mab-5 cDNA ORF clone, Caenorhabditis elegans

Gene
Clones
gRNAs

Summary

Gene Symbol	mab-5
Entrez Gene ID	176091
Full Name	Homeobox protein mab-5
Gene Type	protein-coding
Organism	Caenorhabditis elegans

mRNA and Protein(s)

mRNA	Protein	Name
NM_066294.5	NP_498695.1	Homeobox protein mab-5
NM_066294.6	NP_498695.1	Homeobox protein mab-5

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	hoxc6b	NP_571605.1
Caenorhabditis elegans (roundworm)	mab-5	NP_498695.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.

Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Here we describe a nonautonomous role of mab-5 in regulating both QR and QL descendant migrations, a role masked by redundancy with lin-39 A third Hox gene, egl-5/Abdominal-B, also likely nonautonomously regulates Q descendant migrations.We find that increased levels of MAB-5 in body wall muscle (BWM) can drive the spon-1 promoter adjacent to the Q cells, and
Title: Nonautonomous Roles of MAB-5/Hox and the Secreted Basement Membrane Molecule SPON-1/F-Spondin in Caenorhabditis elegans Neuronal Migration.

EGL-20 mediates an acute inhibition of anterior migration independently of BAR-1 and MAB-5, and a later, possible transcriptional response mediated by BAR-1 and MAB-5.
Title: EGL-20/Wnt and MAB-5/Hox Act Sequentially to Inhibit Anterior Migration of Neuroblasts in C. elegans.

LIN-39 establishes neuroblast anterior polarity by binding to the mig-13 promoter and promoting mig-13 expression, whereas MAB-5 inhibits neuroblast anterior polarity by associating with the lin-39 promoter and downregulating lin-39 and mig-13 expression.
Title: Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration.

Genes regulated by MAB-5 were enriched for those encoding secreted and transmembrane molecules that affect extracellular matrix
Title: Functional transcriptomic analysis of the role of MAB-5/Hox in Q neuroblast migration in Caenorhabditis elegans.

Data show wild-type mab-5 function is necessary for normal P(9-11).p fate.
Title: Re-programming of C. elegans male epidermal precursor fates by Wnt, Hox, and LIN-12/Notch activities.

The following mab-5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the mab-5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCa341002	NM_066294.6 Latest version!	Caenorhabditis elegans Homeobox protein mab-5 (mab-5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OCa341002	NM_066294.5	Caenorhabditis elegans Homeobox protein mab-5 (mab-5), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

mab-5 ( NM_066294.5 ) cDNA ORF clone, Caenorhabditis elegans -> NP_498695.1 Caenorhabditis elegans Homeobox protein mab-5 (mab-5), partial mRNA.

Price & Availability↑

CloneID	OCa341002
Clone ID Related Accession (Same CDS sequence)	NM_066294.5 , NM_066294.6
Accession Version	NM_066294.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-08
Organism	Caenorhabditis elegans
Product	Homeobox protein mab-5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Jun 26, 2012 this sequence version replaced NM_066294.4. COMPLETENESS: incomplete on both ends.

ATGAGCATGT ATCCTGGATG GACAGGCGAC GATTCGTACT GGGCGGGCGC CGGCACAACG 
GCTTCTTCTC AATCCGCATC ATCCGGCACA TCTGCTTCAG CATCGTCTAG TGCTGCCGCT 
GCTGCTGCTG CCAATAATTT GAAAACCTAC GAACTCTACA ATCACACCTA CATGAACAAT 
ATGAAACATA TGCTTGCTGC CGGTTGGATG GATAATTCAT CAAATCCATT CGCCTATAAC 
CCACTTCAAG CAACATCTGC AAATTTTGGT GAAACTAGAA CTTCAATGCC AGCAATCTCG 
CAACCAGTAT TTCCATGGAT GAAGATGGGC GGTGCAAAAG GTGGAGAATC AAAACGCACT 
CGTCAGACAT ATTCAAGAAG TCAAACATTG GAATTAGAAA AGGAATTTCA TTATCACAAA 
TACTTGACTA GGAAACGTCG GCAAGAAATT TCAGAAACAT TGCATTTGAC TGAAAGACAA 
GTAAAAATCT GGTTCCAAAA TCGTCGTATG AAACACAAAA AAGAGGCAAA AGGAGAAGGT 
GGAAGCAATG AATCAGATGA AGAATCAAAT CAAGATGAGC AAAATGAACA ACATTCTTCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_498695.1
CDS	1..603
Translation	MSMYPGWTGDDSYWAGAGTTASSQSASSGTSASASSSAAAAAAANNLKTYELYNHTYMNNMKHMLAAGWMDNSSNPFAYNPLQATSANFGETRTSMPAISQPVFPWMKMGGAKGGESKRTRQTYSRSQTLELEKEFHYHKYLTRKRRQEISETLHLTERQVKIWFQNRRMKHKKEAKGEGGSNESDEESNQDEQNEQHSS

Target ORF information:

RefSeq Version	NM_066294.5
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Homeobox protein mab-5 (mab-5), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_066294.5

ORF Insert Sequence:

ATGAGCATGT ATCCTGGATG GACAGGCGAC GATTCGTACT GGGCGGGCGC CGGCACAACG 
GCTTCTTCTC AATCCGCATC ATCCGGCACA TCTGCTTCAG CATCGTCTAG TGCTGCCGCT 
GCTGCTGCTG CCAATAATTT GAAAACCTAC GAACTCTACA ATCACACCTA CATGAACAAT 
ATGAAACATA TGCTTGCTGC CGGTTGGATG GATAATTCAT CAAATCCATT CGCCTATAAC 
CCACTTCAAG CAACATCTGC AAATTTTGGT GAAACTAGAA CTTCAATGCC AGCAATCTCG 
CAACCAGTAT TTCCATGGAT GAAGATGGGC GGTGCAAAAG GTGGAGAATC AAAACGCACT 
CGTCAGACAT ATTCAAGAAG TCAAACATTG GAATTAGAAA AGGAATTTCA TTATCACAAA 
TACTTGACTA GGAAACGTCG GCAAGAAATT TCAGAAACAT TGCATTTGAC TGAAAGACAA 
GTAAAAATCT GGTTCCAAAA TCGTCGTATG AAACACAAAA AAGAGGCAAA AGGAGAAGGT 
GGAAGCAATG AATCAGATGA AGAATCAAAT CAAGATGAGC AAAATGAACA ACATTCTTCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

mab-5 ( NM_066294.6 ) cDNA ORF clone, Caenorhabditis elegans -> NP_498695.1 Caenorhabditis elegans Homeobox protein mab-5 (mab-5), mRNA.

Price & Availability↑

CloneID	OCa341002
Clone ID Related Accession (Same CDS sequence)	NM_066294.5 , NM_066294.6
Accession Version	NM_066294.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Caenorhabditis elegans
Product	Homeobox protein mab-5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_066294.5.

ATGAGCATGT ATCCTGGATG GACAGGCGAC GATTCGTACT GGGCGGGCGC CGGCACAACG 
GCTTCTTCTC AATCCGCATC ATCCGGCACA TCTGCTTCAG CATCGTCTAG TGCTGCCGCT 
GCTGCTGCTG CCAATAATTT GAAAACCTAC GAACTCTACA ATCACACCTA CATGAACAAT 
ATGAAACATA TGCTTGCTGC CGGTTGGATG GATAATTCAT CAAATCCATT CGCCTATAAC 
CCACTTCAAG CAACATCTGC AAATTTTGGT GAAACTAGAA CTTCAATGCC AGCAATCTCG 
CAACCAGTAT TTCCATGGAT GAAGATGGGC GGTGCAAAAG GTGGAGAATC AAAACGCACT 
CGTCAGACAT ATTCAAGAAG TCAAACATTG GAATTAGAAA AGGAATTTCA TTATCACAAA 
TACTTGACTA GGAAACGTCG GCAAGAAATT TCAGAAACAT TGCATTTGAC TGAAAGACAA 
GTAAAAATCT GGTTCCAAAA TCGTCGTATG AAACACAAAA AAGAGGCAAA AGGAGAAGGT 
GGAAGCAATG AATCAGATGA AGAATCAAAT CAAGATGAGC AAAATGAACA ACATTCTTCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_498695.1
CDS	67..669
Translation	MSMYPGWTGDDSYWAGAGTTASSQSASSGTSASASSSAAAAAAANNLKTYELYNHTYMNNMKHMLAAGWMDNSSNPFAYNPLQATSANFGETRTSMPAISQPVFPWMKMGGAKGGESKRTRQTYSRSQTLELEKEFHYHKYLTRKRRQEISETLHLTERQVKIWFQNRRMKHKKEAKGEGGSNESDEESNQDEQNEQHSS

Target ORF information:

RefSeq Version	NM_066294.6
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Homeobox protein mab-5 (mab-5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_066294.6

ORF Insert Sequence:

ATGAGCATGT ATCCTGGATG GACAGGCGAC GATTCGTACT GGGCGGGCGC CGGCACAACG 
GCTTCTTCTC AATCCGCATC ATCCGGCACA TCTGCTTCAG CATCGTCTAG TGCTGCCGCT 
GCTGCTGCTG CCAATAATTT GAAAACCTAC GAACTCTACA ATCACACCTA CATGAACAAT 
ATGAAACATA TGCTTGCTGC CGGTTGGATG GATAATTCAT CAAATCCATT CGCCTATAAC 
CCACTTCAAG CAACATCTGC AAATTTTGGT GAAACTAGAA CTTCAATGCC AGCAATCTCG 
CAACCAGTAT TTCCATGGAT GAAGATGGGC GGTGCAAAAG GTGGAGAATC AAAACGCACT 
CGTCAGACAT ATTCAAGAAG TCAAACATTG GAATTAGAAA AGGAATTTCA TTATCACAAA 
TACTTGACTA GGAAACGTCG GCAAGAAATT TCAGAAACAT TGCATTTGAC TGAAAGACAA 
GTAAAAATCT GGTTCCAAAA TCGTCGTATG AAACACAAAA AAGAGGCAAA AGGAGAAGGT 
GGAAGCAATG AATCAGATGA AGAATCAAAT CAAGATGAGC AAAATGAACA ACATTCTTCT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

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mab-5 cDNA ORF clone, Caenorhabditis elegans

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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