RABGEF1 cDNA ORF clone, Bos taurus(cattle)

Differential polyubiquitin recognition by tandem ubiquitin binding domains of Rabex-5.
Shin D, Lee SY, Han S, Ren S, Kim S, Aikawa Y, Lee S
Biochemical and biophysical research communications423(4)757-62(2012 Jul)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Ubiquitin binding and conjugation regulate the recruitment of Rabex-5 to early endosomes.
Mattera R, Bonifacino JS
The EMBO journal27(19)2484-94(2008 Oct)

Rabaptin-5-independent membrane targeting and Rab5 activation by Rabex-5 in the cell.
Zhu H, Zhu G, Liu J, Liang Z, Zhang XC, Li G
Molecular biology of the cell18(10)4119-28(2007 Oct)

Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.
Lee S, Tsai YC, Mattera R, Smith WJ, Kostelansky MS, Weissman AM, Bonifacino JS, Hurley JH
Nature structural & molecular biology13(3)264-71(2006 Mar)

these data suggest differential physiological roles of the two ubiquitin binding domains in Rabex-5.
Title: Differential polyubiquitin recognition by tandem ubiquitin binding domains of Rabex-5.

Data show that ubiquitin binding is essential for the recruitment of Rabex-5 from the cytosol to endosomes, independently of its guanine nucleotide exchange factor activity and of Rab5.
Title: Ubiquitin binding and conjugation regulate the recruitment of Rabex-5 to early endosomes.

Rabex-5 can target to early endosomes via the EET domain and activate Rab5 in a Rabaptin-5-independent manner in vivo.
Title: Rabaptin-5-independent membrane targeting and Rab5 activation by Rabex-5 in the cell.

The structure of the N-terminal portion of Rabex-5 bound to ubiquitin at 2.5-A resolution shows that Rabex-5-ubiquitin interactions occur at two sites
Title: Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.

Rabex-5 is a ubiquitin ligase that binds ubiquitin and undergoes ubiquitination; the N-terminal region of Rabex-5 (residues 1-76) is important for ubiquitin binding and ubiquitination.
Title: The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain.