PIK3R2 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	PIK3R2
Entrez Gene ID	282308
Full Name	phosphoinositide-3-kinase regulatory subunit 2
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174576.2	NP_777001.1	phosphatidylinositol 3-kinase regulatory subunit beta

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PIK3R2	XP_512509.2
Gallus gallus (chicken)	PIK3R2	XP_001233341.3
Xenopus tropicalis (tropical clawed frog)	pik3r2	XP_002934855.2
Homo sapiens (human)	PIK3R2	NP_005018.1
	PIK3R2	XP_001114094.1
Danio rerio (zebrafish)	pik3r2	NP_997987.1
Canis lupus familiaris (dog)	PIK3R2	XP_852406.2
Rattus norvegicus (Norway rat)	Pik3r2	NP_071521.2
Bos taurus (cattle)	PIK3R2	NP_777001.1
Mus musculus (house mouse)	Pik3r2	NP_032867.2

Gene Ontology
Bibliography

Related articles in PubMed

Insulin stimulates glucose uptake via a phosphatidylinositide 3-kinase-linked signaling pathway in bovine mammary epithelial cells.
Zhao K, Liu HY, Zhou MM, Zhao FQ, Liu JX
Journal of dairy science97(6)3660-5(2014)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation.
Hale BG, Batty IH, Downes CP, Randall RE
The Journal of biological chemistry283(3)1372-80(2008 Jan)

Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling.
Hale BG, Jackson D, Chen YH, Lamb RA, Randall RE
Proceedings of the National Academy of Sciences of the United States of America103(38)14194-9(2006 Sep)

Localization of the insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments.
Rajala RV, Elliott MH, McClellan ME, Anderson RE
Advances in experimental medicine and biology572491-7(2006)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest a model by which NS1 activates PI3K catalytic activity by masking a normal regulatory element specific to the p85beta inter-SH2 domain.
Title: Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation.

Results report that influenza A virus NS1 binds directly to p85beta, a regulatory subunit of phosphatidylinositol-3-kinase (PI3K), but not to the related p85alpha subunit.
Title: Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling.

insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments
Title: Localization of the insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments.

The following PIK3R2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PIK3R2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa43019	NM_174576.2 Latest version!	Bos taurus phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PIK3R2 ( NM_174576.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_777001.1 Bos taurus phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2), mRNA.

Price & Availability↑

CloneID	OBa43019
Clone ID Related Accession (Same CDS sequence)	NM_174576.2
Accession Version	NM_174576.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2175bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Bos taurus(cattle)
Product	phosphatidylinositol 3-kinase regulatory subunit beta
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC118113.1. On Jul 14, 2006 this sequence version replaced NM_174576.1. ##Evidence-Data-START## Transcript exon combination :: BC118113.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145412, SAMN03145413 [ECO:0000350] ##Evidence-Data-END##

ATGGCTGGCC CTGAGGGCTT CCAATACCGT GCATTGTACC CATTCCGCCG GGAGAGGCCG 
GAGGACCTGG AGCTGCTTCC GGGTGATGTG CTGGTGGTGA GCAGGGCCGC CCTGCAGGCG 
CTGGGCGTGG CCGAGGGCAA CGAGCGCTGC CCGCAGAGCG TAGGCTGGAT GCCTGGCCTC 
AATGAGCGTA CCCGGCAGCG CGGCGACTTC CCTGGCACCT ATGTGGAGTT CCTGGGGCCC 
GTGGCCCTGG CCCGGCCTGG CCCTCGCCCA CGTGGCCCCC GCCCACTGCC CGCCAGGCCC 
CGAGACGGGC CCCCTGAGCC AGGCCTTACA CTCCCTGACC TACCCGAGCA GTTCTCCCCC 
CCTGATGTGG CTCCCCCTAT CCTGGTGAAG CTGGTGGAGG CCATTGAACG GACAGGGCTG 
GACAGCTACA GGCCTGAGCC ACCCGCCGTG CGCACAGACT GGTCCCTGAG TGATGTGGAG 
CAGTGGGATG CGGCAGCCCT GTCAGATGGT GTGAAAGGCT TCCTGCTGGC GCTGCCAGCG 
CCCCTCGTGA CACCCGAGGC TGCGGCCGAG GCACACCGAG CCCTGCGGGA GGCTGCGGGG 
CCCGTGGGGC CGGCGTTGGA GCCCCCGACG CTGCCACTGC ACCATGCGCT CACGCTGCGC 
TTCCTGCTCC AGCACCTGGG CCGGGTGGCC GGGCGCGCCC CAGCCCCGGG CCCCGCGGTC 
CGTGCCCTGG GCGCCACCTT CGGGCCGCTG CTGCTACGCG CGCCGCCGCC GCCCTCTCCG 
CCGCCAGGGG GCGCACCCGA CGGGACCGAG CCCACCCCCG ACTTTCCTGC GCTGCTGGTG 
GAGAAGCTGC TTCAGGAACA TCTGGAGGAG CAGGAGGTTG CCCCCCCAGC ACTGCCACCA 
AAACCCCCCA AGACAAAGCC AGCCCCCACA GGCCTGGCCA ATGGGGGCAG CCCACCCTCC 
CTGCAGGACG CCGAGTGGTA CTGGGGTGAC ATCTCCAGGG AGGAGGTAAA CGAGAAACTG 
CGGGACACGC CCGATGGCAC CTTCCTGGTC CGAGATGCCT CCAGCAAGAT CCAGGGAGAG 
TACACGCTGA CCCTCAGGAA AGGCGGAAAC AACAAGCTGA TCAAGGTCTT CCACCGAGAT 
GGGCACTACG GCTTCTCGGA GCCGCTCACC TTCTGCTCTG TCGTGGACCT CATCACCCAC 
TACCGCCATG AGTCACTGGC CCAGTACAAC GCCAAGCTGG ACACGCGGCT CCTCTACCCA 
GTGTCCAAGT ACCAACAGGA CCAGATCGTC AAGGAGGACA GCGTGGAGGC GGTGGGTGCC 
CAGCTCAAGG TCTACCACCA GCAGTACCAG GACAAGAGCC GCGAGTACGA CCAGCTCTAC 
GAGGAGTACA CACGCACCTC CCAGGAACTG CAGATGAAGC GCACAGCCAT CGAAGCCTTC 
AATGAGACCA TCAAGATCTT TGAAGAGCAG GGCCAGACGC AGGAGAAGTG CAGCAAGGAA 
TACCTGGAGC GCTTCCGACG TGAGGGCAAT GAGAAAGAAA TGCAGAGGAT CCTGCTAAAC 
TCGGAGCGGC TCAAGTCTCG CATTGCCGAG ATCCACGAGA GTCGCACAAA GCTGGAGCAG 
GAGCTGCGGG CACAGGCCTC TGACAACCGA GAGATCGACA AGCGCATGAA CAGCCTCAAG 
CCAGACCTCA TGCAGTTGCG CAAGATCCGA GACCAGTACC TTGTGTGGCT CACTCAGAAG 
GGTGCCCGGC AGAAGAAAAT CAACGAATGG TTGGGGATCA AGAACGAGAC TGAGGACCAG 
TACTCACTGA TGGAGGATGA GGATGACCTC CCCCACCACG AGGAACGCAC CTGGTATGTA 
GGCAAGATCA ACCGCACCCA AGCTGAGGAA ATGCTGAGTG GCAAGCGGGA CGGTACCTTC 
CTCATCCGTG AGAGCAGCCA GCGGGGTTGC TACGCCTGTT CTGTGGTGGT GGACGGGGAT 
ACCAAGCACT GCGTCATCTA CCGCACGGCC ACCGGCTTCG GCTTCGCGGA GCCCTACAAC 
CTGTACGGGT CCCTGAAGGA GCTCGTCCTC CACTACCAGC ACGCCTCGCT GGTGCAGCAC 
AACGACGCGC TGACCGTCAC GCTCGCCCAC CCCGTGCGCG CCCCCGGCCC TGGGCCCCCG 
CCGGCTGCGC GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_777001.1
CDS	498..2672
Translation	MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGNERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLTLPDLPEQFSPPDVAPPILVKLVEAIERTGLDSYRPEPPAVRTDWSLSDVEQWDAAALSDGVKGFLLALPAPLVTPEAAAEAHRALREAAGPVGPALEPPTLPLHHALTLRFLLQHLGRVAGRAPAPGPAVRALGATFGPLLLRAPPPPSPPPGGAPDGTEPTPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKTKPAPTGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYSLMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR

Target ORF information:

RefSeq Version	NM_174576.2
Organism	Bos taurus(cattle)
Definition	Bos taurus phosphoinositide-3-kinase regulatory subunit 2 (PIK3R2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174576.2

ORF Insert Sequence:

ATGGCTGGCC CTGAGGGCTT CCAATACCGT GCATTGTACC CATTCCGCCG GGAGAGGCCG 
GAGGACCTGG AGCTGCTTCC GGGTGATGTG CTGGTGGTGA GCAGGGCCGC CCTGCAGGCG 
CTGGGCGTGG CCGAGGGCAA CGAGCGCTGC CCGCAGAGCG TAGGCTGGAT GCCTGGCCTC 
AATGAGCGTA CCCGGCAGCG CGGCGACTTC CCTGGCACCT ATGTGGAGTT CCTGGGGCCC 
GTGGCCCTGG CCCGGCCTGG CCCTCGCCCA CGTGGCCCCC GCCCACTGCC CGCCAGGCCC 
CGAGACGGGC CCCCTGAGCC AGGCCTTACA CTCCCTGACC TACCCGAGCA GTTCTCCCCC 
CCTGATGTGG CTCCCCCTAT CCTGGTGAAG CTGGTGGAGG CCATTGAACG GACAGGGCTG 
GACAGCTACA GGCCTGAGCC ACCCGCCGTG CGCACAGACT GGTCCCTGAG TGATGTGGAG 
CAGTGGGATG CGGCAGCCCT GTCAGATGGT GTGAAAGGCT TCCTGCTGGC GCTGCCAGCG 
CCCCTCGTGA CACCCGAGGC TGCGGCCGAG GCACACCGAG CCCTGCGGGA GGCTGCGGGG 
CCCGTGGGGC CGGCGTTGGA GCCCCCGACG CTGCCACTGC ACCATGCGCT CACGCTGCGC 
TTCCTGCTCC AGCACCTGGG CCGGGTGGCC GGGCGCGCCC CAGCCCCGGG CCCCGCGGTC 
CGTGCCCTGG GCGCCACCTT CGGGCCGCTG CTGCTACGCG CGCCGCCGCC GCCCTCTCCG 
CCGCCAGGGG GCGCACCCGA CGGGACCGAG CCCACCCCCG ACTTTCCTGC GCTGCTGGTG 
GAGAAGCTGC TTCAGGAACA TCTGGAGGAG CAGGAGGTTG CCCCCCCAGC ACTGCCACCA 
AAACCCCCCA AGACAAAGCC AGCCCCCACA GGCCTGGCCA ATGGGGGCAG CCCACCCTCC 
CTGCAGGACG CCGAGTGGTA CTGGGGTGAC ATCTCCAGGG AGGAGGTAAA CGAGAAACTG 
CGGGACACGC CCGATGGCAC CTTCCTGGTC CGAGATGCCT CCAGCAAGAT CCAGGGAGAG 
TACACGCTGA CCCTCAGGAA AGGCGGAAAC AACAAGCTGA TCAAGGTCTT CCACCGAGAT 
GGGCACTACG GCTTCTCGGA GCCGCTCACC TTCTGCTCTG TCGTGGACCT CATCACCCAC 
TACCGCCATG AGTCACTGGC CCAGTACAAC GCCAAGCTGG ACACGCGGCT CCTCTACCCA 
GTGTCCAAGT ACCAACAGGA CCAGATCGTC AAGGAGGACA GCGTGGAGGC GGTGGGTGCC 
CAGCTCAAGG TCTACCACCA GCAGTACCAG GACAAGAGCC GCGAGTACGA CCAGCTCTAC 
GAGGAGTACA CACGCACCTC CCAGGAACTG CAGATGAAGC GCACAGCCAT CGAAGCCTTC 
AATGAGACCA TCAAGATCTT TGAAGAGCAG GGCCAGACGC AGGAGAAGTG CAGCAAGGAA 
TACCTGGAGC GCTTCCGACG TGAGGGCAAT GAGAAAGAAA TGCAGAGGAT CCTGCTAAAC 
TCGGAGCGGC TCAAGTCTCG CATTGCCGAG ATCCACGAGA GTCGCACAAA GCTGGAGCAG 
GAGCTGCGGG CACAGGCCTC TGACAACCGA GAGATCGACA AGCGCATGAA CAGCCTCAAG 
CCAGACCTCA TGCAGTTGCG CAAGATCCGA GACCAGTACC TTGTGTGGCT CACTCAGAAG 
GGTGCCCGGC AGAAGAAAAT CAACGAATGG TTGGGGATCA AGAACGAGAC TGAGGACCAG 
TACTCACTGA TGGAGGATGA GGATGACCTC CCCCACCACG AGGAACGCAC CTGGTATGTA 
GGCAAGATCA ACCGCACCCA AGCTGAGGAA ATGCTGAGTG GCAAGCGGGA CGGTACCTTC 
CTCATCCGTG AGAGCAGCCA GCGGGGTTGC TACGCCTGTT CTGTGGTGGT GGACGGGGAT 
ACCAAGCACT GCGTCATCTA CCGCACGGCC ACCGGCTTCG GCTTCGCGGA GCCCTACAAC 
CTGTACGGGT CCCTGAAGGA GCTCGTCCTC CACTACCAGC ACGCCTCGCT GGTGCAGCAC 
AACGACGCGC TGACCGTCAC GCTCGCCCAC CCCGTGCGCG CCCCCGGCCC TGGGCCCCCG 
CCGGCTGCGC GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Insulin stimulates glucose uptake via a phosphatidylinositide 3-kinase-linked signaling pathway in bovine mammary epithelial cells.
Journal of dairy science97(6)3660-5(2014)
Zhao K,Liu HY,Zhou MM,Zhao FQ,Liu JX

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation.
The Journal of biological chemistry283(3)1372-80(2008 Jan)
Hale BG,Batty IH,Downes CP,Randall RE

Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling.
Proceedings of the National Academy of Sciences of the United States of America103(38)14194-9(2006 Sep)
Hale BG,Jackson D,Chen YH,Lamb RA,Randall RE

Localization of the insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments.
Advances in experimental medicine and biology572491-7(2006)
Rajala RV,Elliott MH,McClellan ME,Anderson RE

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PIK3R2 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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