TNFRSF1A cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	TNFRSF1A
Entrez Gene ID	282527
Full Name	TNF receptor superfamily member 1A
General protein information	Preferred Names TNF receptor superfamily member 1A Names tumor necrosis factor receptor superfamily member 1A TNF-R1 TNF-RI TNFR-I p55 p60 tumor necrosis factor receptor 1 tumor necrosis factor receptor superfamily, member 1A tumor necrosis factor receptor type I
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174674.2	NP_777099.1	tumor necrosis factor receptor superfamily member 1A precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	TNFRSF1A	NP_777099.1
Gallus gallus (chicken)	TNFRSF1A	NP_001025950.1
Homo sapiens (human)	TNFRSF1A	NP_001056.1
	TNFRSF1A	XP_001118232.2
Mus musculus (house mouse)	Tnfrsf1a	NP_035739.2
Danio rerio (zebrafish)	tnfrsf1a	NP_998355.1
Pan troglodytes (chimpanzee)	TNFRSF1A	XP_522334.3
Canis lupus familiaris (dog)	TNFRSF1A	XP_854474.1
Rattus norvegicus (Norway rat)	Tnfrsf1a	NP_037223.1
Xenopus tropicalis (tropical clawed frog)	tnfrsf1a	NP_001119976.1

Gene Ontology
Bibliography

Related articles in PubMed

Localization of gene and protein expressions of tumor necrosis factor-{alpha} and tumor necrosis factor receptor types I and II in the bovine corpus luteum during the estrous cycle.
Sakumoto R, Vermehren M, Kenngott RA, Okuda K, Sinowatz F
Journal of animal science89(10)3040-7(2011 Oct)

Cellular localization of genes and proteins for tumor necrosis factor-? (TNF), TNF receptor types I and II in bovine endometrium.
Okuda K, Sakumoto R, Okamoto N, Acosta TJ, Abe H, Okada H, Sinowatz F, Skarzynski DJ
Molecular and cellular endocrinology330(1-2)41-8(2010 Dec)

Effects of tumor necrosis factor ? and Interferon ? on the viability and mRNA expression of TNF receptor type I in endothelial cells from the bovine corpus luteum.
HOJO T, ODA A, LEE SH, ACOSTA TJ, OKUDA K
The Journal of reproduction and development56(5)515-9(2010 Oct)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.
Zhang H, Zhang R, Luo Y, D'Alessio A, Pober JS, Min W
The Journal of biological chemistry279(43)44955-65(2004 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that TNF-alpha sources include immune cells, as well as large and small luteal cells, and that TNF-RI and TNF-RII are present in the luteal cells of the bovine corpus luteum.
Title: Localization of gene and protein expressions of tumor necrosis factor-{alpha} and tumor necrosis factor receptor types I and II in the bovine corpus luteum during the estrous cycle.

The expression and cellular localization of tumor necrosis factor-alpha (TNF) and its receptors (TNFRI and TNFRII) mRNAs and proteins, were determined.
Title: Cellular localization of genes and proteins for tumor necrosis factor-? (TNF), TNF receptor types I and II in bovine endometrium.

The upregulation of TNFRI mRNA expression by IFNG suggests that TNF and IFNG synergistically affect the death of luteal endothelial cells resulting in acute luteolysis
Title: Effects of tumor necrosis factor ? and Interferon ? on the viability and mRNA expression of TNF receptor type I in endothelial cells from the bovine corpus luteum.

TNF binding induces release of AIP1 (DAB2IP) from TNFR1, resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD, RIP1, TRAF2, and AIPl.
Title: AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.

The following TNFRSF1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFRSF1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa42087	NM_174674.2 Latest version!	Bos taurus TNF receptor superfamily member 1A (TNFRSF1A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TNFRSF1A ( NM_174674.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_777099.1 Bos taurus TNF receptor superfamily member 1A (TNFRSF1A), mRNA.

Price & Availability↑

CloneID	OBa42087
Clone ID Related Accession (Same CDS sequence)	NM_174674.2
Accession Version	NM_174674.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1416bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Bos taurus(cattle)
Product	tumor necrosis factor receptor superfamily member 1A precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U90937.1. On Jun 3, 2003 this sequence version replaced NM_174674.1. ##Evidence-Data-START## Transcript exon combination :: U90937.1, BC113278.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END##

ATGGGCCTCC CCACCGTGCC TGGCCTGCTG CTGCCACTGG TGCTTCCAGC TCTGTTGGCA 
GATGTGTACC CCGCAGGGGT TCAGGGGCTG GTCCCTCACC CCGGGGACCT GGAGAAGAGA 
GAGAGTCCCT GTCCCCAAGG AAAATATAAC CACCCGCAAA ATAGCACCAT TTGCTGCACC 
AAGTGCCACA AAGGTACCTA TCTGTACAAT GACTGTCCGG GTCCAGGGCG AGACACGGAC 
TGCAGGGTGT GTGCCCCTGG CACCTACACT GCCTTGGAGA ACCATCTCAG ACGATGCCTG 
AGCTGCTCCA GGTGCCGGGA CGAAATGTTC CAGGTGGAGA TTTCGCCTTG TGTAGTGGAC 
CGGGACACTG TGTGCGGCTG CAGGAAGAAC CAGTACCGGG AATACTGGGG TGAAACTGGC 
TTCCGGTGTC TGAACTGCAG CCTCTGTCCC AATGGCACAG TGAATATCCC CTGCCAGGAG 
AGACAGGACA CCATCTGCCA CTGCCATATG GGCTTCTTTC TTAAAGGCGC CAAGTGCATC 
TCCTGTCATG ATTGTAAGAA CAAGGAGTGC GAGAAGTTAT GTCCAACCCG ACCTTCAACT 
GGTAAAGACT CTCAGGACCC AGGCACTACA GTACTATTAC CCCTGGTGAT TGTCTTCGGG 
CTTTGCCTGG CATCCTTCGC CTCTGTCGTC TTAGCATGTC GCTACCAGCG GTGGAAGCCC 
AAGCTCTACT CCATCATTTG CGGGCAGTCG ACTCTGGTAA AAGAGGGGGA GCCAGAACTC 
CTGGTCCCGG CCCCAGGCTT CAACCCCACC ACCACCATCT GCTTCAGCTC CACCCCAAGT 
TCCAGTCCTG TCTCCATTCC CCCTTACATC TCCTGTGACC GGTCCAACTT CGGAGCCGTC 
GCATCTCCCT CCAGCGAGAC GGCCCCGCCC CATCTAAAGG CTGGCCCCAT CCTCCCGGGG 
CCTCCGGCCT CCACCCACCT CTGTACCCCG GGGCCTCCGG CCTCCACCCA CCTCTGTACC 
CCGGGGCCTC CGGCCTCCAC CCACCTCTGC ACCCCAGTTC AGAAGTGGGA AGCCAGCGCC 
CCCAGCGCCC CCGATCAGCT CGCGGATGCC GACCCCGCGA CCCTGTACGC GGTGGTGGAC 
GGCGTGCCCC CGTCGCGCTG GAAGGAGTTG GTGCGGCGGC TGGGACTGAG CGAGCACGAG 
ATCGAGCGGC TGGAGCTGGA GAACGGGCGC CACCTGCGCG AGGCGCAGTA CAGCATGCTG 
GCGGCCTGGC GGCGGCGCAC GCCGCGCCGC GAGGCCACGC TGGAGCTGCT GGGCCGCGTG 
CTCAGGGACA TGGACCTGCT GGGTTGCCTG GAAAACATAG AGGAGGCGCT GGGTGGCGCC 
GCCCGCCTCG CGTCCGAGCC CCGCCTTCTC TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_777099.1
CDS	294..1709
Translation	MGLPTVPGLLLPLVLPALLADVYPAGVQGLVPHPGDLEKRESPCPQGKYNHPQNSTICCTKCHKGTYLYNDCPGPGRDTDCRVCAPGTYTALENHLRRCLSCSRCRDEMFQVEISPCVVDRDTVCGCRKNQYREYWGETGFRCLNCSLCPNGTVNIPCQERQDTICHCHMGFFLKGAKCISCHDCKNKECEKLCPTRPSTGKDSQDPGTTVLLPLVIVFGLCLASFASVVLACRYQRWKPKLYSIICGQSTLVKEGEPELLVPAPGFNPTTTICFSSTPSSSPVSIPPYISCDRSNFGAVASPSSETAPPHLKAGPILPGPPASTHLCTPGPPASTHLCTPGPPASTHLCTPVQKWEASAPSAPDQLADADPATLYAVVDGVPPSRWKELVRRLGLSEHEIERLELENGRHLREAQYSMLAAWRRRTPRREATLELLGRVLRDMDLLGCLENIEEALGGAARLASEPRLLW

Target ORF information:

RefSeq Version	NM_174674.2
Organism	Bos taurus(cattle)
Definition	Bos taurus TNF receptor superfamily member 1A (TNFRSF1A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174674.2

ORF Insert Sequence:

ATGGGCCTCC CCACCGTGCC TGGCCTGCTG CTGCCACTGG TGCTTCCAGC TCTGTTGGCA 
GATGTGTACC CCGCAGGGGT TCAGGGGCTG GTCCCTCACC CCGGGGACCT GGAGAAGAGA 
GAGAGTCCCT GTCCCCAAGG AAAATATAAC CACCCGCAAA ATAGCACCAT TTGCTGCACC 
AAGTGCCACA AAGGTACCTA TCTGTACAAT GACTGTCCGG GTCCAGGGCG AGACACGGAC 
TGCAGGGTGT GTGCCCCTGG CACCTACACT GCCTTGGAGA ACCATCTCAG ACGATGCCTG 
AGCTGCTCCA GGTGCCGGGA CGAAATGTTC CAGGTGGAGA TTTCGCCTTG TGTAGTGGAC 
CGGGACACTG TGTGCGGCTG CAGGAAGAAC CAGTACCGGG AATACTGGGG TGAAACTGGC 
TTCCGGTGTC TGAACTGCAG CCTCTGTCCC AATGGCACAG TGAATATCCC CTGCCAGGAG 
AGACAGGACA CCATCTGCCA CTGCCATATG GGCTTCTTTC TTAAAGGCGC CAAGTGCATC 
TCCTGTCATG ATTGTAAGAA CAAGGAGTGC GAGAAGTTAT GTCCAACCCG ACCTTCAACT 
GGTAAAGACT CTCAGGACCC AGGCACTACA GTACTATTAC CCCTGGTGAT TGTCTTCGGG 
CTTTGCCTGG CATCCTTCGC CTCTGTCGTC TTAGCATGTC GCTACCAGCG GTGGAAGCCC 
AAGCTCTACT CCATCATTTG CGGGCAGTCG ACTCTGGTAA AAGAGGGGGA GCCAGAACTC 
CTGGTCCCGG CCCCAGGCTT CAACCCCACC ACCACCATCT GCTTCAGCTC CACCCCAAGT 
TCCAGTCCTG TCTCCATTCC CCCTTACATC TCCTGTGACC GGTCCAACTT CGGAGCCGTC 
GCATCTCCCT CCAGCGAGAC GGCCCCGCCC CATCTAAAGG CTGGCCCCAT CCTCCCGGGG 
CCTCCGGCCT CCACCCACCT CTGTACCCCG GGGCCTCCGG CCTCCACCCA CCTCTGTACC 
CCGGGGCCTC CGGCCTCCAC CCACCTCTGC ACCCCAGTTC AGAAGTGGGA AGCCAGCGCC 
CCCAGCGCCC CCGATCAGCT CGCGGATGCC GACCCCGCGA CCCTGTACGC GGTGGTGGAC 
GGCGTGCCCC CGTCGCGCTG GAAGGAGTTG GTGCGGCGGC TGGGACTGAG CGAGCACGAG 
ATCGAGCGGC TGGAGCTGGA GAACGGGCGC CACCTGCGCG AGGCGCAGTA CAGCATGCTG 
GCGGCCTGGC GGCGGCGCAC GCCGCGCCGC GAGGCCACGC TGGAGCTGCT GGGCCGCGTG 
CTCAGGGACA TGGACCTGCT GGGTTGCCTG GAAAACATAG AGGAGGCGCT GGGTGGCGCC 
GCCCGCCTCG CGTCCGAGCC CCGCCTTCTC TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Localization of gene and protein expressions of tumor necrosis factor-{alpha} and tumor necrosis factor receptor types I and II in the bovine corpus luteum during the estrous cycle.
Journal of animal science89(10)3040-7(2011 Oct)
Sakumoto R,Vermehren M,Kenngott RA,Okuda K,Sinowatz F

Cellular localization of genes and proteins for tumor necrosis factor-? (TNF), TNF receptor types I and II in bovine endometrium.
Molecular and cellular endocrinology330(1-2)41-8(2010 Dec)
Okuda K,Sakumoto R,Okamoto N,Acosta TJ,Abe H,Okada H,Sinowatz F,Skarzynski DJ

Effects of tumor necrosis factor ? and Interferon ? on the viability and mRNA expression of TNF receptor type I in endothelial cells from the bovine corpus luteum.
The Journal of reproduction and development56(5)515-9(2010 Oct)
HOJO T,ODA A,LEE SH,ACOSTA TJ,OKUDA K

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.
The Journal of biological chemistry279(43)44955-65(2004 Oct)
Zhang H,Zhang R,Luo Y,D'Alessio A,Pober JS,Min W

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TNFRSF1A cDNA ORF clone, Bos taurus(cattle)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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