Gene Symbol | RABGEF1 |
Entrez Gene ID | 282335 |
Full Name | RAB guanine nucleotide exchange factor 1 |
Synonyms | RABEX5 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » RABGEF1 cDNA ORF clone
Gene Symbol | RABGEF1 |
Entrez Gene ID | 282335 |
Full Name | RAB guanine nucleotide exchange factor 1 |
Synonyms | RABEX5 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
NM_174591.1 | NP_777016.1 | rab5 GDP/GTP exchange factor |
LOC695887 | XP_002803299.1 | |
Mus musculus (house mouse) | Rabgef1 | NP_001185988.1 |
Drosophila melanogaster (fruit fly) | Rabex-5 | NP_612093.1 |
Pan troglodytes (chimpanzee) | RABGEF1 | XP_003318527.1 |
Rattus norvegicus (Norway rat) | Rabgef1 | NP_001101803.1 |
Homo sapiens (human) | RABGEF1 | NP_001273990.1 |
Canis lupus familiaris (dog) | RABGEF1 | XP_005620983.1 |
Bos taurus (cattle) | RABGEF1 | NP_777016.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005551 | XP_315556.4 |
Caenorhabditis elegans (roundworm) | rabx-5 | NP_499337.3 |
Oryza sativa (rice) | Os03g0842700 | NP_001051858.1 |
Danio rerio (zebrafish) | rabgef1 | NP_957137.1 |
Differential polyubiquitin recognition by tandem ubiquitin binding domains of Rabex-5.
Shin D, Lee SY, Han S, Ren S, Kim S, Aikawa Y, Lee S
Biochemical and biophysical research communications423(4)757-62(2012 Jul)
A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)
Ubiquitin binding and conjugation regulate the recruitment of Rabex-5 to early endosomes.
Mattera R, Bonifacino JS
The EMBO journal27(19)2484-94(2008 Oct)
Rabaptin-5-independent membrane targeting and Rab5 activation by Rabex-5 in the cell.
Zhu H, Zhu G, Liu J, Liang Z, Zhang XC, Li G
Molecular biology of the cell18(10)4119-28(2007 Oct)
Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.
Lee S, Tsai YC, Mattera R, Smith WJ, Kostelansky MS, Weissman AM, Bonifacino JS, Hurley JH
Nature structural & molecular biology13(3)264-71(2006 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
these data suggest differential physiological roles of the two ubiquitin binding domains in Rabex-5.
Title: Differential polyubiquitin recognition by tandem ubiquitin binding domains of Rabex-5.
Data show that ubiquitin binding is essential for the recruitment of Rabex-5 from the cytosol to endosomes, independently of its guanine nucleotide exchange factor activity and of Rab5.
Title: Ubiquitin binding and conjugation regulate the recruitment of Rabex-5 to early endosomes.
Rabex-5 can target to early endosomes via the EET domain and activate Rab5 in a Rabaptin-5-independent manner in vivo.
Title: Rabaptin-5-independent membrane targeting and Rab5 activation by Rabex-5 in the cell.
The structure of the N-terminal portion of Rabex-5 bound to ubiquitin at 2.5-A resolution shows that Rabex-5-ubiquitin interactions occur at two sites
Title: Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.
Rabex-5 is a ubiquitin ligase that binds ubiquitin and undergoes ubiquitination; the N-terminal region of Rabex-5 (residues 1-76) is important for ubiquitin binding and ubiquitination.
Title: The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain.
The following RABGEF1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RABGEF1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa41848 | |
Clone ID Related Accession (Same CDS sequence) | NM_174591.1 | |
Accession Version | NM_174591.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1479bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-14 | |
Organism | Bos taurus(cattle) | |
Product | rab5 GDP/GTP exchange factor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ001119.1. ##Evidence-Data-START## Transcript exon combination :: AJ001119.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145414 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAGCCTTA AGTCTGAACG CCGAGGAATT CATGTGGATC AGTCGGAGCT CCTATGCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_777016.1 |
CDS | 1..1479 |
Translation |
Target ORF information:
Target ORF information:
|
NM_174591.1 |
1 | ATGAGCCTTA AGTCTGAACG CCGAGGAATT CATGTGGATC AGTCGGAGCT CCTATGCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Differential polyubiquitin recognition by tandem ubiquitin binding domains of Rabex-5. |
A whole-genome assembly of the domestic cow, Bos taurus. |
Ubiquitin binding and conjugation regulate the recruitment of Rabex-5 to early endosomes. |
Rabaptin-5-independent membrane targeting and Rab5 activation by Rabex-5 in the cell. |
Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5. |