Gene Symbol | hmp-1 |
Entrez Gene ID | 179624 |
Full Name | Alpha-catenin-like protein hmp-1 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » hmp-1 cDNA ORF clone
Gene Symbol | hmp-1 |
Entrez Gene ID | 179624 |
Full Name | Alpha-catenin-like protein hmp-1 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_001276936.1 | NP_001263865.1 | Alpha-catenin-like protein hmp-1 |
NM_001276938.1 | NP_001263867.1 | Alpha-catenin-like protein hmp-1 |
NM_001373121.1 | NP_001360176.1 | Alpha-catenin-like protein hmp-1 |
NM_001276938.2 | NP_001263867.1 | Alpha-catenin-like protein hmp-1 |
NM_001129519.3 | NP_001122991.1 | Alpha-catenin-like protein hmp-1 |
NM_001276937.1 | NP_001263866.1 | Alpha-catenin-like protein hmp-1 |
NM_001276937.2 | NP_001263866.1 | Alpha-catenin-like protein hmp-1 |
NM_073584.4 | NP_505985.1 | Alpha-catenin-like protein hmp-1 |
NM_001129519.2 | NP_001122991.1 | Alpha-catenin-like protein hmp-1 |
NM_001269450.1 | NP_001256379.1 | Alpha-catenin-like protein hmp-1 |
NM_073584.5 | NP_505985.1 | Alpha-catenin-like protein hmp-1 |
NM_001269450.2 | NP_001256379.1 | Alpha-catenin-like protein hmp-1 |
Gallus gallus (chicken) | CTNNA2 | NP_990467.1 |
Drosophila melanogaster (fruit fly) | alpha-Cat | NP_524219.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP003424 | XP_311710.4 |
Xenopus tropicalis (tropical clawed frog) | ctnna2 | NP_001090774.1 |
Pan troglodytes (chimpanzee) | CTNNA2 | XP_003309122.1 |
Rattus norvegicus (Norway rat) | Ctnna2 | NP_001100068.1 |
Danio rerio (zebrafish) | ctnna2 | NP_001152844.1 |
Homo sapiens (human) | CTNNA2 | NP_001269526.1 |
CTNNA2 | XP_001112948.1 | |
Canis lupus familiaris (dog) | CTNNA2 | XP_005630556.1 |
Mus musculus (house mouse) | Ctnna2 | NP_001103234.1 |
Caenorhabditis elegans (roundworm) | hmp-1 | NP_001122991.1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Deletion analysis based on the crystal structure shows that the first helix of HMP-1 is necessary for binding HMP-2 avidly in vitro and for efficient recruitment of HMP-1 to adherens junctions in embryos. HMP-2 Ser-47 and Tyr-69 flank its binding interface with HMP-1, and we show that phosphomimetic mutations at these two sites decrease binding affinity of HMP-1 to HMP-2 by 40-100-fold
Title: Cell-cell adhesion in metazoans relies on evolutionarily conserved features of the ?-catenin??-catenin-binding interface.
HMP-1 bound filamentous actin with an affinity in the single micromolar range, even when complexed with the beta-catenin homolog HMP-2 or when present in a complex of HMP-2 and the cadherin homolog HMR-1, indicating that HMP-1 binding to F-actin is not allosterically regulated by the HMP-2.HMR-1 complex.
Title: Structural and functional characterization of
Specific conserved C-terminal amino acids of Caenorhabditis elegans HMP-1/alpha-catenin modulate F-actin binding independently of vinculin
Title: Specific conserved C-terminal amino acids of Caenorhabditis elegans HMP-1/?-catenin modulate F-actin binding independently of vinculin.
In vitro, UNC-94 acts in combination with HMP-1, leading to longer actin bundles than with HMP-1 alone.
Title: Tropomodulin protects ?-catenin-dependent junctional-actin networks under stress during epithelial morphogenesis.
Data suggest that HMP-1 is auto-inhibited
Title: In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans.
