Gene Symbol | MBP |
Entrez Gene ID | 618684 |
Full Name | myelin basic protein |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
Genome |
ORF » Species Summary » Bos taurus » MBP cDNA ORF clone
Gene Symbol | MBP |
Entrez Gene ID | 618684 |
Full Name | myelin basic protein |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_005223934.4 | XP_005223991.2 | myelin basic protein isoform X1 |
XM_005223935.4 | XP_005223992.2 | myelin basic protein isoform X2 |
XM_005223937.4 | XP_005223994.2 | myelin basic protein isoform X4 |
XM_005223934.3 | XP_005223991.2 | myelin basic protein isoform X1 |
XM_005223935.3 | XP_005223992.2 | myelin basic protein isoform X2 |
XM_005223937.3 | XP_005223994.2 | myelin basic protein isoform X4 |
XM_005223936.4 | XP_005223993.1 | myelin basic protein isoform X3 |
NM_001206674.1 | NP_001193603.1 | myelin basic protein |
XM_005223936.3 | XP_005223993.1 | myelin basic protein isoform X3 |
Danio rerio (zebrafish) | mbpb | NP_001258388.1 |
Xenopus tropicalis (tropical clawed frog) | mbp | NP_001016592.1 |
Mus musculus (house mouse) | Mbp | NP_034907.1 |
Gallus gallus (chicken) | MBP | NP_990611.1 |
Pan troglodytes (chimpanzee) | MBP | NP_001229999.1 |
LOC720908 | XP_001116855.1 | |
Bos taurus (cattle) | MBP | NP_001193603.1 |
Homo sapiens (human) | MBP | NP_001020272.1 |
Canis lupus familiaris (dog) | MBP | XP_005615353.1 |
Deimination of the myelin basic protein decelerates its proteasome-mediated metabolism.
Kuzina ES, Kudriaeva AA, Glagoleva IS, Knorre VD, Gabibov AG, Belogurov AA
Doklady. Biochemistry and biophysics469(1)277-80(2016 Jul)
TandeMBP: generation of a unique protein substrate for protein kinase assays.
Kameshita I, Yamashita S, Katayama S, Senga Y, Sueyoshi N
Journal of biochemistry156(3)147-54(2014 Sep)
Myelin basic protein: structural characterization of spherulites formation and preventive action of trehalose.
Di Salvo C, Barreca D, Lagan? G, di Bella M, Tellone E, Ficarra S, Bellocco E
International journal of biological macromolecules5763-8(2013 Jun)
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
Kawakami F, Yabata T, Ohta E, Maekawa T, Shimada N, Suzuki M, Maruyama H, Ichikawa T, Obata F
PloS one7(1)e30834(2012)
LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations.
Ohta E, Kawakami F, Kubo M, Obata F
FEBS letters585(14)2165-70(2011 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its binding to the proteasome and decelerates its degradation by the proteasome in mammalian cells. Potential anticancer drug tetrazole analogue of chloramidine 2, at concentrations greater than 1 microM inhibits the enzymatic activity of PAD in vitro.
Title: Deimination of the myelin basic protein decelerates its proteasome-mediated metabolism.
Data suggest that hybrid protein composed of two different Myelin basic protein (MBP) isoforms (TandeMBP) might become a tool for in vitro assays to analyse various protein kinase activities.
Title: TandeMBP: generation of a unique protein substrate for protein kinase assays.
trehalose completely avoid autocatalytic cleavage properties of MBP up to 4 days of incubation at 37 degrees C and pH 7.4.
Title: Myelin basic protein: structural characterization of spherulites formation and preventive action of trehalose.
formation of an imine between inflammatory-derived aldehydes can lead to structural changes in MBP and a decrease in myelin stability
Title: Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope.
Bovine MBP priming reduces expression of Foxp3 via nitric oxide in inducible nitric oxide synthase-deficient mouse T cells.
Title: Myelin basic protein priming reduces the expression of Foxp3 in T cells via nitric oxide.
The following MBP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MBP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa44263 | |
Clone ID Related Accession (Same CDS sequence) | NM_001206674.1 | |
Accession Version | NM_001206674.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-23 | |
Organism | Bos taurus(cattle) | |
Product | myelin basic protein | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR551098.2, EH376465.1, FD697735.1, BC103033.1, DT893038.1 and EE229725.1. On or before May 3, 2011 this sequence version replaced XM_871008.4, XM_002697647.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145415 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGGGAACC ACGCAGGGAA GCGGGACTTC GGTGCCGAGA AGGGCAATAA GGACAGTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001193603.1 |
CDS | 102..1013 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001206674.1 |
1 | ATGGGGAACC ACGCAGGGAA GCGGGACTTC GGTGCCGAGA AGGGCAATAA GGACAGTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa56771 | |
Clone ID Related Accession (Same CDS sequence) | XM_005223934.3 | |
Accession Version | XM_005223934.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-25 | |
Organism | Bos taurus(cattle) | |
Product | myelin basic protein isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003104565.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_005223934.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGAACC ACGCAGGGAA GCGGGACTTC GGTGCCGAGA AGGGCAATAA GGACAGTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005223991.2 |
CDS | 104..1093 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005223934.3 |
1 | ATGGGGAACC ACGCAGGGAA GCGGGACTTC GGTGCCGAGA AGGGCAATAA GGACAGTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa56772 | |
Clone ID Related Accession (Same CDS sequence) | XM_005223935.3 | |
Accession Version | XM_005223935.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-25 | |
Organism | Bos taurus(cattle) | |
Product | myelin basic protein isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003104565.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_005223935.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGAACC ACGCAGGGAA GCGGGACTTC GGTGCCGAGA AGGGCAATAA GGACAGTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005223992.2 |
CDS | 104..1060 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005223935.3 |
1 | ATGGGGAACC ACGCAGGGAA GCGGGACTTC GGTGCCGAGA AGGGCAATAA GGACAGTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa56773 | |
Clone ID Related Accession (Same CDS sequence) | XM_005223937.3 | |
Accession Version | XM_005223937.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-25 | |
Organism | Bos taurus(cattle) | |
Product | myelin basic protein isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003104565.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_005223937.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGAACC ACGCAGGGAA GCGGGACTTC GGTGCCGAGA AGGGCAATAA GGACAGTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005223994.2 |
CDS | 104..982 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005223937.3 |
1 | ATGGGGAACC ACGCAGGGAA GCGGGACTTC GGTGCCGAGA AGGGCAATAA GGACAGTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa229996 | |
Clone ID Related Accession (Same CDS sequence) | XM_005223934.4 | |
Accession Version | XM_005223934.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | myelin basic protein isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037351.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_005223934.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGAACC ACGCAGGGAA GCGGGACTTC GGTGCCGAGA AGGGCAATAA GGACAGTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005223991.2 |
CDS | 221..1210 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005223934.4 |
1 | ATGGGGAACC ACGCAGGGAA GCGGGACTTC GGTGCCGAGA AGGGCAATAA GGACAGTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa229997 | |
Clone ID Related Accession (Same CDS sequence) | XM_005223935.4 | |
Accession Version | XM_005223935.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | myelin basic protein isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037351.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_005223935.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGAACC ACGCAGGGAA GCGGGACTTC GGTGCCGAGA AGGGCAATAA GGACAGTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005223992.2 |
CDS | 221..1177 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005223935.4 |
1 | ATGGGGAACC ACGCAGGGAA GCGGGACTTC GGTGCCGAGA AGGGCAATAA GGACAGTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa229998 | |
Clone ID Related Accession (Same CDS sequence) | XM_005223936.4 | |
Accession Version | XM_005223936.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1416bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | myelin basic protein isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037351.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_005223936.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTATCGC AGGTCCCTCC CCGCGCTCGG GCGGGGTGGT TCGGCGGCTC AGCCGCGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005223993.1 |
CDS | 16..1431 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005223936.4 |
1 | ATGCTATCGC AGGTCCCTCC CCGCGCTCGG GCGGGGTGGT TCGGCGGCTC AGCCGCGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa229999 | |
Clone ID Related Accession (Same CDS sequence) | XM_005223937.4 | |
Accession Version | XM_005223937.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | myelin basic protein isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037351.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_005223937.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGAACC ACGCAGGGAA GCGGGACTTC GGTGCCGAGA AGGGCAATAA GGACAGTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005223994.2 |
CDS | 221..1099 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005223937.4 |
1 | ATGGGGAACC ACGCAGGGAA GCGGGACTTC GGTGCCGAGA AGGGCAATAA GGACAGTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa32360 | |
Clone ID Related Accession (Same CDS sequence) | XM_005223936.3 | |
Accession Version | XM_005223936.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1416bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-25 | |
Organism | Bos taurus(cattle) | |
Product | myelin basic protein isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003104565.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_005223936.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTATCGC AGGTCCCTCC CCGCGCTCGG GCGGGGTGGT TCGGCGGCTC AGCCGCGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005223993.1 |
CDS | 16..1431 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005223936.3 |
1 | ATGCTATCGC AGGTCCCTCC CCGCGCTCGG GCGGGGTGGT TCGGCGGCTC AGCCGCGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Deimination of the myelin basic protein decelerates its proteasome-mediated metabolism. |
TandeMBP: generation of a unique protein substrate for protein kinase assays. |
Myelin basic protein: structural characterization of spherulites formation and preventive action of trehalose. |
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth. |
LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations. |