egl-1 cDNA ORF clone, Caenorhabditis elegans

Genome sequence of the nematode C. elegans: a platform for investigating biology.

Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

only 1mM DEM caused upregulation of egl-1, a gene controlled by a p53-orthologue, CEP-1.we suppressed GSH biosynthesis in worms by attenuating g-glutamylcysteine synthetase (gcs-1) expression through RNAi.gcs-1 knockdown commencing right after hatching impaired nematode stress resistance and rendered young adult worms prone to vulval ruptures during egg-laying.
Title: Non-linear impact of glutathione depletion on C. elegans life span and stress resistance.

A protein interaction cascade involving EGL-1, CED-9, CED-4, and CED-3 results in the activation of the key cell death protease CED-3, which is tightly controlled by multiple positive and negative regulators.
Title: Programmed Cell Death During Caenorhabditis elegans Development.

LIN-1 binds to, and activates transcription of, the key pro-apoptotic gene egl-1. Our results provide the first evidence that EGF induces PCD at the whole organism level and reveal the molecular basis for the death-promoting function of LIN-3/EGF
Title: LIN-3/EGF promotes the programmed cell death of specific cells in Caenorhabditis elegans by transcriptional activation of the pro-apoptotic gene egl-1.

The transcriptional upregulation of egl-1 in the CEMs in hermaphrodites is necessary, but not sufficient for their death.
Title: Transcriptional upregulation of both egl-1 BH3-only and ced-3 caspase is required for the death of the male-specific CEM neurons.

EGL-1 triggers apoptosis induction predominantly by antagonizing the function of an anti-apoptotic member of the core BCL-2 family. Review.
Title: egl-1: a key activator of apoptotic cell death in C. elegans.