Gene Symbol | smn-1 |
Entrez Gene ID | 172783 |
Full Name | SMN (human Survival Motor Neuron gene) homolog |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » smn-1 cDNA ORF clone
Gene Symbol | smn-1 |
Entrez Gene ID | 172783 |
Full Name | SMN (human Survival Motor Neuron gene) homolog |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_001025863.3 | NP_001021034.1 | SMN (human Survival Motor Neuron gene) homolog |
NM_001025863.4 | NP_001021034.1 | Tudor domain-containing protein |
NM_060124.4 | NP_492525.2 | SMN (human Survival Motor Neuron gene) homolog |
NM_001373454.1 | NP_001359592.1 | Tudor domain-containing protein |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Major sperm protein domain (MSPd) of VAPB homolog VPR-1 signaling is sufficient to remodel the muscle mitochondrial reticulum during adulthood. An RNAi suppressor screen identified survival of motor neuron 1 (SMN-1) as a downstream effector.
Title: The secreted MSP domain of
We show that genes of the classical apoptosis pathway are involved in the smn-1-mediated neuronal death, and that this phenotype can be rescued by the expression of human SMN1, indicating a functional conservation between the two orthologs. Finally, we determined that Plastin3/plst-1 genetically interacts with smn-1 to prevent degeneration, and that treatment with valproic acid is able to rescue the degenerative phenotype
Title: Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism.
Data indicate that knocking down Y47D3A.22/mib-1 improves neuromuscular function in Caenorhabditis elegans deficient in SMN-1.
Title: The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein.
Smn-1 deletion produces a pleiotropic phenotype including late larval arrest, reduced lifespan, sterility and impaired locomotion and pharyngeal activity.
Title: Deletion of smn-1, the Caenorhabditis elegans ortholog of the spinal muscular atrophy gene, results in locomotor dysfunction and reduced lifespan.
The following smn-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the smn-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa335697 | |
Clone ID Related Accession (Same CDS sequence) | NM_060124.4 , NM_001373454.1 | |
Accession Version | NM_060124.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | SMN (human Survival Motor Neuron gene) homolog | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Jun 26, 2012 this sequence version replaced NM_060124.3. COMPLETENESS: incomplete on both ends. |
1 | ATGGAGGTAG ACGATGTTTG GGATGATACG GAGCTAATCA AAATGTATGA TGAATCGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_492525.2 |
CDS | 1..594 |
Translation |
Target ORF information:
Target ORF information:
|
NM_060124.4 |
1 | ATGGAGGTAG ACGATGTTTG GGATGATACG GAGCTAATCA AAATGTATGA TGAATCGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa335697 | |
Clone ID Related Accession (Same CDS sequence) | NM_060124.4 , NM_001373454.1 | |
Accession Version | NM_001373454.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Tudor domain-containing protein | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). |
1 | ATGGAGGTAG ACGATGTTTG GGATGATACG GAGCTAATCA AAATGTATGA TGAATCGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001359592.1 |
CDS | 80..673 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001373454.1 |
1 | ATGGAGGTAG ACGATGTTTG GGATGATACG GAGCTAATCA AAATGTATGA TGAATCGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa336196 | |
Clone ID Related Accession (Same CDS sequence) | NM_001025863.3 , NM_001025863.4 | |
Accession Version | NM_001025863.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | SMN (human Survival Motor Neuron gene) homolog | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Jun 26, 2012 this sequence version replaced NM_001025863.2. COMPLETENESS: incomplete on both ends. |
1 | ATGGCAAAAA TCTGGTCGAA AAGTGGCGAC ATGGAGGTAG ACGATGTTTG GGATGATACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001021034.1 |
CDS | 1..624 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001025863.3 |
1 | ATGGCAAAAA TCTGGTCGAA AAGTGGCGAC ATGGAGGTAG ACGATGTTTG GGATGATACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa336196 | |
Clone ID Related Accession (Same CDS sequence) | NM_001025863.3 , NM_001025863.4 | |
Accession Version | NM_001025863.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Tudor domain-containing protein | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Sep 4, 2019 this sequence version replaced NM_001025863.3. |
1 | ATGGCAAAAA TCTGGTCGAA AAGTGGCGAC ATGGAGGTAG ACGATGTTTG GGATGATACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001021034.1 |
CDS | 139..762 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001025863.4 |
1 | ATGGCAAAAA TCTGGTCGAA AAGTGGCGAC ATGGAGGTAG ACGATGTTTG GGATGATACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |