Gene Symbol | MMACHC |
Entrez Gene ID | 513433 |
Full Name | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria |
Synonyms | cblC |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » MMACHC cDNA ORF clone
Gene Symbol | MMACHC |
Entrez Gene ID | 513433 |
Full Name | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria |
Synonyms | cblC |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
NM_001015588.3 | NP_001015588.2 | methylmalonic aciduria and homocystinuria type C protein homolog |
Homo sapiens (human) | MMACHC | NP_056321.2 |
Canis lupus familiaris (dog) | MMACHC | XP_539631.2 |
Danio rerio (zebrafish) | mmachc | NP_001108361.1 |
MMACHC | XP_001102924.1 | |
Gallus gallus (chicken) | MMACHC | NP_001026452.1 |
Pan troglodytes (chimpanzee) | MMACHC | XP_524565.2 |
Mus musculus (house mouse) | Mmachc | NP_080238.2 |
Rattus norvegicus (Norway rat) | Mmachc | NP_001101432.1 |
Xenopus tropicalis (tropical clawed frog) | mmachc | NP_001016931.1 |
Bos taurus (cattle) | MMACHC | NP_001015588.2 |
Caenorhabditis elegans (roundworm) | cblc-1 | NP_001022524.1 |
Destabilization of a bovine B?? trafficking chaperone protein by oxidized form of glutathione.
Park J, Jeong J, Kim J
Biochemical and biophysical research communications420(3)547-51(2012 Apr)
Glutathione and vitamin B?? cooperate in stabilization of a B?? trafficking chaperone protein.
Park J, Kim J
The protein journal31(2)158-65(2012 Feb)
Glutathione increases the binding affinity of a bovine B?? trafficking chaperone bCblC for vitamin B??.
Jeong J, Kim J
Biochemical and biophysical research communications412(2)360-5(2011 Aug)
A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)
Characterization of 954 bovine full-CDS cDNA sequences.
Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP
BMC genomics6166(2005 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results suggest that GSSG is a negative regulator of bCblCpro and that the molar ratio of [GSH]/[GSSG] in cells may determine the stability of the B(12) trafficking chaperone.
Title: Destabilization of a bovine B?? trafficking chaperone protein by oxidized form of glutathione.
bCblCpro,a bovine homolog of a human B trafficking chaperone appears to be very sensitive to thermal denaturation, indicating that thermolability is a common property of CblC proteins.
Title: Glutathione and vitamin B?? cooperate in stabilization of a B?? trafficking chaperone protein.
The results of this study suggest that GSH positively modulates bCblC by increasing the binding affinity for CNCbl, which would enhance functional efficiency of the protein.
Title: Glutathione increases the binding affinity of a bovine B?? trafficking chaperone bCblC for vitamin B??.
The following MMACHC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MMACHC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa00564 | |
Clone ID Related Accession (Same CDS sequence) | NM_001015588.3 | |
Accession Version | NM_001015588.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 843bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-18 | |
Organism | Bos taurus(cattle) | |
Product | methylmalonic aciduria and homocystinuria type C protein homolog | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC110137.1. On Aug 31, 2012 this sequence version replaced NM_001015588.2. ##Evidence-Data-START## Transcript exon combination :: BC110137.1, BT020992.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145414 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGAGCCGC TAGTCGCAGA GCTGAAGCAG AAGATTGAGG ACACGTTGTG CCCTTTTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001015588.2 |
CDS | 130..972 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001015588.3 |
1 | ATGGAGCCGC TAGTCGCAGA GCTGAAGCAG AAGATTGAGG ACACGTTGTG CCCTTTTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Destabilization of a bovine B?? trafficking chaperone protein by oxidized form of glutathione. |
Glutathione and vitamin B?? cooperate in stabilization of a B?? trafficking chaperone protein. |
Glutathione increases the binding affinity of a bovine B?? trafficking chaperone bCblC for vitamin B??. |
A whole-genome assembly of the domestic cow, Bos taurus. |
Characterization of 954 bovine full-CDS cDNA sequences. |