The following hmp-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the hmp-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa347146 | |
Clone ID Related Accession (Same CDS sequence) | NM_001269450.1 , NM_001269450.2 | |
Accession Version | NM_001269450.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 198bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Alpha-catenin-like protein hmp-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). COMPLETENESS: incomplete on both ends. |
1 | ATGGCTCCAC CAAAGAAACA ACCACTAATT CGACCACAAA AGAATAATGC TATAATCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001256379.1 |
CDS | 1..198 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCTCCAC CAAAGAAACA ACCACTAATT CGACCACAAA AGAATAATGC TATAATCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa347146 | |
Clone ID Related Accession (Same CDS sequence) | NM_001269450.1 , NM_001269450.2 | |
Accession Version | NM_001269450.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 198bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Alpha-catenin-like protein hmp-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Sep 4, 2019 this sequence version replaced NM_001269450.1. COMPLETENESS: incomplete on the 5' end. |
1 | ATGGCTCCAC CAAAGAAACA ACCACTAATT CGACCACAAA AGAATAATGC TATAATCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001256379.1 |
CDS | 1..198 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCTCCAC CAAAGAAACA ACCACTAATT CGACCACAAA AGAATAATGC TATAATCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa346003 | |
Clone ID Related Accession (Same CDS sequence) | NM_001276936.1 , NM_001373121.1 | |
Accession Version | NM_001276936.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2652bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Alpha-catenin-like protein hmp-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). COMPLETENESS: incomplete on both ends. |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001263865.1 |
CDS | 1..2652 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa346003 | |
Clone ID Related Accession (Same CDS sequence) | NM_001276936.1 , NM_001373121.1 | |
Accession Version | NM_001373121.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2652bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Alpha-catenin-like protein hmp-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001360176.1 |
CDS | 2..2653 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa346006 | |
Clone ID Related Accession (Same CDS sequence) | NM_001276937.1 , NM_001276937.2 | |
Accession Version | NM_001276937.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2652bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Alpha-catenin-like protein hmp-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). COMPLETENESS: incomplete on both ends. |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001263866.1 |
CDS | 1..2652 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa346006 | |
Clone ID Related Accession (Same CDS sequence) | NM_001276937.1 , NM_001276937.2 | |
Accession Version | NM_001276937.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2652bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Alpha-catenin-like protein hmp-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Sep 4, 2019 this sequence version replaced NM_001276937.1. COMPLETENESS: incomplete on the 3' end. |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001263866.1 |
CDS | 2..2653 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa346008 | |
Clone ID Related Accession (Same CDS sequence) | NM_001276938.1 , NM_001276938.2 | |
Accession Version | NM_001276938.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2592bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Alpha-catenin-like protein hmp-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). COMPLETENESS: incomplete on both ends. |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001263867.1 |
CDS | 1..2592 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa346008 | |
Clone ID Related Accession (Same CDS sequence) | NM_001276938.1 , NM_001276938.2 | |
Accession Version | NM_001276938.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2592bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Alpha-catenin-like protein hmp-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Sep 4, 2019 this sequence version replaced NM_001276938.1. |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001263867.1 |
CDS | 2..2593 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa346655 | |
Clone ID Related Accession (Same CDS sequence) | NM_073584.4 , NM_073584.5 | |
Accession Version | NM_073584.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2784bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Alpha-catenin-like protein hmp-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Jun 26, 2012 this sequence version replaced NM_073584.3. COMPLETENESS: incomplete on both ends. |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_505985.1 |
CDS | 1..2784 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa346655 | |
Clone ID Related Accession (Same CDS sequence) | NM_073584.4 , NM_073584.5 | |
Accession Version | NM_073584.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2784bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Alpha-catenin-like protein hmp-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Sep 4, 2019 this sequence version replaced NM_073584.4. |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_505985.1 |
CDS | 2..2785 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa348008 | |
Clone ID Related Accession (Same CDS sequence) | NM_001129519.3 , NM_001129519.2 | |
Accession Version | NM_001129519.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2793bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Alpha-catenin-like protein hmp-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Sep 4, 2019 this sequence version replaced NM_001129519.2. |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001122991.1 |
CDS | 2..2794 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa348008 | |
Clone ID Related Accession (Same CDS sequence) | NM_001129519.3 , NM_001129519.2 | |
Accession Version | NM_001129519.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2793bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Alpha-catenin-like protein hmp-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003283). On Jun 26, 2012 this sequence version replaced NM_001129519.1. COMPLETENESS: incomplete on both ends. |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001122991.1 |
CDS | 1..2793 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCTGCGA ATGGCAATTC TCATGCGTAT TTCAACATCG ACGAAGTGCG CTCGAAAAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |