Gene Symbol | tbc-2 |
Entrez Gene ID | 173986 |
Full Name | TBC (Tre-2/Bub2/Cdc16) domain family |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » tbc-2 cDNA ORF clone
Gene Symbol | tbc-2 |
Entrez Gene ID | 173986 |
Full Name | TBC (Tre-2/Bub2/Cdc16) domain family |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_062755.6 | NP_495156.1 | TBC (Tre-2/Bub2/Cdc16) domain family |
NM_062755.7 | NP_495156.1 | TBC (Tre-2/Bub2/Cdc16) domain family |
Bos taurus (cattle) | TBC1D2B | XP_002696708.2 |
Homo sapiens (human) | TBC1D2B | NP_653173.1 |
Canis lupus familiaris (dog) | TBC1D2B | XP_005618492.1 |
Caenorhabditis elegans (roundworm) | tbc-2 | NP_495156.1 |
Pan troglodytes (chimpanzee) | TBC1D2B | XP_510522.4 |
Gallus gallus (chicken) | TBC1D2B | XP_413750.4 |
Mus musculus (house mouse) | Tbc1d2b | NP_919315.2 |
TBC1D2B | XP_001106607.1 | |
Rattus norvegicus (Norway rat) | Tbc1d2b | NP_001101645.1 |
Danio rerio (zebrafish) | tbc1d2b | XP_002666912.2 |
Xenopus tropicalis (tropical clawed frog) | tbc1d2b | NP_001039198.1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
the loss of TBC-2 or AMPH-1 leads to abnormally high spatial overlap of RAB-5 and RAB-10. RAB-10 and AMPH-1 mediated down-regulation of RAB-5 is an important step in recycling, required for cargo exit from early endosomes
Title: Basolateral Endocytic Recycling Requires RAB-10 and AMPH-1 Mediated Recruitment of RAB-5 GAP TBC-2 to Endosomes.
down-regulation of early endosome regulator RAB-5/Rab5 by a CED-5, CED-12, CED-10, TBC-2 cascade is an important step in the transport of cargo through the basolateral recycling endosome for delivery to the plasma membrane.
Title: CED-10/Rac1 regulates endocytic recycling through the RAB-5 GAP TBC-2.
TBC-2 is required for yolk protein storage during embryonic development; yolk constitutes an important energy source for larval survival during L1 diapause
Title: TBC-2 is required for embryonic yolk protein storage and larval survival during L1 diapause in Caenorhabditis elegans.
Data suggest that TBC-2 functions on RAB-7-positive late endosomes to inactivate RAB-5 during endosome maturation.
Title: TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans.
tbc-2 encodes a Rab GTPase activating protein (GAP) and its loss of function affects several events of phagosome maturation
Title: C. elegans Rab GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5.
The following tbc-2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the tbc-2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa339335 | |
Clone ID Related Accession (Same CDS sequence) | NM_062755.6 , NM_062755.7 | |
Accession Version | NM_062755.6 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2727bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | TBC (Tre-2/Bub2/Cdc16) domain family | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003280). On Jun 26, 2012 this sequence version replaced NM_062755.5. COMPLETENESS: incomplete on both ends. |
1 | ATGTCTGCGG CGCCGGGGAC AATCAGCCCA CCAGCTCGCG AACTAAAAAC TTCGGCAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_495156.1 |
CDS | 1..2727 |
Translation |
Target ORF information:
Target ORF information:
|
NM_062755.6 |
1 | ATGTCTGCGG CGCCGGGGAC AATCAGCCCA CCAGCTCGCG AACTAAAAAC TTCGGCAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa339335 | |
Clone ID Related Accession (Same CDS sequence) | NM_062755.6 , NM_062755.7 | |
Accession Version | NM_062755.7 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2727bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | TBC (Tre-2/Bub2/Cdc16) domain family | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003280). On Sep 4, 2019 this sequence version replaced NM_062755.6. |
1 | ATGTCTGCGG CGCCGGGGAC AATCAGCCCA CCAGCTCGCG AACTAAAAAC TTCGGCAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_495156.1 |
CDS | 18..2744 |
Translation |
Target ORF information:
Target ORF information:
|
NM_062755.7 |
1 | ATGTCTGCGG CGCCGGGGAC AATCAGCCCA CCAGCTCGCG AACTAAAAAC TTCGGCAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |