CXCR1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	CXCR1
Entrez Gene ID	281863
Full Name	chemokine (C-X-C motif) receptor 1
Synonyms	CXCR2,IL8RA,IL8RB
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174360.2	NP_776785.1	C-X-C chemokine receptor type 2
XM_024998731.1	XP_024854499.1	C-X-C chemokine receptor type 2 isoform X1
NM_174360.3	NP_776785.2	C-X-C chemokine receptor type 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CXCR2	NP_001096131.1
Canis lupus familiaris (dog)	CXCR1	XP_005640697.1
Rattus norvegicus (Norway rat)	Cxcr2	NP_058879.1
Xenopus tropicalis (tropical clawed frog)	LOC101732165	XP_004917676.1
Canis lupus familiaris (dog)	CXCR2	NP_001003151.1
	IL8RB	XP_001088762.2
Bos taurus (cattle)	CXCR2	NP_776785.1
Mus musculus (house mouse)	Cxcr2	NP_034039.1
Danio rerio (zebrafish)	LOC796724	XP_001337093.2
Homo sapiens (human)	CXCR2	NP_001161770.1

Gene Ontology
Bibliography

Related articles in PubMed

Case-control approach application for finding a relationship between candidate genes and clinical mastitis in Holstein dairy cattle.
Bagheri M, Moradi-Sharhrbabak M, Miraie-Ashtiani R, Safdari-Shahroudi M, Abdollahi-Arpanahi R
Journal of applied genetics57(1)107-12(2016 Feb)

Methylation analysis of CXCR1 in mammary gland tissue of cows with mastitis induced by Staphylococcus aureus.
Mao YJ, Zhu XR, Li R, Chen D, Xin SY, Zhu YH, Liao XX, Wang XL, Zhang HM, Yang ZP, Yang LG
Genetics and molecular research : GMR14(4)12606-15(2015 Oct)

Somatic cell count and milk neutrophil viability of dairy heifers with specific CXCR1 genotypes following experimental intramammary infection with Staphylococcus chromogenes originating from milk.
Verbeke J, Piccart K, Piepers S, Van Poucke M, Peelman L, De Visscher A, De Vliegher S
Veterinary journal (London, England : 1997)204(3)322-6(2015 Jun)

Reactive oxygen species generation by bovine blood neutrophils with different CXCR1 (IL8RA) genotype following Interleukin-8 incubation.
Verbeke J, Boulougouris X, Rogiers C, Burvenich C, Peelman L, De Spiegeleer B, De Vliegher S
BMC veterinary research11104(2015 May)

Association of CXCR1 polymorphisms with apoptosis, necrosis and concentration of milk neutrophils in early lactating dairy heifers.
Verbeke J, Piepers S, Peelman L, Van Poucke M, De Vliegher S
Research in veterinary science97(1)55-9(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Polymorphisms in CXCR1 are significantly associated with bovine mastitis
Title: Case-control approach application for finding a relationship between candidate genes and clinical mastitis in Holstein dairy cattle.

(PCR) was used to detect the methylation status of CXCR1 CpG island, and quantitative fluorescence PCR was used to detect CXCR1 expression in bovine mammary tissue
Title: Methylation analysis of CXCR1 in mammary gland tissue of cows with mastitis induced by Staphylococcus aureus.

The results demonstrate that CXCR1 polymorphism can influence somatic cell count and milk neutrophil viability following experimental mastitis.
Title: Somatic cell count and milk neutrophil viability of dairy heifers with specific CXCR1 genotypes following experimental intramammary infection with Staphylococcus chromogenes originating from milk.

In the present study no association could be detected between superoxide production by isolated bovine neutrophils during early lactation and CXCR1 gene polymorphism. IL-8 showed to possess inhibitory effects on ROS generation in bovine neutrophils.
Title: Reactive oxygen species generation by bovine blood neutrophils with different CXCR1 (IL8RA) genotype following Interleukin-8 incubation.

CXCR1 polymorphisms influence viability and concentration of milk polymorphonuclear neutrophilic leukocytes.
Title: Association of CXCR1 polymorphisms with apoptosis, necrosis and concentration of milk neutrophils in early lactating dairy heifers.

The following CXCR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OBa02372	NM_174360.2 Latest version!	Bos taurus chemokine (C-X-C motif) receptor 1 (CXCR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OBa216424	NM_174360.3 Latest version!	Bos taurus chemokine (C-X-C motif) receptor 1 (CXCR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$258.30 $369.00
OBa227158	XM_024998731.1 Latest version!	Bos taurus chemokine (C-X-C motif) receptor 1 (CXCR1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CXCR1 ( NM_174360.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776785.1 Bos taurus chemokine (C-X-C motif) receptor 1 (CXCR1), mRNA.

Price & Availability↑

CloneID	OBa02372
Clone ID Related Accession (Same CDS sequence)	NM_174360.2
Accession Version	NM_174360.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-03-01
Organism	Bos taurus(Cattle)
Product	C-X-C chemokine receptor type 2
Comment	PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U19947.1. On Jun 3, 2003 this sequence version replaced NM_174360.1. ##Evidence-Data-START## Transcript exon combination :: U19947.1 [ECO:0000332] ##Evidence-Data-END##

ATGACAATCA TCCTGAAAGA TTTATCTAAT AGCAGTATTT TGTGGGAGGG GTTTGAGGAT 
GAGTTTGGAA ATTACAGCGG CACGCCACCC ACAGAAGACT ATGATTATAG TCCCTGTGAG 
ATAAGCACTG AGACACTCAA CAAGTATGCT GTGGTCGTCA TCGATGCCCT GGTCTTCTTG 
CTAAGCCTCC TGGGAAACTC CCTGGTGATG CTGGTCATCT TATACAGCCG GATTGGTCGC 
TCTGTCACTG ATGTCTACCT GCTGAACCTG GCCATGGCTG ACCTGCTCTT CGCCATGACC 
TTGCCTATCT GGACCGCCTC CAAGGCAAAG GGTTGGGTCT TCGGCACACC CCTGTGCAAG 
GTGGTCTCAC TCCTGAAGGA AGTGAACTTC TACAGCGGTA TTCTACTGCT GGCCTGCATC 
AGCATGGACC GCTACCTGGC CATTGTCCAT GCCACACGCA CGCTGACCCA GAAGTGGCAC 
TGGGTCAAGT TCATATGTTT AGGCATCTGG GCCCTGTCCG TGATCCTGGC CCTGCCCATC 
TTCATCTTCC GTGAGGCCTA TCAACCACCG TACTCCGACC TAGTCTGCTA CGAGGACCTG 
GGTGCCAATA CAACGAAATG GCGGATGATA ATGCGTGTCC TGCCCCAGAC CTTTGGCTTC 
CTCCTGCCCC TGCTGGTCAT GCTGTTCTGC TACGGATTCA CCCTGCGCAC GCTATTTTCA 
GCCCAAATGG GGCACAAGCA CCGGGCCATG CGGGTCATCT TTGCTGTCGT GCTCGTCTTC 
CTGCTCTGCT GGCTGCCCTA CAACCTGGTC CTGATCGCGG ACACCCTCAT GAGGGCCCAT 
GTGATTGCTG AGACCTGTCA GCGCCGCAAT GACATTGGCC GGGCCCTGGA TGCCACCGAG 
ATCCTGGGCT TCCTGCACAG CTGCCTCAAC CCCCTCATCT ACGTCTTCAT TGGCCAGAAG 
TTTCGCCACG GACTCCTCAA GATCATGGCC ATCCATGGCC TGATCAGCAA GGAGTTCTTG 
GCCAAGGATG GCAGGCCTTC CTTTGTTGGC TCTTCTTCAG GGAACACGTC TACTACCCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776785.1
CDS	43..1125
Translation	MTIILKDLSNSSILWEGFEDEFGNYSGTPPTEDYDYSPCEISTETLNKYAVVVIDALVFLLSLLGNSLVMLVILYSRIGRSVTDVYLLNLAMADLLFAMTLPIWTASKAKGWVFGTPLCKVVSLLKEVNFYSGILLLACISMDRYLAIVHATRTLTQKWHWVKFICLGIWALSVILALPIFIFREAYQPPYSDLVCYEDLGANTTKWRMIMRVLPQTFGFLLPLLVMLFCYGFTLRTLFSAQMGHKHRAMRVIFAVVLVFLLCWLPYNLVLIADTLMRAHVIAETCQRRNDIGRALDATEILGFLHSCLNPLIYVFIGQKFRHGLLKIMAIHGLISKEFLAKDGRPSFVGSSSGNTSTTL

Target ORF information:

RefSeq Version	NM_174360.2
Organism	Bos taurus(Cattle)
Definition	Bos taurus chemokine (C-X-C motif) receptor 1 (CXCR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174360.2

ORF Insert Sequence:

ATGACAATCA TCCTGAAAGA TTTATCTAAT AGCAGTATTT TGTGGGAGGG GTTTGAGGAT 
GAGTTTGGAA ATTACAGCGG CACGCCACCC ACAGAAGACT ATGATTATAG TCCCTGTGAG 
ATAAGCACTG AGACACTCAA CAAGTATGCT GTGGTCGTCA TCGATGCCCT GGTCTTCTTG 
CTAAGCCTCC TGGGAAACTC CCTGGTGATG CTGGTCATCT TATACAGCCG GATTGGTCGC 
TCTGTCACTG ATGTCTACCT GCTGAACCTG GCCATGGCTG ACCTGCTCTT CGCCATGACC 
TTGCCTATCT GGACCGCCTC CAAGGCAAAG GGTTGGGTCT TCGGCACACC CCTGTGCAAG 
GTGGTCTCAC TCCTGAAGGA AGTGAACTTC TACAGCGGTA TTCTACTGCT GGCCTGCATC 
AGCATGGACC GCTACCTGGC CATTGTCCAT GCCACACGCA CGCTGACCCA GAAGTGGCAC 
TGGGTCAAGT TCATATGTTT AGGCATCTGG GCCCTGTCCG TGATCCTGGC CCTGCCCATC 
TTCATCTTCC GTGAGGCCTA TCAACCACCG TACTCCGACC TAGTCTGCTA CGAGGACCTG 
GGTGCCAATA CAACGAAATG GCGGATGATA ATGCGTGTCC TGCCCCAGAC CTTTGGCTTC 
CTCCTGCCCC TGCTGGTCAT GCTGTTCTGC TACGGATTCA CCCTGCGCAC GCTATTTTCA 
GCCCAAATGG GGCACAAGCA CCGGGCCATG CGGGTCATCT TTGCTGTCGT GCTCGTCTTC 
CTGCTCTGCT GGCTGCCCTA CAACCTGGTC CTGATCGCGG ACACCCTCAT GAGGGCCCAT 
GTGATTGCTG AGACCTGTCA GCGCCGCAAT GACATTGGCC GGGCCCTGGA TGCCACCGAG 
ATCCTGGGCT TCCTGCACAG CTGCCTCAAC CCCCTCATCT ACGTCTTCAT TGGCCAGAAG 
TTTCGCCACG GACTCCTCAA GATCATGGCC ATCCATGGCC TGATCAGCAA GGAGTTCTTG 
GCCAAGGATG GCAGGCCTTC CTTTGTTGGC TCTTCTTCAG GGAACACGTC TACTACCCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CXCR1 ( NM_174360.3 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776785.2 Bos taurus chemokine (C-X-C motif) receptor 1 (CXCR1), mRNA.

Price & Availability↑

CloneID	OBa216424
Clone ID Related Accession (Same CDS sequence)	NM_174360.3
Accession Version	NM_174360.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Bos taurus(cattle)
Product	C-X-C chemokine receptor type 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from NKLS02000002.1. On or before Jun 3, 2017 this sequence version replaced NM_001105038.1, NM_174360.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM367082.1, CN794141.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04335746, SAMN04335749 [ECO:0000348] ##Evidence-Data-END##

ATGGTTGGTG ACTCAGTCTT TCAACCAGAT CACACCATGA CAATCATCCT GAAAGATTTA 
TCTAATAGCA GTATTTTGTG GGAGGGGTTT GAGGATGAGT TTGGAAATTA CAGCGGCACG 
CCACCCACAG AAGACTATGA TTATAGTCCC TGTGAGATAA GCACTGAGAC ACTCAACAAG 
TATGCTGTGG TCGTCATCTA TGCCCTGGTC TTCTTGCTAA GCCTCCTGGG AAACTCCCTG 
GTGATGCTGG TCATCTTATA CAGCCGGATT GGTCGCTCTG TCACTGATGT CTACCTGCTG 
AACCTGGCCA TGGCTGACCT GCTCTTCGCC ATGACCTTGC CTATCTGGGC CGCCTCCAAG 
GCAAAGGGTT GGGTCTTCGG CACACCCCTG TGCAAGGTGG TCTCACTCCT GAAGGAAGTG 
AACTTCTACA GCGGTATTCT ACTGCTGGCC TGCATCAGCA TGGACCGCTA CCTGGCCATT 
GTCCATGCCA CACGCACGCT GACCCAGAAG CGGCACTGGG TCAAGTTCAT ATGTTTAGGC 
ATCTGGGCCC TGTCCGTGAT CCTGGCCCTG CCCATCTTCA TCTTCCGTGA GGCCTATCAA 
CCACCGTACT CCGACCTAGT CTGCTACGAG GACCTGGGTG CCAATACAAC GAAATGGCGG 
ATGATAATGC GTGTCCTGCC CCAGACCTTT GGCTTCCTCC TGCCCCTGCT GGTCATGCTG 
TTCTGCTACG GATTCACCCT GCGCACGCTG TTTTCAGCCC AAATGGGGCA CAAGCACCGG 
GCCATGCGGG TCATCTTTGC TGTCGTGCTC GTCTTCCTGC TCTGCTGGCT GCCCTACAAC 
CTGGTCCTGA TCGCGGACAC CCTCATGAGG GCCCATGTGA TTGCTGAGAC CTGTCAGCGC 
CGCAATGACA TTGGCCGGGC CCTGGATGCC ACCGAGATCC TGGGCTTCCT GCACAGCTGC 
CTCAACCCCC TCATCTACGT CTTCATTGGC CAGAAGTTTC GCCACGGACT CCTCAAGATC 
ATGGCCATCC ATGGCCTGAT CAGCAAGGAG TTCTTGGCCA AGGATGGCAG GCCTTCCTTT 
GTTGGCTCTT CTTCAGGGAA CACGTCTACT ACCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776785.2
CDS	72..1190
Translation	MVGDSVFQPDHTMTIILKDLSNSSILWEGFEDEFGNYSGTPPTEDYDYSPCEISTETLNKYAVVVIYALVFLLSLLGNSLVMLVILYSRIGRSVTDVYLLNLAMADLLFAMTLPIWAASKAKGWVFGTPLCKVVSLLKEVNFYSGILLLACISMDRYLAIVHATRTLTQKRHWVKFICLGIWALSVILALPIFIFREAYQPPYSDLVCYEDLGANTTKWRMIMRVLPQTFGFLLPLLVMLFCYGFTLRTLFSAQMGHKHRAMRVIFAVVLVFLLCWLPYNLVLIADTLMRAHVIAETCQRRNDIGRALDATEILGFLHSCLNPLIYVFIGQKFRHGLLKIMAIHGLISKEFLAKDGRPSFVGSSSGNTSTTL

Target ORF information:

RefSeq Version	NM_174360.3
Organism	Bos taurus(cattle)
Definition	Bos taurus chemokine (C-X-C motif) receptor 1 (CXCR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174360.3

ORF Insert Sequence:

ATGGTTGGTG ACTCAGTCTT TCAACCAGAT CACACCATGA CAATCATCCT GAAAGATTTA 
TCTAATAGCA GTATTTTGTG GGAGGGGTTT GAGGATGAGT TTGGAAATTA CAGCGGCACG 
CCACCCACAG AAGACTATGA TTATAGTCCC TGTGAGATAA GCACTGAGAC ACTCAACAAG 
TATGCTGTGG TCGTCATCTA TGCCCTGGTC TTCTTGCTAA GCCTCCTGGG AAACTCCCTG 
GTGATGCTGG TCATCTTATA CAGCCGGATT GGTCGCTCTG TCACTGATGT CTACCTGCTG 
AACCTGGCCA TGGCTGACCT GCTCTTCGCC ATGACCTTGC CTATCTGGGC CGCCTCCAAG 
GCAAAGGGTT GGGTCTTCGG CACACCCCTG TGCAAGGTGG TCTCACTCCT GAAGGAAGTG 
AACTTCTACA GCGGTATTCT ACTGCTGGCC TGCATCAGCA TGGACCGCTA CCTGGCCATT 
GTCCATGCCA CACGCACGCT GACCCAGAAG CGGCACTGGG TCAAGTTCAT ATGTTTAGGC 
ATCTGGGCCC TGTCCGTGAT CCTGGCCCTG CCCATCTTCA TCTTCCGTGA GGCCTATCAA 
CCACCGTACT CCGACCTAGT CTGCTACGAG GACCTGGGTG CCAATACAAC GAAATGGCGG 
ATGATAATGC GTGTCCTGCC CCAGACCTTT GGCTTCCTCC TGCCCCTGCT GGTCATGCTG 
TTCTGCTACG GATTCACCCT GCGCACGCTG TTTTCAGCCC AAATGGGGCA CAAGCACCGG 
GCCATGCGGG TCATCTTTGC TGTCGTGCTC GTCTTCCTGC TCTGCTGGCT GCCCTACAAC 
CTGGTCCTGA TCGCGGACAC CCTCATGAGG GCCCATGTGA TTGCTGAGAC CTGTCAGCGC 
CGCAATGACA TTGGCCGGGC CCTGGATGCC ACCGAGATCC TGGGCTTCCT GCACAGCTGC 
CTCAACCCCC TCATCTACGT CTTCATTGGC CAGAAGTTTC GCCACGGACT CCTCAAGATC 
ATGGCCATCC ATGGCCTGAT CAGCAAGGAG TTCTTGGCCA AGGATGGCAG GCCTTCCTTT 
GTTGGCTCTT CTTCAGGGAA CACGTCTACT ACCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CXCR1 ( XM_024998731.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024854499.1 Bos taurus chemokine (C-X-C motif) receptor 1 (CXCR1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa227158
Clone ID Related Accession (Same CDS sequence)	XM_024998731.1
Accession Version	XM_024998731.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1140bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	C-X-C chemokine receptor type 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037329.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGAAGC TGATCCTTAA AGCAGCCTGT GACAGAGTCT TTCAACCAGA TCACACCATG 
ACAATCATCC TGAAAGATTT ATCTAATAGC AGTATTTTGT GGGAGGGGTT TGAGGATGAG 
TTTGGAAATT ACAGCGGCAC GCCACCCACA GAAGACTATG ATTATAGTCC CTGTGAGATA 
AGCACTGAGA CACTCAACAA GTATGCTGTG GTCGTCATCT ATGCCCTGGT CTTCTTGCTA 
AGCCTCCTGG GAAACTCCCT GGTGATGCTG GTCATCTTAT ACAGCCGGAT TGGTCGCTCT 
GTCACTGATG TCTACCTGCT GAACCTGGCC ATGGCTGACC TGCTCTTCGC CATGACCTTG 
CCTATCTGGG CCGCCTCCAA GGCAAAGGGT TGGGTCTTCG GCACACCCCT GTGCAAGGTG 
GTCTCACTCC TGAAGGAAGT GAACTTCTAC AGCGGTATTC TACTGCTGGC CTGCATCAGC 
ATGGACCGCT ACCTGGCCAT TGTCCATGCC ACACGCACGC TGACCCAGAA GCGGCACTGG 
GTCAAGTTCA TATGTTTAGG CATCTGGGCC CTGTCCGTGA TCCTGGCCCT GCCCATCTTC 
ATCTTCCGTG AGGCCTATCA ACCACCGTAC TCCGACCTAG TCTGCTACGA GGACCTGGGT 
GCCAATACAA CGAAATGGCG GATGATAATG CGTGTCCTGC CCCAGACCTT TGGCTTCCTC 
CTGCCCCTGC TGGTCATGCT GTTCTGCTAC GGATTCACCC TGCGCACGCT GTTTTCAGCC 
CAAATGGGGC ACAAGCACCG GGCCATGCGG GTCATCTTTG CTGTCGTGCT CGTCTTCCTG 
CTCTGCTGGC TGCCCTACAA CCTGGTCCTG ATCGCGGACA CCCTCATGAG GGCCCATGTG 
ATTGCTGAGA CCTGTCAGCG CCGCAATGAC ATTGGCCGGG CCCTGGATGC CACCGAGATC 
CTGGGCTTCC TGCACAGCTG CCTCAACCCC CTCATCTACG TCTTCATTGG CCAGAAGTTT 
CGCCACGGAC TCCTCAAGAT CATGGCCATC CATGGCCTGA TCAGCAAGGA GTTCTTGGCC 
AAGGATGGCA GGCCTTCCTT TGTTGGCTCT TCTTCAGGGA ACACGTCTAC TACCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024854499.1
CDS	111..1250
Translation	MMKLILKAACDRVFQPDHTMTIILKDLSNSSILWEGFEDEFGNYSGTPPTEDYDYSPCEISTETLNKYAVVVIYALVFLLSLLGNSLVMLVILYSRIGRSVTDVYLLNLAMADLLFAMTLPIWAASKAKGWVFGTPLCKVVSLLKEVNFYSGILLLACISMDRYLAIVHATRTLTQKRHWVKFICLGIWALSVILALPIFIFREAYQPPYSDLVCYEDLGANTTKWRMIMRVLPQTFGFLLPLLVMLFCYGFTLRTLFSAQMGHKHRAMRVIFAVVLVFLLCWLPYNLVLIADTLMRAHVIAETCQRRNDIGRALDATEILGFLHSCLNPLIYVFIGQKFRHGLLKIMAIHGLISKEFLAKDGRPSFVGSSSGNTSTTL

Target ORF information:

RefSeq Version	XM_024998731.1
Organism	Bos taurus(cattle)
Definition	Bos taurus chemokine (C-X-C motif) receptor 1 (CXCR1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024998731.1

ORF Insert Sequence:

ATGATGAAGC TGATCCTTAA AGCAGCCTGT GACAGAGTCT TTCAACCAGA TCACACCATG 
ACAATCATCC TGAAAGATTT ATCTAATAGC AGTATTTTGT GGGAGGGGTT TGAGGATGAG 
TTTGGAAATT ACAGCGGCAC GCCACCCACA GAAGACTATG ATTATAGTCC CTGTGAGATA 
AGCACTGAGA CACTCAACAA GTATGCTGTG GTCGTCATCT ATGCCCTGGT CTTCTTGCTA 
AGCCTCCTGG GAAACTCCCT GGTGATGCTG GTCATCTTAT ACAGCCGGAT TGGTCGCTCT 
GTCACTGATG TCTACCTGCT GAACCTGGCC ATGGCTGACC TGCTCTTCGC CATGACCTTG 
CCTATCTGGG CCGCCTCCAA GGCAAAGGGT TGGGTCTTCG GCACACCCCT GTGCAAGGTG 
GTCTCACTCC TGAAGGAAGT GAACTTCTAC AGCGGTATTC TACTGCTGGC CTGCATCAGC 
ATGGACCGCT ACCTGGCCAT TGTCCATGCC ACACGCACGC TGACCCAGAA GCGGCACTGG 
GTCAAGTTCA TATGTTTAGG CATCTGGGCC CTGTCCGTGA TCCTGGCCCT GCCCATCTTC 
ATCTTCCGTG AGGCCTATCA ACCACCGTAC TCCGACCTAG TCTGCTACGA GGACCTGGGT 
GCCAATACAA CGAAATGGCG GATGATAATG CGTGTCCTGC CCCAGACCTT TGGCTTCCTC 
CTGCCCCTGC TGGTCATGCT GTTCTGCTAC GGATTCACCC TGCGCACGCT GTTTTCAGCC 
CAAATGGGGC ACAAGCACCG GGCCATGCGG GTCATCTTTG CTGTCGTGCT CGTCTTCCTG 
CTCTGCTGGC TGCCCTACAA CCTGGTCCTG ATCGCGGACA CCCTCATGAG GGCCCATGTG 
ATTGCTGAGA CCTGTCAGCG CCGCAATGAC ATTGGCCGGG CCCTGGATGC CACCGAGATC 
CTGGGCTTCC TGCACAGCTG CCTCAACCCC CTCATCTACG TCTTCATTGG CCAGAAGTTT 
CGCCACGGAC TCCTCAAGAT CATGGCCATC CATGGCCTGA TCAGCAAGGA GTTCTTGGCC 
AAGGATGGCA GGCCTTCCTT TGTTGGCTCT TCTTCAGGGA ACACGTCTAC TACCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Case-control approach application for finding a relationship between candidate genes and clinical mastitis in Holstein dairy cattle.
Journal of applied genetics57(1)107-12(2016 Feb)
Bagheri M,Moradi-Sharhrbabak M,Miraie-Ashtiani R,Safdari-Shahroudi M,Abdollahi-Arpanahi R

Methylation analysis of CXCR1 in mammary gland tissue of cows with mastitis induced by Staphylococcus aureus.
Genetics and molecular research : GMR14(4)12606-15(2015 Oct)
Mao YJ,Zhu XR,Li R,Chen D,Xin SY,Zhu YH,Liao XX,Wang XL,Zhang HM,Yang ZP,Yang LG

Somatic cell count and milk neutrophil viability of dairy heifers with specific CXCR1 genotypes following experimental intramammary infection with Staphylococcus chromogenes originating from milk.
Veterinary journal (London, England : 1997)204(3)322-6(2015 Jun)
Verbeke J,Piccart K,Piepers S,Van Poucke M,Peelman L,De Visscher A,De Vliegher S

Reactive oxygen species generation by bovine blood neutrophils with different CXCR1 (IL8RA) genotype following Interleukin-8 incubation.
BMC veterinary research11104(2015 May)
Verbeke J,Boulougouris X,Rogiers C,Burvenich C,Peelman L,De Spiegeleer B,De Vliegher S

Association of CXCR1 polymorphisms with apoptosis, necrosis and concentration of milk neutrophils in early lactating dairy heifers.
Research in veterinary science97(1)55-9(2014 Aug)
Verbeke J,Piepers S,Peelman L,Van Poucke M,De Vliegher S

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CXCR1 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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