PAG1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	PAG1
Entrez Gene ID	281964
Full Name	pregnancy-associated glycoprotein 1
Synonyms	PAG1B
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174411.2	NP_776836.1	pregnancy-associated glycoprotein 1 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Crosstalk between uterine serpin (SERPINA14) and pregnancy-associated glycoproteins at the fetal-maternal interface in pregnant dairy heifers experimentally infected with Neospora caninum.
Serrano-P?rez B, Hansen PJ, Mur-Novales R, Garc?a-Ispierto I, de Sousa NM, Beckers JF, Almer?a S, L?pez-Gatius F
Theriogenology86(3)824-30(2016 Aug)

Experimental Neospora Caninum Infection in Pregnant Dairy Heifers Raises Concentrations of Pregnancy-Associated Glycoproteins 1 and 2 in Foetal Fluids.
Mur-Novales R, L?pez-Gatius F, Serrano-P?rez B, Garc?a-Ispierto I, Darwich L, Cabez?n O, de Sousa NM, Beckers JF, Almer?a S
Reproduction in domestic animals = Zuchthygiene51(2)282-6(2016 Apr)

Gamma interferon production and plasma concentrations of pregnancy-associated glycoproteins 1 and 2 in gestating dairy cows naturally infected with Neospora caninum.
Serrano-P?rez B, Garcia-Ispierto I, de Sousa NM, Beckers JF, Almer?a S, L?pez-Gatius F
Reproduction in domestic animals = Zuchthygiene49(2)275-80(2014 Apr)

Effect of restraint stress on plasma concentrations of cortisol, progesterone and pregnancy associated-glycoprotein-1 in pregnant heifers during late embryonic development.
Szenci O, Karen A, Bajcsy AC, G?sp?rdy A, de Sousa NM, Beckers JF
Theriogenology76(8)1380-5(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study examines expression patterns of the genes SERPINA14, PAG, and PAG2 at the fetal-maternal interface in dairy heifers experimentally infected with N caninum during the second trimester of pregnancy, when most abortions takes place in natural conditions.
Title: Crosstalk between uterine serpin (SERPINA14) and pregnancy-associated glycoproteins at the fetal-maternal interface in pregnant dairy heifers experimentally infected with Neospora caninum.

The clinical implications of these findings are that following infection with N. caninum, most cows will experience some level of placental damage and that this injury correlates with foetal fluid PAG levels and pH.
Title: Experimental Neospora Caninum Infection in Pregnant Dairy Heifers Raises Concentrations of Pregnancy-Associated Glycoproteins 1 and 2 in Foetal Fluids.

These findings indicate that IFN-gamma production correlates negatively and the production of antibodies against N. caninum is uncorrelated with plasma pregnancy-associated glycoproteins levels.
Title: Gamma interferon production and plasma concentrations of pregnancy-associated glycoproteins 1 and 2 in gestating dairy cows naturally infected with Neospora caninum.

Restraint stress for 2 h during early pregnancy in heifers increased blood cortisol, but it did not affect the concentrations of progesterone and PAG-1 between days 30 to 40 of gestation.
Title: Effect of restraint stress on plasma concentrations of cortisol, progesterone and pregnancy associated-glycoprotein-1 in pregnant heifers during late embryonic development.

The following PAG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PAG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41820	NM_174411.2 Latest version!	Bos taurus pregnancy-associated glycoprotein 1 (PAG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PAG1 ( NM_174411.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776836.1 Bos taurus pregnancy-associated glycoprotein 1 (PAG1), mRNA.

Price & Availability↑

CloneID	OBa41820
Clone ID Related Accession (Same CDS sequence)	NM_174411.2
Accession Version	NM_174411.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Bos taurus(cattle)
Product	pregnancy-associated glycoprotein 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M73962.1. On Jun 3, 2003 this sequence version replaced NM_174411.1. ##Evidence-Data-START## Transcript exon combination :: M73962.1, BC134743.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145448 [ECO:0000350] ##Evidence-Data-END##

ATGAAGTGGC TTGTGCTCCT CGGGCTGGTG GCCTTCTCAG AGTGCATAGT CAAAATACCT 
CTAAGGAGAC TGAAGACCAT GAGAAATGTC GTCAGTGGAA AAAACATGCT GAACAATTTT 
CTGAAGGAGC ATGCTTACAG TCTGTCCCAG ATTTCTTTTC GTGGCTCAAA TCTAACTACT 
CACCCGCTGA GAAACATCAA GGATTTGGTC TACATGGGTA ACATCACCAT TGGAACACCC 
CCTCAGGAAT TCCAGGTTGT CTTTGACACA GCCTCATCTG ACTTGTGGGT GCCCTCCGAC 
TTTTGCACTA GTCCAGCCTG TTCTACACAC GTTAGGTTCA GACATCTTCA GTCTTCCACT 
TTCCGGCTTA CCAATAAGAC CTTCAGGATC ACCTATGGAT CTGGGAGAAT GAAAGGAGTT 
GTTGTTCATG ACACAGTTCG GATTGGGAAC CTTGTAAGTA CTGACCAGCC ATTTGGTCTA 
AGCATTGAGG AATACGGGTT TGAGGGCAGA ATTTATGATG GTGTCTTGGG CTTGAACTAC 
CCCAACATAT CCTTCTCTGG AGCCATCCCC ATCTTTGACA AGCTGAAGAA TCAACGTGCC 
ATTTCTGAGC CTGTTTTTGC CTTCTACTTG AGCAAAGATG AGCGGGAGGG CAGTGTGGTG 
ATGTTTGGTG GGGTGGACCA CCGCTATTAT GAGGGAGAGC TCAACTGGGT ACCCCTGATC 
CAAGCAGGCG ACTGGAGTGT ACACATGGAC CGCATCTCCA TTGAAAGAAA GATTATTGCT 
TGTTCTGATG GCTGCAAGGC CCTTGTGGAC ACCGGGACAT CAGATATCGT AGGTCCAAGA 
AGACTGGTCA ATAACATCCA TAGGCTCATC GGTGCCATAC CACGGGGTTC CGAGCACTAC 
GTTCCATGTT CTGAGGTCAA TACCCTGCCC TCTATTGTCT TCACCATCAA CGGCATCAAC 
TACCCAGTGC CAGGTCGAGC CTACATCCTC AAGGATGATA GAGGCCGCTG CTATACCACC 
TTTCAAGAGA ACCGAGTGAG TTCATCTACA GAGACCTGGT ACCTGGGTGA CGTCTTCCTG 
AGACTGTATT TCTCGGTCTT TGATCGAGGA AATGACAGAA TTGGCCTGGC ACGGGCAGTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776836.1
CDS	21..1163
Translation	MKWLVLLGLVAFSECIVKIPLRRLKTMRNVVSGKNMLNNFLKEHAYSLSQISFRGSNLTTHPLRNIKDLVYMGNITIGTPPQEFQVVFDTASSDLWVPSDFCTSPACSTHVRFRHLQSSTFRLTNKTFRITYGSGRMKGVVVHDTVRIGNLVSTDQPFGLSIEEYGFEGRIYDGVLGLNYPNISFSGAIPIFDKLKNQRAISEPVFAFYLSKDEREGSVVMFGGVDHRYYEGELNWVPLIQAGDWSVHMDRISIERKIIACSDGCKALVDTGTSDIVGPRRLVNNIHRLIGAIPRGSEHYVPCSEVNTLPSIVFTINGINYPVPGRAYILKDDRGRCYTTFQENRVSSSTETWYLGDVFLRLYFSVFDRGNDRIGLARAV

Target ORF information:

RefSeq Version	NM_174411.2
Organism	Bos taurus(cattle)
Definition	Bos taurus pregnancy-associated glycoprotein 1 (PAG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174411.2

ORF Insert Sequence:

ATGAAGTGGC TTGTGCTCCT CGGGCTGGTG GCCTTCTCAG AGTGCATAGT CAAAATACCT 
CTAAGGAGAC TGAAGACCAT GAGAAATGTC GTCAGTGGAA AAAACATGCT GAACAATTTT 
CTGAAGGAGC ATGCTTACAG TCTGTCCCAG ATTTCTTTTC GTGGCTCAAA TCTAACTACT 
CACCCGCTGA GAAACATCAA GGATTTGGTC TACATGGGTA ACATCACCAT TGGAACACCC 
CCTCAGGAAT TCCAGGTTGT CTTTGACACA GCCTCATCTG ACTTGTGGGT GCCCTCCGAC 
TTTTGCACTA GTCCAGCCTG TTCTACACAC GTTAGGTTCA GACATCTTCA GTCTTCCACT 
TTCCGGCTTA CCAATAAGAC CTTCAGGATC ACCTATGGAT CTGGGAGAAT GAAAGGAGTT 
GTTGTTCATG ACACAGTTCG GATTGGGAAC CTTGTAAGTA CTGACCAGCC ATTTGGTCTA 
AGCATTGAGG AATACGGGTT TGAGGGCAGA ATTTATGATG GTGTCTTGGG CTTGAACTAC 
CCCAACATAT CCTTCTCTGG AGCCATCCCC ATCTTTGACA AGCTGAAGAA TCAACGTGCC 
ATTTCTGAGC CTGTTTTTGC CTTCTACTTG AGCAAAGATG AGCGGGAGGG CAGTGTGGTG 
ATGTTTGGTG GGGTGGACCA CCGCTATTAT GAGGGAGAGC TCAACTGGGT ACCCCTGATC 
CAAGCAGGCG ACTGGAGTGT ACACATGGAC CGCATCTCCA TTGAAAGAAA GATTATTGCT 
TGTTCTGATG GCTGCAAGGC CCTTGTGGAC ACCGGGACAT CAGATATCGT AGGTCCAAGA 
AGACTGGTCA ATAACATCCA TAGGCTCATC GGTGCCATAC CACGGGGTTC CGAGCACTAC 
GTTCCATGTT CTGAGGTCAA TACCCTGCCC TCTATTGTCT TCACCATCAA CGGCATCAAC 
TACCCAGTGC CAGGTCGAGC CTACATCCTC AAGGATGATA GAGGCCGCTG CTATACCACC 
TTTCAAGAGA ACCGAGTGAG TTCATCTACA GAGACCTGGT ACCTGGGTGA CGTCTTCCTG 
AGACTGTATT TCTCGGTCTT TGATCGAGGA AATGACAGAA TTGGCCTGGC ACGGGCAGTG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crosstalk between uterine serpin (SERPINA14) and pregnancy-associated glycoproteins at the fetal-maternal interface in pregnant dairy heifers experimentally infected with Neospora caninum.
Theriogenology86(3)824-30(2016 Aug)
Serrano-P?rez B,Hansen PJ,Mur-Novales R,Garc?a-Ispierto I,de Sousa NM,Beckers JF,Almer?a S,L?pez-Gatius F

Experimental Neospora Caninum Infection in Pregnant Dairy Heifers Raises Concentrations of Pregnancy-Associated Glycoproteins 1 and 2 in Foetal Fluids.
Reproduction in domestic animals = Zuchthygiene51(2)282-6(2016 Apr)
Mur-Novales R,L?pez-Gatius F,Serrano-P?rez B,Garc?a-Ispierto I,Darwich L,Cabez?n O,de Sousa NM,Beckers JF,Almer?a S

Gamma interferon production and plasma concentrations of pregnancy-associated glycoproteins 1 and 2 in gestating dairy cows naturally infected with Neospora caninum.
Reproduction in domestic animals = Zuchthygiene49(2)275-80(2014 Apr)
Serrano-P?rez B,Garcia-Ispierto I,de Sousa NM,Beckers JF,Almer?a S,L?pez-Gatius F

Effect of restraint stress on plasma concentrations of cortisol, progesterone and pregnancy associated-glycoprotein-1 in pregnant heifers during late embryonic development.
Theriogenology76(8)1380-5(2011 Nov)
Szenci O,Karen A,Bajcsy AC,G?sp?rdy A,de Sousa NM,Beckers JF

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PAG1 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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