Gene Symbol | unc-18 |
Entrez Gene ID | 181030 |
Full Name | Putative acetylcholine regulator unc-18 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » unc-18 cDNA ORF clone
Gene Symbol | unc-18 |
Entrez Gene ID | 181030 |
Full Name | Putative acetylcholine regulator unc-18 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_001029435.5 | NP_001024606.1 | Putative acetylcholine regulator unc-18 |
NM_001029435.3 | NP_001024606.1 | Putative acetylcholine regulator unc-18 |
STXBP1 | XP_001095617.2 | |
Mus musculus (house mouse) | Stxbp1 | NP_033321.2 |
Drosophila melanogaster (fruit fly) | Rop | NP_001261404.1 |
Caenorhabditis elegans (roundworm) | unc-18 | NP_001024606.1 |
Canis lupus familiaris (dog) | STXBP1 | XP_851554.2 |
Danio rerio (zebrafish) | stxbp1a | NP_001020353.1 |
Oryza sativa (rice) | Os04g0252400 | NP_001052319.2 |
Xenopus tropicalis (tropical clawed frog) | stxbp1 | NP_001072521.1 |
Homo sapiens (human) | STXBP1 | NP_001027392.1 |
Bos taurus (cattle) | STXBP1 | NP_777044.1 |
Gallus gallus (chicken) | STXBP1 | XP_004945852.1 |
Arabidopsis thaliana (thale cress) | SEC1A | NP_001184888.1 |
Arabidopsis thaliana (thale cress) | SEC1B | NP_567388.1 |
Pan troglodytes (chimpanzee) | STXBP1 | XP_003312377.1 |
Rattus norvegicus (Norway rat) | Stxbp1 | NP_037170.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP003023 | XP_311854.4 |
Arabidopsis thaliana (thale cress) | KEU | NP_563905.1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Thus, our study provides novel mechanistic insights into how Munc18/UNC-18 primes synaptic vesicle release and how this protein interacts functionally with Munc13/UNC-13 and Tomosyn/TOM-1.
Title: UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in
data demonstrate that an individual DAG-dependent thermosensory behavior of an organism is effected specifically by the downstream PKC-2 phosphorylation of UNC-18 on Ser322 in AFD neurons.
Title: PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion.
data implicate a novel role for an exposed loop in domain 3b of Munc18-1 in transducing regulation of vesicle fusion independent of closed-conformation syntaxin binding
Title: Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis.
Data show that the syntaxin N-peptide is an initiation factor for the assembly of the SNARE-SM membrane fusion complex.
Title: Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex.
binding of UNC-18 to closed syntaxin is dispensable for membrane fusion, whereas interaction with the syntaxin N-terminus is essential for neuronal exocytosis in vivo
Title: Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans.
The following unc-18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the unc-18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa349598 | |
Clone ID Related Accession (Same CDS sequence) | NM_001029435.5 , NM_001029435.3 | |
Accession Version | NM_001029435.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1776bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Putative acetylcholine regulator unc-18 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Oct 18, 2019 this sequence version replaced NM_001029435.4. |
1 | ATGTCACTCA AACAAATCGT TGGGCACAAA CTGCTCAACG ATGTAATCCG TCCACTGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001024606.1 |
CDS | 37..1812 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001029435.5 |
1 | ATGTCACTCA AACAAATCGT TGGGCACAAA CTGCTCAACG ATGTAATCCG TCCACTGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa349598 | |
Clone ID Related Accession (Same CDS sequence) | NM_001029435.5 , NM_001029435.3 | |
Accession Version | NM_001029435.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1776bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Putative acetylcholine regulator unc-18 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Jun 26, 2012 this sequence version replaced NM_001029435.2. COMPLETENESS: incomplete on both ends. |
1 | ATGTCACTCA AACAAATCGT TGGGCACAAA CTGCTCAACG ATGTAATCCG TCCACTGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001024606.1 |
CDS | 1..1776 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001029435.3 |
1 | ATGTCACTCA AACAAATCGT TGGGCACAAA CTGCTCAACG ATGTAATCCG TCCACTGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |