA TATGAGGAAC 
TCTAAATATC CCCAGGACCT GATGCTGATG GAGGGGAAGA TCATGAACTA CTGCACTACA 
GGCCAGATGT GGGCTCGTAG CAGCTACTTG GGGGCAGTAT TCAATCTCAC CAGTGCTGAC 
CATTTGTATG TCAATGTATC TGAACTATCT CTGGTCAGTT TTGAAGAATC TAAGACATTT 
TTTGGCTTAT ATAAGCTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.
Immunogenetics68(2)125-32(2016 Feb)
Premzl M

CD95 (FAS) and CD178 (FASL) induce the apoptosis of CD4+ and CD8+ cells isolated from the peripheral blood and spleen of dogs naturally infected with Leishmania spp.
Veterinary parasitology197(3-4)470-6(2013 Nov)
Silva KL,Melo LM,Perosso J,Oliveira BB,Santos PS,Eug?nio Fde R,Lima VM