LALBA cDNA ORF clone, Bos taurus(cattle)

Dimeric but not monomeric ?-lactalbumin potentiates apoptosis by up regulation of ATF3 and reduction of histone deacetylase activity in primary and immortalised cells.
Sharp JA, Brennan AJ, Polekhina G, Ascher DB, Lefevre C, Nicholas KR
Cellular signalling3386-97(2017 May)

Thermal Stabilization of Proteins by Mono- and Oligosaccharides: Measurement and Analysis in the Context of an Excluded Volume Model.
Beg I, Minton AP, Hassan I, Islam A, Ahmad F
Biochemistry54(23)3594-603(2015 Jun)

Macromolecular crowding induces holo ?-lactalbumin aggregation by converting to its apo form.
Mittal S, Singh LR
PloS one9(12)e114029(2014)

Association between a polymorphism of the ?-lactalbumin gene and milk production traits in Chinese Holstein cows.
Zhou JP, Dong CH
Genetics and molecular research : GMR12(3)3375-82(2013 Sep)

Amino acid sequence determinants in self-assembly of insulin chiral amyloid superstructures: role of C-terminus of B-chain in association of fibrils.
Babenko V, Dzwolak W
FEBS letters587(6)625-30(2013 Mar)

This study shows, for the first time, that alpha-lactalbumin isolated in a rare 28kDa dimeric form induces cell death, while 14kDa monomeric alpha-lactalbumin is inactive.
Title: Dimeric but not monomeric ?-lactalbumin potentiates apoptosis by up regulation of ATF3 and reduction of histone deacetylase activity in primary and immortalised cells.

Data suggest that stabilization of apo-alpha-lactalbumin by mono- and oligo-saccharides can be accounted for by simplified statistical-thermodynamic model considering volume exclusion deriving from steric repulsion between protein and saccharides.
Title: Thermal Stabilization of Proteins by Mono- and Oligosaccharides: Measurement and Analysis in the Context of an Excluded Volume Model.

Macromolecular crowding reduces the calcium binding affinity of holo-lactalbumin alpha resulting in the formation of apo-lactalbumin alpha (the calcium-depleted form of holo-LA) leading to aggregate formation.
Title: Macromolecular crowding induces holo ?-lactalbumin aggregation by converting to its apo form.

These findings suggest that the SNP alpha-LA2516 in the alpha-LA gene likely does not have potential as a molecular marker for milk production traits in Chinese Holstein cows.
Title: Association between a polymorphism of the ?-lactalbumin gene and milk production traits in Chinese Holstein cows.

alphaLA forms a misfolded disulfide bond shuffled isomer, X-alphaLA which represents a different low energy fold for the protein; binding calcium plays an important role in both maintaining the native structure of alphaLA and providing a mechanism for distinguishing between folded and misfolded species.
Title: Characterization of an alternative low energy fold for bovine ?-lactalbumin formed by disulfide bond shuffling.