Gene Symbol | par-4 |
Entrez Gene ID | 180185 |
Full Name | Serine/threonine-protein kinase par-4 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » par-4 cDNA ORF clone
Gene Symbol | par-4 |
Entrez Gene ID | 180185 |
Full Name | Serine/threonine-protein kinase par-4 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_001269849.2 | NP_001256778.1 | Serine/threonine-protein kinase par-4 |
NM_001269851.1 | NP_001256780.1 | Serine/threonine-protein kinase par-4 |
NM_001269849.1 | NP_001256778.1 | Serine/threonine-protein kinase par-4 |
NM_001269850.2 | NP_001256779.1 | Serine/threonine-protein kinase par-4 |
NM_001269850.1 | NP_001256779.1 | Serine/threonine-protein kinase par-4 |
NM_001269851.2 | NP_001256780.1 | Serine/threonine-protein kinase par-4 |
Homo sapiens (human) | STK11 | NP_000446.1 |
Pan troglodytes (chimpanzee) | STK11 | XP_524028.2 |
Canis lupus familiaris (dog) | STK11 | XP_542206.2 |
Mus musculus (house mouse) | Stk11 | NP_035622.1 |
Gallus gallus (chicken) | STK11 | NP_001039298.1 |
Xenopus tropicalis (tropical clawed frog) | stk11 | NP_001016533.1 |
Danio rerio (zebrafish) | stk11 | NP_001017839.1 |
Caenorhabditis elegans (roundworm) | par-4 | NP_001256779.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP003158 | XP_312848.5 |
STK11 | XP_001093806.1 | |
Rattus norvegicus (Norway rat) | Stk11 | NP_001101539.1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
our results imply that DAF-18/PTEN, through PAR-4/LKB1, can activate AAK-1/AMPK in the absence of apparent energy stress. As all components are conserved, similar signalling cascades may regulate stem cell activities in other organisms and be widely implicated in cancer.
Title: DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation.
We report here that din-1S is required in parallel to par-4/LKB1 signaling within the gonad to establish cell cycle quiescence during the onset of the dauer stage.
Title: Developmental and Cell Cycle Quiescence Is Mediated by the Nuclear Hormone Receptor Coregulator DIN-1S in the Caenorhabditis elegans Dauer Larva.
PAR-4/LKB1 impinges on myosin via two pathways, an anillin-dependent pathway that also responds to the cullin CUL-5 and an anillin-independent pathway involving the kinase PIG-1/MELK.
Title: PAR-4 and anillin regulate myosin to coordinate spindle and furrow position during asymmetric division.
DNA replication is asymmetrically regulated in the two-cell stage embryo and the PAR-4 and PAR-1 polarity proteins dampen DNA replication dynamics specifically in the posterior blastomere.
Title: PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo.
Par-4 activates PIG-1 by phosphorylation of T169.
Title: Caenorhabditis elegans PIG-1/MELK acts in a conserved PAR-4/LKB1 polarity pathway to promote asymmetric neuroblast divisions.
The following par-4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the par-4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa347173 | |
Clone ID Related Accession (Same CDS sequence) | NM_001269851.1 , NM_001269851.2 | |
Accession Version | NM_001269851.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Serine/threonine-protein kinase par-4 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). COMPLETENESS: incomplete on both ends. |
1 | ATGCGTCAAT TTATCAATCA ACAAGTGAAT AATGCAATGA TGTTTAATCA GGATAATTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001256780.1 |
CDS | 1..1431 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001269851.1 |
1 | ATGCGTCAAT TTATCAATCA ACAAGTGAAT AATGCAATGA TGTTTAATCA GGATAATTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa347173 | |
Clone ID Related Accession (Same CDS sequence) | NM_001269851.1 , NM_001269851.2 | |
Accession Version | NM_001269851.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Serine/threonine-protein kinase par-4 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Sep 4, 2019 this sequence version replaced NM_001269851.1. COMPLETENESS: incomplete on the 5' end. |
1 | ATGCGTCAAT TTATCAATCA ACAAGTGAAT AATGCAATGA TGTTTAATCA GGATAATTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001256780.1 |
CDS | 1..1431 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001269851.2 |
1 | ATGCGTCAAT TTATCAATCA ACAAGTGAAT AATGCAATGA TGTTTAATCA GGATAATTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa345486 | |
Clone ID Related Accession (Same CDS sequence) | NM_001269849.2 , NM_001269849.1 | |
Accession Version | NM_001269849.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1854bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Serine/threonine-protein kinase par-4 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Sep 4, 2019 this sequence version replaced NM_001269849.1. |
1 | ATGGATGCTC CGTCGACATC CTCGGGAGCA CAAAGCAAAC TTCTGATGCC TGGAGATGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001256778.1 |
CDS | 12..1865 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001269849.2 |
1 | ATGGATGCTC CGTCGACATC CTCGGGAGCA CAAAGCAAAC TTCTGATGCC TGGAGATGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa345486 | |
Clone ID Related Accession (Same CDS sequence) | NM_001269849.2 , NM_001269849.1 | |
Accession Version | NM_001269849.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1854bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Serine/threonine-protein kinase par-4 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). COMPLETENESS: incomplete on both ends. |
1 | ATGGATGCTC CGTCGACATC CTCGGGAGCA CAAAGCAAAC TTCTGATGCC TGGAGATGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001256778.1 |
CDS | 1..1854 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001269849.1 |
1 | ATGGATGCTC CGTCGACATC CTCGGGAGCA CAAAGCAAAC TTCTGATGCC TGGAGATGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa347174 | |
Clone ID Related Accession (Same CDS sequence) | NM_001269850.2 , NM_001269850.1 | |
Accession Version | NM_001269850.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1842bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Serine/threonine-protein kinase par-4 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Sep 4, 2019 this sequence version replaced NM_001269850.1. COMPLETENESS: incomplete on the 5' end. |
1 | ATGGATGCTC CGTCGACATC CTCGGGAGCA CAAAGCAAAC TTCTGATGCC TGGAGATGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001256779.1 |
CDS | 1..1842 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001269850.2 |
1 | ATGGATGCTC CGTCGACATC CTCGGGAGCA CAAAGCAAAC TTCTGATGCC TGGAGATGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa347174 | |
Clone ID Related Accession (Same CDS sequence) | NM_001269850.2 , NM_001269850.1 | |
Accession Version | NM_001269850.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1842bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Serine/threonine-protein kinase par-4 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). COMPLETENESS: incomplete on both ends. |
1 | ATGGATGCTC CGTCGACATC CTCGGGAGCA CAAAGCAAAC TTCTGATGCC TGGAGATGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001256779.1 |
CDS | 1..1842 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001269850.1 |
1 | ATGGATGCTC CGTCGACATC CTCGGGAGCA CAAAGCAAAC TTCTGATGCC TGGAGATGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |