DNASE1L1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	DNASE1L1
Entrez Gene ID	515176
Full Name	deoxyribonuclease 1 like 1
General protein information	Preferred Names deoxyribonuclease 1 like 1 Names deoxyribonuclease-1-like 1 DNase I-like 1 DNase X deoxyribonuclease I-like 1
Gene Type	protein-coding
Organism	Bos taurus(cattle)
Summary	This gene encodes a member of the deoxyribonuclease family and the protein shows high sequence similarity to lysosomal DNase I. In contrast to the human and mouse orthologs, porcine and bovine mRNAs for this gene use a conserved CUG triplet for translation initiation. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001038634.1	NP_001033723.1	deoxyribonuclease-1-like 1 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	DNASE1L1	XP_005642080.1
Rattus norvegicus (Norway rat)	Dnase1l1	NP_001014245.2
Homo sapiens (human)	DNASE1L1	NP_001009934.1
Mus musculus (house mouse)	Dnase1l1	NP_001165625.1
Xenopus tropicalis (tropical clawed frog)	LOC100490914	XP_004919701.1
Bos taurus (cattle)	DNASE1L1	NP_001033723.1
	DNASE1L1	XP_002806489.1

Gene Ontology
Bibliography

Related articles in PubMed

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Putative secondary active site of bovine pancreatic deoxyribonuclease I.
Chen WJ, Huang PT, Cheng YC, Liao TH
Protein and peptide letters15(6)640-6(2008)

Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X.
Shiokawa D, Shika Y, Saito K, Yamazaki K, Tanuma S
The Biochemical journal392(Pt 3)511-7(2005 Dec)

Characterization of 954 bovine full-CDS cDNA sequences.
Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP
BMC genomics6166(2005 Nov)

Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle.
Smith TP, Grosse WM, Freking BA, Roberts AJ, Stone RT, Casas E, Wray JE, White J, Cho J, Fahrenkrug SC, Bennett GL, Heaton MP, Laegreid WW, Rohrer GA, Chitko-McKown CG, Pertea G, Holt I, Karamycheva S, Liang F, Quackenbush J, Keele JW
Genome research11(4)626-30(2001 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggested that His44 may play a critical role in substrate DNA binding in this putative secondary active site.
Title: Putative secondary active site of bovine pancreatic deoxyribonuclease I.

Interestingly, the translation of porcine and bovine DNase X proteins occurs in the absence of an in-frame AUG initiation codon
Title: Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X.

The following DNASE1L1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DNASE1L1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa42642	NM_001038634.1 Latest version!	Bos taurus deoxyribonuclease 1 like 1 (DNASE1L1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DNASE1L1 ( NM_001038634.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001033723.1 Bos taurus deoxyribonuclease 1 like 1 (DNASE1L1), mRNA.

Price & Availability↑

CloneID	OBa42642
Clone ID Related Accession (Same CDS sequence)	NM_001038634.1
Accession Version	NM_001038634.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 951bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	deoxyribonuclease-1-like 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DQ116783.1. On Jan 14, 2006 this sequence version replaced XM_593149.2. ##Evidence-Data-START## Transcript exon combination :: DQ116783.1, BC148924.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145412, SAMN03145413 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 16107205 ##RefSeq-Attributes-END##

CTGCATTCCT CTGGAGGGTT CCAGAAGGCC ATACACGGCC ATGCTCTGCT CTTGCTCCTC 
CTCCTGGCCA GTGGGGCTGA GACCTTTCGC ATCTGTGCCT TCAATGCGCA GCGGCTGACA 
CTTGCCAAGG TGGCCAGGGA ACCTGTGCTC GACACCTTAG TGAAGATTCT GGCTCGCTGT 
GACATCATGG TGCTGCAGGA GGTGGTGGAC TCTTCTGACA CTGCCATCCC CCTCTTACTT 
CGAGAACTCA ATCGATTTGG TGACTCTGGG CCCTACGCCT CCCACAGCAG CCTCCTGCTG 
GGGCGCAGCA CATACAAGGA GAAGTACGTG TATCTCTACC GGTCACATGA GGCAGAGGTC 
CGGGACTCCT ACATGTACGA TGATCAGGAT GATCTCTTTA CCCGGGAGCC CTTTGTGTGC 
TGGTTCTCTT TACGCAGCAA GGTTCTTCCC AGCCTCGTGC TGGTCCCACT GCACACCACT 
CCGAAGGCTG TGGAGACGGA GCTGAATGCC CTGTATGACG TGTTTCTGGA TGCTTCCGGG 
CGCTGGCAGA CCAAGGATGT GATCCTGCTC GGAGACTTCA ATGCTGACTG CACGTCGCTG 
ACCAAAAAGC GCCTGGATGA CCTAGTTCTT CGGACTCAGG CTGGCTTCCA CTGGGCCATC 
GCCGACGGCG TGGACACTAC GGTGCGGGCC AGCACCCACT GCACCTATGA CCGCATCGTG 
CTCCACGGGG AGCTCCTCCA GAGCCTGCTG CGTGGCGCGG CCGCCTTCGA CTTCCCCCAG 
AGCTTTGGGC TCACTGAGCA GGAGGCTCTC AACATCAGTG ACCACTACCC TGTGGAGGTG 
GACCTGGCGC TGAGCTGGGC AGTGCATGGG GTCCAGCCCC CCTGCCTGGC CACTCTATGG 
CTGTCACTGC TGCTGCCCCT CCTAGCCCCC CAGCTGGGCC TGGTGGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001033723.1
CDS	185..1135
Translation	LHSSGGFQKAIHGHALLLLLLLASGAETFRICAFNAQRLTLAKVAREPVLDTLVKILARCDIMVLQEVVDSSDTAIPLLLRELNRFGDSGPYASHSSLLLGRSTYKEKYVYLYRSHEAEVRDSYMYDDQDDLFTREPFVCWFSLRSKVLPSLVLVPLHTTPKAVETELNALYDVFLDASGRWQTKDVILLGDFNADCTSLTKKRLDDLVLRTQAGFHWAIADGVDTTVRASTHCTYDRIVLHGELLQSLLRGAAAFDFPQSFGLTEQEALNISDHYPVEVDLALSWAVHGVQPPCLATLWLSLLLPLLAPQLGLVA

Target ORF information:

RefSeq Version	NM_001038634.1
Organism	Bos taurus(cattle)
Definition	Bos taurus deoxyribonuclease 1 like 1 (DNASE1L1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001038634.1

ORF Insert Sequence:

CTGCATTCCT CTGGAGGGTT CCAGAAGGCC ATACACGGCC ATGCTCTGCT CTTGCTCCTC 
CTCCTGGCCA GTGGGGCTGA GACCTTTCGC ATCTGTGCCT TCAATGCGCA GCGGCTGACA 
CTTGCCAAGG TGGCCAGGGA ACCTGTGCTC GACACCTTAG TGAAGATTCT GGCTCGCTGT 
GACATCATGG TGCTGCAGGA GGTGGTGGAC TCTTCTGACA CTGCCATCCC CCTCTTACTT 
CGAGAACTCA ATCGATTTGG TGACTCTGGG CCCTACGCCT CCCACAGCAG CCTCCTGCTG 
GGGCGCAGCA CATACAAGGA GAAGTACGTG TATCTCTACC GGTCACATGA GGCAGAGGTC 
CGGGACTCCT ACATGTACGA TGATCAGGAT GATCTCTTTA CCCGGGAGCC CTTTGTGTGC 
TGGTTCTCTT TACGCAGCAA GGTTCTTCCC AGCCTCGTGC TGGTCCCACT GCACACCACT 
CCGAAGGCTG TGGAGACGGA GCTGAATGCC CTGTATGACG TGTTTCTGGA TGCTTCCGGG 
CGCTGGCAGA CCAAGGATGT GATCCTGCTC GGAGACTTCA ATGCTGACTG CACGTCGCTG 
ACCAAAAAGC GCCTGGATGA CCTAGTTCTT CGGACTCAGG CTGGCTTCCA CTGGGCCATC 
GCCGACGGCG TGGACACTAC GGTGCGGGCC AGCACCCACT GCACCTATGA CCGCATCGTG 
CTCCACGGGG AGCTCCTCCA GAGCCTGCTG CGTGGCGCGG CCGCCTTCGA CTTCCCCCAG 
AGCTTTGGGC TCACTGAGCA GGAGGCTCTC AACATCAGTG ACCACTACCC TGTGGAGGTG 
GACCTGGCGC TGAGCTGGGC AGTGCATGGG GTCCAGCCCC CCTGCCTGGC CACTCTATGG 
CTGTCACTGC TGCTGCCCCT CCTAGCCCCC CAGCTGGGCC TGGTGGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Putative secondary active site of bovine pancreatic deoxyribonuclease I.
Protein and peptide letters15(6)640-6(2008)
Chen WJ,Huang PT,Cheng YC,Liao TH

Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X.
The Biochemical journal392(Pt 3)511-7(2005 Dec)
Shiokawa D,Shika Y,Saito K,Yamazaki K,Tanuma S

Characterization of 954 bovine full-CDS cDNA sequences.
BMC genomics6166(2005 Nov)
Harhay GP,Sonstegard TS,Keele JW,Heaton MP,Clawson ML,Snelling WM,Wiedmann RT,Van Tassell CP,Smith TP

Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle.
Genome research11(4)626-30(2001 Apr)
Smith TP,Grosse WM,Freking BA,Roberts AJ,Stone RT,Casas E,Wray JE,White J,Cho J,Fahrenkrug SC,Bennett GL,Heaton MP,Laegreid WW,Rohrer GA,Chitko-McKown CG,Pertea G,Holt I,Karamycheva S,Liang F,Quackenbush J,Keele JW

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DNASE1L1 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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