| Gene Symbol | UIMC1 |
| Entrez Gene ID | 508607 |
| Full Name | ubiquitin interaction motif containing 1 |
| Synonyms | RAP80 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Bos taurus(cattle) |
| Summary | This gene encodes a member of the RAP80 family of proteins, which are characterized by two tandem ubiquitin-interacting motifs (UIMs). The encoded protein is a subunit of the BRCA1-A complex and functions to recruit this complex to sites of DNA double-strand breaks through its ability to bind poly-ubiquitin chains found at these sites. Homozygous knockout mice for this gene exhibit enhanced sensitivity to ionizing radiation and risk for B-cell lymphoma and impaired DNA double-strand break repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. |







































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